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Squamous Cell Carcinoma

Interpretations

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Tier 3
APC
Variants
APC E1317Q
APC codon(s) 1307 frameshift
Primary Sites
Lung
Tumor Types
Squamous Cell Carcinoma
Adenocarcinoma
Interpretation

APC mutations have been reported in lung squamous cell carcinoma and small-cell lung carcinoma, but rarely in lung adenocarcinoma. However, variants in the APC gene have not been well characterized in lung adenocarcinoma and their clinical significance is unclear. According to ClinVar, this particular variant is a likely benign germline variant (https://preview.ncbi.nlm.nih.gov/clinvar/variation/829/).

Last updated: 2019-02-22 18:05:35 UTC
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Tier 2
CDKN2A
Variants
CDKN2A W110*
CDKN2A Y129*
CDKN2A any frameshift
CDKN2A H83Y
CDKN2A codon(s) 58 frameshift
CDKN2A codon(s) 80 frameshift
CDKN2A D108H
Primary Sites
Lung
Tumor Types
Squamous Cell Carcinoma
Interpretation

Somatic mutations of CDKN2A are present in various tumor types, including, squamous cell carcinoma of the lung, clear cell sarcoma, head and neck cancer, melanoma and esophageal cancer. Majority of the CDKN2A mutations span exon 2 and result in loss or decreased binding to CDK4/6 leading to uncontrolled cell growth through inactivation of Rb and p53 pathways. Multiple preclinical and clinical studies are ongoing for CDKN2A deficient tumors in multiple tumor types.

Last updated: 2018-06-13 19:01:26 UTC
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Tier 2
EGFR
Variants
EGFR P753S
Primary Sites
Skin
Tumor Types
Squamous Cell Carcinoma
Interpretation

It is unclear what effect the EGFR P753S varaints has on the EGFR protein. However the location of the variant in the splice site acceptor of Exon 19 may activate the kinase domain. The identification of the EGFR P735S mutation in the context of a dramatic response to cetuximab in a patient with cutaneous squamous cell carcinoma, indicates a new potential pairing of EGFR mutation and targeted therapy for patients with cSCC.

Last updated: 2015-12-09 20:16:21 UTC
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Tier 2
KRAS
Variants
KRAS G12A
KRAS G12V
KRAS G12D
KRAS G12C
KRAS G12S
KRAS G12R
KRAS G13D
KRAS G13C
KRAS G13S
KRAS G13R
KRAS Q61H
KRAS Q61L
KRAS Q61K
KRAS Q61R
KRAS codon(s) 12, 13, 61, 117, 146 any
Primary Sites
Lung
Tumor Types
Squamous Cell Carcinoma
Interpretation

KRAS belongs to the RAS family of oncogenes. In lung, KRAS mutations are detected in approximately 20% to 25% of adenocarcinoma and less than 10% of squamous cell carcinoma which demonstrate a minor glandular component. KRAS mutations in NSCLC most often occur in codons 12 or 13 and with a lower frequency in codon 61. Mutations in KRAS are usually mutually exclusive with other oncogenic driver aberrations including EGFR, BRAF, HER2 mutations and ALK and ROS1 rearrangements. Contrary to most other oncogenic driver mutations, KRAS is more often found in smokers and is detected at lower frequency in East Asian patient cohorts. The prognostic as well as predictive role of KRAS mutations continues to be studied. Although various attempts inhibiting KRAS have been made, there is no established therapy specific for this large patient subpopulation. Recommend correlation with other clinical and lab findings.

Last updated: 2016-10-05 22:34:23 UTC
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Tier 2
PIK3CA
Variants
PIK3CA exon(s) 10, 20, 21 any
Primary Sites
Lung
Tumor Types
Adenocarcinoma
Squamous Cell Carcinoma
Interpretation

Somatic mutations in PIK3CA have been found in 1–3% of NSCLC. These mutations typically occur within specific hotspot regions. PIK3CA mutations appear to be more common in squamous cell histology compared to adenocarcinoma and can occur with or without a history of smoking. PIK3CA mutations can co-occur with EGFR mutations and PIK3CA mutations have been detected in a small percentage (approximately 5%) of EGFR-mutated lung cancers with acquired resistance to EGFR TKI therapy.

Last updated: 2016-02-11 21:44:04 UTC
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Tier 2
TP53
Variants
TP53 G245C
TP53 E204*
Primary Sites
Lung
Pancreas
Tumor Types
Adenocarcinoma
Squamous Cell Carcinoma
Interpretation

Somatic mutations in TP53 are frequent in human cancer. Germline TP53 mutations cause of Li-Fraumeni syndrome, which is associated with a range of early-onset cancers. The types and positions of TP53 mutations are diverse. TP53 mutations may be potential prognostic and predictive markers in some tumor types, as well as targets for pharmacological intervention in some clinical settings. The IARC TP53 Database (http://www-p53.iarc.fr/) is a useful resource which catalogues TP53 mutations found in cancer.

Last updated: 2016-06-07 02:09:42 UTC
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Tier 2
CDKN2A
Variants
Primary Sites
Colon
Rectum
Tumor Types
Adenocarcinoma
Squamous Cell Carcinoma
Interpretation

CDKN2A gene functions as an important tumour suppressor in various human malignancies including colorectal cancer, and its activation prevents carcinogenesis via induction of cell growth arrest and senescence. Majority of the CDKN2A mutations span exon 2 and result in loss or decreased binding to CDK4/6 leading to uncontrolled cell growth through inactivation of Rb and p53 pathways. Somatic mutations of CDKN2A are present in various tumor types but have not been well characterized in colorectal cancer. However, epigenetic silencing of CDKN2A by hypermethylation has been reported be a possible predictive factor of poor prognosis in patients with colorectal cancer.

Last updated: 2016-11-04 00:48:03 UTC
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Tier 1
EGFR
Variants
EGFR S768I
EGFR G724S
Primary Sites
Lung
Tumor Types
Adenocarcinoma
Squamous Cell Carcinoma
Interpretation

Somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) gene are present in approximately 80% of the lung adenocarcinomas that respond to first and second generation EGFR tyrosine kinase inhibitors (eg, gefitinib, erlotinib and afatinib). Two types of mutations account for approximately 80-90% of all EGFR mutations: short in-frame deletions in Exon 19 and a point mutation in exon 21 at codon 858 (L858R). Other less common mutations in exons 18, 20, and 21 are found in 10-20% of EGFR-mutated cases. EGFR Exon 19 deletions, EGFR Exon 21 L858R and EGFR Exon 18 G719 mutations correlate strongly with sensitivity to specific EGFR inhibitors and the response rate to therapy with TKIs has been reported to be up to 80% in such cases. EGFR S768I (exon 20) occurs in 1–2% of EGFR mutant lung cancers and is often coincident with other EGFR mutations. EGFR S768I is reported to be sensitive to EGFR-TKIs. EGFR G724S (exon 18) is very rare and its significance is unknown.

Last updated: 2016-05-05 13:32:06 UTC
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Tier 2
IDH2
Variants
IDH2 R140Q
IDH2 codon(s) 140, 172 any
Primary Sites
Lung
Tumor Types
Adenocarcinoma
Squamous Cell Carcinoma
Non-Small Cell Lung Carcinoma
Interpretation

IDH2 is a mitochondrial enzyme involved in citrate metabolism. Mutations at Arg140 and Arg172 of IDH2 are typically heterozygous and are considered gain-of-function mutations that lead to increased levels of 2-hydroxyglutarate believed to alter epigenetic regulation in various tumors, especially in myeloid neoplasms. The Arg140 mutation of IDH2 has not been reported previously in lung tumors. However, a few other IDH2 mutations have been described in non-small cell lung cancers (NSCLC) in a very small number of patients in the literature. The prognostic impact of IDH2 mutations in NSCLC remains uncertain at this time. Mutant IDH2 may provide a potential therapeutic target in some settings. Clinical correlation is recommended.

Last updated: 2016-06-25 19:44:17 UTC
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Tier 3
PTPN11
Variants
Primary Sites
Lung
Tumor Types
Adenocarcinoma
Squamous Cell Carcinoma
Non-Small Cell Lung Carcinoma
Interpretation

The PTPN11gene encodes SHP-2, a widely expressed cytoplasmic protein tyrosine phosphatase. SHP-2 is essential for activation of the RAS/MAPK signaling cascade. Most mutations are gain-of-function and result in prolonged ligand-dependent activation of the RAS/MAPK cascade. Germ-line PTPN11 mutations cause Noonan syndrome, a developmental disorder characterized by an increased risk of malignancies. Activating somatic mutations in PTPN11 have been documented in certain hematologic malignancies but they are infrequent in solid tumors. About 3% of all lung cancers harbor somatic mutations in PTPN11 gene but their prognostic and therapeutic significance remains to be fully elucidated. The utility of SHP2 inhibitors continues to be explored in some preclinical studies.

Last updated: 2016-06-25 19:48:14 UTC
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Tier 2
EGFR
Variants
EGFR T790M
Primary Sites
Stomach
Tumor Types
Adenocarcinoma
Squamous Cell Carcinoma
Interpretation

EGFR mutations have been reported in up to 5% of gastric cancers. The prognostic and predictive implications of EGFR mutations in gastric cancer have not been fully determined. Multiple clinical trials involving EGFR small molecule inhibitors and monoclonal antibodies are present, but limited and conflicting data preclude the therapeutic significance of EGFR mutations in gastric cancer. In NSCLC, an acquired T790M mutation in exon 20 is associated with resistance to some EGFR inhibitors. Third generation TKIs (e.g. osimertinib) have been shown to be effective in lung adenocarcinomas with the EGFR T790M mutation. A germline EGFR T790M mutation results in a rare lung cancer hereditary syndrome associated with increased risk in never-smokers. The presence of a germline EGFR T790M mutation also predicts for resistance to standard TKIs. The significance of EGFR T790M in gastric cancer should be considered in a relevant clinical context. Drug Resistance: Afatinib Erlotinib Gefitinib

Last updated: 2018-04-18 14:23:32 UTC
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Tier 2
PIK3CA
Variants
PIK3CA E542K
PIK3CA E545K
PIK3CA H1047R
PIK3CA codon(s) 542, 545, 1047 any
Primary Sites
Anus
Oral Cavity
Pharynx
Lung
Tumor Types
Squamous Cell Carcinoma
Interpretation

The catalytic subunit (p110a) of phosphatidylinositol-3-kinase (PI3K) is encoded by the PIK3CA gene and acts to activate several signaling cascades, including the well-characterized AKT-mTOR pathway that promotes cell survival, proliferation, growth and motility. PIK3CA is among the most commonly mutated genes in cancer and aberrant activation of PI3K is a transforming event. Somatic mutations in PIK3CA have been found in 1--3% of NSCLC and genetic alteration in PIK3CA have been identified in 7% of lung adenocarcinomas. These mutations typically occur within specific hotspot regions. PIK3CA mutations activate the PI3K-PTEN-AKT pathway which is downstream from both the EGFR and the RAS-RAF-MAPK pathways. The somatic mutations found thus far in PIK3CA are oncogenic, and the majority of them are clustered within exon 9 and 20 (helical and kinase domains), with three hotspots (E542K, E545K, and H1047R/L). PIK3CA mutations have been reported in 8-21% and 20-33% of head/neck and anal squamous cell carcinoma, respectively. PIK3CA mutations, especially ones involving the helical domain, in these types of squamous cell carcinoma are highly associated with HPV. The predictive and prognostic significance of PIK3CA mutations in squamous cell carcinoma is unclear and needs further elucidation. Clinical trials targeting PI3K/Akt/mTor pathway inhibitors are available for patients with PIK3CA mutated tumors.

Last updated: 2019-03-11 16:30:45 UTC
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Tier 2
HRAS
Variants
HRAS codon(s) 12, 13, 61 any
HRAS Q61R
HRAS Q61K
Primary Sites
Anus
Vulva
Oral Cavity
Pharynx
Larynx
Tumor Types
Squamous Cell Carcinoma
Interpretation

RAS is a family of small GTPases and acts as an oncogene. Point mutations in codons 12 and 13 of RAS gene increases its affinity for GTP and those in codon 61 inactivate its autocatalytic GTPase function, resulting in permanent RAS activation and stimulation of its downstream targets along the MAPK and PI3K/AKT signaling pathways. HRAS mutation has been reported in up to 5% and 9% of head/neck and vulvar squamous cell carcinoma, respectively. The predictive and prognostic significance of HRAS mutations in squamous cell carcinoma is unclear and needs further elucidation.

Last updated: 2018-12-14 14:07:45 UTC
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Tier 1
PTCH1
Variants
Primary Sites
Skin
Tumor Types
Adenocarcinoma
Basal Cell Carcinoma
Squamous Cell Carcinoma
Small Cell Carcinoma
Interpretation

PTCH1 loss of function mutations are associated with Vismodegib sensitivity in basal cell carcinoma. However, the clinical significance in other tumor types is unknown.

Last updated: 2017-01-20 03:36:18 UTC
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Tier 1
FGFR2
Variants
Primary Sites
Oral Cavity
Tumor Types
Squamous Cell Carcinoma
Interpretation

FGFR2 mutation in a patient with oral squamous cell carcinoma was associated with response to the multitargeted tyrosine kinase inhibitor pazopanib.

Last updated: 2017-01-20 03:39:38 UTC
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Tier 1
FGFR1
Variants
FGFR1 copy number gain
Primary Sites
Lung
Tumor Types
Squamous Cell Carcinoma
Interpretation

FGFR1 amplification is associated with poor survival in patients with resected squamous cell lung cancer. FGRF1 amplification may be associated with sensitivity to the multitargeted tyrosine kinase inhibitor pazopanib.

Last updated: 2017-01-20 03:40:24 UTC
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Tier 2
CCND1
Variants
CCND1 copy number gain
Primary Sites
Bladder
Esophagus
Oral Cavity
Larynx
Bladder
Lung
Breast
Prostate
Ovary
Stomach
Pancreas
Tumor Types
Adenocarcinoma
Urothelial Carcinoma
Squamous Cell Carcinoma
Interpretation

The protein of CCND1 (Cyclin D 1) belongs to the highly conserved cyclin family, functioning as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Amplification of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors. Cyclin D1 and the mechanisms it regulates have the potential to be a therapeutic target for cancer drugs, including inhibition of Cyclin D1, induction of Cyclin D1 degradation, and inhibition of Cyclin D1/CDK 4/6 complex.

Last updated: 2017-02-09 20:02:30 UTC
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Tier 2
FGFR2
Variants
FGFR2 copy number gain
Primary Sites
Lung
Oral Cavity
Breast
Uterus
Stomach
Bladder
Testis
Ovary
Tumor Types
Squamous Cell Carcinoma
Urothelial Carcinoma
Adenocarcinoma
Germ Cell Tumor
Interpretation

Activation of FGFR protein family can lead to the activation of RAS-MAPK and PI3K-AKT pathways. Amplification of FGFR2 has been observed in lung adenocarcinoma, lung squamous cell carcinoma, endometrial carcinoma, urothelial carcinoma, germ cell tumor and breast cancers. Anti-FGFR2 agents are actively under multiple clinical trials against many types of solid tumor, including lung squamous cell carcinoma, gastric cancer, endometrial cancer, and cholangiocarcinoma. Germeline mutations in FGFR2 are also associated with multiple craniosynostosis syndromes.

Last updated: 2017-02-09 23:55:11 UTC
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Tier 3
SMAD4
Variants
Primary Sites
Cervix
Tumor Types
Adenocarcinoma
Squamous Cell Carcinoma
Interpretation

SMAD4 is a tumor suppressor gene encoding an intracellular mediator in the transforming growth factor β (TGF β) signal transduction pathway. SMAD4 mutations have been observed in ~3% of cervical cancers. Functional inactivation of SMAD4 was found in 4 of 13 cervical squamous cancer cell lines, mostly due to homozygous loss. Loss of protein expression did not correlate with loss of heterozygosity and mutations in cervical squamous carcinomas; however, it was associated with poor disease-free and overall 5-year survival in one study. The predictive and prognostic significance of SMAD4 mutations in cervical cancers needs further elucidation. Results should be interpreted in conjunction with other laboratory and clinical findings.

