Glioblastoma
Interpretations
| ID | Tumor | Tissue | Variants | Tier | Interpretation |
|---|---|---|---|---|---|
| 121 | Glioblastoma | Spinal Cord Brain Brain, Supratentorial Brain, Infratentorial | EGFR A289V EGFR A289D EGFR G598V EGFR P596L EGFR codon(s) 289, 596, 598 any | 2 | EGFR mutations in GBM cluster in the extracellular (EC) domain and include in-frame deletions (such as the common “variant III” del 6-273) and missense mutations (A289V, A289D, T263P, G598V). In vitro and in vivo studies reveal anchorage-independent growth and tumorigenic potential when the A289 and G598 variants are stably expressed in NIH-3T3 cells. The A289 and G598 mutations sensitize Ba/F3 cells to erlotinib in vitro according to some reports, although other reports state glioma-specific EGFR EC mutants are poorly inhibited by EGFR inhibitors that target the active kinase conformation (e.g., erlotinib). The A289 variant has been reported to show sensitivity towards BAY846, a tyrosine kinase inhibitor in brain tumors. In addition, according to some reports, inhibitors which bind to the inactive EGFR conformation potently inhibit EGFR EC mutants and induce cell death in EGFR mutant GBM cells. |
| 128 | Glioblastoma | Brain Spinal Cord Brain, Supratentorial Brain, Infratentorial | EGFR exon(s) 20 insertion | 2 | In GBM, EGFR mutations typically cluster in the extracellular domain and include in-frame deletions (such as the common “variant III” del 6-273) and missense mutations (A289V, A289D, T263P, G598V). EGFR exon 20 insertions have not been previously reported in GBM. The clinical significance of this mutation with regards to response to anti-EGFR therapy in GBM is unknown. In general, EGFR exon 20 mutations have been reported in approximately 9% of all EGFR-mutated cases of lung cancer and studies show that in contrast to the more classic activating EGFR mutations, these insertions have been associated with de novo resistance or only partial response to approved EGFR-TKIs (erlotinib and gefitinib) in lung cancer. |
| 134 | Glioblastoma | Spinal Cord Brain Brain, Supratentorial Brain, Infratentorial | EGFR E709K | 2 | In GBM, EGFR mutations typically cluster in the extracellular domain and include in-frame deletions (such as the common “variant III” del 6-273) and missense mutations (A289V, A289D, T263P, G598V). However, the p.E709K mutation in the tyrosine kinase domain of EGFR has not been previously reported in GBM. In vitro functional characterization of mutations at E709 have been reported to be activivating mutations that are associated with sensitivity to EGFR inhibitors in vitro in some cell systems. The clinical significance of this mutation with regards to response to anti-EGFR therapy in GBM is unknown. |
| 194 | Glioblastoma | Brain Brain, Infratentorial Brain, Supratentorial | EGFR copy number gain | 2 | Greater than 40% of glioblastomas (GBM) harbor focal amplification of the EGFR locus and there is evidence to suggest that these are driver alterations in these patients, making the EGFR pathway a potential therapeutic target in some clinical settings. Moreover, this alteration is relatively specific for GBM with very few other diffusely infiltrative gliomas having been shown to carry focal amplification of this locus (<3%). In GBM, this alteration frequently occurs in combination with other alterations of EGFR including polysomy 7, intragenic inframe deletions (e.g. EGFRvIII), and/or somatic point mutations. Based on current evidence, the independent predictive value of EGFR amplification in GBM is unclear. The relationship between individual and concurrent EGFR alterations and clinical response to small molecular inhibitors targeting EGFR is currently under investigation in clinical trials. |
| 143 | Glioblastoma Astrocytoma, Anaplastic Oligodendroglioma Astrocytoma, Diffusely Infiltrating Infiltrating Glioma, NOS Neuroepithelial neoplasm, high grade Neuroepithelial Neoplasm, NOS | Spinal Cord Brain Brain, Supratentorial Brain, Infratentorial | IDH1 R132H IDH1 R132L IDH1 R132C IDH1 codon(s) 132 any | 1 | IDH1 or IDH2 mutations are found in >70% of lower grade diffusely infiltrative gliomas and in >90% of secondary glioblastoma. IDH mutational status has been reported to be a favorable prognostic indicator relative to wild-type gliomas of similar histology, regardless of grade. Therapeutic strategies exploiting mutated IDH protein, including through direct inhibition and vaccine-based approaches, are currently the subject of preclinical research and clinical trials. |
| 147 | Glioblastoma Astrocytoma, Anaplastic Ependymoma Oligodendroglioma | Spinal Cord Brain Brain, Supratentorial Brain, Infratentorial | IDH2 R140Q IDH2 R172K IDH2 codon(s) 140, 172 any | 1 | IDH1 or IDH2 mutations are found in >70% of lower grade diffusely infiltrative gliomas and in >90% of secondary glioblastoma. IDH mutational status has been reported to be a favorable prognostic indicator relative to wild-type gliomas of similar histology, regardless of grade. Therapeutic strategies exploiting mutated IDH protein, including through direct inhibition and vaccine-based approaches, are currently the subject of preclinical research and clinical trials. |
| 202 | Glioblastoma | Brain | 2 | Somatic mutations in TP53 are frequent in human cancer. Germline TP53 mutations cause of Li-Fraumeni syndrome, which is associated with a range of early-onset cancers. The types and positions of TP53 mutations are diverse. TP53 mutations may be potential prognostic and predictive markers in some tumor types, as well as targets for pharmacological intervention in some clinical settings. The IARC TP53 Database (http://www-p53.iarc.fr/) is a useful resource which catalogues TP53 mutations found in cancer. | |
| 221 | Glioblastoma | Brain | PTEN any deletion PTEN G129R | 2 | PTEN is an obligate haplo-insufficient tumor suppressor gene and is mutated in a large number of cancers. It encodes a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/mTOR signaling pathway. Most PTEN mutations are loss-of-function mutations. Mono-allelic or bi-allelic loss of PTEN is found in a considerable fraction of tumors, including gliomas (75%). In glioblastoma, PTEN loss/deletion is associated with poor patient prognosis, and/or shorter disease-free survival. There are ongoing clinical trials investigating anti-tumor activity of agents in recurrent glioblastoma with this mutation. |
| 225 | Glioblastoma | Brain | MET T1010I | 3 | MET is frequently overexpressed in glioblastomas (GBM), and some gliomas show hepatocyte growth factor (HGF) autocrine activation of the MET signaling pathway. Several studies have found that HGF and MET are expressed at higher levels in human gliomas than in control brain tissue, and that expression levels correlate with tumor grade. Some studies have shown that the HGF expression in high-grade (WHO Grade III–IV) tumors was significantly higher than in low-grade (WHO I–II) tumors. Similarly, coexpression of HGF and MET is observed more frequently in Grade IV GBM than in low-grade glioma, consistent with the contribution of an HGF/MET autocrine loop to malignant progression in these tumors. However, MET sequence alterations have been rare. The p.T1010I mutation, in the cytoplasmic juxtamembrane domain of MET has been reported in some tumor types and also has been reported as a germline variant present in less than 1% of the general population. Its role in tumor development and progression continues to be studied. The utility of MET pathway inhibitors also continues to be explored. |
| 229 | Glioblastoma | Brain | 3 | The APC gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. APC promotes rapid degradation of beta-catenin and participates in Wnt signaling as a negative regulator. APC is also involved in other processes including cell migration, cell adhesion, transcriptional activation and apoptosis. Germline defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. Somatic mutations in this gene may be observed in colorectal cancer (CRC), stomach cancer and desmoid tumors. Although APC mutations have been reported in up to 5% of low grade gliomas and up to 13% primary glioblastomas (GBM), evidence regarding their involvement in CNS tumors is still limited. Further studies are needed to explore the clinical value of these mutations in CNS tumors. | |
| 239 | Adenocarcinoma Cholangiocarcinoma Glioblastoma | Colon Gall Bladder Brain | IRS2 copy number gain | 3 | IRS1 and IRS2 are the key protein effectors for transmitting insulin signals from the insulin-like growth factor receptor to the nucleus via the PI3K / AKT / mTOR pathway. IRS2 has been previously noted to be recurrently focally amplified in several anecdotal studies across multiple cancer types (colorectal cancer PMID: 23594372, cholangiocarcinoma PMID:26684807, glioblastoma PMID: 14655756, rhabdomyosarcoma PMID: 23578105), suggesting that this could be a "driver" alteration in a subset of cancer.. IRS2 amplifications have also been associated with sensitivity to the insulin receptor inhibitor BMS-754807 in colorectal cancer cell lines (PMID: 25527633). There is no direct evidence to connect IRS2 amplification status with sensitivity to any targeted therapy regimen in patients; however, an attractive hypothesis is that tumors harboring IRS2 amplifications could be sensitive to drugs targeting insulin signaling, PI3K, AKT, and mTOR. Drug sensitivity and exome sequencing data from colorectal patient derived tumor xenografts have associated IRS2 copy gains with sensitivity to anti-EGFR therapies (PMID: 26416732). |
| 252 | Glioblastoma | Brain, Supratentorial | SEPT14 copy number gain | 2 | The SEPT14 gene has been described as a fusion partner with EGFR in up to 4% of glioblastomas. In that context, glioma cell lines harboring this gene fusion were found to be susceptible to EGFR inhibitors in vitro. The functional significance of an isolated partial amplification of this gene would be of uncertain significance. Detection of rearrangement of this locus with a fusion partner such as EGFR would require an alternative methodology such as RNAseq or FISH analysis. |
| 253 | Glioblastoma | Brain | CDKN2A copy number loss | 2 | The CDKN2A gene locus is altered in up to approximately 57% of glioblastoma, most commonly as a homozygous deletion, and frequently with concurrent deletion of the CDKN2B locus. CDKN2A/CDKN2B loss may be associated with increased sensitivity to CDK4/6 inhibitors. The efficacy and toxicity profiles of these inhibitors in the context of a variety of cancer types are currently under evaluation in clinical trials. |
| 254 | Glioblastoma | Brain | CDKN2B copy number loss | 1 | The CDKN2B gene locus is altered in up to approximately 55% of glioblastoma, most commonly as a homozygous deletion, and frequently with concurrent deletion of the CDKN2A locus. CDKN2A/CDKN2B loss may be associated with increased sensitivity to CDK4/6 inhibitors. The efficacy and toxicity profiles of these inhibitors in the context of a variety of cancer types are currently under evaluation in clinical trials. |
| 259 | Glioblastoma | Brain | 3 | The PTPN11gene encodes SHP-2, a widely expressed cytoplasmic protein tyrosine phosphatase. SHP-2 is essential for activation of the RAS/MAPK signaling cascade. Most mutations are gain-of-function and result in prolonged ligand-dependent activation of the RAS/MAPK cascade. Germ-line PTPN11 mutations cause Noonan syndrome, a developmental disorder characterized by an increased risk of malignancies. Activating somatic mutations in PTPN11 have been documented in certain hematologic malignancies but they are infrequent in solid tumors. According to TCGA data base, about 2% of all the glial tumors harbor somatic mutations in PTPN11 gene but their prognostic and therapeutic significance remains to be fully elucidated. The utility of SHP2 inhibitors continues to be explored in some preclinical studies. | |
| 322 | Glioblastoma | Brain | 2 | The protein encoded by the RB1 gene is a negative regulator of the cell cycle and was the first tumor suppressor gene identified. The active, hypophosphorylated form of the protein binds transcription factor E2F1. RB1 alterations including mutations and deletions are seen in up to 11% of glioblastomas. It has been suggested that patients with RB1-deficient tumors do not respond to cyclin-dependent kinase (CDK) inhibitors. The predictive and prognostic significance of RB1 mutations in glioblastoma needs to be further studied. | |
| 345 | Glioblastoma Neuroblastoma Astrocytoma, Anaplastic Oligodendroglioma Ependymoma Ependymoma, Anaplastic | Brain Brain, Infratentorial Brain, Supratentorial | 1 | In AML, presence of exon 17 mutations in KIT may confer an adverse prognosis or increased relapse rate. However, its significance in brain tumors is yet to be determined. | |
| 349 | Renal Cell Carcinoma Glioblastoma | Kidney Brain | 1 | FGFR2 mutation in a patient with oral squamous cell carcinoma was associated with response to the multitargeted tyrosine kinase inhibitor pazopanib. The clinical significance of this finding in this tumor type is unknown. | |
| 372 | Glioblastoma | Brain | EGFR V774M | 2 | EGFR mutations have been reported in up to 21% of glioblastoma tumors (GBM). In GBM, EGFR mutations typically cluster in the extracellular domain and include in-frame deletions and missense mutations. However, mutations (such as V774M) in the tyrosine kinase domain of EGFR have been previously reported in GBM. The clinical significance of this mutation with regards to response to TKI therapy in GBM needs further elucidation. Results should be interpreted in conjunction with other laboratory and clinical findings. |
