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610

Genes

2247

Variants

1766

Interpretations

156

Tumor Types

108

Primary Sites

264
Tier 1

Interpretations

1406
Tier 2

Interpretations

96
Tier 3

Interpretations

Tier Definitions

Tier 1 - Variants with strong evidence of clinical utility
  • Variants with strong evidence1 of clinical actionability for this tumor type, including FDA-approved targeted therapies for this tumor type.
  • Variants with strong evidence1 of prognostic significance for this tumor type.
  • Variants recognized as entity-defining molecular alterations by current WHO guidelines for this tumor type.
Tier 2 - Variants with potential clinical relevance
  • Strong evidence1 of clinical actionability in this tumor or in a different tumor type.
  • Known investigational studies targeting this variant in this tumor type.
  • Variants may be included in this tier if they are characteristic of a particular tumor type and/or are thought to have functional relevance for this tumor type, but they do not meet criteria for Tier 1.
Tier 3 - Variants of undetermined clinical significance
  • The functional and clinical relevance of these variants are undetermined for this tumor type. These variants are provided in the event that they are proven to be of clinical utility at a later date.
1 Evidence is considered “strong” if there is/are:
  • An FDA-approved therapy included in professional guidelines related to this variant for this tumor type, and/or
  • Well-powered studies with consensus from experts in the field that guide therapy based on this variant as an independent parameter in this tumor type.
PMKB Bot
  • Genes
  • Variants
  • Interpretations
  • Tumor Types
  • Primary Sites
  • Activity

Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The Englander Institute for Precision Medicine at Weill Cornell Medicine makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.


When using PMKB, please cite: Huang et al., JAMIA 2017


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