Last updated: 2017-02-21 13:41:17 UTC
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Tier 2
ARID1A
Variants
ARID1A any mutation
Primary Sites
Adrenal Gland
Anus
Ampulla (Pancreaticobiliary Duct)
Appendix
Bladder
Blood
Bone
Bone Marrow
Brain
Breast
Spinal Cord
Cervix
Chest Wall
Colon
Endometrium
Esophagus
Eye
Fallopian Tube
Fibroadipose Tissue
Gall Bladder
Kidney
Larynx
Liver
Lung
Lymph Node
Nasal Cavity
Oral Cavity
Ovary
Pancreas
Parathyroid
Penis
Peripheral Nervous System
Peritoneum
Pharynx
Pituitary
Placenta
Pleura
Prostate
Retroperitoneum
Salivary Gland
Seminal Vesicle
Skeletal Muscle
Skin
Small Intestine
Soft Tissue
Spleen
Stomach
Testis
Thymus
Thyroid
Tonsil
Unknown
Ureter
Uterus
Vagina
Rectum
Cartilage
Blood Vessel
Buccal Swab
Heart
Trachea
Salivary Duct
Spermatic Cord
Vulva
Brain, Infratentorial
Brain, Supratentorial
Gastroesophageal Junction
Sellar
Suprasellar
Tumor Types
Acinar Cell Carcinoma
Acinic Cell Carcinoma
Acute Myeloid Leukemia
Adenocarcinoma
Adenoid Cystic Carcinoma
Adenosarcoma
Ameloblastic Tumor
Anaplastic Large Cell Lymphoma
Angioimmunoblastic T-Cell Lymphoma
Angiomatoid Fibrous Histiocytoma
Angiomatosis
Angiomyolipoma
Angiosarcoma
Astrocytoma, Anaplastic
Atypical Chronic Myeloid Leukemia
B Lymphoblastic Leukemia/Lymphoma
Basal Cell Carcinoma
Burkitt Lymphoma
Carcinoid Tumor
Carcinoma
Carcinosarcoma
Cholangiocarcinoma
Chondrosarcoma
Chordoma
Choriocarcinoma
Chromophobe Renal Cell Carcinoma
Chronic Lymphocytic Leukemia
Chronic Myeloid Leukemia
Chronic Myelomonocytic Leukemia
Chronic Neutrophilic Leukemia
Classical Hodgkin Lymphoma
Clear Cell Carcinoma
Clear Cell Renal Cell Carcinoma
Craniopharyngioma
Dermatofibrosarcoma
Desmoplastic Small Round Cell Tumor
Diffuse Large B Cell Lymphoma
Ductal Carcinoma
Ependymoma
Essential Thrombocythemia
Ewing Sarcoma
Fibromatosis
Follicular Carcinoma
Follicular Lymphoma
Gastrointestinal Stromal Tumor
Germ Cell Tumor
Giant Cell Tumor
Glioblastoma
Glomus Tumor
Granular Cell Tumor
Hairy Cell Leukemia
Hemangioendothelioma
Hepatocellular Carcinoma
Histiocytic and Dendritic Cell Neoplasms
Invasive Ductal Carcinoma
Kaposi Sarcoma
Langerhans Cell Histiocytosis
Leiomyoma
Leiomyosarcoma
Lipoma
Liposarcoma
Lobular Carcinoma
Lymphoplasmacytic Lymphoma
Malignant Mullerian Mixed Tumor
Mantle Cell Lymphoma
Marginal Zone B Cell Lymphoma
Mast Cell Neoplasm
MDS with Ring Sideroblasts
Medullary Carcinoma
Medulloblastoma
Melanoma
Meningioma
Merkel Cell Carcinoma
Mesothelioma
Mucinous Adenocarcinoma
Mucinous Tumors of Ovary
Mucoepidermoid Carcinoma
Myelodysplastic Syndrome
Myeloproliferative Neoplasm
Myxofibrosarcoma
Nasopharyngeal Carcinoma
Neuroblastoma
Neuroendocrine Carcinoma
Neuroendocrine Neoplasm
NK Cell Lymphoproliferative Disorder
NLPHL
Non-Small Cell Lung Carcinoma
Oligodendroglioma
Osteosarcoma
Papillary Carcinoma
Papillary Renal Cell Carcinoma
Peripheral T Cell Lymphoma
Pheochromocytoma
Plasma Cell Disorder
Polycythemia Vera
Post-Transplant Lymphoproliferative Disorder
Primary Myelofibrosis
Primitive Neuroectodermal Tumor
Renal Cell Carcinoma
Reninoma
Retinoblastoma
Rhabdomyosarcoma
Sarcoma
Schwannoma
Serous Carcinoma
Sex Cord Stromal Tumor
Small Cell Carcinoma
Solid Pseudopapillary Tumor of Pancreas
Spindle Cell Neoplasm
Squamous Cell Carcinoma
T Cell Lymphoproliferative Disorder
T Lymphoblastic Leukemia/Lymphoma
T-Cell LGL Leukemia
Thymic Carcinoma
Thymoma
Urothelial Carcinoma
Tumors of Peripheral Nerves
Unknown
Wilms Tumor
Ependymoma, Anaplastic
Astrocytoma, Pilocytic
Ganglioglioma
Neuroepithelial Neoplasm, NOS
Pleomorphic Carcinoma
Solitary Fibrous Tumor
Neuroepithelial neoplasm, high grade
Leukocytosis
Thrombocytosis
Monocytosis
Cytopenia
Other Acute Leukemia
Astrocytoma, NOS
Acute Leukemia of Unspecified Cell Type
Anemia, Unspecified
Astrocytoma, Diffusely Infiltrating
Diffuse Midline Glioma
Infiltrating Glioma, NOS
Intraductal Papillary Mucinous Neoplasm (IPMN)
Leukopenia
Lymphadenopathy
Lymphocytosis, Symptomatic
Monoclonal Gammopathy
Mucinous or Serous Cystic Neoplasms of Pancreas
Mycosis Fungoides, Unspecified Site
Oligodendroglioma, Anaplastic
Pleomorphic Xanthoastrocytoma
Rash and Other Nonspecific Skin Eruption
Thrombocytopenia, Unspecified
Interpretation

This gene is a known cancer gene. ARID1A/BAF250A subunit of the SWI/SNF (BAF) chromatin remodeling complex has emerged as recurrently mutated in a broad array of tumor types and a potential tumor suppressor. There is evidence indicating that ARID1A-mutated cancers may be subjected to therapeutic intervention.

Last updated: 2018-03-06 21:16:43 UTC
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Tier 2
TP53
Variants
TP53 any mutation
Primary Sites
Adrenal Gland
Anus
Ampulla (Pancreaticobiliary Duct)
Appendix
Bladder
Blood
Bone
Bone Marrow
Brain
Breast
Spinal Cord
Cervix
Chest Wall
Endometrium
Esophagus
Eye
Fallopian Tube
Fibroadipose Tissue
Gall Bladder
Kidney
Larynx
Liver
Lung
Lymph Node
Nasal Cavity
Oral Cavity
Ovary
Pancreas
Parathyroid
Penis
Peripheral Nervous System
Peritoneum
Pharynx
Pituitary
Placenta
Pleura
Prostate
Retroperitoneum
Salivary Gland
Seminal Vesicle
Skeletal Muscle
Skin
Small Intestine
Soft Tissue
Spleen
Stomach
Testis
Thymus
Thyroid
Tonsil
Unknown
Ureter
Uterus
Vagina
Rectum
Cartilage
Blood Vessel
Buccal Swab
Heart
Trachea
Salivary Duct
Spermatic Cord
Vulva
Brain, Infratentorial
Brain, Supratentorial
Gastroesophageal Junction
Sellar
Suprasellar
Colon
Tumor Types
Acinar Cell Carcinoma
Acinic Cell Carcinoma
Adenocarcinoma
Adenoid Cystic Carcinoma
Adenosarcoma
Ameloblastic Tumor
Anaplastic Large Cell Lymphoma
Angioimmunoblastic T-Cell Lymphoma
Angiomatoid Fibrous Histiocytoma
Angiomatosis
Angiomyolipoma
Angiosarcoma
Astrocytoma, Anaplastic
Basal Cell Carcinoma
Burkitt Lymphoma
Carcinoid Tumor
Carcinoma
Carcinosarcoma
Cholangiocarcinoma
Chondrosarcoma
Chordoma
Choriocarcinoma
Chromophobe Renal Cell Carcinoma
Chronic Lymphocytic Leukemia
Classical Hodgkin Lymphoma
Clear Cell Carcinoma
Clear Cell Renal Cell Carcinoma
Craniopharyngioma
Dermatofibrosarcoma
Desmoplastic Small Round Cell Tumor
Diffuse Large B Cell Lymphoma
Ductal Carcinoma
Ependymoma
Ewing Sarcoma
Fibromatosis
Follicular Carcinoma
Follicular Lymphoma
Gastrointestinal Stromal Tumor
Germ Cell Tumor
Giant Cell Tumor
Glioblastoma
Glomus Tumor
Granular Cell Tumor
Hairy Cell Leukemia
Hemangioendothelioma
Hepatocellular Carcinoma
Invasive Ductal Carcinoma
Kaposi Sarcoma
Leiomyoma
Leiomyosarcoma
Lipoma
Liposarcoma
Lobular Carcinoma
Lymphoplasmacytic Lymphoma
Malignant Mullerian Mixed Tumor
Mantle Cell Lymphoma
Marginal Zone B Cell Lymphoma
Medullary Carcinoma
Medulloblastoma
Melanoma
Meningioma
Merkel Cell Carcinoma
Mesothelioma
Mucinous Adenocarcinoma
Mucinous Tumors of Ovary
Mucoepidermoid Carcinoma
Myxofibrosarcoma
Nasopharyngeal Carcinoma
Neuroblastoma
Neuroendocrine Carcinoma
Neuroendocrine Neoplasm
NK Cell Lymphoproliferative Disorder
NLPHL
Non-Small Cell Lung Carcinoma
Oligodendroglioma
Osteosarcoma
Papillary Carcinoma
Papillary Renal Cell Carcinoma
Peripheral T Cell Lymphoma
Pheochromocytoma
Plasma Cell Disorder
Post-Transplant Lymphoproliferative Disorder
Primitive Neuroectodermal Tumor
Renal Cell Carcinoma
Reninoma
Retinoblastoma
Rhabdomyosarcoma
Sarcoma
Schwannoma
Serous Carcinoma
Sex Cord Stromal Tumor
Small Cell Carcinoma
Solid Pseudopapillary Tumor of Pancreas
Spindle Cell Neoplasm
Squamous Cell Carcinoma
T Cell Lymphoproliferative Disorder
T-Cell LGL Leukemia
Thymic Carcinoma
Thymoma
Urothelial Carcinoma
Tumors of Peripheral Nerves
Unknown
Wilms Tumor
Ependymoma, Anaplastic
Astrocytoma, Pilocytic
Ganglioglioma
Neuroepithelial Neoplasm, NOS
Pleomorphic Carcinoma
Solitary Fibrous Tumor
Neuroepithelial neoplasm, high grade
Astrocytoma, NOS
Astrocytoma, Diffusely Infiltrating
Diffuse Midline Glioma
Infiltrating Glioma, NOS
Intraductal Papillary Mucinous Neoplasm (IPMN)
Lymphadenopathy
Lymphocytosis, Symptomatic
Monoclonal Gammopathy
Mucinous or Serous Cystic Neoplasms of Pancreas
Mycosis Fungoides, Unspecified Site
Oligodendroglioma, Anaplastic
Pleomorphic Xanthoastrocytoma
Rash and Other Nonspecific Skin Eruption
Interpretation

Somatic mutations in TP53 are frequent in human cancer. Germline TP53 mutations cause of Li-Fraumeni syndrome, which is associated with a range of early-onset cancers. The types and positions of TP53 mutations are diverse. TP53 mutations may be potential prognostic and predictive markers in some tumor types, as well as targets for pharmacological intervention in some clinical settings. The IARC TP53 Database (http://www-p53.iarc.fr/) is a useful resource which catalogues TP53 mutations found in cancer.

Last updated: 2018-11-12 20:38:55 UTC
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Tier 2
CDKN2A
Variants
CDKN2A codon(s) 80 frameshift
Primary Sites
Esophagus
Tumor Types
Squamous Cell Carcinoma
Interpretation

CDKN2A gene functions as an important tumor suppressor via induction of cell growth arrest and senescence. Majority of the CDKN2A mutations result in loss or decreased binding to CDK4/6 leading to uncontrolled cell growth through inactivation of RB and p53 pathways. CDKN2A alterations have been reported as frequent mutations in squamous cell carcinomas of different primary sites including the lung, head and neck, and skin. CDKN2A R80* results in a premature truncation and confers a loss of function to the CDKN2A protein as demonstrated by loss of CDK binding. CDKN2A truncating mutations, including R80*, have been described in approximately 4% of esophageal squamous cell carcinomas. CDKN2A/CDKN2B loss may be associated with increased sensitivity to CDK4/6 inhibitors. The efficacy and toxicity profiles of these inhibitors in the context of a variety of cancer types are currently under evaluation in clinical trials. The clinical significance of the loss of one copy of CDKN2A remains to be fully elucidated in squamous cell carcinoma of the esophagus. These results should be interpreted in the clinicopathologic context.

Last updated: 2018-03-06 18:01:09 UTC
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Tier 2
CDKN2A
Variants
CDKN2A codon(s) 58 frameshift
Primary Sites
Bladder
Tumor Types
Squamous Cell Carcinoma
Interpretation

CDKN2A gene functions as an important tumor suppressor via induction of cell growth arrest and senescence. Majority of the CDKN2A mutations result in loss or decreased binding to CDK4/6 leading to uncontrolled cell growth through inactivation of RB and p53 pathways. CDKN2A alterations have been reported as frequent mutations in squamous cell carcinomas of different primary sites including the lung, head and neck, and skin. CDKN2A R58* results in a premature truncation and confers a loss of function to the CDKN2A protein as demonstrated by loss of CDK binding. CDKN2A/CDKN2B loss may be associated with increased sensitivity to CDK4/6 inhibitors. The efficacy and toxicity profiles of these inhibitors in the context of a variety of cancer types are currently under evaluation in clinical trials. The clinical significance of the loss of one copy of CDKN2A remains to be fully elucidated in squamous cell carcinoma of the bladder. These results should be interpreted in the clinicopathologic context.

Last updated: 2018-03-06 18:01:26 UTC
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Tier 2
BRAF
Variants
BRAF G469A
Primary Sites
Skin
Tumor Types
Squamous Cell Carcinoma
Interpretation

BRAF is a member of the RAF-family of kinases which plays an important role in the RAS-RAF-MEK-ERK mitotic signaling pathway. Approximately 10% of cutaneous squamous cell carcinomas harbor somatic mutations in BRAF. The G469A mutation in exon 11 results in an amino acid substitution at position 469 in BRAF, which occurs in the highly conserved motif of the kinase domain. Most mutant BRAF proteins, such as G469A, have increased kinase activity and are transforming in vitro. Though BRAF mutations and targeted therapies have been have been studied in other solid tumors, the predicative and prognostic significant in cutaneous squamous cell carcinoma is unclear and needs to be further investigated.

Last updated: 2018-03-12 15:41:26 UTC
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Tier 3
FBXW7
Variants
FBXW7 R505G
Primary Sites
Esophagus
Tumor Types
Squamous Cell Carcinoma
Carcinoma
Adenocarcinoma
Interpretation

FBXW7 is a tumor suppressor gene that is mutated in several tumors including colorectal, liver, bladder and ovarian cancers. It is also mutated in endometrial, esophageal, and head and neck squamous cancers. FBXW7 is a tumor suppressor gene responsible for the degradation of several proto-oncogenes. mTOR is one of the substrates of FBXW7-mediated protein degradation, and loss of function of FBXW7 increases the levels of total and activated mTOR. FBXW7 R505G lies within the WD repeat 4 of the FBXW7 protein. R505G has been identified in the scientific literature, but has not been biochemically characterized and therefore, its effect on FBXW7 protein function is unknown. Preclinical data suggest that FBXW7 mutations may sensitize cells to mTOR inhibitors, however, the response to mTOR inhibitors and the clinicopathologic effects of FBXW7 R505G remains to be further elucidated.

Last updated: 2018-04-02 16:07:40 UTC
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Tier 3
RET
Variants
RET E623K
Primary Sites
Lung
Tumor Types
Squamous Cell Carcinoma
Interpretation

Proto-oncogene tyrosine-protein kinase receptor RET, activates the MAPK pathway for cell proliferation and the PI3K/AKT pathway for cell survival. Certain inherited mutations in the RET proto-oncogene predispose individuals to the multiple endocrine neoplasia type 2 (MEN 2) cancer syndromes including MEN 2A and 2B, and familial medullary thyroid carcinoma. Somatic mutations in RET are rare in squamous cell carcinoma of the lung and are found in 2-3% of cases. RET E623K lies within the extracellular domain of the RET protein, but has not been characterized and therefore its effect on RET protein function is unknown. RET E623K has been reported as a benign germline mutation in ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/variation/24906/). These results should be interpreted in the clinical context.

Last updated: 2018-04-05 01:43:43 UTC
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Tier 3
FGFR3
Variants
FGFR3 F384L
Primary Sites
Lung
Breast
Colon
Pancreas
Thyroid
Liver
Tumor Types
Adenocarcinoma
Carcinoma
Squamous Cell Carcinoma
Papillary Carcinoma
Follicular Carcinoma
Interpretation

FGFR3 is one of 4 high affinity tyrosine kinase receptors for the fibroblast growth factor family of ligands. On ligand stimulation, FGFR3 undergoes dimerization and tyrosine autophosphorylation, resulting in cell proliferation or differentiation, , through the mitogen-activated protein kinase (MAPK) and phospholipase Cg signal transduction pathways. Some FGFR3 mutations are believed to result in ligand-independent activation of the receptor. However, FGFR3 F384L mutation is not associated with activation of FGFR and, in NIH-3T3 cells, it was demonstrated to be devoid of any transforming activity. In some cases, the possibility of FGFR3 variants being of germline origin, cannot be excluded. The FGFR3 F384L mutation has been reported as a benign/likely benign germline variant in ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/variation/134404/). Clinical correlation is recommended.