| 405 | Glioblastoma Astrocytoma, Anaplastic Astrocytoma, Pilocytic | Brain | MET E168D | 3 | MET is a member of the receptor tyrosine kinase and proto-oncogene playing a major role in tumor development and metastasis. MET mutations have been reported in up to 3.3% of low-grade gliomas and 2.2% of glioblastomas. MET E168D mutation is located in a conserved domain containing the ligand binding site. In vitro studies have shown that E168D may be associated with higher ligand affinity and higher susceptibility to c-Met inhibitors in lung cancer. The predictive and prognostic significance of MET mutations in brain tumors is unclear and needs to be further studied. Correlation with other clinical and laboratory findings is recommended. |
| 408 | Glioblastoma | Brain | EGFR R108K | 2 | EGFR mutations in GBM cluster in the extracellular (EC) domain and include in-frame deletions (such as the common “variant III” del 6-273) and missense mutations (A289V, A289D, T263P, G598V). Mutations involving residue R108 have been reported in GBM, frequently occurring with other EGFR mutations at amino acids A289, P596, and G598. In vitro studies have shown that R108K mutation leads to increased ligand-binding affinity and shows anchorage-independent growth and tumorigenic potential when stably expressed in NIH-3T3 cells. The predictive and prognostic significance of this mutation at R108 needs further elucidation. Correlation with other clinical and laboratory findings is recommended. |
| 413 | Astrocytoma, Anaplastic Glioblastoma | Brain Brain, Supratentorial Brain, Infratentorial | PDGFRA copy number gain | 2 | PDGFRA amplification is reportedly present in up to 29% of pediatric and 21% of adult high-grade astrocytomas when assessed by flourescent in situ hydridization. Copy number alterations of this gene have been repoted in approximately 11% of adult glioblastoma making it the second most commonly altered receptor tyrosine kinase after EGFR. In those adult glioblastomas that are IDH-mutant, there is evidence to suggest that amplification of PDGFRA is associated with worse overall survival. |
| 1579 | Acinar Cell Carcinoma Acinic Cell Carcinoma Acute Myeloid Leukemia Adenocarcinoma Adenoid Cystic Carcinoma Adenosarcoma Ameloblastic Tumor Anaplastic Large Cell Lymphoma Angioimmunoblastic T-Cell Lymphoma Angiomatoid Fibrous Histiocytoma Angiomatosis Angiomyolipoma Angiosarcoma Astrocytoma, Anaplastic Atypical Chronic Myeloid Leukemia B Lymphoblastic Leukemia/Lymphoma Basal Cell Carcinoma Burkitt Lymphoma Carcinoid Tumor Carcinoma Carcinosarcoma Cholangiocarcinoma Chondrosarcoma Chordoma Choriocarcinoma Chromophobe Renal Cell Carcinoma Chronic Lymphocytic Leukemia Chronic Myeloid Leukemia Chronic Myelomonocytic Leukemia Chronic Neutrophilic Leukemia Classical Hodgkin Lymphoma Clear Cell Carcinoma Clear Cell Renal Cell Carcinoma Craniopharyngioma Dermatofibrosarcoma Desmoplastic Small Round Cell Tumor Diffuse Large B Cell Lymphoma Ductal Carcinoma Ependymoma Essential Thrombocythemia Ewing Sarcoma Fibromatosis Follicular Carcinoma Follicular Lymphoma Gastrointestinal Stromal Tumor Germ Cell Tumor Giant Cell Tumor Glioblastoma Glomus Tumor Granular Cell Tumor Hairy Cell Leukemia Hemangioendothelioma Hepatocellular Carcinoma Histiocytic and Dendritic Cell Neoplasms Invasive Ductal Carcinoma Kaposi Sarcoma Langerhans Cell Histiocytosis Leiomyoma Leiomyosarcoma Lipoma Liposarcoma Lobular Carcinoma Lymphoplasmacytic Lymphoma Malignant Mullerian Mixed Tumor Mantle Cell Lymphoma Marginal Zone B Cell Lymphoma Mast Cell Neoplasm MDS with Ring Sideroblasts Medullary Carcinoma Medulloblastoma Melanoma Meningioma Merkel Cell Carcinoma Mesothelioma Mucinous Tumors of Appendix Mucinous Tumors of Ovary Mucoepidermoid Carcinoma Myelodysplastic Syndrome Myeloproliferative Neoplasm Myxofibrosarcoma Nasopharyngeal Carcinoma Neuroblastoma Neuroendocrine Carcinoma Neuroendocrine Neoplasm NK Cell Lymphoproliferative Disorder NLPHL Non-Small Cell Lung Carcinoma Oligodendroglioma Osteosarcoma Papillary Carcinoma Papillary Renal Cell Carcinoma Peripheral T Cell Lymphoma Pheochromocytoma Plasma Cell Disorder Polycythemia Vera Post-Transplant Lymphoproliferative Disorder Primary Myelofibrosis Primitive Neuroectodermal Tumor Renal Cell Carcinoma Reninoma Retinoblastoma Rhabdomyosarcoma Sarcoma Schwannoma Serous Carcinoma Sex Cord Stromal Tumor Small Cell Carcinoma Solid Pseudopapillary Tumor of Pancreas Spindle Cell Neoplasm Squamous Cell Carcinoma T Cell Lymphoproliferative Disorder T Lymphoblastic Leukemia/Lymphoma T-Cell LGL Leukemia Thymic Carcinoma Thymoma Urothelial Carcinoma Tumors of Peripheral Nerves Unknown Wilms Tumor Ependymoma, Anaplastic Astrocytoma, Pilocytic Ganglioglioma Neuroepithelial Neoplasm, NOS Pleomorphic Carcinoma Solitary Fibrous Tumor Neuroepithelial neoplasm, high grade Leukocytosis Thrombocytosis Monocytosis Cytopenia Other Acute Leukemia Astrocytoma, NOS Acute Leukemia of Unspecified Cell Type Anemia, Unspecified Astrocytoma, Diffusely Infiltrating Diffuse Midline Glioma Infiltrating Glioma, NOS Intraductal Papillary Mucinous Neoplasm (IPMN) Leukopenia Lymphadenopathy Lymphocytosis, Symptomatic Monoclonal Gammopathy Mucinous or Serous Cystic Neoplasms of Pancreas Mycosis Fungoides, Unspecified Site Oligodendroglioma, Anaplastic Pleomorphic Xanthoastrocytoma Rash and Other Nonspecific Skin Eruption Thrombocytopenia, Unspecified | Adrenal Gland Anus Ampulla (Pancreaticobiliary Duct) Appendix Bladder Blood Bone Bone Marrow Brain Breast Spinal Cord Cervix Chest Wall Colon Endometrium Esophagus Eye Fallopian Tube Fibroadipose Tissue Gall Bladder Kidney Larynx Liver Lung Lymph Node Nasal Cavity Oral Cavity Ovary Pancreas Parathyroid Penis Peripheral Nervous System Peritoneum Pharynx Pituitary Placenta Pleura Prostate Retroperitoneum Salivary Gland Seminal Vesicle Skeletal Muscle Skin Small Intestine Soft Tissue Spleen Stomach Testis Thymus Thyroid Tonsil Unknown Ureter Uterus Vagina Rectum Cartilage Blood Vessel Buccal Swab Heart Trachea Salivary Duct Spermatic Cord Vulva Brain, Infratentorial Brain, Supratentorial Gastroesophageal Junction Sellar Suprasellar | ARID1A any mutation | 2 | This gene is a known cancer gene. ARID1A/BAF250A subunit of the SWI/SNF (BAF) chromatin remodeling complex has emerged as recurrently mutated in a broad array of tumor types and a potential tumor suppressor. There is evidence indicating that ARID1A-mutated cancers may be subjected to therapeutic intervention. |
| 2085 | Acinar Cell Carcinoma Acinic Cell Carcinoma Adenocarcinoma Adenoid Cystic Carcinoma Adenosarcoma Ameloblastic Tumor Anaplastic Large Cell Lymphoma Angioimmunoblastic T-Cell Lymphoma Angiomatoid Fibrous Histiocytoma Angiomatosis Angiomyolipoma Angiosarcoma Astrocytoma, Anaplastic Basal Cell Carcinoma Burkitt Lymphoma Carcinoid Tumor Carcinoma Carcinosarcoma Cholangiocarcinoma Chondrosarcoma Chordoma Choriocarcinoma Chromophobe Renal Cell Carcinoma Chronic Lymphocytic Leukemia Classical Hodgkin Lymphoma Clear Cell Carcinoma Clear Cell Renal Cell Carcinoma Craniopharyngioma Dermatofibrosarcoma Desmoplastic Small Round Cell Tumor Diffuse Large B Cell Lymphoma Ductal Carcinoma Ependymoma Ewing Sarcoma Fibromatosis Follicular Carcinoma Follicular Lymphoma Gastrointestinal Stromal Tumor Germ Cell Tumor Giant Cell Tumor Glioblastoma Glomus Tumor Granular Cell Tumor Hairy Cell Leukemia Hemangioendothelioma Hepatocellular Carcinoma Invasive Ductal Carcinoma Kaposi Sarcoma Leiomyoma Leiomyosarcoma Lipoma Liposarcoma Lobular Carcinoma Lymphoplasmacytic Lymphoma Malignant Mullerian Mixed Tumor Mantle Cell Lymphoma Marginal Zone B Cell Lymphoma Medullary Carcinoma Medulloblastoma Melanoma Meningioma Merkel Cell Carcinoma Mesothelioma Mucinous Tumors of Appendix Mucinous Tumors of Ovary Mucoepidermoid Carcinoma Myxofibrosarcoma Nasopharyngeal Carcinoma Neuroblastoma Neuroendocrine Carcinoma Neuroendocrine Neoplasm NK Cell Lymphoproliferative Disorder NLPHL Non-Small Cell Lung Carcinoma Oligodendroglioma Osteosarcoma Papillary Carcinoma Papillary Renal Cell Carcinoma Peripheral T Cell Lymphoma Pheochromocytoma Plasma Cell Disorder Post-Transplant Lymphoproliferative Disorder Primitive Neuroectodermal Tumor Renal Cell Carcinoma Reninoma Retinoblastoma Rhabdomyosarcoma Sarcoma Schwannoma Serous Carcinoma Sex Cord Stromal Tumor Small Cell Carcinoma Solid Pseudopapillary Tumor of Pancreas Spindle Cell Neoplasm Squamous Cell Carcinoma T Cell Lymphoproliferative Disorder T-Cell LGL Leukemia Thymic Carcinoma Thymoma Urothelial Carcinoma Tumors of Peripheral Nerves Unknown Wilms Tumor Ependymoma, Anaplastic Astrocytoma, Pilocytic Ganglioglioma Neuroepithelial Neoplasm, NOS Pleomorphic Carcinoma Solitary Fibrous Tumor Neuroepithelial neoplasm, high grade Astrocytoma, NOS Astrocytoma, Diffusely Infiltrating Diffuse Midline Glioma Infiltrating Glioma, NOS Intraductal Papillary Mucinous Neoplasm (IPMN) Lymphadenopathy Lymphocytosis, Symptomatic Monoclonal Gammopathy Mucinous or Serous Cystic Neoplasms of Pancreas Mycosis Fungoides, Unspecified Site Oligodendroglioma, Anaplastic Pleomorphic Xanthoastrocytoma Rash and Other Nonspecific Skin Eruption | Adrenal Gland Anus Ampulla (Pancreaticobiliary Duct) Appendix Bladder Blood Bone Bone Marrow Brain Breast Spinal Cord Cervix Chest Wall Endometrium Esophagus Eye Fallopian Tube Fibroadipose Tissue Gall Bladder Kidney Larynx Liver Lung Lymph Node Nasal Cavity Oral Cavity Ovary Pancreas Parathyroid Penis Peripheral Nervous System Peritoneum Pharynx Pituitary Placenta Pleura Prostate Retroperitoneum Salivary Gland Seminal Vesicle Skeletal Muscle Skin Small Intestine Soft Tissue Spleen Stomach Testis Thymus Thyroid Tonsil Unknown Ureter Uterus Vagina Rectum Cartilage Blood Vessel Buccal Swab Heart Trachea Salivary Duct Spermatic Cord Vulva Brain, Infratentorial Brain, Supratentorial Gastroesophageal Junction Sellar Suprasellar Colon | TP53 any mutation | 2 | Somatic mutations in TP53 are frequent in human cancer. Germline TP53 mutations cause of Li-Fraumeni syndrome, which is associated with a range of early-onset cancers. The types and positions of TP53 mutations are diverse. TP53 mutations may be potential prognostic and predictive markers in some tumor types, as well as targets for pharmacological intervention in some clinical settings. The IARC TP53 Database (http://www-p53.iarc.fr/) is a useful resource which catalogues TP53 mutations found in cancer. |
| 2133 | Glioblastoma | Brain Brain, Infratentorial Brain, Supratentorial | CDKN2A H83Y | 2 | CDKN2A H83Y lies within the ANK3 domain of the CDKN2A protein. H83Y confers a loss of function to the CDKN2A protein as demonstrated by loss of cell cycle control. The CDKN2A gene locus is altered in up to approximately 57% of glioblastoma, most commonly as a homozygous deletion, and frequently with concurrent deletion of the CDKN2B locus. CDKN2A/CDKN2B loss may be associated with increased sensitivity to CDK4/6 inhibitors. The efficacy and toxicity profiles of these inhibitors in the context of a variety of cancer types are currently under evaluation in clinical trials. CDKN2A mutations account for only 1-3% of glioblastomas and the clinical significance remains to be elucidated. |
| 2146 | Astrocytoma, NOS Astrocytoma, Anaplastic Glioblastoma | Brain | SMAD4 I525V | 3 | SMAD4 is tumor suppressor gene and it encodes an intracellular mediator in the transforming growth factor b (TGF b) signal transduction pathway. Somatic mutations in SMAD4 are exceedingly rare in glial neoplasms. SMAD4 I525V has been reported as a likely benign germline variant in ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/variation/41788/). These results should be interpreted in the clinical context. |
| 2147 | Astrocytoma, NOS Astrocytoma, Anaplastic Astrocytoma, Diffusely Infiltrating Glioblastoma Infiltrating Glioma, NOS | Brain Spinal Cord | NRAS codon(s) 12, 13, 61, 146 any | 2 | NRAS gene belongs to the family of RAS genes. It encodes a G protein that is important in the transmission of growth-promoting signals from the cell surface receptors to the nucleus through RAS-RAF-mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)-AKT cell signaling pathways. NRAS mutations are rare in glial neoplasms and are found in about 1% of cases. The clinicopathologic significance of NRAS mutations in glial neoplasms remains to be further elucidated. |
| 2149 | Glioblastoma Astrocytoma, NOS Astrocytoma, Anaplastic | Brain | CDKN2A W110* | 2 | The CDKN2A gene locus is altered in up to approximately 57% of glioblastoma, most commonly as a homozygous deletion, and frequently with concurrent deletion of the CDKN2B locus. CDKN2A/CDKN2B loss may be associated with increased sensitivity to CDK4/6 inhibitors. W110* results in early truncation and confers a loss of function as demonstrated by loss of CDK binding and cell cycle control in culture. The clinicopathologic effects of the heterozygous rather than homozygous loss of CDKN2A in glial neoplasms remains to be further elucidated. The efficacy and toxicity profiles of these inhibitors in the context of a variety of cancer types are currently under evaluation in clinical trials. |
