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BRAF
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Interpretation 2320
Tier 2
BRAF
Variants
BRAF V600E
Primary Sites
Larynx
Oral Cavity
Tumor Types
Squamous Cell Carcinoma
Interpretation

B-RAF is a member of the RAF-family of kinases which plays an important role in the RAS-RAF-MEK-ERK mitotic signaling pathway. Mutations of B-RAF have been described in <2% of head and neck squamous cell carcinomas. The hotspot for mutations in BRAF is at codon Val600 and the most common one is p.Val600Glu (V600E). Various B-RAF inhibitors have been FDA approved for cancer therapy in certain settings.

Citations
  1. Head and Neck Squamous Cell Carcinoma (TCGA, Nature 2015)
  2. Davies H, et al. Mutations of the BRAF gene in human cancer. Nature 2002;417(6892):949-54
Last updated: 2019-01-22 18:51:59 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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