Last updated: 2019-02-22 18:08:17 UTC
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Tier 1
FGFR3
Variants
FGFR3 copy number gain
Primary Sites
Lung
Oral Cavity
Tumor Types
Squamous Cell Carcinoma
Interpretation

FGFR3 amplification may be associated with response to the multitargeted tyrosine kinase inhibitor pazopanib.

Last updated: 2018-11-12 20:40:32 UTC
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Tier 2
PTEN
Variants
PTEN any frameshift
PTEN any deletion
Primary Sites
Larynx
Oral Cavity
Tumor Types
Squamous Cell Carcinoma
Interpretation

PTEN is a lipid and protein phosphatase that negatively regulates the PI3K/AKT/mTOR pathway. Cancer-associated alterations in this gene often result in loss of PTEN protein and upregulation of the PI3K/AKT/mTOR pathway. PTEN mutations have been reported in ~2% of head and neck squamous cell carcinomas and 15% of anaplastic thyroid carcinomas. Germline mutations of PTEN lead to inherited hamartoma and Cowden syndrome. This particular variant M134I has been reported as a likely pathogenic germline variant (ClinVar, https://preview.ncbi.nlm.nih.gov/clinvar/variation/428267/) and has also been reported as a somatic variant. Clinical trials using PI3K-beta inhibitor are available for patients with PTEN-deficient tumors.

Last updated: 2019-01-22 18:51:41 UTC
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Tier 2
BRAF
Variants
BRAF V600E
Primary Sites
Larynx
Oral Cavity
Tumor Types
Squamous Cell Carcinoma
Interpretation

B-RAF is a member of the RAF-family of kinases which plays an important role in the RAS-RAF-MEK-ERK mitotic signaling pathway. Mutations of B-RAF have been described in <2% of head and neck squamous cell carcinomas. The hotspot for mutations in BRAF is at codon Val600 and the most common one is p.Val600Glu (V600E). Various B-RAF inhibitors have been FDA approved for cancer therapy in certain settings.

Last updated: 2019-01-22 18:51:59 UTC
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Tier 2
STK11
Variants
STK11 codon(s) 60-1 deletion
Primary Sites
Skin
Tumor Types
Squamous Cell Carcinoma
Interpretation

The STK11 is a tumor suppressor gene located on chromosome 19p13.3. The encoded protein has serine--threonine kinase activity. Functionally, STK11 regulates cellular energy metabolism and cell polarity by activating AMP-activated protein kinase (AMPK) and other members of the AMPK family. Germline mutations in the STK11 gene are responsible for Peutz--Jeghers syndrome, an autosomal dominant disorder with variable clinical phenotype and increased risk of some cancers. Somatic mutations of STK11 gene are reported in several tumors including ~5% of cutaneous squamous cell carcinomas. According to Clinvar, this variant (c.597+1G>A) is considered to be oncogenic (https://preview.ncbi.nlm.nih.gov/clinvar/variation/265451/). This variant has been described as a germline variant that results in exon 4 skipping in a family with Peutz--Jeghers syndrome. Clinical correlation is recommended.

Last updated: 2019-01-22 19:24:25 UTC
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Tier 2
RB1
Variants
RB1 R320*
Primary Sites
Lung
Tumor Types
Adenocarcinoma
Squamous Cell Carcinoma
Non-Small Cell Lung Carcinoma
Interpretation

The protein encoded by the RB1 gene is a negative regulator of the cell cycle and was the first tumor suppressor gene identified. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Inactivation of RB1 and loss of RB1 tumor suppressor function has been identified in many early stage cancers. RB1 alterations are found in approximately 8% of non-small cell lung cancers. RB1 S576fs*34 results in early truncation of the RB1 protein and presumably loss of function. The predictive and prognostic significance of RB1 mutations in lung non-small cell carcinoma is undergoing further investigation. It has been suggested that patients with RB1-deficient tumors do not respond to cyclin-dependent kinase (CDK) inhibitors; however, the clinical implication of the loss of a single copy of RB1, as in this patient's case, remains to be fully elucidated. These results should be interpreted in the clinical context.

Last updated: 2019-01-22 19:25:15 UTC
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Tier 2
PTEN
Variants
PTEN Q214*
Primary Sites
Lung
Tumor Types
Squamous Cell Carcinoma
Interpretation

PTEN is a tumor suppressor gene, and loss of PTEN results in upregulation of the PI3K/ AKT pathway. Loss of PTEN is most commonly due to promoter hypermethylation, while homozygous deletion and nonsense mutations with loss of heterozygosity (LOH) may also occur. PTEN mutations may occur in multiple exons. Somatic mutations in PTEN have been found in 4--8% of non-small cell carcinomas (NSCLC) including adenocarcinomas and squamous cell carcinomas. This particular variant is likely to be oncogenic. In preclinical studies, PTEN loss is associated with decreased sensitivity of EGFR mutant lung tumors to EGFR TKIs. Clinical trials assessing the efficacy of PI3K inhibitors in PTEN loss are being explored.

Last updated: 2019-02-22 18:04:55 UTC
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Tier 2
CDKN2A
Variants
CDKN2A D84V
Primary Sites
Lung
Unknown
Skin
Tumor Types
Adenosarcoma
Squamous Cell Carcinoma
Melanoma
Interpretation

Somatic mutations of CDKN2A are present in various tumor types, including, squamous cell carcinoma of the lung, clear cell sarcoma, head and neck cancer, melanoma and esophageal cancer. Majority of the CDKN2A mutations span exon 2 and result in loss or decreased binding to CDK4/6 leading to uncontrolled cell growth through inactivation of Rb and p53 pathways. The D84V mutant is predicted to confer loss of function to the CDKN2A protein as demonstrated by an inability to bind and inhibit the cyclin-dependent kinases CDK4 and CDK6. Multiple preclinical and clinical studies are ongoing for CDKN2A deficient tumors in multiple tumor types.

Last updated: 2019-07-15 15:41:03 UTC
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Generic Interpretations