| 2242 | Glioblastoma Astrocytoma, NOS Astrocytoma, Pilocytic Astrocytoma, Diffusely Infiltrating | Brain | MLH1 V384D | 3 | MLH1 is a component of the cellular DNA mismatch repair (MMR) machinery. The MLH1 V384D mutation has been associated with cancer risk in some tumor types. This variant encodes in a partially impaired protein with diminished interaction with PMS2 protein and reduced MMR activity in vitro. The MLH1 V384D variant has not been reported as a somatic mutation in glial brain tumors. This variant has an allele frequency of 4% in the East Asian population. Some studies have shown that patients carrying the MLH V384D variant have an increased risk of the development of microsatellite-instable as well as -stable colorectal cancer. MLH1 V384D variant has also been reported to be associated with primary resistance to EGFR-TKIs in patients with EGFR L858R-positive lung adenocarcinoma. Of note, this variant is reported as a benign germline variant in ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/variation/41632/). Clinical correlation is recommended. |
| 2249 | Glioblastoma Astrocytoma, NOS | Brain | PDGFRA N659K | 2 | PDGFRA amplification is reportedly present in up to 29% of pediatric and 21% of adult high-grade astrocytomas when assessed by flourescent in situ hydridization. Copy number alterations of this gene have been reported in approximately 11% of adult glioblastoma making it the second most commonly altered receptor tyrosine kinase after EGFR. In those adult glioblastomas that are IDH-mutant, there is evidence to suggest that amplification of PDGFRA is associated with worse overall survival. Somatic mutations within the PDGFRA gene are less frequent than amplifications. PGDFRA N659K is within the tyrosine kinase domain and confers a gain of function. Preclinical trials in N659K mutant cell lines have shown sensitivity to multi-targeted tyrosine kinase inhibitors including imatinib and crenolanib. |
| 2258 | Glioblastoma | Brain | SMAD4 P472T | 3 | SMAD4 is a tumor suppressor gene and it encodes an intracellular mediator in the transforming growth factor b (TGF b) signal transduction pathway. SMAD4 mutations are very rare in glioblastoma and are present in less than 1% of cases and the significance of these mutations are unclear in this tumor type. The effect on protein function of SMAD4 P472T remains to be further elucidated. These results should be interpreted in the clinicopathologic context. |
| 2259 | Glioblastoma | Brain | PTEN P169H | 3 | PTEN is an obligate haplo-insufficient tumor suppressor gene and is mutated in a large number of cancers. It encodes a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/mTOR signaling pathway. Most PTEN mutations are loss-of-function mutations. Mono-allelic or bi-allelic loss of PTEN is found in a considerable fraction of tumors, including gliomas (75%). In glioblastoma, PTEN loss/deletion is associated with poor patient prognosis, and/or shorter disease-free survival. The PTEN P169H mutation, however, is not definitively known to cause a loss-of-function change in the PTEN protein and has been shown to confer a phosphatase activity similar to wild-type PTEN in yeast. This variant has been identified in one case of glioblastoma according to the literature. This result should be interpreted in the clinicopathologic context. |
| 2260 | Glioblastoma | Brain | KIT D45N | 3 | KIT, also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a growth factor receptor of the tyrosine kinase subclass III family, normally expressed in a variety of tissue types. Signaling through CD117 plays a role in cell survival, proliferation, and differentiation. KIT is found in approximately 1% of glioblastomas. The KIT D45N variant is in the extracellular domain, however, its effect on protein function is unknown. The clinical significance of KIT in glioblastoma and the clinicopathologic effect of this variant remains to be further elucidated. |
| 2261 | Glioblastoma | Brain | CDH1 A403T | 3 | CDH1 on 16q22.1 encodes E-cadherin which functions in intercellular adhesion. E-cadherin is involved in transmitting chemical signals and controlling cell maturation and movement, and acts as a tumor suppressor. CDH1 is rare in this tumor type and is found in approximately 1% of glioblastomas. The CDH1 A403T variant has not been characterized in the literature and therefore has an unknown effect on protein function and is best classified as a variant of uncertain significance (VUS). The clinical significance of CDH1 in glioblastoma is unknown and its clinicopathologic effect remains to be further elucidated. |
| 109 | Glioblastoma Pleomorphic Xanthoastrocytoma Ganglioglioma Neuroepithelial Neoplasm, NOS Neuroepithelial neoplasm, high grade Astrocytoma, NOS Astrocytoma, Pilocytic | Spinal Cord Brain Brain, Supratentorial Brain, Infratentorial | BRAF V600E BRAF codon(s) 600 any | 1 | BRAF alterations have been described in a wide spectrum of brain tumors, including in gliomas and glioneuronal tumors. BRAFV600E mutations have been found in approximately 10--15% of pilocytic astrocytoma and in approximately 5--10% of pediatric diffusely infiltrating gliomas, including diffuse astrocytomas (WHO grade II), anaplastic astrocytomas (WHO grade III) and glioblastomas (WHO grade IV), but in less than 2% of comparable adult gliomas. This mutation is potentially targetable. |
Generic Interpretations
| ID | Variants | Tier | Interpretation |
|---|---|---|---|
| 417 | ABI1 copy number gain ABI1 copy number loss | 2 | This gene is a known cancer gene. |
| 418 | ABL1 copy number gain ABL1 copy number loss | 2 | This gene is a known cancer gene. |
| 419 | ABL2 copy number gain ABL2 copy number loss | 2 | This gene is a known cancer gene. |
| 420 | ACKR3 copy number gain ACKR3 copy number loss | 2 | This gene is a known cancer gene. |
| 421 | ACSL3 copy number gain ACSL3 copy number loss | 2 | This gene is a known cancer gene. |
| 422 | ACSL6 copy number gain ACSL6 copy number loss | 2 | This gene is a known cancer gene. |
| 423 | ACVR1 copy number gain ACVR1 copy number loss | 2 | This gene is a known cancer gene. |
| 424 | AFF1 copy number gain AFF1 copy number loss | 2 | This gene is a known cancer gene. |
| 425 | AFF3 copy number gain AFF3 copy number loss | 2 | This gene is a known cancer gene. |
| 426 | AFF4 copy number gain AFF4 copy number loss | 2 | This gene is a known cancer gene. |
| 427 | AKAP9 copy number gain AKAP9 copy number loss | 2 | This gene is a known cancer gene. |
| 428 | AKT1 copy number gain AKT1 copy number loss | 2 | This gene is a known cancer gene. |
| 429 | AKT2 copy number gain AKT2 copy number loss | 2 | This gene is a known cancer gene. |
| 430 | ALDH2 copy number gain ALDH2 copy number loss | 2 | This gene is a known cancer gene. |
| 431 | ALK copy number gain ALK copy number loss | 2 | This gene is a known cancer gene. |
| 432 | AMER1 copy number gain AMER1 copy number loss | 2 | This gene is a known cancer gene. |
| 433 | APC copy number gain APC copy number loss | 2 | This gene is a known cancer gene. |
| 434 | AR copy number gain AR copy number loss | 2 | This gene is a known cancer gene. |
| 435 | ARHGAP26 copy number gain ARHGAP26 copy number loss | 2 | This gene is a known cancer gene. |
| 436 | ARHGEF12 copy number gain ARHGEF12 copy number loss | 2 | This gene is a known cancer gene. |
| 437 | ARID1A copy number gain ARID1A copy number loss | 2 | This gene is a known cancer gene. |
| 438 | ARID1B copy number gain ARID1B copy number loss | 2 | This gene is a known cancer gene. |
| 439 | ARID2 copy number gain ARID2 copy number loss | 2 | This gene is a known cancer gene. |
| 440 | ARNT copy number gain ARNT copy number loss | 2 | This gene is a known cancer gene. |
| 441 | ASPSCR1 copy number gain ASPSCR1 copy number loss | 2 | This gene is a known cancer gene. |
| 442 | ASXL1 copy number gain ASXL1 copy number loss | 2 | This gene is a known cancer gene. |
| 443 | ATF1 copy number gain ATF1 copy number loss | 2 | This gene is a known cancer gene. |
| 444 | ATIC copy number gain ATIC copy number loss | 2 | This gene is a known cancer gene. |
| 445 | ATM copy number gain ATM copy number loss | 2 | This gene is a known cancer gene. |
| 446 | ATP1A1 copy number gain ATP1A1 copy number loss | 2 | This gene is a known cancer gene. |
| 447 | ATP2B3 copy number gain ATP2B3 copy number loss | 2 | This gene is a known cancer gene. |
| 448 | ATR copy number gain ATR copy number loss | 2 | This gene is a known cancer gene. |
| 449 | ATRX copy number gain ATRX copy number loss | 2 | This gene is a known cancer gene. |
| 450 | AXIN1 copy number gain AXIN1 copy number loss | 2 | This gene is a known cancer gene. |
| 451 | AXIN2 copy number gain AXIN2 copy number loss | 2 | This gene is a known cancer gene. |
| 452 | BAP1 copy number gain BAP1 copy number loss | 2 | This gene is a known cancer gene. |
| 453 | BCL10 copy number gain BCL10 copy number loss | 2 | This gene is a known cancer gene. |
| 454 | BCL11A copy number gain BCL11A copy number loss | 2 | This gene is a known cancer gene. |
| 455 | BCL11B copy number gain BCL11B copy number loss | 2 | This gene is a known cancer gene. |
| 456 | BCL2 copy number gain BCL2 copy number loss | 2 | This gene is a known cancer gene. |
| 457 | BCL3 copy number gain BCL3 copy number loss | 2 | This gene is a known cancer gene. |
| 458 | BCL6 copy number gain BCL6 copy number loss | 2 | This gene is a known cancer gene. |
| 459 | BCL7A copy number gain BCL7A copy number loss | 2 | This gene is a known cancer gene. |
| 460 | BCL9 copy number gain BCL9 copy number loss | 2 | This gene is a known cancer gene. |
| 461 | BCOR copy number gain BCOR copy number loss | 2 | This gene is a known cancer gene. |
| 462 | BCR copy number gain BCR copy number loss | 2 | This gene is a known cancer gene. |
| 463 | BIRC3 copy number gain BIRC3 copy number loss | 2 | This gene is a known cancer gene. |
| 464 | BLM copy number gain BLM copy number loss | 2 | This gene is a known cancer gene. |
| 465 | BMPR1A copy number gain BMPR1A copy number loss | 2 | This gene is a known cancer gene. |
| 466 | BRAF copy number gain BRAF copy number loss | 2 | This gene is a known cancer gene. |
| 467 | BRCA1 copy number gain BRCA1 copy number loss | 2 | This gene is a known cancer gene. |
| 468 | BRCA2 copy number gain BRCA2 copy number loss | 2 | This gene is a known cancer gene. |
| 469 | BRD3 copy number gain BRD3 copy number loss | 2 | This gene is a known cancer gene. |
| 470 | BRD4 copy number gain BRD4 copy number loss | 2 | This gene is a known cancer gene. |
| 471 | BRIP1 copy number gain BRIP1 copy number loss | 2 | This gene is a known cancer gene. |
| 472 | BTG1 copy number gain BTG1 copy number loss | 2 | This gene is a known cancer gene. |
| 473 | BUB1B copy number gain BUB1B copy number loss | 2 | This gene is a known cancer gene. |
| 474 | C15ORF65 copy number gain C15ORF65 copy number loss | 2 | This gene is a known cancer gene. |
| 475 | C2ORF44 copy number gain C2ORF44 copy number loss | 2 | This gene is a known cancer gene. |
| 476 | CACNA1D copy number gain CACNA1D copy number loss | 2 | This gene is a known cancer gene. |
| 477 | CALR copy number gain CALR copy number loss | 2 | This gene is a known cancer gene. |
| 478 | CAMTA1 copy number gain CAMTA1 copy number loss | 2 | This gene is a known cancer gene. |
| 479 | CANT1 copy number gain CANT1 copy number loss | 2 | This gene is a known cancer gene. |
| 480 | CARD11 copy number gain CARD11 copy number loss | 2 | This gene is a known cancer gene. |
| 481 | CARS copy number gain CARS copy number loss | 2 | This gene is a known cancer gene. |
| 482 | CASC5 copy number gain CASC5 copy number loss | 2 | This gene is a known cancer gene. |
| 483 | CASP8 copy number gain CASP8 copy number loss | 2 | This gene is a known cancer gene. |
| 484 | CBFA2T3 copy number gain CBFA2T3 copy number loss | 2 | This gene is a known cancer gene. |
| 485 | CBFB copy number gain CBFB copy number loss | 2 | This gene is a known cancer gene. |
| 486 | CBL copy number gain CBL copy number loss | 2 | This gene is a known cancer gene. |
| 487 | CBLB copy number gain CBLB copy number loss | 2 | This gene is a known cancer gene. |
| 488 | CBLC copy number gain CBLC copy number loss | 2 | This gene is a known cancer gene. |
| 489 | CCDC6 copy number gain CCDC6 copy number loss | 2 | This gene is a known cancer gene. |
| 490 | CCNB1IP1 copy number gain CCNB1IP1 copy number loss | 2 | This gene is a known cancer gene. |
| 491 | CCND1 copy number gain CCND1 copy number loss | 2 | This gene is a known cancer gene. |
| 492 | CCND2 copy number gain CCND2 copy number loss | 2 | This gene is a known cancer gene. |
| 493 | CCND3 copy number gain CCND3 copy number loss | 2 | This gene is a known cancer gene. |
| 494 | CCNE1 copy number gain CCNE1 copy number loss | 2 | This gene is a known cancer gene. |
| 495 | CD274 copy number gain CD274 copy number loss | 2 | This gene is a known cancer gene. |
| 496 | CD74 copy number gain CD74 copy number loss | 2 | This gene is a known cancer gene. |
| 497 | CD79A copy number gain CD79A copy number loss | 2 | This gene is a known cancer gene. |
| 498 | CD79B copy number gain CD79B copy number loss | 2 | This gene is a known cancer gene. |
| 499 | CDC73 copy number gain CDC73 copy number loss | 2 | This gene is a known cancer gene. |
| 500 | CDH1 copy number gain CDH1 copy number loss | 2 | This gene is a known cancer gene. |