TierInterpretationGeneVariants
2This gene is a known cancer gene.ABI1
ABI1 copy number gain
ABI1 copy number loss
2This gene is a known cancer gene.ABL1
ABL1 copy number gain
ABL1 copy number loss
2This gene is a known cancer gene.ABL2
ABL2 copy number gain
ABL2 copy number loss
2This gene is a known cancer gene.ACKR3
ACKR3 copy number gain
ACKR3 copy number loss
2This gene is a known cancer gene.ACSL3
ACSL3 copy number gain
ACSL3 copy number loss
2This gene is a known cancer gene.ACSL6
ACSL6 copy number gain
ACSL6 copy number loss
2This gene is a known cancer gene.ACVR1
ACVR1 copy number gain
ACVR1 copy number loss
2This gene is a known cancer gene.AFF1
AFF1 copy number gain
AFF1 copy number loss
2This gene is a known cancer gene.AFF3
AFF3 copy number gain
AFF3 copy number loss
2This gene is a known cancer gene.AFF4
AFF4 copy number gain
AFF4 copy number loss
2This gene is a known cancer gene.AKAP9
AKAP9 copy number gain
AKAP9 copy number loss
2This gene is a known cancer gene.AKT1
AKT1 copy number gain
AKT1 copy number loss
2This gene is a known cancer gene.AKT2
AKT2 copy number gain
AKT2 copy number loss
2This gene is a known cancer gene.ALDH2
ALDH2 copy number gain
ALDH2 copy number loss
2This gene is a known cancer gene.ALK
ALK copy number gain
ALK copy number loss
2This gene is a known cancer gene.AMER1
AMER1 copy number gain
AMER1 copy number loss
2This gene is a known cancer gene.APC
APC copy number gain
APC copy number loss
2This gene is a known cancer gene.AR
AR copy number gain
AR copy number loss
2This gene is a known cancer gene.ARHGAP26
ARHGAP26 copy number gain
ARHGAP26 copy number loss
2This gene is a known cancer gene.ARHGEF12
ARHGEF12 copy number gain
ARHGEF12 copy number loss
2This gene is a known cancer gene.ARID1A
ARID1A copy number gain
ARID1A copy number loss
2This gene is a known cancer gene.ARID1B
ARID1B copy number gain
ARID1B copy number loss
2This gene is a known cancer gene.ARID2
ARID2 copy number gain
ARID2 copy number loss
2This gene is a known cancer gene.ARNT
ARNT copy number gain
ARNT copy number loss
2This gene is a known cancer gene.ASPSCR1
ASPSCR1 copy number gain
ASPSCR1 copy number loss
2This gene is a known cancer gene.ASXL1
ASXL1 copy number gain
ASXL1 copy number loss
2This gene is a known cancer gene.ATF1
ATF1 copy number gain
ATF1 copy number loss
2This gene is a known cancer gene.ATIC
ATIC copy number gain
ATIC copy number loss
2This gene is a known cancer gene.ATM
ATM copy number gain
ATM copy number loss
2This gene is a known cancer gene.ATP1A1
ATP1A1 copy number gain
ATP1A1 copy number loss
2This gene is a known cancer gene.ATP2B3
ATP2B3 copy number gain
ATP2B3 copy number loss
2This gene is a known cancer gene.ATR
ATR copy number gain
ATR copy number loss
2This gene is a known cancer gene.ATRX
ATRX copy number gain
ATRX copy number loss
2This gene is a known cancer gene.AXIN1
AXIN1 copy number gain
AXIN1 copy number loss
2This gene is a known cancer gene.AXIN2
AXIN2 copy number gain
AXIN2 copy number loss
2This gene is a known cancer gene.BAP1
BAP1 copy number gain
BAP1 copy number loss
2This gene is a known cancer gene.BCL10
BCL10 copy number gain
BCL10 copy number loss
2This gene is a known cancer gene.BCL11A
BCL11A copy number gain
BCL11A copy number loss
2This gene is a known cancer gene.BCL11B
BCL11B copy number gain
BCL11B copy number loss
2This gene is a known cancer gene.BCL2
BCL2 copy number gain
BCL2 copy number loss
2This gene is a known cancer gene.BCL3
BCL3 copy number gain
BCL3 copy number loss
2This gene is a known cancer gene.BCL6
BCL6 copy number gain
BCL6 copy number loss
2This gene is a known cancer gene.BCL7A
BCL7A copy number gain
BCL7A copy number loss
2This gene is a known cancer gene.BCL9
BCL9 copy number gain
BCL9 copy number loss
2This gene is a known cancer gene.BCOR
BCOR copy number gain
BCOR copy number loss
2This gene is a known cancer gene.BCR
BCR copy number gain
BCR copy number loss
2This gene is a known cancer gene.BIRC3
BIRC3 copy number gain
BIRC3 copy number loss
2This gene is a known cancer gene.BLM
BLM copy number gain
BLM copy number loss
2This gene is a known cancer gene.BMPR1A
BMPR1A copy number gain
BMPR1A copy number loss
2This gene is a known cancer gene.BRAF
BRAF copy number gain
BRAF copy number loss
2This gene is a known cancer gene.BRCA1
BRCA1 copy number gain
BRCA1 copy number loss
2This gene is a known cancer gene.BRCA2
BRCA2 copy number gain
BRCA2 copy number loss
2This gene is a known cancer gene.BRD3
BRD3 copy number gain
BRD3 copy number loss
2This gene is a known cancer gene.BRD4
BRD4 copy number gain
BRD4 copy number loss
2This gene is a known cancer gene.BRIP1
BRIP1 copy number gain
BRIP1 copy number loss
2This gene is a known cancer gene.BTG1
BTG1 copy number gain
BTG1 copy number loss
2This gene is a known cancer gene.BUB1B
BUB1B copy number gain
BUB1B copy number loss
2This gene is a known cancer gene.C15ORF65
C15ORF65 copy number gain
C15ORF65 copy number loss
2This gene is a known cancer gene.C2ORF44
C2ORF44 copy number gain
C2ORF44 copy number loss
2This gene is a known cancer gene.CACNA1D
CACNA1D copy number gain
CACNA1D copy number loss
2This gene is a known cancer gene.CALR
CALR copy number gain
CALR copy number loss
2This gene is a known cancer gene.CAMTA1
CAMTA1 copy number gain
CAMTA1 copy number loss
2This gene is a known cancer gene.CANT1
CANT1 copy number gain
CANT1 copy number loss
2This gene is a known cancer gene.CARD11
CARD11 copy number gain
CARD11 copy number loss
2This gene is a known cancer gene.CARS
CARS copy number gain
CARS copy number loss
2This gene is a known cancer gene.CASC5
CASC5 copy number gain
CASC5 copy number loss
2This gene is a known cancer gene.CASP8
CASP8 copy number gain
CASP8 copy number loss
2This gene is a known cancer gene.CBFA2T3
CBFA2T3 copy number gain
CBFA2T3 copy number loss
2This gene is a known cancer gene.CBFB
CBFB copy number gain
CBFB copy number loss
2This gene is a known cancer gene.CBL
CBL copy number gain
CBL copy number loss
2This gene is a known cancer gene.CBLB
CBLB copy number gain
CBLB copy number loss
2This gene is a known cancer gene.CBLC
CBLC copy number gain
CBLC copy number loss
2This gene is a known cancer gene.CCDC6
CCDC6 copy number gain
CCDC6 copy number loss
2This gene is a known cancer gene.CCNB1IP1
CCNB1IP1 copy number gain
CCNB1IP1 copy number loss
2This gene is a known cancer gene.CCND1
CCND1 copy number gain
CCND1 copy number loss
2This gene is a known cancer gene.CCND2
CCND2 copy number gain
CCND2 copy number loss
2This gene is a known cancer gene.CCND3
CCND3 copy number gain
CCND3 copy number loss
2This gene is a known cancer gene.CCNE1
CCNE1 copy number gain
CCNE1 copy number loss
2This gene is a known cancer gene.CD274
CD274 copy number gain
CD274 copy number loss
2This gene is a known cancer gene.CD74
CD74 copy number gain
CD74 copy number loss
2This gene is a known cancer gene.CD79A
CD79A copy number gain
CD79A copy number loss
2This gene is a known cancer gene.CD79B
CD79B copy number gain
CD79B copy number loss
2This gene is a known cancer gene.CDC73
CDC73 copy number gain
CDC73 copy number loss
2This gene is a known cancer gene.CDH1
CDH1 copy number gain
CDH1 copy number loss
2This gene is a known cancer gene.CDH11
CDH11 copy number gain
CDH11 copy number loss
2This gene is a known cancer gene.CDK12
CDK12 copy number gain
CDK12 copy number loss
2This gene is a known cancer gene.CDK4
CDK4 copy number gain
CDK4 copy number loss
2This gene is a known cancer gene.CDK6
CDK6 copy number gain
CDK6 copy number loss
2This gene is a known cancer gene.CDKN1B
CDKN1B copy number gain
CDKN1B copy number loss
2This gene is a known cancer gene.CDKN2A
CDKN2A copy number gain
CDKN2A copy number loss
2This gene is a known cancer gene.CDKN2B
CDKN2B copy number gain
CDKN2B copy number loss
2This gene is a known cancer gene.CDKN2C
CDKN2C copy number gain
CDKN2C copy number loss
2This gene is a known cancer gene.CDX2
CDX2 copy number gain
CDX2 copy number loss
2This gene is a known cancer gene.CEBPA
CEBPA copy number gain
CEBPA copy number loss
2This gene is a known cancer gene.CEP89
CEP89 copy number gain
CEP89 copy number loss
2This gene is a known cancer gene.CHCHD7
CHCHD7 copy number gain
CHCHD7 copy number loss
2This gene is a known cancer gene.CHEK2
CHEK2 copy number gain
CHEK2 copy number loss
2This gene is a known cancer gene.CHIC2
CHIC2 copy number gain
CHIC2 copy number loss
2This gene is a known cancer gene.CHN1
CHN1 copy number gain
CHN1 copy number loss
2This gene is a known cancer gene.CIC
CIC copy number gain
CIC copy number loss
2This gene is a known cancer gene.CIITA
CIITA copy number gain
CIITA copy number loss
2This gene is a known cancer gene.CLIP1
CLIP1 copy number gain
CLIP1 copy number loss
2This gene is a known cancer gene.CLP1
CLP1 copy number gain
CLP1 copy number loss
2This gene is a known cancer gene.CLTC
CLTC copy number gain
CLTC copy number loss
2This gene is a known cancer gene.CLTCL1
CLTCL1 copy number gain
CLTCL1 copy number loss
2This gene is a known cancer gene.CNBP
CNBP copy number gain
CNBP copy number loss
2This gene is a known cancer gene.CNOT3
CNOT3 copy number gain
CNOT3 copy number loss
2This gene is a known cancer gene.CNTRL
CNTRL copy number gain
CNTRL copy number loss
2This gene is a known cancer gene.COL1A1
COL1A1 copy number gain
COL1A1 copy number loss
2This gene is a known cancer gene.COL2A1
COL2A1 copy number gain
COL2A1 copy number loss
2This gene is a known cancer gene.COX6C
COX6C copy number gain
COX6C copy number loss
2This gene is a known cancer gene.CREB1
CREB1 copy number gain
CREB1 copy number loss
2This gene is a known cancer gene.CREB3L1
CREB3L1 copy number gain
CREB3L1 copy number loss
2This gene is a known cancer gene.CREB3L2
CREB3L2 copy number gain
CREB3L2 copy number loss
2This gene is a known cancer gene.CREBBP
CREBBP copy number gain
CREBBP copy number loss
2This gene is a known cancer gene.CRLF2
CRLF2 copy number gain
CRLF2 copy number loss
2This gene is a known cancer gene.CRTC1
CRTC1 copy number gain
CRTC1 copy number loss
2This gene is a known cancer gene.CRTC3
CRTC3 copy number gain
CRTC3 copy number loss
2This gene is a known cancer gene.CSF1R
CSF1R copy number gain
CSF1R copy number loss
2This gene is a known cancer gene.CSF3R
CSF3R copy number gain
CSF3R copy number loss
2This gene is a known cancer gene.CTNNB1
CTNNB1 copy number gain
CTNNB1 copy number loss
2This gene is a known cancer gene.CUX1
CUX1 copy number gain
CUX1 copy number loss
2This gene is a known cancer gene.CYLD
CYLD copy number gain
CYLD copy number loss
2This gene is a known cancer gene.DAXX
DAXX copy number gain
DAXX copy number loss
2This gene is a known cancer gene.DCTN1
DCTN1 copy number gain
DCTN1 copy number loss
2This gene is a known cancer gene.DDB2
DDB2 copy number gain
DDB2 copy number loss
2This gene is a known cancer gene.DDIT3
DDIT3 copy number gain
DDIT3 copy number loss
2This gene is a known cancer gene.DDX10
DDX10 copy number gain
DDX10 copy number loss
2This gene is a known cancer gene.DDX5
DDX5 copy number gain
DDX5 copy number loss
2This gene is a known cancer gene.DDX6
DDX6 copy number gain
DDX6 copy number loss
2This gene is a known cancer gene.DEK
DEK copy number gain
DEK copy number loss
2This gene is a known cancer gene.DICER1
DICER1 copy number gain
DICER1 copy number loss
2This gene is a known cancer gene.DNM2
DNM2 copy number gain
DNM2 copy number loss
2This gene is a known cancer gene.DNMT3A
DNMT3A copy number gain
DNMT3A copy number loss
2This gene is a known cancer gene.DUX4
DUX4 copy number gain
DUX4 copy number loss
2This gene is a known cancer gene.EBF1
EBF1 copy number gain
EBF1 copy number loss
2This gene is a known cancer gene.ECT2L
ECT2L copy number gain
ECT2L copy number loss
2This gene is a known cancer gene.EGFR
EGFR copy number gain
EGFR copy number loss
2This gene is a known cancer gene.EIF3E
EIF3E copy number gain
EIF3E copy number loss
2This gene is a known cancer gene.EIF4A2
EIF4A2 copy number gain
EIF4A2 copy number loss
2This gene is a known cancer gene.ELF4
ELF4 copy number gain
ELF4 copy number loss
2This gene is a known cancer gene.ELK4
ELK4 copy number gain
ELK4 copy number loss
2This gene is a known cancer gene.ELL
ELL copy number gain
ELL copy number loss
2This gene is a known cancer gene.ELN
ELN copy number gain
ELN copy number loss
2This gene is a known cancer gene.EML4
EML4 copy number gain
EML4 copy number loss
2This gene is a known cancer gene.EPHA3
EPHA3 copy number gain
EPHA3 copy number loss
2This gene is a known cancer gene.EP300
EP300 copy number gain
EP300 copy number loss
2This gene is a known cancer gene.EPS15
EPS15 copy number gain
EPS15 copy number loss
2This gene is a known cancer gene.ERBB2
ERBB2 copy number gain
ERBB2 copy number loss
2This gene is a known cancer gene.ERBB3
ERBB3 copy number gain
ERBB3 copy number loss
2This gene is a known cancer gene.ERC1
ERC1 copy number gain
ERC1 copy number loss
2This gene is a known cancer gene.ERCC2
ERCC2 copy number gain
ERCC2 copy number loss
2This gene is a known cancer gene.ERCC3
ERCC3 copy number gain
ERCC3 copy number loss
2This gene is a known cancer gene.ERCC4
ERCC4 copy number gain
ERCC4 copy number loss
2This gene is a known cancer gene.ERCC5
ERCC5 copy number gain
ERCC5 copy number loss
2This gene is a known cancer gene.ERG
ERG copy number gain
ERG copy number loss
2This gene is a known cancer gene.ESR1
ESR1 copy number gain
ESR1 copy number loss
2This gene is a known cancer gene.ETNK1
ETNK1 copy number gain
ETNK1 copy number loss
2This gene is a known cancer gene.ETV1
ETV1 copy number gain
ETV1 copy number loss
2This gene is a known cancer gene.ETV4
ETV4 copy number gain
ETV4 copy number loss
2This gene is a known cancer gene.ETV5
ETV5 copy number gain
ETV5 copy number loss
2This gene is a known cancer gene.ETV6
ETV6 copy number gain
ETV6 copy number loss
2This gene is a known cancer gene.EWSR1
EWSR1 copy number gain
EWSR1 copy number loss
2This gene is a known cancer gene.EXT1
EXT1 copy number gain
EXT1 copy number loss
2This gene is a known cancer gene.EXT2
EXT2 copy number gain
EXT2 copy number loss
2This gene is a known cancer gene.EZH2
EZH2 copy number gain
EZH2 copy number loss
2This gene is a known cancer gene.EZR
EZR copy number gain
EZR copy number loss
2This gene is a known cancer gene.FAM131B
FAM131B copy number gain
FAM131B copy number loss
2This gene is a known cancer gene.FAM46C
FAM46C copy number gain
FAM46C copy number loss
2This gene is a known cancer gene.FANCA
FANCA copy number gain
FANCA copy number loss
2This gene is a known cancer gene.FANCC
FANCC copy number gain
FANCC copy number loss
2This gene is a known cancer gene.FANCD2
FANCD2 copy number gain
FANCD2 copy number loss
2This gene is a known cancer gene.FANCE
FANCE copy number gain
FANCE copy number loss
2This gene is a known cancer gene.FANCF
FANCF copy number gain
FANCF copy number loss
2This gene is a known cancer gene.FANCG
FANCG copy number gain
FANCG copy number loss
2This gene is a known cancer gene.FAS
FAS copy number gain
FAS copy number loss
2This gene is a known cancer gene.FBXO11
FBXO11 copy number gain
FBXO11 copy number loss
2This gene is a known cancer gene.FBXW7
FBXW7 copy number gain
FBXW7 copy number loss
2This gene is a known cancer gene.FCGR2B
FCGR2B copy number gain
FCGR2B copy number loss
2This gene is a known cancer gene.FCRL4
FCRL4 copy number gain
FCRL4 copy number loss
2This gene is a known cancer gene.FEV
FEV copy number gain
FEV copy number loss
2This gene is a known cancer gene.FGFR1
FGFR1 copy number gain
FGFR1 copy number loss
2This gene is a known cancer gene.FGFR1OP
FGFR1OP copy number gain
FGFR1OP copy number loss
2This gene is a known cancer gene.FGFR2
FGFR2 copy number gain
FGFR2 copy number loss
2This gene is a known cancer gene.FGFR4
FGFR4 copy number gain
FGFR4 copy number loss
2This gene is a known cancer gene.FH
FH copy number gain
FH copy number loss
2This gene is a known cancer gene.FHIT
FHIT copy number gain
FHIT copy number loss
2This gene is a known cancer gene.FIP1L1
FIP1L1 copy number gain
FIP1L1 copy number loss
2This gene is a known cancer gene.FLCN
FLCN copy number gain
FLCN copy number loss
2This gene is a known cancer gene.FLI1
FLI1 copy number gain
FLI1 copy number loss
2This gene is a known cancer gene.FLT3
FLT3 copy number gain
FLT3 copy number loss
2This gene is a known cancer gene.FLT4
FLT4 copy number gain
FLT4 copy number loss
2This gene is a known cancer gene.FNBP1
FNBP1 copy number gain
FNBP1 copy number loss
2This gene is a known cancer gene.FOXA1
FOXA1 copy number gain
FOXA1 copy number loss
2This gene is a known cancer gene.FOXL2
FOXL2 copy number gain
FOXL2 copy number loss
2This gene is a known cancer gene.FOXO1
FOXO1 copy number gain
FOXO1 copy number loss
2This gene is a known cancer gene.FOXO3
FOXO3 copy number gain
FOXO3 copy number loss
2This gene is a known cancer gene.FOXO4
FOXO4 copy number gain
FOXO4 copy number loss
2This gene is a known cancer gene.FOXO4
FOXO4 copy number gain
FOXO4 copy number loss
2This gene is a known cancer gene.FOXP1
FOXP1 copy number gain
FOXP1 copy number loss
2This gene is a known cancer gene.FSTL3
FSTL3 copy number gain
FSTL3 copy number loss
2This gene is a known cancer gene.FUBP1
FUBP1 copy number gain
FUBP1 copy number loss
2This gene is a known cancer gene.FUS
FUS copy number gain
FUS copy number loss
2This gene is a known cancer gene.GAS7
GAS7 copy number gain
GAS7 copy number loss
2This gene is a known cancer gene.GATA1
GATA1 copy number gain
GATA1 copy number loss
2This gene is a known cancer gene.GATA2
GATA2 copy number gain
GATA2 copy number loss
2This gene is a known cancer gene.GATA3
GATA3 copy number gain
GATA3 copy number loss
2This gene is a known cancer gene.GMPS
GMPS copy number gain
GMPS copy number loss
2This gene is a known cancer gene.GNA11
GNA11 copy number gain
GNA11 copy number loss
2This gene is a known cancer gene.GNAQ
GNAQ copy number gain
GNAQ copy number loss
2This gene is a known cancer gene.GNAS
GNAS copy number gain
GNAS copy number loss
2This gene is a known cancer gene.GOLGA5
GOLGA5 copy number gain
GOLGA5 copy number loss
2This gene is a known cancer gene.GOPC
GOPC copy number gain
GOPC copy number loss
2This gene is a known cancer gene.GPC3
GPC3 copy number gain
GPC3 copy number loss
2This gene is a known cancer gene.GPHN
GPHN copy number gain
GPHN copy number loss
2This gene is a known cancer gene.GRIN2A
GRIN2A copy number gain
GRIN2A copy number loss
2This gene is a known cancer gene.H3F3A
H3F3A copy number gain
H3F3A copy number loss
2This gene is a known cancer gene.H3F3B
H3F3B copy number gain
H3F3B copy number loss
2This gene is a known cancer gene.HERPUD1
HERPUD1 copy number gain
HERPUD1 copy number loss
2This gene is a known cancer gene.HEY1
HEY1 copy number gain
HEY1 copy number loss
2This gene is a known cancer gene.HIP1
HIP1 copy number gain
HIP1 copy number loss
2This gene is a known cancer gene.HIST1H3B
HIST1H3B copy number gain
HIST1H3B copy number loss
2This gene is a known cancer gene.HIST1H4I
HIST1H4I copy number gain
HIST1H4I copy number loss
2This gene is a known cancer gene.HLA-A
HLA-A copy number gain
HLA-A copy number loss
2This gene is a known cancer gene.HLF
HLF copy number gain
HLF copy number loss
2This gene is a known cancer gene.HMGA1
HMGA1 copy number gain
HMGA1 copy number loss
2This gene is a known cancer gene.HMGA2
HMGA2 copy number gain
HMGA2 copy number loss
2This gene is a known cancer gene.HNF1A
HNF1A copy number gain
HNF1A copy number loss
2This gene is a known cancer gene.HNRNPA2B1
HNRNPA2B1 copy number gain
HNRNPA2B1 copy number loss
2This gene is a known cancer gene.HOOK3
HOOK3 copy number gain
HOOK3 copy number loss
2This gene is a known cancer gene.HOXA11
HOXA11 copy number gain
HOXA11 copy number loss
2This gene is a known cancer gene.HOXA13
HOXA13 copy number gain
HOXA13 copy number loss
2This gene is a known cancer gene.HOXA9
HOXA9 copy number gain
HOXA9 copy number loss
2This gene is a known cancer gene.HOXC11
HOXC11 copy number gain
HOXC11 copy number loss
2This gene is a known cancer gene.HOXC13
HOXC13 copy number gain
HOXC13 copy number loss
2This gene is a known cancer gene.HOXD11
HOXD11 copy number gain
HOXD11 copy number loss
2This gene is a known cancer gene.HOXD13
HOXD13 copy number gain
HOXD13 copy number loss
2This gene is a known cancer gene.HRAS
HRAS copy number gain
HRAS copy number loss
2This gene is a known cancer gene.HSP90AA1
HSP90AA1 copy number gain
HSP90AA1 copy number loss
2This gene is a known cancer gene.HSP90AB1
HSP90AB1 copy number gain
HSP90AB1 copy number loss
2This gene is a known cancer gene.IDH1
IDH1 copy number gain
IDH1 copy number loss
2This gene is a known cancer gene.IDH2
IDH2 copy number gain
IDH2 copy number loss
2This gene is a known cancer gene.IKBKB
IKBKB copy number gain
IKBKB copy number loss
2This gene is a known cancer gene.IKZF1
IKZF1 copy number gain
IKZF1 copy number loss
2This gene is a known cancer gene.IL2
IL2 copy number gain
IL2 copy number loss
2This gene is a known cancer gene.IL21R
IL21R copy number gain
IL21R copy number loss
2This gene is a known cancer gene.IL6ST
IL6ST copy number gain
IL6ST copy number loss
2This gene is a known cancer gene.IL7R
IL7R copy number gain
IL7R copy number loss
2This gene is a known cancer gene.IRF4
IRF4 copy number gain
IRF4 copy number loss
2This gene is a known cancer gene.ITK
ITK copy number gain
ITK copy number loss
2This gene is a known cancer gene.JAK1
JAK1 copy number gain
JAK1 copy number loss
2This gene is a known cancer gene.JAK2
JAK2 copy number gain
JAK2 copy number loss
2This gene is a known cancer gene.JAK3
JAK3 copy number gain
JAK3 copy number loss
2This gene is a known cancer gene.JAZF1
JAZF1 copy number gain
JAZF1 copy number loss
2This gene is a known cancer gene.JUN
JUN copy number gain
JUN copy number loss
2This gene is a known cancer gene.KAT6A
KAT6A copy number gain
KAT6A copy number loss
2This gene is a known cancer gene.KAT6B
KAT6B copy number gain
KAT6B copy number loss
2This gene is a known cancer gene.KCNJ5
KCNJ5 copy number gain
KCNJ5 copy number loss
2This gene is a known cancer gene.KDM5A
KDM5A copy number gain
KDM5A copy number loss
2This gene is a known cancer gene.KDM5C
KDM5C copy number gain
KDM5C copy number loss
2This gene is a known cancer gene.KDM6A
KDM6A copy number gain
KDM6A copy number loss
2This gene is a known cancer gene.KDR
KDR copy number gain
KDR copy number loss
2This gene is a known cancer gene.KDSR
KDSR copy number gain
KDSR copy number loss
2This gene is a known cancer gene.KIAA1549
KIAA1549 copy number gain
KIAA1549 copy number loss
2This gene is a known cancer gene.KIAA1598
KIAA1598 copy number gain
KIAA1598 copy number loss
2This gene is a known cancer gene.KIF5B
KIF5B copy number gain
KIF5B copy number loss
2This gene is a known cancer gene.KIT
KIT copy number gain
KIT copy number loss
2This gene is a known cancer gene.KLF4
KLF4 copy number gain
KLF4 copy number loss
2This gene is a known cancer gene.KLF6
KLF6 copy number gain
KLF6 copy number loss
2This gene is a known cancer gene.KLK2
KLK2 copy number gain
KLK2 copy number loss
2This gene is a known cancer gene.KMT2A
KMT2A copy number gain
KMT2A copy number loss
2This gene is a known cancer gene.KMT2C
KMT2C copy number gain
KMT2C copy number loss
2This gene is a known cancer gene.KMT2D
KMT2D copy number gain
KMT2D copy number loss
2This gene is a known cancer gene.KRAS
KRAS copy number gain
KRAS copy number loss
2This gene is a known cancer gene.KTN1
KTN1 copy number gain
KTN1 copy number loss
2This gene is a known cancer gene.LASP1
LASP1 copy number gain
LASP1 copy number loss
2This gene is a known cancer gene.LCK
LCK copy number gain
LCK copy number loss
2This gene is a known cancer gene.LCP1
LCP1 copy number gain
LCP1 copy number loss
2This gene is a known cancer gene.LHFP
LHFP copy number gain
LHFP copy number loss
2This gene is a known cancer gene.LIFR
LIFR copy number gain
LIFR copy number loss
2This gene is a known cancer gene.LMNA
LMNA copy number gain
LMNA copy number loss
2This gene is a known cancer gene.LMO1
LMO1 copy number gain
LMO1 copy number loss
2This gene is a known cancer gene.LMO2
LMO2 copy number gain
LMO2 copy number loss
2This gene is a known cancer gene.LPP
LPP copy number gain
LPP copy number loss
2This gene is a known cancer gene.LRIG3
LRIG3 copy number gain
LRIG3 copy number loss
2This gene is a known cancer gene.LSM14A
LSM14A copy number gain
LSM14A copy number loss
2This gene is a known cancer gene.LYL1
LYL1 copy number gain
LYL1 copy number loss
2This gene is a known cancer gene.LZTR1
LZTR1 copy number gain
LZTR1 copy number loss
2This gene is a known cancer gene.MAF
MAF copy number gain
MAF copy number loss
2This gene is a known cancer gene.MAFB
MAFB copy number gain
MAFB copy number loss
2This gene is a known cancer gene.MALT1
MALT1 copy number gain
MALT1 copy number loss
2This gene is a known cancer gene.MAML2
MAML2 copy number gain
MAML2 copy number loss
2This gene is a known cancer gene.MAP2K1
MAP2K1 copy number gain
MAP2K1 copy number loss
2This gene is a known cancer gene.MAP2K2
MAP2K2 copy number gain
MAP2K2 copy number loss
2This gene is a known cancer gene.MAP2K4
MAP2K4 copy number gain
MAP2K4 copy number loss
2This gene is a known cancer gene.MAP3K1
MAP3K1 copy number gain
MAP3K1 copy number loss
2This gene is a known cancer gene.MAP3K13
MAP3K13 copy number gain
MAP3K13 copy number loss
2This gene is a known cancer gene.MAX
MAX copy number gain
MAX copy number loss
2This gene is a known cancer gene.MDM2
MDM2 copy number gain
MDM2 copy number loss
2This gene is a known cancer gene.MDM4
MDM4 copy number gain
MDM4 copy number loss
2This gene is a known cancer gene.MDS2
MDS2 copy number gain
MDS2 copy number loss
2This gene is a known cancer gene.MECOM
MECOM copy number gain
MECOM copy number loss
2This gene is a known cancer gene.MED12
MED12 copy number gain
MED12 copy number loss
2This gene is a known cancer gene.MEN1
MEN1 copy number gain
MEN1 copy number loss
2This gene is a known cancer gene.MET
MET copy number gain
MET copy number loss
2This gene is a known cancer gene.MITF
MITF copy number gain
MITF copy number loss
2This gene is a known cancer gene.MKL1
MKL1 copy number gain
MKL1 copy number loss
2This gene is a known cancer gene.MLF1
MLF1 copy number gain
MLF1 copy number loss
2This gene is a known cancer gene.MLH1
MLH1 copy number gain
MLH1 copy number loss
2This gene is a known cancer gene.MLLT1
MLLT1 copy number gain
MLLT1 copy number loss
2This gene is a known cancer gene.MLLT10
MLLT10 copy number gain
MLLT10 copy number loss
2This gene is a known cancer gene.MLLT11
MLLT11 copy number gain
MLLT11 copy number loss
2This gene is a known cancer gene.MLLT3
MLLT3 copy number gain
MLLT3 copy number loss
2This gene is a known cancer gene.MLLT4
MLLT4 copy number gain
MLLT4 copy number loss
2This gene is a known cancer gene.MLLT6
MLLT6 copy number gain
MLLT6 copy number loss
2This gene is a known cancer gene.MN1
MN1 copy number gain
MN1 copy number loss
2This gene is a known cancer gene.MNX1
MNX1 copy number gain
MNX1 copy number loss
2This gene is a known cancer gene.MPL
MPL copy number gain
MPL copy number loss
2This gene is a known cancer gene.MSH2
MSH2 copy number gain
MSH2 copy number loss
2This gene is a known cancer gene.MSH6
MSH6 copy number gain
MSH6 copy number loss
2This gene is a known cancer gene.MSI2
MSI2 copy number gain
MSI2 copy number loss
2This gene is a known cancer gene.MSN
MSN copy number gain
MSN copy number loss
2This gene is a known cancer gene.MTCP1
MTCP1 copy number gain
MTCP1 copy number loss
2This gene is a known cancer gene.MUC1
MUC1 copy number gain
MUC1 copy number loss
2This gene is a known cancer gene.MUTYH
MUTYH copy number gain
MUTYH copy number loss
2This gene is a known cancer gene.MYB
MYB copy number gain
MYB copy number loss
2This gene is a known cancer gene.MYC
MYC copy number gain
MYC copy number loss
2This gene is a known cancer gene.MYCL
MYCL copy number gain
MYCL copy number loss
2This gene is a known cancer gene.MYCN
MYCN copy number gain
MYCN copy number loss
2This gene is a known cancer gene.MYD88
MYD88 copy number gain
MYD88 copy number loss
2This gene is a known cancer gene.MYH11
MYH11 copy number gain
MYH11 copy number loss
2This gene is a known cancer gene.MYH9
MYH9 copy number gain
MYH9 copy number loss
2This gene is a known cancer gene.MYO5A
MYO5A copy number gain
MYO5A copy number loss
2This gene is a known cancer gene.MYOD1
MYOD1 copy number gain
MYOD1 copy number loss
2This gene is a known cancer gene.NAB2
NAB2 copy number gain
NAB2 copy number loss
2This gene is a known cancer gene.NACA
NACA copy number gain
NACA copy number loss
2This gene is a known cancer gene.NBN
NBN copy number gain
NBN copy number loss
2This gene is a known cancer gene.NCKIPSD
NCKIPSD copy number gain
NCKIPSD copy number loss
2This gene is a known cancer gene.NCOA1
NCOA1 copy number gain
NCOA1 copy number loss
2This gene is a known cancer gene.NCOA2
NCOA2 copy number gain
NCOA2 copy number loss
2This gene is a known cancer gene.NCOA4
NCOA4 copy number gain
NCOA4 copy number loss
2This gene is a known cancer gene.NCOR1
NCOR1 copy number gain
NCOR1 copy number loss
2This gene is a known cancer gene.NDRG1
NDRG1 copy number gain
NDRG1 copy number loss
2This gene is a known cancer gene.NF1
NF1 copy number gain
NF1 copy number loss
2This gene is a known cancer gene.NF2
NF2 copy number gain
NF2 copy number loss
2This gene is a known cancer gene.NFATC2
NFATC2 copy number gain
NFATC2 copy number loss
2This gene is a known cancer gene.NFE2L2
NFE2L2 copy number gain
NFE2L2 copy number loss
2This gene is a known cancer gene.NFIB
NFIB copy number gain
NFIB copy number loss
2This gene is a known cancer gene.NFKB2
NFKB2 copy number gain
NFKB2 copy number loss
2This gene is a known cancer gene.NFKBIE
NFKBIE copy number gain
NFKBIE copy number loss
2This gene is a known cancer gene.NIN
NIN copy number gain
NIN copy number loss
2This gene is a known cancer gene.NKX2-1
NKX2-1 copy number gain
NKX2-1 copy number loss
2This gene is a known cancer gene.NONO
NONO copy number gain
NONO copy number loss
2This gene is a known cancer gene.NOTCH1
NOTCH1 copy number gain
NOTCH1 copy number loss
2This gene is a known cancer gene.NOTCH2
NOTCH2 copy number gain
NOTCH2 copy number loss
2This gene is a known cancer gene.NOTCH3
NOTCH3 copy number gain
NOTCH3 copy number loss
2This gene is a known cancer gene.NPM1
NPM1 copy number gain
NPM1 copy number loss
2This gene is a known cancer gene.NR4A3
NR4A3 copy number gain
NR4A3 copy number loss
2This gene is a known cancer gene.NRAS
NRAS copy number gain
NRAS copy number loss
2This gene is a known cancer gene.NRG1
NRG1 copy number gain
NRG1 copy number loss
2This gene is a known cancer gene.NSD1
NSD1 copy number gain
NSD1 copy number loss
2This gene is a known cancer gene.NT5C2
NT5C2 copy number gain
NT5C2 copy number loss
2This gene is a known cancer gene.NTRK1
NTRK1 copy number gain
NTRK1 copy number loss
2This gene is a known cancer gene.NTRK3
NTRK3 copy number gain
NTRK3 copy number loss
2This gene is a known cancer gene.NUMA1
NUMA1 copy number gain
NUMA1 copy number loss
2This gene is a known cancer gene.NUP214
NUP214 copy number gain
NUP214 copy number loss
2This gene is a known cancer gene.NUP98
NUP98 copy number gain
NUP98 copy number loss
2This gene is a known cancer gene.NUTM1
NUTM1 copy number gain
NUTM1 copy number loss
2This gene is a known cancer gene.NUTM2A
NUTM2A copy number gain
NUTM2A copy number loss
2This gene is a known cancer gene.NUTM2B
NUTM2B copy number gain
NUTM2B copy number loss
2This gene is a known cancer gene.OLIG2
OLIG2 copy number gain
OLIG2 copy number loss
2This gene is a known cancer gene.OMD
OMD copy number gain
OMD copy number loss
2This gene is a known cancer gene.P2RY8
P2RY8 copy number gain
P2RY8 copy number loss
2This gene is a known cancer gene.PAFAH1B2
PAFAH1B2 copy number gain
PAFAH1B2 copy number loss
2This gene is a known cancer gene.PALB2
PALB2 copy number gain
PALB2 copy number loss
2This gene is a known cancer gene.PAX3
PAX3 copy number gain
PAX3 copy number loss
2This gene is a known cancer gene.PAX5
PAX5 copy number gain
PAX5 copy number loss
2This gene is a known cancer gene.PAX7
PAX7 copy number gain
PAX7 copy number loss
2This gene is a known cancer gene.PAX8
PAX8 copy number gain
PAX8 copy number loss
2This gene is a known cancer gene.PBRM1
PBRM1 copy number gain
PBRM1 copy number loss
2This gene is a known cancer gene.PBX1
PBX1 copy number gain
PBX1 copy number loss
2This gene is a known cancer gene.PCM1
PCM1 copy number gain
PCM1 copy number loss