| 501 | CDH11 copy number gain CDH11 copy number loss | 2 | This gene is a known cancer gene. |
| 502 | CDK12 copy number gain CDK12 copy number loss | 2 | This gene is a known cancer gene. |
| 503 | CDK4 copy number gain CDK4 copy number loss | 2 | This gene is a known cancer gene. |
| 504 | CDK6 copy number gain CDK6 copy number loss | 2 | This gene is a known cancer gene. |
| 505 | CDKN1B copy number gain CDKN1B copy number loss | 2 | This gene is a known cancer gene. |
| 507 | CDKN2B copy number gain CDKN2B copy number loss | 2 | This gene is a known cancer gene. |
| 508 | CDKN2C copy number gain CDKN2C copy number loss | 2 | This gene is a known cancer gene. |
| 509 | CDX2 copy number gain CDX2 copy number loss | 2 | This gene is a known cancer gene. |
| 510 | CEBPA copy number gain CEBPA copy number loss | 2 | This gene is a known cancer gene. |
| 511 | CEP89 copy number gain CEP89 copy number loss | 2 | This gene is a known cancer gene. |
| 512 | CHCHD7 copy number gain CHCHD7 copy number loss | 2 | This gene is a known cancer gene. |
| 513 | CHEK2 copy number gain CHEK2 copy number loss | 2 | This gene is a known cancer gene. |
| 514 | CHIC2 copy number gain CHIC2 copy number loss | 2 | This gene is a known cancer gene. |
| 515 | CHN1 copy number gain CHN1 copy number loss | 2 | This gene is a known cancer gene. |
| 516 | CIC copy number gain CIC copy number loss | 2 | This gene is a known cancer gene. |
| 517 | CIITA copy number gain CIITA copy number loss | 2 | This gene is a known cancer gene. |
| 518 | CLIP1 copy number gain CLIP1 copy number loss | 2 | This gene is a known cancer gene. |
| 519 | CLP1 copy number gain CLP1 copy number loss | 2 | This gene is a known cancer gene. |
| 520 | CLTC copy number gain CLTC copy number loss | 2 | This gene is a known cancer gene. |
| 521 | CLTCL1 copy number gain CLTCL1 copy number loss | 2 | This gene is a known cancer gene. |
| 522 | CNBP copy number gain CNBP copy number loss | 2 | This gene is a known cancer gene. |
| 523 | CNOT3 copy number gain CNOT3 copy number loss | 2 | This gene is a known cancer gene. |
| 524 | CNTRL copy number gain CNTRL copy number loss | 2 | This gene is a known cancer gene. |
| 525 | COL1A1 copy number gain COL1A1 copy number loss | 2 | This gene is a known cancer gene. |
| 526 | COL2A1 copy number gain COL2A1 copy number loss | 2 | This gene is a known cancer gene. |
| 527 | COX6C copy number gain COX6C copy number loss | 2 | This gene is a known cancer gene. |
| 528 | CREB1 copy number gain CREB1 copy number loss | 2 | This gene is a known cancer gene. |
| 529 | CREB3L1 copy number gain CREB3L1 copy number loss | 2 | This gene is a known cancer gene. |
| 530 | CREB3L2 copy number gain CREB3L2 copy number loss | 2 | This gene is a known cancer gene. |
| 531 | CREBBP copy number gain CREBBP copy number loss | 2 | This gene is a known cancer gene. |
| 532 | CRLF2 copy number gain CRLF2 copy number loss | 2 | This gene is a known cancer gene. |
| 533 | CRTC1 copy number gain CRTC1 copy number loss | 2 | This gene is a known cancer gene. |
| 534 | CRTC3 copy number gain CRTC3 copy number loss | 2 | This gene is a known cancer gene. |
| 535 | CSF1R copy number gain CSF1R copy number loss | 2 | This gene is a known cancer gene. |
| 536 | CSF3R copy number gain CSF3R copy number loss | 2 | This gene is a known cancer gene. |
| 537 | CTNNB1 copy number gain CTNNB1 copy number loss | 2 | This gene is a known cancer gene. |
| 538 | CUX1 copy number gain CUX1 copy number loss | 2 | This gene is a known cancer gene. |
| 539 | CYLD copy number gain CYLD copy number loss | 2 | This gene is a known cancer gene. |
| 540 | DAXX copy number gain DAXX copy number loss | 2 | This gene is a known cancer gene. |
| 541 | DCTN1 copy number gain DCTN1 copy number loss | 2 | This gene is a known cancer gene. |
| 542 | DDB2 copy number gain DDB2 copy number loss | 2 | This gene is a known cancer gene. |
| 543 | DDIT3 copy number gain DDIT3 copy number loss | 2 | This gene is a known cancer gene. |
| 544 | DDX10 copy number gain DDX10 copy number loss | 2 | This gene is a known cancer gene. |
| 545 | DDX5 copy number gain DDX5 copy number loss | 2 | This gene is a known cancer gene. |
| 546 | DDX6 copy number gain DDX6 copy number loss | 2 | This gene is a known cancer gene. |
| 547 | DEK copy number gain DEK copy number loss | 2 | This gene is a known cancer gene. |
| 548 | DICER1 copy number gain DICER1 copy number loss | 2 | This gene is a known cancer gene. |
| 549 | DNM2 copy number gain DNM2 copy number loss | 2 | This gene is a known cancer gene. |
| 550 | DNMT3A copy number gain DNMT3A copy number loss | 2 | This gene is a known cancer gene. |
| 551 | DUX4 copy number gain DUX4 copy number loss | 2 | This gene is a known cancer gene. |
| 552 | EBF1 copy number gain EBF1 copy number loss | 2 | This gene is a known cancer gene. |
| 553 | ECT2L copy number gain ECT2L copy number loss | 2 | This gene is a known cancer gene. |
| 554 | EGFR copy number gain EGFR copy number loss | 2 | This gene is a known cancer gene. |
| 555 | EIF3E copy number gain EIF3E copy number loss | 2 | This gene is a known cancer gene. |
| 556 | EIF4A2 copy number gain EIF4A2 copy number loss | 2 | This gene is a known cancer gene. |
| 557 | ELF4 copy number gain ELF4 copy number loss | 2 | This gene is a known cancer gene. |
| 558 | ELK4 copy number gain ELK4 copy number loss | 2 | This gene is a known cancer gene. |
| 559 | ELL copy number gain ELL copy number loss | 2 | This gene is a known cancer gene. |
| 560 | ELN copy number gain ELN copy number loss | 2 | This gene is a known cancer gene. |
| 561 | EML4 copy number gain EML4 copy number loss | 2 | This gene is a known cancer gene. |
| 562 | EPHA3 copy number gain EPHA3 copy number loss | 2 | This gene is a known cancer gene. |
| 563 | EP300 copy number gain EP300 copy number loss | 2 | This gene is a known cancer gene. |
| 564 | EPS15 copy number gain EPS15 copy number loss | 2 | This gene is a known cancer gene. |
| 565 | ERBB2 copy number gain ERBB2 copy number loss | 2 | This gene is a known cancer gene. |
| 566 | ERBB3 copy number gain ERBB3 copy number loss | 2 | This gene is a known cancer gene. |
| 567 | ERC1 copy number gain ERC1 copy number loss | 2 | This gene is a known cancer gene. |
| 568 | ERCC2 copy number gain ERCC2 copy number loss | 2 | This gene is a known cancer gene. |
| 569 | ERCC3 copy number gain ERCC3 copy number loss | 2 | This gene is a known cancer gene. |
| 570 | ERCC4 copy number gain ERCC4 copy number loss | 2 | This gene is a known cancer gene. |
| 571 | ERCC5 copy number gain ERCC5 copy number loss | 2 | This gene is a known cancer gene. |
| 572 | ERG copy number gain ERG copy number loss | 2 | This gene is a known cancer gene. |
| 573 | ESR1 copy number gain ESR1 copy number loss | 2 | This gene is a known cancer gene. |
| 574 | ETNK1 copy number gain ETNK1 copy number loss | 2 | This gene is a known cancer gene. |
| 575 | ETV1 copy number gain ETV1 copy number loss | 2 | This gene is a known cancer gene. |
| 576 | ETV4 copy number gain ETV4 copy number loss | 2 | This gene is a known cancer gene. |
| 577 | ETV5 copy number gain ETV5 copy number loss | 2 | This gene is a known cancer gene. |
| 578 | ETV6 copy number gain ETV6 copy number loss | 2 | This gene is a known cancer gene. |
| 579 | EWSR1 copy number gain EWSR1 copy number loss | 2 | This gene is a known cancer gene. |
| 580 | EXT1 copy number gain EXT1 copy number loss | 2 | This gene is a known cancer gene. |
| 581 | EXT2 copy number gain EXT2 copy number loss | 2 | This gene is a known cancer gene. |
| 582 | EZH2 copy number gain EZH2 copy number loss | 2 | This gene is a known cancer gene. |
| 583 | EZR copy number gain EZR copy number loss | 2 | This gene is a known cancer gene. |
| 584 | FAM131B copy number gain FAM131B copy number loss | 2 | This gene is a known cancer gene. |
| 585 | FAM46C copy number gain FAM46C copy number loss | 2 | This gene is a known cancer gene. |
| 586 | FANCA copy number gain FANCA copy number loss | 2 | This gene is a known cancer gene. |
| 587 | FANCC copy number gain FANCC copy number loss | 2 | This gene is a known cancer gene. |
| 588 | FANCD2 copy number gain FANCD2 copy number loss | 2 | This gene is a known cancer gene. |
| 589 | FANCE copy number gain FANCE copy number loss | 2 | This gene is a known cancer gene. |
| 590 | FANCF copy number gain FANCF copy number loss | 2 | This gene is a known cancer gene. |
| 591 | FANCG copy number gain FANCG copy number loss | 2 | This gene is a known cancer gene. |
| 592 | FAS copy number gain FAS copy number loss | 2 | This gene is a known cancer gene. |
| 593 | FBXO11 copy number gain FBXO11 copy number loss | 2 | This gene is a known cancer gene. |
| 594 | FBXW7 copy number gain FBXW7 copy number loss | 2 | This gene is a known cancer gene. |
| 595 | FCGR2B copy number gain FCGR2B copy number loss | 2 | This gene is a known cancer gene. |
| 596 | FCRL4 copy number gain FCRL4 copy number loss | 2 | This gene is a known cancer gene. |
| 597 | FEV copy number gain FEV copy number loss | 2 | This gene is a known cancer gene. |
| 598 | FGFR1 copy number gain FGFR1 copy number loss | 2 | This gene is a known cancer gene. |
| 599 | FGFR1OP copy number gain FGFR1OP copy number loss | 2 | This gene is a known cancer gene. |
| 600 | FGFR2 copy number gain FGFR2 copy number loss | 2 | This gene is a known cancer gene. |
| 601 | FGFR3 copy number gain FGFR3 copy number loss | 2 | This gene is a known cancer gene. |
| 602 | FGFR4 copy number gain FGFR4 copy number loss | 2 | This gene is a known cancer gene. |
| 603 | FH copy number gain FH copy number loss | 2 | This gene is a known cancer gene. |
| 604 | FHIT copy number gain FHIT copy number loss | 2 | This gene is a known cancer gene. |
| 605 | FIP1L1 copy number gain FIP1L1 copy number loss | 2 | This gene is a known cancer gene. |
| 606 | FLCN copy number gain FLCN copy number loss | 2 | This gene is a known cancer gene. |
| 607 | FLI1 copy number gain FLI1 copy number loss | 2 | This gene is a known cancer gene. |
| 608 | FLT3 copy number gain FLT3 copy number loss | 2 | This gene is a known cancer gene. |
| 609 | FLT4 copy number gain FLT4 copy number loss | 2 | This gene is a known cancer gene. |
| 610 | FNBP1 copy number gain FNBP1 copy number loss | 2 | This gene is a known cancer gene. |
| 611 | FOXA1 copy number gain FOXA1 copy number loss | 2 | This gene is a known cancer gene. |
| 612 | FOXL2 copy number gain FOXL2 copy number loss | 2 | This gene is a known cancer gene. |
| 613 | FOXO1 copy number gain FOXO1 copy number loss | 2 | This gene is a known cancer gene. |
| 614 | FOXO3 copy number gain FOXO3 copy number loss | 2 | This gene is a known cancer gene. |
| 615 | FOXO4 copy number gain FOXO4 copy number loss | 2 | This gene is a known cancer gene. |
| 616 | FOXO4 copy number gain FOXO4 copy number loss | 2 | This gene is a known cancer gene. |
| 617 | FOXP1 copy number gain FOXP1 copy number loss | 2 | This gene is a known cancer gene. |
| 618 | FSTL3 copy number gain FSTL3 copy number loss | 2 | This gene is a known cancer gene. |
| 619 | FUBP1 copy number gain FUBP1 copy number loss | 2 | This gene is a known cancer gene. |
| 620 | FUS copy number gain FUS copy number loss | 2 | This gene is a known cancer gene. |
| 621 | GAS7 copy number gain GAS7 copy number loss | 2 | This gene is a known cancer gene. |
| 622 | GATA1 copy number gain GATA1 copy number loss | 2 | This gene is a known cancer gene. |
| 623 | GATA2 copy number gain GATA2 copy number loss | 2 | This gene is a known cancer gene. |
| 624 | GATA3 copy number gain GATA3 copy number loss | 2 | This gene is a known cancer gene. |
| 625 | GMPS copy number gain GMPS copy number loss | 2 | This gene is a known cancer gene. |
| 626 | GNA11 copy number gain GNA11 copy number loss | 2 | This gene is a known cancer gene. |
| 627 | GNAQ copy number gain GNAQ copy number loss | 2 | This gene is a known cancer gene. |
| 628 | GNAS copy number gain GNAS copy number loss | 2 | This gene is a known cancer gene. |
| 629 | GOLGA5 copy number gain GOLGA5 copy number loss | 2 | This gene is a known cancer gene. |
| 630 | GOPC copy number gain GOPC copy number loss | 2 | This gene is a known cancer gene. |
| 631 | GPC3 copy number gain GPC3 copy number loss | 2 | This gene is a known cancer gene. |
| 632 | GPHN copy number gain GPHN copy number loss | 2 | This gene is a known cancer gene. |
| 633 | GRIN2A copy number gain GRIN2A copy number loss | 2 | This gene is a known cancer gene. |
| 634 | H3F3A copy number gain H3F3A copy number loss | 2 | This gene is a known cancer gene. |
| 635 | H3F3B copy number gain H3F3B copy number loss | 2 | This gene is a known cancer gene. |
| 636 | HERPUD1 copy number gain HERPUD1 copy number loss | 2 | This gene is a known cancer gene. |
| 637 | HEY1 copy number gain HEY1 copy number loss | 2 | This gene is a known cancer gene. |
| 638 | HIP1 copy number gain HIP1 copy number loss | 2 | This gene is a known cancer gene. |
| 639 | HIST1H3B copy number gain HIST1H3B copy number loss | 2 | This gene is a known cancer gene. |
| 640 | HIST1H4I copy number gain HIST1H4I copy number loss | 2 | This gene is a known cancer gene. |
| 641 | HLA-A copy number gain HLA-A copy number loss | 2 | This gene is a known cancer gene. |
| 642 | HLF copy number gain HLF copy number loss | 2 | This gene is a known cancer gene. |