2This gene is a known cancer gene.PCSK7
PCSK7 copy number gain
PCSK7 copy number loss
2This gene is a known cancer gene.PDCD1LG2
PDCD1LG2 copy number gain
PDCD1LG2 copy number loss
2This gene is a known cancer gene.PDE4DIP
PDE4DIP copy number gain
PDE4DIP copy number loss
2This gene is a known cancer gene.PDGFB
PDGFB copy number gain
PDGFB copy number loss
2This gene is a known cancer gene.PDGFRA
PDGFRA copy number gain
PDGFRA copy number loss
2This gene is a known cancer gene.PDGFRB
PDGFRB copy number gain
PDGFRB copy number loss
2This gene is a known cancer gene.PER1
PER1 copy number gain
PER1 copy number loss
2This gene is a known cancer gene.PHF6
PHF6 copy number gain
PHF6 copy number loss
2This gene is a known cancer gene.PHOX2B
PHOX2B copy number gain
PHOX2B copy number loss
2This gene is a known cancer gene.PICALM
PICALM copy number gain
PICALM copy number loss
2This gene is a known cancer gene.PIK3CA
PIK3CA copy number gain
PIK3CA copy number loss
2This gene is a known cancer gene.PIK3R1
PIK3R1 copy number gain
PIK3R1 copy number loss
2This gene is a known cancer gene.PIM1
PIM1 copy number gain
PIM1 copy number loss
2This gene is a known cancer gene.PLAG1
PLAG1 copy number gain
PLAG1 copy number loss
2This gene is a known cancer gene.PLCG1
PLCG1 copy number gain
PLCG1 copy number loss
2This gene is a known cancer gene.PML
PML copy number gain
PML copy number loss
2This gene is a known cancer gene.PMS1
PMS1 copy number gain
PMS1 copy number loss
2This gene is a known cancer gene.PMS2
PMS2 copy number gain
PMS2 copy number loss
2This gene is a known cancer gene.POLE
POLE copy number gain
POLE copy number loss
2This gene is a known cancer gene.POT1
POT1 copy number gain
POT1 copy number loss
2This gene is a known cancer gene.POU2AF1
POU2AF1 copy number gain
POU2AF1 copy number loss
2This gene is a known cancer gene.POU5F1
POU5F1 copy number gain
POU5F1 copy number loss
2This gene is a known cancer gene.PPARG
PPARG copy number gain
PPARG copy number loss
2This gene is a known cancer gene.PPFIBP1
PPFIBP1 copy number gain
PPFIBP1 copy number loss
2This gene is a known cancer gene.PPP2R1A
PPP2R1A copy number gain
PPP2R1A copy number loss
2This gene is a known cancer gene.PPP6C
PPP6C copy number gain
PPP6C copy number loss
2This gene is a known cancer gene.PRCC
PRCC copy number gain
PRCC copy number loss
2This gene is a known cancer gene.PRDM1
PRDM1 copy number gain
PRDM1 copy number loss
2This gene is a known cancer gene.PRDM16
PRDM16 copy number gain
PRDM16 copy number loss
2This gene is a known cancer gene.PRF1
PRF1 copy number gain
PRF1 copy number loss
2This gene is a known cancer gene.PRKAR1A
PRKAR1A copy number gain
PRKAR1A copy number loss
2This gene is a known cancer gene.PRRX1
PRRX1 copy number gain
PRRX1 copy number loss
2This gene is a known cancer gene.PSIP1
PSIP1 copy number gain
PSIP1 copy number loss
2This gene is a known cancer gene.PTCH1
PTCH1 copy number gain
PTCH1 copy number loss
2This gene is a known cancer gene.PTEN
PTEN copy number gain
PTEN copy number loss
2This gene is a known cancer gene.PTPN11
PTPN11 copy number gain
PTPN11 copy number loss
2This gene is a known cancer gene.PTPRB
PTPRB copy number gain
PTPRB copy number loss
2This gene is a known cancer gene.PTPRC
PTPRC copy number gain
PTPRC copy number loss
2This gene is a known cancer gene.PTPRK
PTPRK copy number gain
PTPRK copy number loss
2This gene is a known cancer gene.PWWP2A
PWWP2A copy number gain
PWWP2A copy number loss
2This gene is a known cancer gene.RABEP1
RABEP1 copy number gain
RABEP1 copy number loss
2This gene is a known cancer gene.RAC1
RAC1 copy number gain
RAC1 copy number loss
2This gene is a known cancer gene.RAD21
RAD21 copy number gain
RAD21 copy number loss
2This gene is a known cancer gene.RAD51B
RAD51B copy number gain
RAD51B copy number loss
2This gene is a known cancer gene.RAF1
RAF1 copy number gain
RAF1 copy number loss
2This gene is a known cancer gene.RALGDS
RALGDS copy number gain
RALGDS copy number loss
2This gene is a known cancer gene.RANBP17
RANBP17 copy number gain
RANBP17 copy number loss
2This gene is a known cancer gene.RANBP2
RANBP2 copy number gain
RANBP2 copy number loss
2This gene is a known cancer gene.RAP1GDS1
RAP1GDS1 copy number gain
RAP1GDS1 copy number loss
2This gene is a known cancer gene.RARA
RARA copy number gain
RARA copy number loss
2This gene is a known cancer gene.RB1
RB1 copy number gain
RB1 copy number loss
2This gene is a known cancer gene.RBM15
RBM15 copy number gain
RBM15 copy number loss
2This gene is a known cancer gene.RECQL4
RECQL4 copy number gain
RECQL4 copy number loss
2This gene is a known cancer gene.REL
REL copy number gain
REL copy number loss
2This gene is a known cancer gene.RET
RET copy number gain
RET copy number loss
2This gene is a known cancer gene.RHOA
RHOA copy number gain
RHOA copy number loss
2This gene is a known cancer gene.RHOH
RHOH copy number gain
RHOH copy number loss
2This gene is a known cancer gene.RMI2
RMI2 copy number gain
RMI2 copy number loss
2This gene is a known cancer gene.RNF213
RNF213 copy number gain
RNF213 copy number loss
2This gene is a known cancer gene.RNF43
RNF43 copy number gain
RNF43 copy number loss
2This gene is a known cancer gene.ROS1
ROS1 copy number gain
ROS1 copy number loss
2This gene is a known cancer gene.RPL10
RPL10 copy number gain
RPL10 copy number loss
2This gene is a known cancer gene.RPL22
RPL22 copy number gain
RPL22 copy number loss
2This gene is a known cancer gene.RPL5
RPL5 copy number gain
RPL5 copy number loss
2This gene is a known cancer gene.RPN1
RPN1 copy number gain
RPN1 copy number loss
2This gene is a known cancer gene.RSPO2
RSPO2 copy number gain
RSPO2 copy number loss
2This gene is a known cancer gene.RSPO3
RSPO3 copy number gain
RSPO3 copy number loss
2This gene is a known cancer gene.SNX29
SNX29 copy number gain
SNX29 copy number loss
2This gene is a known cancer gene.RUNX1
RUNX1 copy number gain
RUNX1 copy number loss
2This gene is a known cancer gene.RUNX1T1
RUNX1T1 copy number gain
RUNX1T1 copy number loss
2This gene is a known cancer gene.SBDS
SBDS copy number gain
SBDS copy number loss
2This gene is a known cancer gene.SDC4
SDC4 copy number gain
SDC4 copy number loss
2This gene is a known cancer gene.SDHAF2
SDHAF2 copy number gain
SDHAF2 copy number loss
2This gene is a known cancer gene.SDHB
SDHB copy number gain
SDHB copy number loss
2This gene is a known cancer gene.SDHC
SDHC copy number gain
SDHC copy number loss
2This gene is a known cancer gene.SEPT5
SEPT5 copy number gain
SEPT5 copy number loss
2This gene is a known cancer gene.SEPT6
SEPT6 copy number gain
SEPT6 copy number loss
2This gene is a known cancer gene.SEPT9
SEPT9 copy number gain
SEPT9 copy number loss
2This gene is a known cancer gene.SET
SET copy number gain
SET copy number loss
2This gene is a known cancer gene.SETBP1
SETBP1 copy number gain
SETBP1 copy number loss
2This gene is a known cancer gene.SETD2
SETD2 copy number gain
SETD2 copy number loss
2This gene is a known cancer gene.SF3B1
SF3B1 copy number gain
SF3B1 copy number loss
2This gene is a known cancer gene.SFPQ
SFPQ copy number gain
SFPQ copy number loss
2This gene is a known cancer gene.SH2B3
SH2B3 copy number gain
SH2B3 copy number loss
2This gene is a known cancer gene.SH3GL1
SH3GL1 copy number gain
SH3GL1 copy number loss
2This gene is a known cancer gene.SLC34A2
SLC34A2 copy number gain
SLC34A2 copy number loss
2This gene is a known cancer gene.SLC45A3
SLC45A3 copy number gain
SLC45A3 copy number loss
2This gene is a known cancer gene.SMAD4
SMAD4 copy number gain
SMAD4 copy number loss
2This gene is a known cancer gene.SMARCA4
SMARCA4 copy number gain
SMARCA4 copy number loss
2This gene is a known cancer gene.SMARCB1
SMARCB1 copy number gain
SMARCB1 copy number loss
2This gene is a known cancer gene.SMARCD1
SMARCD1 copy number gain
SMARCD1 copy number loss
2This gene is a known cancer gene.SMARCE1
SMARCE1 copy number gain
SMARCE1 copy number loss
2This gene is a known cancer gene.SMO
SMO copy number gain
SMO copy number loss
2This gene is a known cancer gene.SND1
SND1 copy number gain
SND1 copy number loss
2This gene is a known cancer gene.SOCS1
SOCS1 copy number gain
SOCS1 copy number loss
2This gene is a known cancer gene.SOX2
SOX2 copy number gain
SOX2 copy number loss
2This gene is a known cancer gene.SPECC1
SPECC1 copy number gain
SPECC1 copy number loss
2This gene is a known cancer gene.SPEN
SPEN copy number gain
SPEN copy number loss
2This gene is a known cancer gene.SPOP
SPOP copy number gain
SPOP copy number loss
2This gene is a known cancer gene.SRGAP3
SRGAP3 copy number gain
SRGAP3 copy number loss
2This gene is a known cancer gene.SRSF2
SRSF2 copy number gain
SRSF2 copy number loss
2This gene is a known cancer gene.SRSF3
SRSF3 copy number gain
SRSF3 copy number loss
2This gene is a known cancer gene.SS18
SS18 copy number gain
SS18 copy number loss
2This gene is a known cancer gene.SS18L1
SS18L1 copy number gain
SS18L1 copy number loss
2This gene is a known cancer gene.SSX1
SSX1 copy number gain
SSX1 copy number loss
2This gene is a known cancer gene.SSX2
SSX2 copy number gain
SSX2 copy number loss
2This gene is a known cancer gene.SSX4
SSX4 copy number gain
SSX4 copy number loss
2This gene is a known cancer gene.STAG2
STAG2 copy number gain
STAG2 copy number loss
2This gene is a known cancer gene.STAT3
STAT3 copy number gain
STAT3 copy number loss
2This gene is a known cancer gene.STAT5B
STAT5B copy number gain
STAT5B copy number loss
2This gene is a known cancer gene.STAT6
STAT6 copy number gain
STAT6 copy number loss
2This gene is a known cancer gene.STIL
STIL copy number gain
STIL copy number loss
2This gene is a known cancer gene.STK11
STK11 copy number gain
STK11 copy number loss
2This gene is a known cancer gene.STRN
STRN copy number gain
STRN copy number loss
2This gene is a known cancer gene.SUFU
SUFU copy number gain
SUFU copy number loss
2This gene is a known cancer gene.SUZ12
SUZ12 copy number gain
SUZ12 copy number loss
2This gene is a known cancer gene.SYK
SYK copy number gain
SYK copy number loss
2This gene is a known cancer gene.TAF15
TAF15 copy number gain
TAF15 copy number loss
2This gene is a known cancer gene.TAL1
TAL1 copy number gain
TAL1 copy number loss
2This gene is a known cancer gene.TAL2
TAL2 copy number gain
TAL2 copy number loss
2This gene is a known cancer gene.TBL1XR1
TBL1XR1 copy number gain
TBL1XR1 copy number loss
2This gene is a known cancer gene.TBX3
TBX3 copy number gain
TBX3 copy number loss
2This gene is a known cancer gene.TCEA1
TCEA1 copy number gain
TCEA1 copy number loss
2This gene is a known cancer gene.TCF12
TCF12 copy number gain
TCF12 copy number loss
2This gene is a known cancer gene.TCF3
TCF3 copy number gain
TCF3 copy number loss
2This gene is a known cancer gene.TCF7L2
TCF7L2 copy number gain
TCF7L2 copy number loss
2This gene is a known cancer gene.TCL1A
TCL1A copy number gain
TCL1A copy number loss
2This gene is a known cancer gene.TERT
TERT copy number gain
TERT copy number loss
2This gene is a known cancer gene.TET1
TET1 copy number gain
TET1 copy number loss
2This gene is a known cancer gene.TET2
TET2 copy number gain
TET2 copy number loss
2This gene is a known cancer gene.TFE3
TFE3 copy number gain
TFE3 copy number loss
2This gene is a known cancer gene.TFEB
TFEB copy number gain
TFEB copy number loss
2This gene is a known cancer gene.TFG
TFG copy number gain
TFG copy number loss
2This gene is a known cancer gene.TFPT
TFPT copy number gain
TFPT copy number loss
2This gene is a known cancer gene.TFRC
TFRC copy number gain
TFRC copy number loss
2This gene is a known cancer gene.THRAP3
THRAP3 copy number gain
THRAP3 copy number loss
2This gene is a known cancer gene.TLX1
TLX1 copy number gain
TLX1 copy number loss
2This gene is a known cancer gene.TLX3
TLX3 copy number gain
TLX3 copy number loss
2This gene is a known cancer gene.TMPRSS2
TMPRSS2 copy number gain
TMPRSS2 copy number loss
2This gene is a known cancer gene.TNFAIP3
TNFAIP3 copy number gain
TNFAIP3 copy number loss
2This gene is a known cancer gene.TNFRSF14
TNFRSF14 copy number gain
TNFRSF14 copy number loss
2This gene is a known cancer gene.TNFRSF17
TNFRSF17 copy number gain
TNFRSF17 copy number loss
2This gene is a known cancer gene.TOP1
TOP1 copy number gain
TOP1 copy number loss
2This gene is a known cancer gene.TP53
TP53 copy number gain
TP53 copy number loss
2This gene is a known cancer gene.TPM3
TPM3 copy number gain
TPM3 copy number loss
2This gene is a known cancer gene.TPM4
TPM4 copy number gain
TPM4 copy number loss
2This gene is a known cancer gene.TPR
TPR copy number gain
TPR copy number loss
2This gene is a known cancer gene.TRAF7
TRAF7 copy number gain
TRAF7 copy number loss
2This gene is a known cancer gene.TRIM24
TRIM24 copy number gain
TRIM24 copy number loss
2This gene is a known cancer gene.TRIM27
TRIM27 copy number gain
TRIM27 copy number loss
2This gene is a known cancer gene.TRIM33
TRIM33 copy number gain
TRIM33 copy number loss
2This gene is a known cancer gene.TRIP11
TRIP11 copy number gain
TRIP11 copy number loss
2This gene is a known cancer gene.TRRAP
TRRAP copy number gain
TRRAP copy number loss
2This gene is a known cancer gene.TSC1
TSC1 copy number gain
TSC1 copy number loss
2This gene is a known cancer gene.TSC2
TSC2 copy number gain
TSC2 copy number loss
2This gene is a known cancer gene.TSHR
TSHR copy number gain
TSHR copy number loss
2This gene is a known cancer gene.TTL
TTL copy number gain
TTL copy number loss
2This gene is a known cancer gene.U2AF1
U2AF1 copy number gain
U2AF1 copy number loss
2This gene is a known cancer gene.UBR5
UBR5 copy number gain
UBR5 copy number loss
2This gene is a known cancer gene.USP6
USP6 copy number gain
USP6 copy number loss
2This gene is a known cancer gene.VHL
VHL copy number gain
VHL copy number loss
2This gene is a known cancer gene.VTI1A
VTI1A copy number gain
VTI1A copy number loss
2This gene is a known cancer gene.WAS
WAS copy number gain
WAS copy number loss
2This gene is a known cancer gene.WHSC1
WHSC1 copy number gain
WHSC1 copy number loss
2This gene is a known cancer gene.WHSC1L1
WHSC1L1 copy number gain
WHSC1L1 copy number loss
2This gene is a known cancer gene.WIF1
WIF1 copy number gain
WIF1 copy number loss
2This gene is a known cancer gene.WRN
WRN copy number gain
WRN copy number loss
2This gene is a known cancer gene.WT1
WT1 copy number gain
WT1 copy number loss
2This gene is a known cancer gene.WWTR1
WWTR1 copy number gain
WWTR1 copy number loss
2This gene is a known cancer gene.XPA
XPA copy number gain
XPA copy number loss
2This gene is a known cancer gene.XPC
XPC copy number gain
XPC copy number loss
2This gene is a known cancer gene.XPO1
XPO1 copy number gain
XPO1 copy number loss
2This gene is a known cancer gene.YWHAE
YWHAE copy number gain
YWHAE copy number loss
2This gene is a known cancer gene.ZBTB16
ZBTB16 copy number gain
ZBTB16 copy number loss
2This gene is a known cancer gene.ZCCHC8
ZCCHC8 copy number gain
ZCCHC8 copy number loss
2This gene is a known cancer gene.ZMYM2
ZMYM2 copy number gain
ZMYM2 copy number loss
2This gene is a known cancer gene.PATZ1
PATZ1 copy number gain
PATZ1 copy number loss
2This gene is a known cancer gene.ZNF331
ZNF331 copy number gain
ZNF331 copy number loss
2This gene is a known cancer gene.ZNF384
ZNF384 copy number gain
ZNF384 copy number loss
2This gene is a known cancer gene.ZNF521
ZNF521 copy number gain
ZNF521 copy number loss
2This gene is a known cancer gene.ZRSR2
ZRSR2 copy number gain
ZRSR2 copy number loss
2This gene is a known cancer gene.ABI1
ABI1 any mutation
2This gene is a known cancer gene.ABL1
ABL1 any mutation
2This gene is a known cancer gene.ACKR3
ACKR3 any mutation
2This gene is a known cancer gene.ACSL3
ACSL3 any mutation
2This gene is a known cancer gene.ACSL6
ACSL6 any mutation
2This gene is a known cancer gene.ABL2
ABL2 any mutation
2This gene is a known cancer gene.ACVR1
ACVR1 any mutation
2This gene is a known cancer gene.AFF1
AFF1 any mutation
2This gene is a known cancer gene.AFF3
AFF3 any mutation
2This gene is a known cancer gene.AFF4
AFF4 any mutation
2This gene is a known cancer gene.AKAP9
AKAP9 any mutation
2This gene is a known cancer gene.AKT1
AKT1 any mutation
2This gene is a known cancer gene.AKT2
AKT2 any mutation
2This gene is a known cancer gene.ALDH2
ALDH2 any mutation
2This gene is a known cancer gene.ALK
ALK any mutation
2This gene is a known cancer gene.AMER1
AMER1 any mutation
2This gene is a known cancer gene.APC
APC any mutation
2This gene is a known cancer gene.AR
AR any mutation
2This gene is a known cancer gene.ARHGAP26
ARHGAP26 any mutation
2This gene is a known cancer gene.ARHGEF12
ARHGEF12 any mutation
2This gene is a known cancer gene.ARID1B
ARID1B any mutation
2This gene is a known cancer gene.ARID2
ARID2 any mutation
2This gene is a known cancer gene.ARNT
ARNT any mutation
2This gene is a known cancer gene.ASPSCR1
ASPSCR1 any mutation
2This gene is a known cancer gene.ASXL1
ASXL1 any mutation
2This gene is a known cancer gene.ATF1
ATF1 any mutation
2This gene is a known cancer gene.ATIC
ATIC any mutation
2This gene is a known cancer gene.ATM
ATM any mutation
2This gene is a known cancer gene.ATP1A1
ATP1A1 any mutation
2This gene is a known cancer gene.ATP2B3
ATP2B3 any mutation
2This gene is a known cancer gene.ATR
ATR any mutation
2This gene is a known cancer gene.ATRX
ATRX any mutation
2This gene is a known cancer gene.AXIN1
AXIN1 any mutation
2This gene is a known cancer gene.AXIN2
AXIN2 any mutation
2This gene is a known cancer gene.BAP1
BAP1 any mutation
2This gene is a known cancer gene.BCL10
BCL10 any mutation
2This gene is a known cancer gene.BCL11A
BCL11A any mutation
2This gene is a known cancer gene.BCL11B
BCL11B any mutation
2This gene is a known cancer gene.BCL2
BCL2 any mutation
2This gene is a known cancer gene.BCL3
BCL3 any mutation
2This gene is a known cancer gene.BCL6
BCL6 any mutation
2This gene is a known cancer gene.BCL7A
BCL7A any mutation
2This gene is a known cancer gene.BCL9
BCL9 any mutation
2This gene is a known cancer gene.BCOR
BCOR any mutation
2This gene is a known cancer gene.BCR
BCR any mutation
2This gene is a known cancer gene.BIRC3
BIRC3 any mutation
2This gene is a known cancer gene.BLM
BLM any mutation
2This gene is a known cancer gene.BMPR1A
BMPR1A any mutation
2This gene is a known cancer gene.BRAF
BRAF any mutation
2This gene is a known cancer gene.BRCA1
BRCA1 any mutation
2This gene is a known cancer gene.BRCA2
BRCA2 any mutation
2This gene is a known cancer gene.BRD3
BRD3 any mutation
2This gene is a known cancer gene.BRD4
BRD4 any mutation
2This gene is a known cancer gene.BRIP1
BRIP1 any mutation
2This gene is a known cancer gene.BTG1
BTG1 any mutation
2This gene is a known cancer gene.BUB1B
BUB1B any mutation
2This gene is a known cancer gene.C15ORF65
C15ORF65 any mutation
2This gene is a known cancer gene.C2ORF44
C2ORF44 any mutation
2This gene is a known cancer gene.CACNA1D
CACNA1D any mutation
2This gene is a known cancer gene.CALR
CALR any mutation
2This gene is a known cancer gene.CAMTA1
CAMTA1 any mutation
2This gene is a known cancer gene.CANT1
CANT1 any mutation
2This gene is a known cancer gene.CARD11
CARD11 any mutation
2This gene is a known cancer gene.CARS
CARS any mutation
2This gene is a known cancer gene.CASC5
CASC5 any mutation
2This gene is a known cancer gene.CASP8
CASP8 any mutation
2This gene is a known cancer gene.CBFA2T3
CBFA2T3 any mutation
2This gene is a known cancer gene.CBFB
CBFB any mutation
2This gene is a known cancer gene.CBL
CBL any mutation
2This gene is a known cancer gene.CBLB
CBLB any mutation
2This gene is a known cancer gene.CBLC
CBLC any mutation
2This gene is a known cancer gene.CCDC6
CCDC6 any mutation
2This gene is a known cancer gene.CCNB1IP1
CCNB1IP1 any mutation
2This gene is a known cancer gene.CCND1
CCND1 any mutation
2This gene is a known cancer gene.CCND2
CCND2 any mutation
2This gene is a known cancer gene.CCND3
CCND3 any mutation
2This gene is a known cancer gene.CCNE1
CCNE1 any mutation
2This gene is a known cancer gene.CD274
CD274 any mutation
2This gene is a known cancer gene.CD74
CD74 any mutation
2This gene is a known cancer gene.CD79A
CD79A any mutation
2This gene is a known cancer gene.CD79B
CD79B any mutation
2This gene is a known cancer gene.CDC73
CDC73 any mutation
2This gene is a known cancer gene.CDH1
CDH1 any mutation
2This gene is a known cancer gene.CDH11
CDH11 any mutation
2This gene is a known cancer gene.CDK12
CDK12 any mutation
2This gene is a known cancer gene.CDK4
CDK4 any mutation
2This gene is a known cancer gene.CDK6
CDK6 any mutation
2This gene is a known cancer gene.CDKN1B
CDKN1B any mutation
2This gene is a known cancer gene.CDKN2A
CDKN2A any mutation
2This gene is a known cancer gene.CDKN2B
CDKN2B any mutation
2This gene is a known cancer gene.CDKN2C
CDKN2C any mutation
2This gene is a known cancer gene.CDX2
CDX2 any mutation
2This gene is a known cancer gene.CEBPA
CEBPA any mutation
2This gene is a known cancer gene.CEP89
CEP89 any mutation
2This gene is a known cancer gene.CHCHD7
CHCHD7 any mutation
2This gene is a known cancer gene.CHEK2
CHEK2 any mutation
2This gene is a known cancer gene.CHIC2
CHIC2 any mutation
2This gene is a known cancer gene.CHN1
CHN1 any mutation
2This gene is a known cancer gene.CIC
CIC any mutation
2This gene is a known cancer gene.CIITA
CIITA any mutation
2This gene is a known cancer gene.CLIP1
CLIP1 any mutation
2This gene is a known cancer gene.CLP1
CLP1 any mutation
2This gene is a known cancer gene.CLTC
CLTC any mutation
2This gene is a known cancer gene.CLTCL1
CLTCL1 any mutation
2This gene is a known cancer gene.CNBP
CNBP any mutation
2This gene is a known cancer gene.CNOT3
CNOT3 any mutation
2This gene is a known cancer gene.CNTRL
CNTRL any mutation
2This gene is a known cancer gene.COL1A1
COL1A1 any mutation
2This gene is a known cancer gene.COL2A1
COL2A1 any mutation
2This gene is a known cancer gene.COX6C
COX6C any mutation
2This gene is a known cancer gene.CREB1
CREB1 any mutation
2This gene is a known cancer gene.CREB3L1
CREB3L1 any mutation
2This gene is a known cancer gene.CREB3L2
CREB3L2 any mutation
2This gene is a known cancer gene.CREBBP
CREBBP any mutation
2This gene is a known cancer gene.CRLF2
CRLF2 any mutation
2This gene is a known cancer gene.CRTC1
CRTC1 any mutation
2This gene is a known cancer gene.CRTC3
CRTC3 any mutation
2This gene is a known cancer gene.CSF1R
CSF1R any mutation
2This gene is a known cancer gene.CSF3R
CSF3R any mutation
2This gene is a known cancer gene.CTNNB1
CTNNB1 any mutation
2This gene is a known cancer gene.CUX1
CUX1 any mutation
2This gene is a known cancer gene.CYLD
CYLD any mutation
2This gene is a known cancer gene.DAXX
DAXX any mutation
2This gene is a known cancer gene.DCTN1
DCTN1 any mutation
2This gene is a known cancer gene.DDB2
DDB2 any mutation
2This gene is a known cancer gene.DDIT3
DDIT3 any mutation
2This gene is a known cancer gene.DDX10
DDX10 any mutation
2This gene is a known cancer gene.DDX5
DDX5 any mutation
2This gene is a known cancer gene.DDX6
DDX6 any mutation
2This gene is a known cancer gene.DEK
DEK any mutation
2This gene is a known cancer gene.DICER1
DICER1 any mutation
2This gene is a known cancer gene.DNM2
DNM2 any mutation
2This gene is a known cancer gene.DNMT3A
DNMT3A any mutation
2This gene is a known cancer gene.DUX4
DUX4 any mutation
2This gene is a known cancer gene.EBF1
EBF1 any mutation
2This gene is a known cancer gene.ECT2L
ECT2L any mutation
2This gene is a known cancer gene.EGFR
EGFR any mutation
2This gene is a known cancer gene.EIF3E
EIF3E any mutation
2This gene is a known cancer gene.EIF4A2
EIF4A2 any mutation
2This gene is a known cancer gene.ELF4
ELF4 any mutation
2This gene is a known cancer gene.ELK4
ELK4 any mutation
2This gene is a known cancer gene.ELL
ELL any mutation
2This gene is a known cancer gene.ELN
ELN any mutation
2This gene is a known cancer gene.EML4
EML4 any mutation
2This gene is a known cancer gene.EPHA3
EPHA3 any mutation
2This gene is a known cancer gene.EP300
EP300 any mutation
2This gene is a known cancer gene.EPS15
EPS15 any mutation
2This gene is a known cancer gene.ERBB2
ERBB2 any mutation
2This gene is a known cancer gene.ERBB3
ERBB3 any mutation
2This gene is a known cancer gene.ERC1
ERC1 any mutation
2This gene is a known cancer gene.ERCC2
ERCC2 any mutation
2This gene is a known cancer gene.ERCC3
ERCC3 any mutation
2This gene is a known cancer gene.ERCC4
ERCC4 any mutation
2This gene is a known cancer gene.ERCC5
ERCC5 any mutation
2This gene is a known cancer gene.ERG
ERG any mutation
2This gene is a known cancer gene.ESR1
ESR1 any mutation
2This gene is a known cancer gene.ETNK1
ETNK1 any mutation
2This gene is a known cancer gene.ETV1
ETV1 any mutation
2This gene is a known cancer gene.ETV4
ETV4 any mutation
2This gene is a known cancer gene.ETV5
ETV5 any mutation
2This gene is a known cancer gene.ETV6
ETV6 any mutation
2This gene is a known cancer gene.EWSR1
EWSR1 any mutation
2This gene is a known cancer gene.EXT1
EXT1 any mutation
2This gene is a known cancer gene.EXT2
EXT2 any mutation
2This gene is a known cancer gene.EZH2
EZH2 any mutation
2This gene is a known cancer gene.EZR
EZR any mutation
2This gene is a known cancer gene.FAM131B
FAM131B any mutation
2This gene is a known cancer gene.FAM46C
FAM46C any mutation
2This gene is a known cancer gene.FANCA
FANCA any mutation
2This gene is a known cancer gene.FANCC
FANCC any mutation
2This gene is a known cancer gene.FANCD2
FANCD2 any mutation
2This gene is a known cancer gene.FANCE
FANCE any mutation
2This gene is a known cancer gene.FANCF
FANCF any mutation
2This gene is a known cancer gene.FANCG
FANCG any mutation
2This gene is a known cancer gene.FAS
FAS any mutation
2This gene is a known cancer gene.FBXO11
FBXO11 any mutation
2This gene is a known cancer gene.FBXW7
FBXW7 any mutation
2This gene is a known cancer gene.FCGR2B
FCGR2B any mutation
2This gene is a known cancer gene.FCRL4
FCRL4 any mutation
2This gene is a known cancer gene.FEV
FEV any mutation
2This gene is a known cancer gene.FGFR1
FGFR1 any mutation
2This gene is a known cancer gene.FGFR1OP
FGFR1OP any mutation
2This gene is a known cancer gene.FGFR2
FGFR2 any mutation
2This gene is a known cancer gene.FGFR3
FGFR3 any mutation
2This gene is a known cancer gene.FGFR4
FGFR4 any mutation
2This gene is a known cancer gene.FH
FH any mutation
2This gene is a known cancer gene.FHIT
FHIT any mutation
2This gene is a known cancer gene.FIP1L1
FIP1L1 any mutation
2This gene is a known cancer gene.FLCN
FLCN any mutation
2This gene is a known cancer gene.FLI1
FLI1 any mutation
2This gene is a known cancer gene.FLT3
FLT3 any mutation
2This gene is a known cancer gene.FLT4
FLT4 any mutation
2This gene is a known cancer gene.FNBP1
FNBP1 any mutation
2This gene is a known cancer gene.FOXA1
FOXA1 any mutation
2This gene is a known cancer gene.FOXL2
FOXL2 any mutation
2This gene is a known cancer gene.FOXO1
FOXO1 any mutation
2This gene is a known cancer gene.FOXO3
FOXO3 any mutation
2This gene is a known cancer gene.FOXO4
FOXO4 any mutation
2This gene is a known cancer gene.FOXO4
FOXO4 any mutation
2This gene is a known cancer gene.FOXP1
FOXP1 any mutation
2This gene is a known cancer gene.FSTL3
FSTL3 any mutation
2This gene is a known cancer gene.FUBP1
FUBP1 any mutation
2This gene is a known cancer gene.FUS
FUS any mutation
2This gene is a known cancer gene.GAS7
GAS7 any mutation
2This gene is a known cancer gene.GATA1
GATA1 any mutation
2This gene is a known cancer gene.GATA2
GATA2 any mutation
2This gene is a known cancer gene.GATA3
GATA3 any mutation
2This gene is a known cancer gene.GMPS
GMPS any mutation
2This gene is a known cancer gene.GNA11
GNA11 any mutation
2This gene is a known cancer gene.GNAQ
GNAQ any mutation
2This gene is a known cancer gene.GNAS
GNAS any mutation
2This gene is a known cancer gene.GOLGA5
GOLGA5 any mutation
2This gene is a known cancer gene.GOPC
GOPC any mutation
2This gene is a known cancer gene.GPC3
GPC3 any mutation
2This gene is a known cancer gene.GPHN
GPHN any mutation
2This gene is a known cancer gene.GRIN2A
GRIN2A any mutation
2This gene is a known cancer gene.H3F3A
H3F3A any mutation
2This gene is a known cancer gene.H3F3B
H3F3B any mutation
2This gene is a known cancer gene.HERPUD1
HERPUD1 any mutation
2This gene is a known cancer gene.HEY1
HEY1 any mutation
2This gene is a known cancer gene.HIP1
HIP1 any mutation
2This gene is a known cancer gene.HIST1H3B
HIST1H3B any mutation
2This gene is a known cancer gene.HIST1H4I
HIST1H4I any mutation
2This gene is a known cancer gene.HLA-A
HLA-A any mutation
2This gene is a known cancer gene.HLF
HLF any mutation
2This gene is a known cancer gene.HMGA1
HMGA1 any mutation
2This gene is a known cancer gene.HMGA2
HMGA2 any mutation
2This gene is a known cancer gene.HNF1A
HNF1A any mutation
2This gene is a known cancer gene.HNRNPA2B1
HNRNPA2B1 any mutation
2This gene is a known cancer gene.HOOK3
HOOK3 any mutation
2This gene is a known cancer gene.HOXA11
HOXA11 any mutation
2This gene is a known cancer gene.HOXA13
HOXA13 any mutation
2This gene is a known cancer gene.HOXA9
HOXA9 any mutation
2This gene is a known cancer gene.HOXC11
HOXC11 any mutation
2This gene is a known cancer gene.HOXC13
HOXC13 any mutation
2This gene is a known cancer gene.HOXD11
HOXD11 any mutation
2This gene is a known cancer gene.HOXD13
HOXD13 any mutation
2This gene is a known cancer gene.HRAS
HRAS any mutation
2This gene is a known cancer gene.HSP90AA1
HSP90AA1 any mutation
2This gene is a known cancer gene.HSP90AB1
HSP90AB1 any mutation
2This gene is a known cancer gene.IDH1
IDH1 any mutation
2This gene is a known cancer gene.IDH2
IDH2 any mutation
2This gene is a known cancer gene.IKBKB
IKBKB any mutation
2This gene is a known cancer gene.IKZF1
IKZF1 any mutation
2This gene is a known cancer gene.IL2
IL2 any mutation
2This gene is a known cancer gene.IL21R
IL21R any mutation
2This gene is a known cancer gene.IL6ST
IL6ST any mutation
2This gene is a known cancer gene.IL7R
IL7R any mutation
2This gene is a known cancer gene.IRF4
IRF4 any mutation
2This gene is a known cancer gene.ITK
ITK any mutation
2This gene is a known cancer gene.JAK1
JAK1 any mutation
2This gene is a known cancer gene.JAK2
JAK2 any mutation
2This gene is a known cancer gene.JAK3
JAK3 any mutation
2This gene is a known cancer gene.JAZF1
JAZF1 any mutation
2This gene is a known cancer gene.JUN
JUN any mutation
2This gene is a known cancer gene.KAT6A
KAT6A any mutation
2This gene is a known cancer gene.KAT6B
KAT6B any mutation
2This gene is a known cancer gene.KCNJ5
KCNJ5 any mutation
2This gene is a known cancer gene.KDM5A
KDM5A any mutation
2This gene is a known cancer gene.KDM5C
KDM5C any mutation
2This gene is a known cancer gene.KDM6A
KDM6A any mutation
2This gene is a known cancer gene.KDR
KDR any mutation
2This gene is a known cancer gene.KDSR
KDSR any mutation
2This gene is a known cancer gene.KIAA1549
KIAA1549 any mutation
2This gene is a known cancer gene.KIAA1598
KIAA1598 any mutation
2This gene is a known cancer gene.KIF5B
KIF5B any mutation
2This gene is a known cancer gene.KIT
KIT any mutation
2This gene is a known cancer gene.KLF4
KLF4 any mutation
2This gene is a known cancer gene.KLF6
KLF6 any mutation
2This gene is a known cancer gene.KLK2
KLK2 any mutation
2This gene is a known cancer gene.KMT2A
KMT2A any mutation
2This gene is a known cancer gene.KMT2C
KMT2C any mutation
2This gene is a known cancer gene.KMT2D
KMT2D any mutation
2This gene is a known cancer gene.KRAS
KRAS any mutation
2This gene is a known cancer gene.KTN1
KTN1 any mutation
2This gene is a known cancer gene.LASP1
LASP1 any mutation
2This gene is a known cancer gene.LCK
LCK any mutation
2This gene is a known cancer gene.LCP1
LCP1 any mutation
2This gene is a known cancer gene.LHFP
LHFP any mutation
2This gene is a known cancer gene.LIFR
LIFR any mutation
2This gene is a known cancer gene.LMNA
LMNA any mutation
2This gene is a known cancer gene.LMO1
LMO1 any mutation
2This gene is a known cancer gene.LMO2
LMO2 any mutation
2This gene is a known cancer gene.LPP
LPP any mutation
2This gene is a known cancer gene.LRIG3
LRIG3 any mutation
2This gene is a known cancer gene.LSM14A
LSM14A any mutation
2This gene is a known cancer gene.LYL1
LYL1 any mutation
2This gene is a known cancer gene.LZTR1
LZTR1 any mutation
2This gene is a known cancer gene.MAF
MAF any mutation
2This gene is a known cancer gene.MAFB
MAFB any mutation
2This gene is a known cancer gene.MALT1
MALT1 any mutation