| 643 | HMGA1 copy number gain HMGA1 copy number loss | 2 | This gene is a known cancer gene. |
| 644 | HMGA2 copy number gain HMGA2 copy number loss | 2 | This gene is a known cancer gene. |
| 645 | HNF1A copy number gain HNF1A copy number loss | 2 | This gene is a known cancer gene. |
| 646 | HNRNPA2B1 copy number gain HNRNPA2B1 copy number loss | 2 | This gene is a known cancer gene. |
| 647 | HOOK3 copy number gain HOOK3 copy number loss | 2 | This gene is a known cancer gene. |
| 648 | HOXA11 copy number gain HOXA11 copy number loss | 2 | This gene is a known cancer gene. |
| 649 | HOXA13 copy number gain HOXA13 copy number loss | 2 | This gene is a known cancer gene. |
| 650 | HOXA9 copy number gain HOXA9 copy number loss | 2 | This gene is a known cancer gene. |
| 651 | HOXC11 copy number gain HOXC11 copy number loss | 2 | This gene is a known cancer gene. |
| 652 | HOXC13 copy number gain HOXC13 copy number loss | 2 | This gene is a known cancer gene. |
| 653 | HOXD11 copy number gain HOXD11 copy number loss | 2 | This gene is a known cancer gene. |
| 654 | HOXD13 copy number gain HOXD13 copy number loss | 2 | This gene is a known cancer gene. |
| 655 | HRAS copy number gain HRAS copy number loss | 2 | This gene is a known cancer gene. |
| 656 | HSP90AA1 copy number gain HSP90AA1 copy number loss | 2 | This gene is a known cancer gene. |
| 657 | HSP90AB1 copy number gain HSP90AB1 copy number loss | 2 | This gene is a known cancer gene. |
| 658 | IDH1 copy number gain IDH1 copy number loss | 2 | This gene is a known cancer gene. |
| 659 | IDH2 copy number gain IDH2 copy number loss | 2 | This gene is a known cancer gene. |
| 660 | IKBKB copy number gain IKBKB copy number loss | 2 | This gene is a known cancer gene. |
| 661 | IKZF1 copy number gain IKZF1 copy number loss | 2 | This gene is a known cancer gene. |
| 662 | IL2 copy number gain IL2 copy number loss | 2 | This gene is a known cancer gene. |
| 663 | IL21R copy number gain IL21R copy number loss | 2 | This gene is a known cancer gene. |
| 664 | IL6ST copy number gain IL6ST copy number loss | 2 | This gene is a known cancer gene. |
| 665 | IL7R copy number gain IL7R copy number loss | 2 | This gene is a known cancer gene. |
| 666 | IRF4 copy number gain IRF4 copy number loss | 2 | This gene is a known cancer gene. |
| 667 | ITK copy number gain ITK copy number loss | 2 | This gene is a known cancer gene. |
| 668 | JAK1 copy number gain JAK1 copy number loss | 2 | This gene is a known cancer gene. |
| 669 | JAK2 copy number gain JAK2 copy number loss | 2 | This gene is a known cancer gene. |
| 670 | JAK3 copy number gain JAK3 copy number loss | 2 | This gene is a known cancer gene. |
| 671 | JAZF1 copy number gain JAZF1 copy number loss | 2 | This gene is a known cancer gene. |
| 672 | JUN copy number gain JUN copy number loss | 2 | This gene is a known cancer gene. |
| 673 | KAT6A copy number gain KAT6A copy number loss | 2 | This gene is a known cancer gene. |
| 674 | KAT6B copy number gain KAT6B copy number loss | 2 | This gene is a known cancer gene. |
| 675 | KCNJ5 copy number gain KCNJ5 copy number loss | 2 | This gene is a known cancer gene. |
| 676 | KDM5A copy number gain KDM5A copy number loss | 2 | This gene is a known cancer gene. |
| 677 | KDM5C copy number gain KDM5C copy number loss | 2 | This gene is a known cancer gene. |
| 678 | KDM6A copy number gain KDM6A copy number loss | 2 | This gene is a known cancer gene. |
| 679 | KDR copy number gain KDR copy number loss | 2 | This gene is a known cancer gene. |
| 680 | KDSR copy number gain KDSR copy number loss | 2 | This gene is a known cancer gene. |
| 681 | KIAA1549 copy number gain KIAA1549 copy number loss | 2 | This gene is a known cancer gene. |
| 682 | KIAA1598 copy number gain KIAA1598 copy number loss | 2 | This gene is a known cancer gene. |
| 683 | KIF5B copy number gain KIF5B copy number loss | 2 | This gene is a known cancer gene. |
| 684 | KIT copy number gain KIT copy number loss | 2 | This gene is a known cancer gene. |
| 685 | KLF4 copy number gain KLF4 copy number loss | 2 | This gene is a known cancer gene. |
| 686 | KLF6 copy number gain KLF6 copy number loss | 2 | This gene is a known cancer gene. |
| 687 | KLK2 copy number gain KLK2 copy number loss | 2 | This gene is a known cancer gene. |
| 688 | KMT2A copy number gain KMT2A copy number loss | 2 | This gene is a known cancer gene. |
| 689 | KMT2C copy number gain KMT2C copy number loss | 2 | This gene is a known cancer gene. |
| 690 | KMT2D copy number gain KMT2D copy number loss | 2 | This gene is a known cancer gene. |
| 691 | KRAS copy number gain KRAS copy number loss | 2 | This gene is a known cancer gene. |
| 692 | KTN1 copy number gain KTN1 copy number loss | 2 | This gene is a known cancer gene. |
| 693 | LASP1 copy number gain LASP1 copy number loss | 2 | This gene is a known cancer gene. |
| 694 | LCK copy number gain LCK copy number loss | 2 | This gene is a known cancer gene. |
| 695 | LCP1 copy number gain LCP1 copy number loss | 2 | This gene is a known cancer gene. |
| 696 | LHFP copy number gain LHFP copy number loss | 2 | This gene is a known cancer gene. |
| 697 | LIFR copy number gain LIFR copy number loss | 2 | This gene is a known cancer gene. |
| 698 | LMNA copy number gain LMNA copy number loss | 2 | This gene is a known cancer gene. |
| 699 | LMO1 copy number gain LMO1 copy number loss | 2 | This gene is a known cancer gene. |
| 700 | LMO2 copy number gain LMO2 copy number loss | 2 | This gene is a known cancer gene. |
| 701 | LPP copy number gain LPP copy number loss | 2 | This gene is a known cancer gene. |
| 702 | LRIG3 copy number gain LRIG3 copy number loss | 2 | This gene is a known cancer gene. |
| 703 | LSM14A copy number gain LSM14A copy number loss | 2 | This gene is a known cancer gene. |
| 704 | LYL1 copy number gain LYL1 copy number loss | 2 | This gene is a known cancer gene. |
| 705 | LZTR1 copy number gain LZTR1 copy number loss | 2 | This gene is a known cancer gene. |
| 706 | MAF copy number gain MAF copy number loss | 2 | This gene is a known cancer gene. |
| 707 | MAFB copy number gain MAFB copy number loss | 2 | This gene is a known cancer gene. |
| 708 | MALT1 copy number gain MALT1 copy number loss | 2 | This gene is a known cancer gene. |
| 709 | MAML2 copy number gain MAML2 copy number loss | 2 | This gene is a known cancer gene. |
| 710 | MAP2K1 copy number gain MAP2K1 copy number loss | 2 | This gene is a known cancer gene. |
| 711 | MAP2K2 copy number gain MAP2K2 copy number loss | 2 | This gene is a known cancer gene. |
| 712 | MAP2K4 copy number gain MAP2K4 copy number loss | 2 | This gene is a known cancer gene. |
| 713 | MAP3K1 copy number gain MAP3K1 copy number loss | 2 | This gene is a known cancer gene. |
| 714 | MAP3K13 copy number gain MAP3K13 copy number loss | 2 | This gene is a known cancer gene. |
| 715 | MAX copy number gain MAX copy number loss | 2 | This gene is a known cancer gene. |
| 716 | MDM2 copy number gain MDM2 copy number loss | 2 | This gene is a known cancer gene. |
| 717 | MDM4 copy number gain MDM4 copy number loss | 2 | This gene is a known cancer gene. |
| 718 | MDS2 copy number gain MDS2 copy number loss | 2 | This gene is a known cancer gene. |
| 719 | MECOM copy number gain MECOM copy number loss | 2 | This gene is a known cancer gene. |
| 720 | MED12 copy number gain MED12 copy number loss | 2 | This gene is a known cancer gene. |
| 721 | MEN1 copy number gain MEN1 copy number loss | 2 | This gene is a known cancer gene. |
| 722 | MET copy number gain MET copy number loss | 2 | This gene is a known cancer gene. |
| 723 | MITF copy number gain MITF copy number loss | 2 | This gene is a known cancer gene. |
| 724 | MKL1 copy number gain MKL1 copy number loss | 2 | This gene is a known cancer gene. |
| 725 | MLF1 copy number gain MLF1 copy number loss | 2 | This gene is a known cancer gene. |
| 726 | MLH1 copy number gain MLH1 copy number loss | 2 | This gene is a known cancer gene. |
| 727 | MLLT1 copy number gain MLLT1 copy number loss | 2 | This gene is a known cancer gene. |
| 728 | MLLT10 copy number gain MLLT10 copy number loss | 2 | This gene is a known cancer gene. |
| 729 | MLLT11 copy number gain MLLT11 copy number loss | 2 | This gene is a known cancer gene. |
| 730 | MLLT3 copy number gain MLLT3 copy number loss | 2 | This gene is a known cancer gene. |
| 731 | MLLT4 copy number gain MLLT4 copy number loss | 2 | This gene is a known cancer gene. |
| 732 | MLLT6 copy number gain MLLT6 copy number loss | 2 | This gene is a known cancer gene. |
| 733 | MN1 copy number gain MN1 copy number loss | 2 | This gene is a known cancer gene. |
| 734 | MNX1 copy number gain MNX1 copy number loss | 2 | This gene is a known cancer gene. |
| 735 | MPL copy number gain MPL copy number loss | 2 | This gene is a known cancer gene. |
| 736 | MSH2 copy number gain MSH2 copy number loss | 2 | This gene is a known cancer gene. |
| 737 | MSH6 copy number gain MSH6 copy number loss | 2 | This gene is a known cancer gene. |
| 738 | MSI2 copy number gain MSI2 copy number loss | 2 | This gene is a known cancer gene. |
| 739 | MSN copy number gain MSN copy number loss | 2 | This gene is a known cancer gene. |
| 740 | MTCP1 copy number gain MTCP1 copy number loss | 2 | This gene is a known cancer gene. |
| 741 | MUC1 copy number gain MUC1 copy number loss | 2 | This gene is a known cancer gene. |
| 742 | MUTYH copy number gain MUTYH copy number loss | 2 | This gene is a known cancer gene. |
| 743 | MYB copy number gain MYB copy number loss | 2 | This gene is a known cancer gene. |
| 744 | MYC copy number gain MYC copy number loss | 2 | This gene is a known cancer gene. |
| 745 | MYCL copy number gain MYCL copy number loss | 2 | This gene is a known cancer gene. |
| 746 | MYCN copy number gain MYCN copy number loss | 2 | This gene is a known cancer gene. |
| 747 | MYD88 copy number gain MYD88 copy number loss | 2 | This gene is a known cancer gene. |
| 748 | MYH11 copy number gain MYH11 copy number loss | 2 | This gene is a known cancer gene. |
| 749 | MYH9 copy number gain MYH9 copy number loss | 2 | This gene is a known cancer gene. |
| 750 | MYO5A copy number gain MYO5A copy number loss | 2 | This gene is a known cancer gene. |
| 751 | MYOD1 copy number gain MYOD1 copy number loss | 2 | This gene is a known cancer gene. |
| 752 | NAB2 copy number gain NAB2 copy number loss | 2 | This gene is a known cancer gene. |
| 753 | NACA copy number gain NACA copy number loss | 2 | This gene is a known cancer gene. |
| 754 | NBN copy number gain NBN copy number loss | 2 | This gene is a known cancer gene. |
| 755 | NCKIPSD copy number gain NCKIPSD copy number loss | 2 | This gene is a known cancer gene. |
| 756 | NCOA1 copy number gain NCOA1 copy number loss | 2 | This gene is a known cancer gene. |
| 757 | NCOA2 copy number gain NCOA2 copy number loss | 2 | This gene is a known cancer gene. |
| 758 | NCOA4 copy number gain NCOA4 copy number loss | 2 | This gene is a known cancer gene. |
| 759 | NCOR1 copy number gain NCOR1 copy number loss | 2 | This gene is a known cancer gene. |
| 760 | NDRG1 copy number gain NDRG1 copy number loss | 2 | This gene is a known cancer gene. |
| 761 | NF1 copy number gain NF1 copy number loss | 2 | This gene is a known cancer gene. |
| 762 | NF2 copy number gain NF2 copy number loss | 2 | This gene is a known cancer gene. |
| 763 | NFATC2 copy number gain NFATC2 copy number loss | 2 | This gene is a known cancer gene. |
| 764 | NFE2L2 copy number gain NFE2L2 copy number loss | 2 | This gene is a known cancer gene. |
| 765 | NFIB copy number gain NFIB copy number loss | 2 | This gene is a known cancer gene. |
| 766 | NFKB2 copy number gain NFKB2 copy number loss | 2 | This gene is a known cancer gene. |
| 767 | NFKBIE copy number gain NFKBIE copy number loss | 2 | This gene is a known cancer gene. |
| 768 | NIN copy number gain NIN copy number loss | 2 | This gene is a known cancer gene. |
| 769 | NKX2-1 copy number gain NKX2-1 copy number loss | 2 | This gene is a known cancer gene. |
| 770 | NONO copy number gain NONO copy number loss | 2 | This gene is a known cancer gene. |
| 771 | NOTCH1 copy number gain NOTCH1 copy number loss | 2 | This gene is a known cancer gene. |
| 772 | NOTCH2 copy number gain NOTCH2 copy number loss | 2 | This gene is a known cancer gene. |
| 773 | NOTCH3 copy number gain NOTCH3 copy number loss | 2 | This gene is a known cancer gene. |
| 774 | NPM1 copy number gain NPM1 copy number loss | 2 | This gene is a known cancer gene. |
| 775 | NR4A3 copy number gain NR4A3 copy number loss | 2 | This gene is a known cancer gene. |
| 776 | NRAS copy number gain NRAS copy number loss | 2 | This gene is a known cancer gene. |
| 777 | NRG1 copy number gain NRG1 copy number loss | 2 | This gene is a known cancer gene. |
| 778 | NSD1 copy number gain NSD1 copy number loss | 2 | This gene is a known cancer gene. |
| 779 | NT5C2 copy number gain NT5C2 copy number loss | 2 | This gene is a known cancer gene. |
| 780 | NTRK1 copy number gain NTRK1 copy number loss | 2 | This gene is a known cancer gene. |
| 781 | NTRK3 copy number gain NTRK3 copy number loss | 2 | This gene is a known cancer gene. |
| 782 | NUMA1 copy number gain NUMA1 copy number loss | 2 | This gene is a known cancer gene. |
| 783 | NUP214 copy number gain NUP214 copy number loss | 2 | This gene is a known cancer gene. |