2This gene is a known cancer gene.MAML2
MAML2 any mutation
2This gene is a known cancer gene.MAP2K1
MAP2K1 any mutation
2This gene is a known cancer gene.MAP2K2
MAP2K2 any mutation
2This gene is a known cancer gene.MAP2K4
MAP2K4 any mutation
2This gene is a known cancer gene.MAP3K1
MAP3K1 any mutation
2This gene is a known cancer gene.MAP3K13
MAP3K13 any mutation
2This gene is a known cancer gene.MAX
MAX any mutation
2This gene is a known cancer gene.MDM2
MDM2 any mutation
2This gene is a known cancer gene.MDM4
MDM4 any mutation
2This gene is a known cancer gene.MDS2
MDS2 any mutation
2This gene is a known cancer gene.MECOM
MECOM any mutation
2This gene is a known cancer gene.MED12
MED12 any mutation
2This gene is a known cancer gene.MEN1
MEN1 any mutation
2This gene is a known cancer gene.MET
MET any mutation
2This gene is a known cancer gene.MITF
MITF any mutation
2This gene is a known cancer gene.MKL1
MKL1 any mutation
2This gene is a known cancer gene.MLF1
MLF1 any mutation
2This gene is a known cancer gene.MLH1
MLH1 any mutation
2This gene is a known cancer gene.MLLT1
MLLT1 any mutation
2This gene is a known cancer gene.MLLT10
MLLT10 any mutation
2This gene is a known cancer gene.MLLT11
MLLT11 any mutation
2This gene is a known cancer gene.MLLT3
MLLT3 any mutation
2This gene is a known cancer gene.MLLT4
MLLT4 any mutation
2This gene is a known cancer gene.MLLT6
MLLT6 any mutation
2This gene is a known cancer gene.MN1
MN1 any mutation
2This gene is a known cancer gene.MNX1
MNX1 any mutation
2This gene is a known cancer gene.MPL
MPL any mutation
2This gene is a known cancer gene.MSH2
MSH2 any mutation
2This gene is a known cancer gene.MSH6
MSH6 any mutation
2This gene is a known cancer gene.MSI2
MSI2 any mutation
2This gene is a known cancer gene.MSN
MSN any mutation
2This gene is a known cancer gene.MTCP1
MTCP1 any mutation
2This gene is a known cancer gene.MUC1
MUC1 any mutation
2This gene is a known cancer gene.MUTYH
MUTYH any mutation
2This gene is a known cancer gene.MYB
MYB any mutation
2This gene is a known cancer gene.MYC
MYC any mutation
2This gene is a known cancer gene.MYCL
MYCL any mutation
2This gene is a known cancer gene.MYCN
MYCN any mutation
2This gene is a known cancer gene.MYD88
MYD88 any mutation
2This gene is a known cancer gene.MYH11
MYH11 any mutation
2This gene is a known cancer gene.MYH9
MYH9 any mutation
2This gene is a known cancer gene.MYO5A
MYO5A any mutation
2This gene is a known cancer gene.MYOD1
MYOD1 any mutation
2This gene is a known cancer gene.NAB2
NAB2 any mutation
2This gene is a known cancer gene.NACA
NACA any mutation
2This gene is a known cancer gene.NBN
NBN any mutation
2This gene is a known cancer gene.NCKIPSD
NCKIPSD any mutation
2This gene is a known cancer gene.NCOA1
NCOA1 any mutation
2This gene is a known cancer gene.NCOA2
NCOA2 any mutation
2This gene is a known cancer gene.NCOA4
NCOA4 any mutation
2This gene is a known cancer gene.NCOR1
NCOR1 any mutation
2This gene is a known cancer gene.NDRG1
NDRG1 any mutation
2This gene is a known cancer gene.NF1
NF1 any mutation
2This gene is a known cancer gene.NF2
NF2 any mutation
2This gene is a known cancer gene.NFATC2
NFATC2 any mutation
2This gene is a known cancer gene.NFE2L2
NFE2L2 any mutation
2This gene is a known cancer gene.NFIB
NFIB any mutation
2This gene is a known cancer gene.NFKB2
NFKB2 any mutation
2This gene is a known cancer gene.NFKBIE
NFKBIE any mutation
2This gene is a known cancer gene.NIN
NIN any mutation
2This gene is a known cancer gene.NKX2-1
NKX2-1 any mutation
2This gene is a known cancer gene.NONO
NONO any mutation
2This gene is a known cancer gene.NOTCH1
NOTCH1 any mutation
2This gene is a known cancer gene.NOTCH2
NOTCH2 any mutation
2This gene is a known cancer gene.NOTCH3
NOTCH3 any mutation
2This gene is a known cancer gene.NPM1
NPM1 any mutation
2This gene is a known cancer gene.NR4A3
NR4A3 any mutation
2This gene is a known cancer gene.NRAS
NRAS any mutation
2This gene is a known cancer gene.NRG1
NRG1 any mutation
2This gene is a known cancer gene.NSD1
NSD1 any mutation
2This gene is a known cancer gene.NT5C2
NT5C2 any mutation
2This gene is a known cancer gene.NTRK1
NTRK1 any mutation
2This gene is a known cancer gene.NTRK3
NTRK3 any mutation
2This gene is a known cancer gene.NUMA1
NUMA1 any mutation
2This gene is a known cancer gene.NUP214
NUP214 any mutation
2This gene is a known cancer gene.NUP98
NUP98 any mutation
2This gene is a known cancer gene.NUTM1
NUTM1 any mutation
2This gene is a known cancer gene.NUTM2A
NUTM2A any mutation
2This gene is a known cancer gene.NUTM2B
NUTM2B any mutation
2This gene is a known cancer gene.OLIG2
OLIG2 any mutation
2This gene is a known cancer gene.OMD
OMD any mutation
2This gene is a known cancer gene.P2RY8
P2RY8 any mutation
2This gene is a known cancer gene.PAFAH1B2
PAFAH1B2 any mutation
2This gene is a known cancer gene.PALB2
PALB2 any mutation
2This gene is a known cancer gene.PAX3
PAX3 any mutation
2This gene is a known cancer gene.PAX5
PAX5 any mutation
2This gene is a known cancer gene.PAX7
PAX7 any mutation
2This gene is a known cancer gene.PAX8
PAX8 any mutation
2This gene is a known cancer gene.PBRM1
PBRM1 any mutation
2This gene is a known cancer gene.PBX1
PBX1 any mutation
2This gene is a known cancer gene.PCM1
PCM1 any mutation
2This gene is a known cancer gene.PCSK7
PCSK7 any mutation
2This gene is a known cancer gene.PDCD1LG2
PDCD1LG2 any mutation
2This gene is a known cancer gene.PDE4DIP
PDE4DIP any mutation
2This gene is a known cancer gene.PDGFB
PDGFB any mutation
2This gene is a known cancer gene.PDGFRA
PDGFRA any mutation
2This gene is a known cancer gene.PDGFRB
PDGFRB any mutation
2This gene is a known cancer gene.PER1
PER1 any mutation
2This gene is a known cancer gene.PHF6
PHF6 any mutation
2This gene is a known cancer gene.PHOX2B
PHOX2B any mutation
2This gene is a known cancer gene.PICALM
PICALM any mutation
2This gene is a known cancer gene.PIK3CA
PIK3CA any mutation
2This gene is a known cancer gene.PIK3R1
PIK3R1 any mutation
2This gene is a known cancer gene.PIM1
PIM1 any mutation
2This gene is a known cancer gene.PLAG1
PLAG1 any mutation
2This gene is a known cancer gene.PLCG1
PLCG1 any mutation
2This gene is a known cancer gene.PML
PML any mutation
2This gene is a known cancer gene.PMS1
PMS1 any mutation
2This gene is a known cancer gene.PMS2
PMS2 any mutation
2This gene is a known cancer gene.POLE
POLE any mutation
2This gene is a known cancer gene.POT1
POT1 any mutation
2This gene is a known cancer gene.POU2AF1
POU2AF1 any mutation
2This gene is a known cancer gene.POU5F1
POU5F1 any mutation
2This gene is a known cancer gene.PPARG
PPARG any mutation
2This gene is a known cancer gene.PPFIBP1
PPFIBP1 any mutation
2This gene is a known cancer gene.PPP2R1A
PPP2R1A any mutation
2This gene is a known cancer gene.PPP6C
PPP6C any mutation
2This gene is a known cancer gene.PRCC
PRCC any mutation
2This gene is a known cancer gene.PRDM1
PRDM1 any mutation
2This gene is a known cancer gene.PRDM16
PRDM16 any mutation
2This gene is a known cancer gene.PRF1
PRF1 any mutation
2This gene is a known cancer gene.PRKAR1A
PRKAR1A any mutation
2This gene is a known cancer gene.PRRX1
PRRX1 any mutation
2This gene is a known cancer gene.PSIP1
PSIP1 any mutation
2This gene is a known cancer gene.PTCH1
PTCH1 any mutation
2This gene is a known cancer gene.PTEN
PTEN any mutation
2This gene is a known cancer gene.PTPN11
PTPN11 any mutation
2This gene is a known cancer gene.PTPRB
PTPRB any mutation
2This gene is a known cancer gene.PTPRC
PTPRC any mutation
2This gene is a known cancer gene.PTPRK
PTPRK any mutation
2This gene is a known cancer gene.PWWP2A
PWWP2A any mutation
2This gene is a known cancer gene.RABEP1
RABEP1 any mutation
2This gene is a known cancer gene.RAC1
RAC1 any mutation
2This gene is a known cancer gene.RAD21
RAD21 any mutation
2This gene is a known cancer gene.RAD51B
RAD51B any mutation
2This gene is a known cancer gene.RAF1
RAF1 any mutation
2This gene is a known cancer gene.RALGDS
RALGDS any mutation
2This gene is a known cancer gene.RANBP17
RANBP17 any mutation
2This gene is a known cancer gene.RANBP2
RANBP2 any mutation
2This gene is a known cancer gene.RAP1GDS1
RAP1GDS1 any mutation
2This gene is a known cancer gene.RARA
RARA any mutation
2This gene is a known cancer gene.RB1
RB1 any mutation
2This gene is a known cancer gene.RBM15
RBM15 any mutation
2This gene is a known cancer gene.RECQL4
RECQL4 any mutation
2This gene is a known cancer gene.REL
REL any mutation
2This gene is a known cancer gene.RET
RET any mutation
2This gene is a known cancer gene.RHOA
RHOA any mutation
2This gene is a known cancer gene.RHOH
RHOH any mutation
2This gene is a known cancer gene.RMI2
RMI2 any mutation
2This gene is a known cancer gene.RNF213
RNF213 any mutation
2This gene is a known cancer gene.RNF43
RNF43 any mutation
2This gene is a known cancer gene.ROS1
ROS1 any mutation
2This gene is a known cancer gene.RPL10
RPL10 any mutation
2This gene is a known cancer gene.RPL22
RPL22 any mutation
2This gene is a known cancer gene.RPL5
RPL5 any mutation
2This gene is a known cancer gene.RPN1
RPN1 any mutation
2This gene is a known cancer gene.RSPO2
RSPO2 any mutation
2This gene is a known cancer gene.RSPO3
RSPO3 any mutation
2This gene is a known cancer gene.SNX29
SNX29 any mutation
2This gene is a known cancer gene.RUNX1
RUNX1 any mutation
2This gene is a known cancer gene.RUNX1T1
RUNX1T1 any mutation
2This gene is a known cancer gene.SBDS
SBDS any mutation
2This gene is a known cancer gene.SDC4
SDC4 any mutation
2This gene is a known cancer gene.SDHAF2
SDHAF2 any mutation
2This gene is a known cancer gene.SDHB
SDHB any mutation
2This gene is a known cancer gene.SDHC
SDHC any mutation
2This gene is a known cancer gene.SEPT5
SEPT5 any mutation
2This gene is a known cancer gene.SEPT6
SEPT6 any mutation
2This gene is a known cancer gene.SEPT9
SEPT9 any mutation
2This gene is a known cancer gene.SET
SET any mutation
2This gene is a known cancer gene.SETBP1
SETBP1 any mutation
2This gene is a known cancer gene.SETD2
SETD2 any mutation
2This gene is a known cancer gene.SF3B1
SF3B1 any mutation
2This gene is a known cancer gene.SFPQ
SFPQ any mutation
2This gene is a known cancer gene.SH2B3
SH2B3 any mutation
2This gene is a known cancer gene.SH3GL1
SH3GL1 any mutation
2This gene is a known cancer gene.SLC34A2
SLC34A2 any mutation
2This gene is a known cancer gene.SLC45A3
SLC45A3 any mutation
2This gene is a known cancer gene.SMAD4
SMAD4 any mutation
2This gene is a known cancer gene.SMARCA4
SMARCA4 any mutation
2This gene is a known cancer gene.SMARCB1
SMARCB1 any mutation
2This gene is a known cancer gene.SMARCD1
SMARCD1 any mutation
2This gene is a known cancer gene.SMARCE1
SMARCE1 any mutation
2This gene is a known cancer gene.SMO
SMO any mutation
2This gene is a known cancer gene.SND1
SND1 any mutation
2This gene is a known cancer gene.SOCS1
SOCS1 any mutation
2This gene is a known cancer gene.SOX2
SOX2 any mutation
2This gene is a known cancer gene.SPECC1
SPECC1 any mutation
2This gene is a known cancer gene.SPEN
SPEN any mutation
2This gene is a known cancer gene.SPOP
SPOP any mutation
2This gene is a known cancer gene.SRGAP3
SRGAP3 any mutation
2This gene is a known cancer gene.SRSF2
SRSF2 any mutation
2This gene is a known cancer gene.SRSF3
SRSF3 any mutation
2This gene is a known cancer gene.SS18
SS18 any mutation
2This gene is a known cancer gene.SS18L1
SS18L1 any mutation
2This gene is a known cancer gene.SSX1
SSX1 any mutation
2This gene is a known cancer gene.SSX2
SSX2 any mutation
2This gene is a known cancer gene.SSX4
SSX4 any mutation
2This gene is a known cancer gene.STAG2
STAG2 any mutation
2This gene is a known cancer gene.STAT3
STAT3 any mutation
2This gene is a known cancer gene.STAT5B
STAT5B any mutation
2This gene is a known cancer gene.STAT6
STAT6 any mutation
2This gene is a known cancer gene.STIL
STIL any mutation
2This gene is a known cancer gene.STK11
STK11 any mutation
2This gene is a known cancer gene.STRN
STRN any mutation
2This gene is a known cancer gene.SUFU
SUFU any mutation
2This gene is a known cancer gene.SUZ12
SUZ12 any mutation
2This gene is a known cancer gene.SYK
SYK any mutation
2This gene is a known cancer gene.TAF15
TAF15 any mutation
2This gene is a known cancer gene.TAL1
TAL1 any mutation
2This gene is a known cancer gene.TAL2
TAL2 any mutation
2This gene is a known cancer gene.TBL1XR1
TBL1XR1 any mutation
2This gene is a known cancer gene.TBX3
TBX3 any mutation
2This gene is a known cancer gene.TCEA1
TCEA1 any mutation
2This gene is a known cancer gene.TCF12
TCF12 any mutation
2This gene is a known cancer gene.TCF3
TCF3 any mutation
2This gene is a known cancer gene.TCF7L2
TCF7L2 any mutation
2This gene is a known cancer gene.TCL1A
TCL1A any mutation
2This gene is a known cancer gene.TERT
TERT any mutation
2This gene is a known cancer gene.TET1
TET1 any mutation
2This gene is a known cancer gene.TET2
TET2 any mutation
2This gene is a known cancer gene.TFE3
TFE3 any mutation
2This gene is a known cancer gene.TFEB
TFEB any mutation
2This gene is a known cancer gene.TFG
TFG any mutation
2This gene is a known cancer gene.TFPT
TFPT any mutation
2This gene is a known cancer gene.TFRC
TFRC any mutation
2This gene is a known cancer gene.THRAP3
THRAP3 any mutation
2This gene is a known cancer gene.TLX1
TLX1 any mutation
2This gene is a known cancer gene.TLX3
TLX3 any mutation
2This gene is a known cancer gene.TMPRSS2
TMPRSS2 any mutation
2This gene is a known cancer gene.TNFAIP3
TNFAIP3 any mutation
2This gene is a known cancer gene.TNFRSF14
TNFRSF14 any mutation
2This gene is a known cancer gene.TNFRSF17
TNFRSF17 any mutation
2This gene is a known cancer gene.TOP1
TOP1 any mutation
2This gene is a known cancer gene.TPM3
TPM3 any mutation
2This gene is a known cancer gene.TPM4
TPM4 any mutation
2This gene is a known cancer gene.TPR
TPR any mutation
2This gene is a known cancer gene.TRAF7
TRAF7 any mutation
2This gene is a known cancer gene.TRIM24
TRIM24 any mutation
2This gene is a known cancer gene.TRIM27
TRIM27 any mutation
2This gene is a known cancer gene.TRIM33
TRIM33 any mutation
2This gene is a known cancer gene.TRIP11
TRIP11 any mutation
2This gene is a known cancer gene.TRRAP
TRRAP any mutation
2This gene is a known cancer gene.TSC1
TSC1 any mutation
2This gene is a known cancer gene.TSC2
TSC2 any mutation
2This gene is a known cancer gene.TSHR
TSHR any mutation
2This gene is a known cancer gene.TTL
TTL any mutation
2This gene is a known cancer gene.U2AF1
U2AF1 any mutation
2This gene is a known cancer gene.UBR5
UBR5 any mutation
2This gene is a known cancer gene.USP6
USP6 any mutation
2This gene is a known cancer gene.VHL
VHL any mutation
2This gene is a known cancer gene.VTI1A
VTI1A any mutation
2This gene is a known cancer gene.WAS
WAS any mutation
2This gene is a known cancer gene.WHSC1
WHSC1 any mutation
2This gene is a known cancer gene.WHSC1L1
WHSC1L1 any mutation
2This gene is a known cancer gene.WIF1
WIF1 any mutation
2This gene is a known cancer gene.WRN
WRN any mutation
2This gene is a known cancer gene.WT1
WT1 any mutation
2This gene is a known cancer gene.WWTR1
WWTR1 any mutation
2This gene is a known cancer gene.XPA
XPA any mutation
2This gene is a known cancer gene.XPC
XPC any mutation
2This gene is a known cancer gene.XPO1
XPO1 any mutation
2This gene is a known cancer gene.YWHAE
YWHAE any mutation
2This gene is a known cancer gene.ZBTB16
ZBTB16 any mutation
2This gene is a known cancer gene.ZCCHC8
ZCCHC8 any mutation
2This gene is a known cancer gene.ZMYM2
ZMYM2 any mutation
2This gene is a known cancer gene.PATZ1
PATZ1 any mutation
2This gene is a known cancer gene.ZNF331
ZNF331 any mutation
2This gene is a known cancer gene.ZNF384
ZNF384 any mutation
2This gene is a known cancer gene.ZNF521
ZNF521 any mutation
2This gene is a known cancer gene.ZRSR2
ZRSR2 any mutation
PMKB Bot
  • Genes
  • Variants
  • Interpretations
  • Tumor Types
  • Primary Sites
  • Activity

Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The Englander Institute for Precision Medicine at Weill Cornell Medicine makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.


When using PMKB, please cite: Huang et al., JAMIA 2017


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