| 784 | NUP98 copy number gain NUP98 copy number loss | 2 | This gene is a known cancer gene. |
| 785 | NUTM1 copy number gain NUTM1 copy number loss | 2 | This gene is a known cancer gene. |
| 786 | NUTM2A copy number gain NUTM2A copy number loss | 2 | This gene is a known cancer gene. |
| 787 | NUTM2B copy number gain NUTM2B copy number loss | 2 | This gene is a known cancer gene. |
| 788 | OLIG2 copy number gain OLIG2 copy number loss | 2 | This gene is a known cancer gene. |
| 789 | OMD copy number gain OMD copy number loss | 2 | This gene is a known cancer gene. |
| 790 | P2RY8 copy number gain P2RY8 copy number loss | 2 | This gene is a known cancer gene. |
| 791 | PAFAH1B2 copy number gain PAFAH1B2 copy number loss | 2 | This gene is a known cancer gene. |
| 792 | PALB2 copy number gain PALB2 copy number loss | 2 | This gene is a known cancer gene. |
| 793 | PAX3 copy number gain PAX3 copy number loss | 2 | This gene is a known cancer gene. |
| 794 | PAX5 copy number gain PAX5 copy number loss | 2 | This gene is a known cancer gene. |
| 795 | PAX7 copy number gain PAX7 copy number loss | 2 | This gene is a known cancer gene. |
| 796 | PAX8 copy number gain PAX8 copy number loss | 2 | This gene is a known cancer gene. |
| 797 | PBRM1 copy number gain PBRM1 copy number loss | 2 | This gene is a known cancer gene. |
| 798 | PBX1 copy number gain PBX1 copy number loss | 2 | This gene is a known cancer gene. |
| 799 | PCM1 copy number gain PCM1 copy number loss | 2 | This gene is a known cancer gene. |
| 800 | PCSK7 copy number gain PCSK7 copy number loss | 2 | This gene is a known cancer gene. |
| 801 | PDCD1LG2 copy number gain PDCD1LG2 copy number loss | 2 | This gene is a known cancer gene. |
| 802 | PDE4DIP copy number gain PDE4DIP copy number loss | 2 | This gene is a known cancer gene. |
| 803 | PDGFB copy number gain PDGFB copy number loss | 2 | This gene is a known cancer gene. |
| 804 | PDGFRA copy number gain PDGFRA copy number loss | 2 | This gene is a known cancer gene. |
| 805 | PDGFRB copy number gain PDGFRB copy number loss | 2 | This gene is a known cancer gene. |
| 806 | PER1 copy number gain PER1 copy number loss | 2 | This gene is a known cancer gene. |
| 807 | PHF6 copy number gain PHF6 copy number loss | 2 | This gene is a known cancer gene. |
| 808 | PHOX2B copy number gain PHOX2B copy number loss | 2 | This gene is a known cancer gene. |
| 809 | PICALM copy number gain PICALM copy number loss | 2 | This gene is a known cancer gene. |
| 810 | PIK3CA copy number gain PIK3CA copy number loss | 2 | This gene is a known cancer gene. |
| 811 | PIK3R1 copy number gain PIK3R1 copy number loss | 2 | This gene is a known cancer gene. |
| 812 | PIM1 copy number gain PIM1 copy number loss | 2 | This gene is a known cancer gene. |
| 813 | PLAG1 copy number gain PLAG1 copy number loss | 2 | This gene is a known cancer gene. |
| 814 | PLCG1 copy number gain PLCG1 copy number loss | 2 | This gene is a known cancer gene. |
| 815 | PML copy number gain PML copy number loss | 2 | This gene is a known cancer gene. |
| 816 | PMS1 copy number gain PMS1 copy number loss | 2 | This gene is a known cancer gene. |
| 817 | PMS2 copy number gain PMS2 copy number loss | 2 | This gene is a known cancer gene. |
| 818 | POLE copy number gain POLE copy number loss | 2 | This gene is a known cancer gene. |
| 819 | POT1 copy number gain POT1 copy number loss | 2 | This gene is a known cancer gene. |
| 820 | POU2AF1 copy number gain POU2AF1 copy number loss | 2 | This gene is a known cancer gene. |
| 821 | POU5F1 copy number gain POU5F1 copy number loss | 2 | This gene is a known cancer gene. |
| 822 | PPARG copy number gain PPARG copy number loss | 2 | This gene is a known cancer gene. |
| 823 | PPFIBP1 copy number gain PPFIBP1 copy number loss | 2 | This gene is a known cancer gene. |
| 824 | PPP2R1A copy number gain PPP2R1A copy number loss | 2 | This gene is a known cancer gene. |
| 825 | PPP6C copy number gain PPP6C copy number loss | 2 | This gene is a known cancer gene. |
| 826 | PRCC copy number gain PRCC copy number loss | 2 | This gene is a known cancer gene. |
| 827 | PRDM1 copy number gain PRDM1 copy number loss | 2 | This gene is a known cancer gene. |
| 828 | PRDM16 copy number gain PRDM16 copy number loss | 2 | This gene is a known cancer gene. |
| 829 | PRF1 copy number gain PRF1 copy number loss | 2 | This gene is a known cancer gene. |
| 830 | PRKAR1A copy number gain PRKAR1A copy number loss | 2 | This gene is a known cancer gene. |
| 831 | PRRX1 copy number gain PRRX1 copy number loss | 2 | This gene is a known cancer gene. |
| 832 | PSIP1 copy number gain PSIP1 copy number loss | 2 | This gene is a known cancer gene. |
| 833 | PTCH1 copy number gain PTCH1 copy number loss | 2 | This gene is a known cancer gene. |
| 834 | PTEN copy number gain PTEN copy number loss | 2 | This gene is a known cancer gene. |
| 835 | PTPN11 copy number gain PTPN11 copy number loss | 2 | This gene is a known cancer gene. |
| 836 | PTPRB copy number gain PTPRB copy number loss | 2 | This gene is a known cancer gene. |
| 837 | PTPRC copy number gain PTPRC copy number loss | 2 | This gene is a known cancer gene. |
| 838 | PTPRK copy number gain PTPRK copy number loss | 2 | This gene is a known cancer gene. |
| 839 | PWWP2A copy number gain PWWP2A copy number loss | 2 | This gene is a known cancer gene. |
| 840 | RABEP1 copy number gain RABEP1 copy number loss | 2 | This gene is a known cancer gene. |
| 841 | RAC1 copy number gain RAC1 copy number loss | 2 | This gene is a known cancer gene. |
| 842 | RAD21 copy number gain RAD21 copy number loss | 2 | This gene is a known cancer gene. |
| 843 | RAD51B copy number gain RAD51B copy number loss | 2 | This gene is a known cancer gene. |
| 844 | RAF1 copy number gain RAF1 copy number loss | 2 | This gene is a known cancer gene. |
| 845 | RALGDS copy number gain RALGDS copy number loss | 2 | This gene is a known cancer gene. |
| 846 | RANBP17 copy number gain RANBP17 copy number loss | 2 | This gene is a known cancer gene. |
| 847 | RANBP2 copy number gain RANBP2 copy number loss | 2 | This gene is a known cancer gene. |
| 848 | RAP1GDS1 copy number gain RAP1GDS1 copy number loss | 2 | This gene is a known cancer gene. |
| 849 | RARA copy number gain RARA copy number loss | 2 | This gene is a known cancer gene. |
| 850 | RB1 copy number gain RB1 copy number loss | 2 | This gene is a known cancer gene. |
| 851 | RBM15 copy number gain RBM15 copy number loss | 2 | This gene is a known cancer gene. |
| 852 | RECQL4 copy number gain RECQL4 copy number loss | 2 | This gene is a known cancer gene. |
| 853 | REL copy number gain REL copy number loss | 2 | This gene is a known cancer gene. |
| 854 | RET copy number gain RET copy number loss | 2 | This gene is a known cancer gene. |
| 855 | RHOA copy number gain RHOA copy number loss | 2 | This gene is a known cancer gene. |
| 856 | RHOH copy number gain RHOH copy number loss | 2 | This gene is a known cancer gene. |
| 857 | RMI2 copy number gain RMI2 copy number loss | 2 | This gene is a known cancer gene. |
| 858 | RNF213 copy number gain RNF213 copy number loss | 2 | This gene is a known cancer gene. |
| 859 | RNF43 copy number gain RNF43 copy number loss | 2 | This gene is a known cancer gene. |
| 860 | ROS1 copy number gain ROS1 copy number loss | 2 | This gene is a known cancer gene. |
| 861 | RPL10 copy number gain RPL10 copy number loss | 2 | This gene is a known cancer gene. |
| 862 | RPL22 copy number gain RPL22 copy number loss | 2 | This gene is a known cancer gene. |
| 863 | RPL5 copy number gain RPL5 copy number loss | 2 | This gene is a known cancer gene. |
| 864 | RPN1 copy number gain RPN1 copy number loss | 2 | This gene is a known cancer gene. |
| 865 | RSPO2 copy number gain RSPO2 copy number loss | 2 | This gene is a known cancer gene. |
| 866 | RSPO3 copy number gain RSPO3 copy number loss | 2 | This gene is a known cancer gene. |
| 867 | SNX29 copy number gain SNX29 copy number loss | 2 | This gene is a known cancer gene. |
| 868 | RUNX1 copy number gain RUNX1 copy number loss | 2 | This gene is a known cancer gene. |
| 869 | RUNX1T1 copy number gain RUNX1T1 copy number loss | 2 | This gene is a known cancer gene. |
| 870 | SBDS copy number gain SBDS copy number loss | 2 | This gene is a known cancer gene. |
| 871 | SDC4 copy number gain SDC4 copy number loss | 2 | This gene is a known cancer gene. |
| 872 | SDHAF2 copy number gain SDHAF2 copy number loss | 2 | This gene is a known cancer gene. |
| 873 | SDHB copy number gain SDHB copy number loss | 2 | This gene is a known cancer gene. |
| 874 | SDHC copy number gain SDHC copy number loss | 2 | This gene is a known cancer gene. |
| 875 | SEPT5 copy number gain SEPT5 copy number loss | 2 | This gene is a known cancer gene. |
| 876 | SEPT6 copy number gain SEPT6 copy number loss | 2 | This gene is a known cancer gene. |
| 877 | SEPT9 copy number gain SEPT9 copy number loss | 2 | This gene is a known cancer gene. |
| 878 | SET copy number gain SET copy number loss | 2 | This gene is a known cancer gene. |
| 879 | SETBP1 copy number gain SETBP1 copy number loss | 2 | This gene is a known cancer gene. |
| 880 | SETD2 copy number gain SETD2 copy number loss | 2 | This gene is a known cancer gene. |
| 881 | SF3B1 copy number gain SF3B1 copy number loss | 2 | This gene is a known cancer gene. |
| 882 | SFPQ copy number gain SFPQ copy number loss | 2 | This gene is a known cancer gene. |
| 883 | SH2B3 copy number gain SH2B3 copy number loss | 2 | This gene is a known cancer gene. |
| 884 | SH3GL1 copy number gain SH3GL1 copy number loss | 2 | This gene is a known cancer gene. |
| 885 | SLC34A2 copy number gain SLC34A2 copy number loss | 2 | This gene is a known cancer gene. |
| 886 | SLC45A3 copy number gain SLC45A3 copy number loss | 2 | This gene is a known cancer gene. |
| 887 | SMAD4 copy number gain SMAD4 copy number loss | 2 | This gene is a known cancer gene. |
| 888 | SMARCA4 copy number gain SMARCA4 copy number loss | 2 | This gene is a known cancer gene. |
| 889 | SMARCB1 copy number gain SMARCB1 copy number loss | 2 | This gene is a known cancer gene. |
| 890 | SMARCD1 copy number gain SMARCD1 copy number loss | 2 | This gene is a known cancer gene. |
| 891 | SMARCE1 copy number gain SMARCE1 copy number loss | 2 | This gene is a known cancer gene. |
| 892 | SMO copy number gain SMO copy number loss | 2 | This gene is a known cancer gene. |
| 893 | SND1 copy number gain SND1 copy number loss | 2 | This gene is a known cancer gene. |
| 894 | SOCS1 copy number gain SOCS1 copy number loss | 2 | This gene is a known cancer gene. |
| 895 | SOX2 copy number gain SOX2 copy number loss | 2 | This gene is a known cancer gene. |
| 896 | SPECC1 copy number gain SPECC1 copy number loss | 2 | This gene is a known cancer gene. |
| 897 | SPEN copy number gain SPEN copy number loss | 2 | This gene is a known cancer gene. |
| 898 | SPOP copy number gain SPOP copy number loss | 2 | This gene is a known cancer gene. |
| 899 | SRGAP3 copy number gain SRGAP3 copy number loss | 2 | This gene is a known cancer gene. |
| 900 | SRSF2 copy number gain SRSF2 copy number loss | 2 | This gene is a known cancer gene. |
| 901 | SRSF3 copy number gain SRSF3 copy number loss | 2 | This gene is a known cancer gene. |
| 902 | SS18 copy number gain SS18 copy number loss | 2 | This gene is a known cancer gene. |
| 903 | SS18L1 copy number gain SS18L1 copy number loss | 2 | This gene is a known cancer gene. |
| 904 | SSX1 copy number gain SSX1 copy number loss | 2 | This gene is a known cancer gene. |
| 905 | SSX2 copy number gain SSX2 copy number loss | 2 | This gene is a known cancer gene. |
| 906 | SSX4 copy number gain SSX4 copy number loss | 2 | This gene is a known cancer gene. |
| 907 | STAG2 copy number gain STAG2 copy number loss | 2 | This gene is a known cancer gene. |
| 908 | STAT3 copy number gain STAT3 copy number loss | 2 | This gene is a known cancer gene. |
| 909 | STAT5B copy number gain STAT5B copy number loss | 2 | This gene is a known cancer gene. |
| 910 | STAT6 copy number gain STAT6 copy number loss | 2 | This gene is a known cancer gene. |
| 911 | STIL copy number gain STIL copy number loss | 2 | This gene is a known cancer gene. |
| 912 | STK11 copy number gain STK11 copy number loss | 2 | This gene is a known cancer gene. |
| 913 | STRN copy number gain STRN copy number loss | 2 | This gene is a known cancer gene. |
| 914 | SUFU copy number gain SUFU copy number loss | 2 | This gene is a known cancer gene. |
| 915 | SUZ12 copy number gain SUZ12 copy number loss | 2 | This gene is a known cancer gene. |
| 916 | SYK copy number gain SYK copy number loss | 2 | This gene is a known cancer gene. |
| 917 | TAF15 copy number gain TAF15 copy number loss | 2 | This gene is a known cancer gene. |
| 918 | TAL1 copy number gain TAL1 copy number loss | 2 | This gene is a known cancer gene. |
| 919 | TAL2 copy number gain TAL2 copy number loss | 2 | This gene is a known cancer gene. |
| 920 | TBL1XR1 copy number gain TBL1XR1 copy number loss | 2 | This gene is a known cancer gene. |
| 921 | TBX3 copy number gain TBX3 copy number loss | 2 | This gene is a known cancer gene. |
| 922 | TCEA1 copy number gain TCEA1 copy number loss | 2 | This gene is a known cancer gene. |
| 923 | TCF12 copy number gain TCF12 copy number loss | 2 | This gene is a known cancer gene. |
| 924 | TCF3 copy number gain TCF3 copy number loss | 2 | This gene is a known cancer gene. |
| 925 | TCF7L2 copy number gain TCF7L2 copy number loss | 2 | This gene is a known cancer gene. |
| 926 | TCL1A copy number gain TCL1A copy number loss | 2 | This gene is a known cancer gene. |
| 927 | TERT copy number gain TERT copy number loss | 2 | This gene is a known cancer gene. |
| 928 | TET1 copy number gain TET1 copy number loss | 2 | This gene is a known cancer gene. |
| 929 | TET2 copy number gain TET2 copy number loss | 2 | This gene is a known cancer gene. |
| 930 | TFE3 copy number gain TFE3 copy number loss | 2 | This gene is a known cancer gene. |
| 931 | TFEB copy number gain TFEB copy number loss | 2 | This gene is a known cancer gene. |
| 932 | TFG copy number gain TFG copy number loss | 2 | This gene is a known cancer gene. |
| 933 | TFPT copy number gain TFPT copy number loss | 2 | This gene is a known cancer gene. |
| 934 | TFRC copy number gain TFRC copy number loss | 2 | This gene is a known cancer gene. |
| 935 | THRAP3 copy number gain THRAP3 copy number loss | 2 | This gene is a known cancer gene. |
| 936 | TLX1 copy number gain TLX1 copy number loss | 2 | This gene is a known cancer gene. |
| 937 | TLX3 copy number gain TLX3 copy number loss | 2 | This gene is a known cancer gene. |
| 938 | TMPRSS2 copy number gain TMPRSS2 copy number loss | 2 | This gene is a known cancer gene. |
| 939 | TNFAIP3 copy number gain TNFAIP3 copy number loss | 2 | This gene is a known cancer gene. |
| 940 | TNFRSF14 copy number gain TNFRSF14 copy number loss | 2 | This gene is a known cancer gene. |
| 941 | TNFRSF17 copy number gain TNFRSF17 copy number loss | 2 | This gene is a known cancer gene. |
| 942 | TOP1 copy number gain TOP1 copy number loss | 2 | This gene is a known cancer gene. |
| 943 | TP53 copy number gain TP53 copy number loss | 2 | This gene is a known cancer gene. |
| 944 | TPM3 copy number gain TPM3 copy number loss | 2 | This gene is a known cancer gene. |
| 945 | TPM4 copy number gain TPM4 copy number loss | 2 | This gene is a known cancer gene. |
| 946 | TPR copy number gain TPR copy number loss | 2 | This gene is a known cancer gene. |
| 947 | TRAF7 copy number gain TRAF7 copy number loss | 2 | This gene is a known cancer gene. |
| 948 | TRIM24 copy number gain TRIM24 copy number loss | 2 | This gene is a known cancer gene. |
| 949 | TRIM27 copy number gain TRIM27 copy number loss | 2 | This gene is a known cancer gene. |
| 950 | TRIM33 copy number gain TRIM33 copy number loss | 2 | This gene is a known cancer gene. |
| 951 | TRIP11 copy number gain TRIP11 copy number loss | 2 | This gene is a known cancer gene. |
| 952 | TRRAP copy number gain TRRAP copy number loss | 2 | This gene is a known cancer gene. |
| 953 | TSC1 copy number gain TSC1 copy number loss | 2 | This gene is a known cancer gene. |
| 954 | TSC2 copy number gain TSC2 copy number loss | 2 | This gene is a known cancer gene. |
| 955 | TSHR copy number gain TSHR copy number loss | 2 | This gene is a known cancer gene. |
| 956 | TTL copy number gain TTL copy number loss | 2 | This gene is a known cancer gene. |
| 957 | U2AF1 copy number gain U2AF1 copy number loss | 2 | This gene is a known cancer gene. |
| 958 | UBR5 copy number gain UBR5 copy number loss | 2 | This gene is a known cancer gene. |
| 959 | USP6 copy number gain USP6 copy number loss | 2 | This gene is a known cancer gene. |
| 960 | VHL copy number gain VHL copy number loss | 2 | This gene is a known cancer gene. |
| 961 | VTI1A copy number gain VTI1A copy number loss | 2 | This gene is a known cancer gene. |
| 962 | WAS copy number gain WAS copy number loss | 2 | This gene is a known cancer gene. |
| 963 | WHSC1 copy number gain WHSC1 copy number loss | 2 | This gene is a known cancer gene. |
| 964 | WHSC1L1 copy number gain WHSC1L1 copy number loss | 2 | This gene is a known cancer gene. |
| 965 | WIF1 copy number gain WIF1 copy number loss | 2 | This gene is a known cancer gene. |
| 966 | WRN copy number gain WRN copy number loss | 2 | This gene is a known cancer gene. |
| 967 | WT1 copy number gain WT1 copy number loss | 2 | This gene is a known cancer gene. |
| 968 | WWTR1 copy number gain WWTR1 copy number loss | 2 | This gene is a known cancer gene. |
| 969 | XPA copy number gain XPA copy number loss | 2 | This gene is a known cancer gene. |
| 970 | XPC copy number gain XPC copy number loss | 2 | This gene is a known cancer gene. |
| 971 | XPO1 copy number gain XPO1 copy number loss | 2 | This gene is a known cancer gene. |
| 972 | YWHAE copy number gain YWHAE copy number loss | 2 | This gene is a known cancer gene. |
| 973 | ZBTB16 copy number gain ZBTB16 copy number loss | 2 | This gene is a known cancer gene. |
| 974 | ZCCHC8 copy number gain ZCCHC8 copy number loss | 2 | This gene is a known cancer gene. |
| 975 | ZMYM2 copy number gain ZMYM2 copy number loss | 2 | This gene is a known cancer gene. |
| 976 | PATZ1 copy number gain PATZ1 copy number loss | 2 | This gene is a known cancer gene. |
| 977 | ZNF331 copy number gain ZNF331 copy number loss | 2 | This gene is a known cancer gene. |
| 978 | ZNF384 copy number gain ZNF384 copy number loss | 2 | This gene is a known cancer gene. |
| 979 | ZNF521 copy number gain ZNF521 copy number loss | 2 | This gene is a known cancer gene. |
| 980 | ZRSR2 copy number gain ZRSR2 copy number loss | 2 | This gene is a known cancer gene. |
| 1547 | ABI1 any mutation | 2 | This gene is a known cancer gene. |
| 1548 | ABL1 any mutation | 2 | This gene is a known cancer gene. |
| 1550 | ACKR3 any mutation | 2 | This gene is a known cancer gene. |
| 1551 | ACSL3 any mutation | 2 | This gene is a known cancer gene. |
| 1552 | ACSL6 any mutation | 2 | This gene is a known cancer gene. |
| 1561 | ABL2 any mutation | 2 | This gene is a known cancer gene. |
| 1565 | ACVR1 any mutation | 2 | This gene is a known cancer gene. |
| 1566 | AFF1 any mutation | 2 | This gene is a known cancer gene. |
| 1567 | AFF3 any mutation | 2 | This gene is a known cancer gene. |
| 1568 | AFF4 any mutation | 2 | This gene is a known cancer gene. |
| 1569 | AKAP9 any mutation | 2 | This gene is a known cancer gene. |
| 1570 | AKT1 any mutation | 2 | This gene is a known cancer gene. |
| 1571 | AKT2 any mutation | 2 | This gene is a known cancer gene. |
| 1572 | ALDH2 any mutation | 2 | This gene is a known cancer gene. |
| 1573 | ALK any mutation | 2 | This gene is a known cancer gene. |
| 1574 | AMER1 any mutation | 2 | This gene is a known cancer gene. |
| 1575 | APC any mutation | 2 | This gene is a known cancer gene. |
| 1576 | AR any mutation | 2 | This gene is a known cancer gene. |
| 1577 | ARHGAP26 any mutation | 2 | This gene is a known cancer gene. |
| 1578 | ARHGEF12 any mutation | 2 | This gene is a known cancer gene. |
| 1580 | ARID1B any mutation | 2 | This gene is a known cancer gene. |
| 1581 | ARID2 any mutation | 2 | This gene is a known cancer gene. |
| 1582 | ARNT any mutation | 2 | This gene is a known cancer gene. |
| 1583 | ASPSCR1 any mutation | 2 | This gene is a known cancer gene. |
| 1584 | ASXL1 any mutation | 2 | This gene is a known cancer gene. |
| 1585 | ATF1 any mutation | 2 | This gene is a known cancer gene. |
| 1586 | ATIC any mutation | 2 | This gene is a known cancer gene. |
| 1587 | ATM any mutation | 2 | This gene is a known cancer gene. |
| 1588 | ATP1A1 any mutation | 2 | This gene is a known cancer gene. |
| 1589 | ATP2B3 any mutation | 2 | This gene is a known cancer gene. |
| 1590 | ATR any mutation | 2 | This gene is a known cancer gene. |
| 1591 | ATRX any mutation | 2 | This gene is a known cancer gene. |
| 1592 | AXIN1 any mutation | 2 | This gene is a known cancer gene. |
| 1593 | AXIN2 any mutation | 2 | This gene is a known cancer gene. |
| 1594 | BAP1 any mutation | 2 | This gene is a known cancer gene. |
| 1595 | BCL10 any mutation | 2 | This gene is a known cancer gene. |
| 1596 | BCL11A any mutation | 2 | This gene is a known cancer gene. |
| 1597 | BCL11B any mutation | 2 | This gene is a known cancer gene. |
| 1598 | BCL2 any mutation | 2 | This gene is a known cancer gene. |
| 1599 | BCL3 any mutation | 2 | This gene is a known cancer gene. |
| 1600 | BCL6 any mutation | 2 | This gene is a known cancer gene. |
| 1601 | BCL7A any mutation | 2 | This gene is a known cancer gene. |
| 1602 | BCL9 any mutation | 2 | This gene is a known cancer gene. |
| 1603 | BCOR any mutation | 2 | This gene is a known cancer gene. |
| 1604 | BCR any mutation | 2 | This gene is a known cancer gene. |
| 1605 | BIRC3 any mutation | 2 | This gene is a known cancer gene. |
| 1606 | BLM any mutation | 2 | This gene is a known cancer gene. |
| 1607 | BMPR1A any mutation | 2 | This gene is a known cancer gene. |
| 1608 | BRAF any mutation | 2 | This gene is a known cancer gene. |
| 1609 | BRCA1 any mutation | 2 | This gene is a known cancer gene. |
| 1610 | BRCA2 any mutation | 2 | This gene is a known cancer gene. |
| 1611 | BRD3 any mutation | 2 | This gene is a known cancer gene. |
| 1612 | BRD4 any mutation | 2 | This gene is a known cancer gene. |
| 1613 | BRIP1 any mutation | 2 | This gene is a known cancer gene. |
| 1614 | BTG1 any mutation | 2 | This gene is a known cancer gene. |
| 1615 | BUB1B any mutation | 2 | This gene is a known cancer gene. |
| 1616 | C15ORF65 any mutation | 2 | This gene is a known cancer gene. |
| 1617 | C2ORF44 any mutation | 2 | This gene is a known cancer gene. |
| 1618 | CACNA1D any mutation | 2 | This gene is a known cancer gene. |
| 1619 | CALR any mutation | 2 | This gene is a known cancer gene. |
| 1620 | CAMTA1 any mutation | 2 | This gene is a known cancer gene. |
| 1621 | CANT1 any mutation | 2 | This gene is a known cancer gene. |
| 1622 | CARD11 any mutation | 2 | This gene is a known cancer gene. |
| 1623 | CARS any mutation | 2 | This gene is a known cancer gene. |
| 1624 | CASC5 any mutation | 2 | This gene is a known cancer gene. |
| 1625 | CASP8 any mutation | 2 | This gene is a known cancer gene. |
| 1626 | CBFA2T3 any mutation | 2 | This gene is a known cancer gene. |
| 1627 | CBFB any mutation | 2 | This gene is a known cancer gene. |
| 1628 | CBL any mutation | 2 | This gene is a known cancer gene. |
| 1629 | CBLB any mutation | 2 | This gene is a known cancer gene. |
| 1630 | CBLC any mutation | 2 | This gene is a known cancer gene. |
| 1631 | CCDC6 any mutation | 2 | This gene is a known cancer gene. |
| 1632 | CCNB1IP1 any mutation | 2 | This gene is a known cancer gene. |
| 1633 | CCND1 any mutation | 2 | This gene is a known cancer gene. |
| 1634 | CCND2 any mutation | 2 | This gene is a known cancer gene. |
| 1635 | CCND3 any mutation | 2 | This gene is a known cancer gene. |
| 1636 | CCNE1 any mutation | 2 | This gene is a known cancer gene. |
| 1637 | CD274 any mutation | 2 | This gene is a known cancer gene. |
| 1638 | CD74 any mutation | 2 | This gene is a known cancer gene. |
| 1639 | CD79A any mutation | 2 | This gene is a known cancer gene. |
| 1640 | CD79B any mutation | 2 | This gene is a known cancer gene. |
| 1641 | CDC73 any mutation | 2 | This gene is a known cancer gene. |
| 1642 | CDH1 any mutation | 2 | This gene is a known cancer gene. |
| 1643 | CDH11 any mutation | 2 | This gene is a known cancer gene. |
| 1644 | CDK12 any mutation | 2 | This gene is a known cancer gene. |
| 1645 | CDK4 any mutation | 2 | This gene is a known cancer gene. |
| 1646 | CDK6 any mutation | 2 | This gene is a known cancer gene. |
| 1647 | CDKN1B any mutation | 2 | This gene is a known cancer gene. |
| 1648 | CDKN2A any mutation | 2 | This gene is a known cancer gene. |
| 1649 | CDKN2B any mutation | 2 | This gene is a known cancer gene. |
| 1650 | CDKN2C any mutation | 2 | This gene is a known cancer gene. |
| 1651 | CDX2 any mutation | 2 | This gene is a known cancer gene. |
| 1652 | CEBPA any mutation | 2 | This gene is a known cancer gene. |
| 1653 | CEP89 any mutation | 2 | This gene is a known cancer gene. |
| 1654 | CHCHD7 any mutation | 2 | This gene is a known cancer gene. |
| 1655 | CHEK2 any mutation | 2 | This gene is a known cancer gene. |
| 1656 | CHIC2 any mutation | 2 | This gene is a known cancer gene. |
| 1657 | CHN1 any mutation | 2 | This gene is a known cancer gene. |
| 1658 | CIC any mutation | 2 | This gene is a known cancer gene. |
| 1659 | CIITA any mutation | 2 | This gene is a known cancer gene. |
| 1660 | CLIP1 any mutation | 2 | This gene is a known cancer gene. |
| 1661 | CLP1 any mutation | 2 | This gene is a known cancer gene. |
| 1662 | CLTC any mutation | 2 | This gene is a known cancer gene. |
| 1663 | CLTCL1 any mutation | 2 | This gene is a known cancer gene. |
| 1664 | CNBP any mutation | 2 | This gene is a known cancer gene. |
| 1665 | CNOT3 any mutation | 2 | This gene is a known cancer gene. |
| 1666 | CNTRL any mutation | 2 | This gene is a known cancer gene. |
| 1667 | COL1A1 any mutation | 2 | This gene is a known cancer gene. |
| 1668 | COL2A1 any mutation | 2 | This gene is a known cancer gene. |
| 1669 | COX6C any mutation | 2 | This gene is a known cancer gene. |
| 1670 | CREB1 any mutation | 2 | This gene is a known cancer gene. |
| 1671 | CREB3L1 any mutation | 2 | This gene is a known cancer gene. |
| 1672 | CREB3L2 any mutation | 2 | This gene is a known cancer gene. |
| 1673 | CREBBP any mutation | 2 | This gene is a known cancer gene. |
| 1674 | CRLF2 any mutation | 2 | This gene is a known cancer gene. |
| 1675 | CRTC1 any mutation | 2 | This gene is a known cancer gene. |
| 1676 | CRTC3 any mutation | 2 | This gene is a known cancer gene. |
| 1677 | CSF1R any mutation | 2 | This gene is a known cancer gene. |
| 1678 | CSF3R any mutation | 2 | This gene is a known cancer gene. |
| 1679 | CTNNB1 any mutation | 2 | This gene is a known cancer gene. |
| 1680 | CUX1 any mutation | 2 | This gene is a known cancer gene. |
| 1681 | CYLD any mutation | 2 | This gene is a known cancer gene. |
| 1682 | DAXX any mutation | 2 | This gene is a known cancer gene. |
| 1683 | DCTN1 any mutation | 2 | This gene is a known cancer gene. |
| 1684 | DDB2 any mutation | 2 | This gene is a known cancer gene. |
| 1685 | DDIT3 any mutation | 2 | This gene is a known cancer gene. |
| 1686 | DDX10 any mutation | 2 | This gene is a known cancer gene. |
| 1687 | DDX5 any mutation | 2 | This gene is a known cancer gene. |
| 1688 | DDX6 any mutation | 2 | This gene is a known cancer gene. |
| 1689 | DEK any mutation | 2 | This gene is a known cancer gene. |
| 1690 | DICER1 any mutation | 2 | This gene is a known cancer gene. |
| 1691 | DNM2 any mutation | 2 | This gene is a known cancer gene. |
| 1692 | DNMT3A any mutation | 2 | This gene is a known cancer gene. |
| 1693 | DUX4 any mutation | 2 | This gene is a known cancer gene. |
| 1694 | EBF1 any mutation | 2 | This gene is a known cancer gene. |
| 1695 | ECT2L any mutation | 2 | This gene is a known cancer gene. |
| 1696 | EGFR any mutation | 2 | This gene is a known cancer gene. |
| 1697 | EIF3E any mutation | 2 | This gene is a known cancer gene. |
| 1698 | EIF4A2 any mutation | 2 | This gene is a known cancer gene. |
| 1699 | ELF4 any mutation | 2 | This gene is a known cancer gene. |
| 1700 | ELK4 any mutation | 2 | This gene is a known cancer gene. |
| 1701 | ELL any mutation | 2 | This gene is a known cancer gene. |
| 1702 | ELN any mutation | 2 | This gene is a known cancer gene. |
| 1703 | EML4 any mutation | 2 | This gene is a known cancer gene. |
| 1704 | EPHA3 any mutation | 2 | This gene is a known cancer gene. |
| 1705 | EP300 any mutation | 2 | This gene is a known cancer gene. |
| 1706 | EPS15 any mutation | 2 | This gene is a known cancer gene. |
| 1707 | ERBB2 any mutation | 2 | This gene is a known cancer gene. |
| 1708 | ERBB3 any mutation | 2 | This gene is a known cancer gene. |
| 1709 | ERC1 any mutation | 2 | This gene is a known cancer gene. |
| 1710 | ERCC2 any mutation | 2 | This gene is a known cancer gene. |
| 1711 | ERCC3 any mutation | 2 | This gene is a known cancer gene. |
| 1712 | ERCC4 any mutation | 2 | This gene is a known cancer gene. |
| 1713 | ERCC5 any mutation | 2 | This gene is a known cancer gene. |
| 1714 | ERG any mutation | 2 | This gene is a known cancer gene. |
| 1715 | ESR1 any mutation | 2 | This gene is a known cancer gene. |
| 1716 | ETNK1 any mutation | 2 | This gene is a known cancer gene. |
| 1717 | ETV1 any mutation | 2 | This gene is a known cancer gene. |
| 1718 | ETV4 any mutation | 2 | This gene is a known cancer gene. |
| 1719 | ETV5 any mutation | 2 | This gene is a known cancer gene. |
| 1720 | ETV6 any mutation | 2 | This gene is a known cancer gene. |
| 1721 | EWSR1 any mutation | 2 | This gene is a known cancer gene. |
| 1722 | EXT1 any mutation | 2 | This gene is a known cancer gene. |
| 1723 | EXT2 any mutation | 2 | This gene is a known cancer gene. |
| 1724 | EZH2 any mutation | 2 | This gene is a known cancer gene. |
| 1725 | EZR any mutation | 2 | This gene is a known cancer gene. |
| 1726 | FAM131B any mutation | 2 | This gene is a known cancer gene. |
| 1727 | FAM46C any mutation | 2 | This gene is a known cancer gene. |
| 1728 | FANCA any mutation | 2 | This gene is a known cancer gene. |
| 1729 | FANCC any mutation | 2 | This gene is a known cancer gene. |
| 1730 | FANCD2 any mutation | 2 | This gene is a known cancer gene. |
| 1731 | FANCE any mutation | 2 | This gene is a known cancer gene. |
| 1732 | FANCF any mutation | 2 | This gene is a known cancer gene. |
| 1733 | FANCG any mutation | 2 | This gene is a known cancer gene. |
| 1734 | FAS any mutation | 2 | This gene is a known cancer gene. |
| 1735 | FBXO11 any mutation | 2 | This gene is a known cancer gene. |
| 1736 | FBXW7 any mutation | 2 | This gene is a known cancer gene. |
| 1737 | FCGR2B any mutation | 2 | This gene is a known cancer gene. |
| 1738 | FCRL4 any mutation | 2 | This gene is a known cancer gene. |
| 1739 | FEV any mutation | 2 | This gene is a known cancer gene. |
| 1740 | FGFR1 any mutation | 2 | This gene is a known cancer gene. |
| 1741 | FGFR1OP any mutation | 2 | This gene is a known cancer gene. |
| 1742 | FGFR2 any mutation | 2 | This gene is a known cancer gene. |
| 1743 | FGFR3 any mutation | 2 | This gene is a known cancer gene. |
| 1744 | FGFR4 any mutation | 2 | This gene is a known cancer gene. |
| 1745 | FH any mutation | 2 | This gene is a known cancer gene. |
| 1746 | FHIT any mutation | 2 | This gene is a known cancer gene. |
| 1747 | FIP1L1 any mutation | 2 | This gene is a known cancer gene. |
| 1748 | FLCN any mutation | 2 | This gene is a known cancer gene. |
| 1749 | FLI1 any mutation | 2 | This gene is a known cancer gene. |
| 1750 | FLT3 any mutation | 2 | This gene is a known cancer gene. |
| 1751 | FLT4 any mutation | 2 | This gene is a known cancer gene. |
| 1752 | FNBP1 any mutation | 2 | This gene is a known cancer gene. |
| 1753 | FOXA1 any mutation | 2 | This gene is a known cancer gene. |
| 1754 | FOXL2 any mutation | 2 | This gene is a known cancer gene. |
| 1755 | FOXO1 any mutation | 2 | This gene is a known cancer gene. |
| 1756 | FOXO3 any mutation | 2 | This gene is a known cancer gene. |
| 1757 | FOXO4 any mutation | 2 | This gene is a known cancer gene. |
| 1758 | FOXO4 any mutation | 2 | This gene is a known cancer gene. |
| 1759 | FOXP1 any mutation | 2 | This gene is a known cancer gene. |
| 1760 | FSTL3 any mutation | 2 | This gene is a known cancer gene. |
| 1761 | FUBP1 any mutation | 2 | This gene is a known cancer gene. |
| 1762 | FUS any mutation | 2 | This gene is a known cancer gene. |
| 1763 | GAS7 any mutation | 2 | This gene is a known cancer gene. |
| 1764 | GATA1 any mutation | 2 | This gene is a known cancer gene. |
| 1765 | GATA2 any mutation | 2 | This gene is a known cancer gene. |
| 1766 | GATA3 any mutation | 2 | This gene is a known cancer gene. |
| 1767 | GMPS any mutation | 2 | This gene is a known cancer gene. |
| 1768 | GNA11 any mutation | 2 | This gene is a known cancer gene. |
| 1769 | GNAQ any mutation | 2 | This gene is a known cancer gene. |
| 1770 | GNAS any mutation | 2 | This gene is a known cancer gene. |
| 1771 | GOLGA5 any mutation | 2 | This gene is a known cancer gene. |
| 1772 | GOPC any mutation | 2 | This gene is a known cancer gene. |
| 1773 | GPC3 any mutation | 2 | This gene is a known cancer gene. |
| 1774 | GPHN any mutation | 2 | This gene is a known cancer gene. |
| 1775 | GRIN2A any mutation | 2 | This gene is a known cancer gene. |
| 1776 | H3F3A any mutation | 2 | This gene is a known cancer gene. |
| 1777 | H3F3B any mutation | 2 | This gene is a known cancer gene. |
| 1778 | HERPUD1 any mutation | 2 | This gene is a known cancer gene. |
| 1779 | HEY1 any mutation | 2 | This gene is a known cancer gene. |
| 1780 | HIP1 any mutation | 2 | This gene is a known cancer gene. |
| 1781 | HIST1H3B any mutation | 2 | This gene is a known cancer gene. |
| 1782 | HIST1H4I any mutation | 2 | This gene is a known cancer gene. |
| 1783 | HLA-A any mutation | 2 | This gene is a known cancer gene. |
| 1784 | HLF any mutation | 2 | This gene is a known cancer gene. |
| 1785 | HMGA1 any mutation | 2 | This gene is a known cancer gene. |
| 1786 | HMGA2 any mutation | 2 | This gene is a known cancer gene. |
| 1787 | HNF1A any mutation | 2 | This gene is a known cancer gene. |
| 1788 | HNRNPA2B1 any mutation | 2 | This gene is a known cancer gene. |
| 1789 | HOOK3 any mutation | 2 | This gene is a known cancer gene. |
| 1790 | HOXA11 any mutation | 2 | This gene is a known cancer gene. |
| 1791 | HOXA13 any mutation | 2 | This gene is a known cancer gene. |
| 1792 | HOXA9 any mutation | 2 | This gene is a known cancer gene. |
| 1793 | HOXC11 any mutation | 2 | This gene is a known cancer gene. |
| 1794 | HOXC13 any mutation | 2 | This gene is a known cancer gene. |
| 1795 | HOXD11 any mutation | 2 | This gene is a known cancer gene. |
| 1796 | HOXD13 any mutation | 2 | This gene is a known cancer gene. |
| 1797 | HRAS any mutation | 2 | This gene is a known cancer gene. |
| 1798 | HSP90AA1 any mutation | 2 | This gene is a known cancer gene. |
| 1799 | HSP90AB1 any mutation | 2 | This gene is a known cancer gene. |
| 1800 | IDH1 any mutation | 2 | This gene is a known cancer gene. |
| 1801 | IDH2 any mutation | 2 | This gene is a known cancer gene. |
| 1802 | IKBKB any mutation | 2 | This gene is a known cancer gene. |
| 1803 | IKZF1 any mutation | 2 | This gene is a known cancer gene. |
| 1804 | IL2 any mutation | 2 | This gene is a known cancer gene. |
| 1805 | IL21R any mutation | 2 | This gene is a known cancer gene. |
| 1806 | IL6ST any mutation | 2 | This gene is a known cancer gene. |
| 1807 | IL7R any mutation | 2 | This gene is a known cancer gene. |
| 1808 | IRF4 any mutation | 2 | This gene is a known cancer gene. |
| 1809 | ITK any mutation | 2 | This gene is a known cancer gene. |
| 1810 | JAK1 any mutation | 2 | This gene is a known cancer gene. |
| 1811 | JAK2 any mutation | 2 | This gene is a known cancer gene. |
| 1812 | JAK3 any mutation | 2 | This gene is a known cancer gene. |
| 1813 | JAZF1 any mutation | 2 | This gene is a known cancer gene. |
| 1814 | JUN any mutation | 2 | This gene is a known cancer gene. |
| 1815 | KAT6A any mutation | 2 | This gene is a known cancer gene. |
| 1816 | KAT6B any mutation | 2 | This gene is a known cancer gene. |
| 1817 | KCNJ5 any mutation | 2 | This gene is a known cancer gene. |
| 1818 | KDM5A any mutation | 2 | This gene is a known cancer gene. |
| 1819 | KDM5C any mutation | 2 | This gene is a known cancer gene. |
| 1820 | KDM6A any mutation | 2 | This gene is a known cancer gene. |
| 1821 | KDR any mutation | 2 | This gene is a known cancer gene. |
| 1822 | KDSR any mutation | 2 | This gene is a known cancer gene. |
| 1823 | KIAA1549 any mutation | 2 | This gene is a known cancer gene. |
| 1824 | KIAA1598 any mutation | 2 | This gene is a known cancer gene. |
| 1825 | KIF5B any mutation | 2 | This gene is a known cancer gene. |
| 1826 | KIT any mutation | 2 | This gene is a known cancer gene. |
| 1827 | KLF4 any mutation | 2 | This gene is a known cancer gene. |
| 1828 | KLF6 any mutation | 2 | This gene is a known cancer gene. |
| 1829 | KLK2 any mutation | 2 | This gene is a known cancer gene. |
| 1830 | KMT2A any mutation | 2 | This gene is a known cancer gene. |
| 1831 | KMT2C any mutation | 2 | This gene is a known cancer gene. |
| 1832 | KMT2D any mutation | 2 | This gene is a known cancer gene. |
| 1833 | KRAS any mutation | 2 | This gene is a known cancer gene. |
| 1834 | KTN1 any mutation | 2 | This gene is a known cancer gene. |
| 1835 | LASP1 any mutation | 2 | This gene is a known cancer gene. |
| 1836 | LCK any mutation | 2 | This gene is a known cancer gene. |
| 1837 | LCP1 any mutation | 2 | This gene is a known cancer gene. |
| 1838 | LHFP any mutation | 2 | This gene is a known cancer gene. |
| 1839 | LIFR any mutation | 2 | This gene is a known cancer gene. |
| 1840 | LMNA any mutation | 2 | This gene is a known cancer gene. |
| 1841 | LMO1 any mutation | 2 | This gene is a known cancer gene. |
| 1842 | LMO2 any mutation | 2 | This gene is a known cancer gene. |
| 1843 | LPP any mutation | 2 | This gene is a known cancer gene. |
| 1844 | LRIG3 any mutation | 2 | This gene is a known cancer gene. |
| 1845 | LSM14A any mutation | 2 | This gene is a known cancer gene. |
| 1846 | LYL1 any mutation | 2 | This gene is a known cancer gene. |
| 1847 | LZTR1 any mutation | 2 | This gene is a known cancer gene. |
| 1848 | MAF any mutation | 2 | This gene is a known cancer gene. |
| 1849 | MAFB any mutation | 2 | This gene is a known cancer gene. |
| 1850 | MALT1 any mutation | 2 | This gene is a known cancer gene. |
| 1851 | MAML2 any mutation | 2 | This gene is a known cancer gene. |
| 1852 | MAP2K1 any mutation | 2 | This gene is a known cancer gene. |
| 1853 | MAP2K2 any mutation | 2 | This gene is a known cancer gene. |
| 1854 | MAP2K4 any mutation | 2 | This gene is a known cancer gene. |
| 1855 | MAP3K1 any mutation | 2 | This gene is a known cancer gene. |
| 1856 | MAP3K13 any mutation | 2 | This gene is a known cancer gene. |
| 1857 | MAX any mutation | 2 | This gene is a known cancer gene. |
| 1858 | MDM2 any mutation | 2 | This gene is a known cancer gene. |
| 1859 | MDM4 any mutation | 2 | This gene is a known cancer gene. |
| 1860 | MDS2 any mutation | 2 | This gene is a known cancer gene. |
| 1861 | MECOM any mutation | 2 | This gene is a known cancer gene. |
| 1862 | MED12 any mutation | 2 | This gene is a known cancer gene. |
| 1863 | MEN1 any mutation | 2 | This gene is a known cancer gene. |
| 1864 | MET any mutation | 2 | This gene is a known cancer gene. |
| 1865 | MITF any mutation | 2 | This gene is a known cancer gene. |
| 1866 | MKL1 any mutation | 2 | This gene is a known cancer gene. |
| 1867 | MLF1 any mutation | 2 | This gene is a known cancer gene. |
| 1868 | MLH1 any mutation | 2 | This gene is a known cancer gene. |
| 1869 | MLLT1 any mutation | 2 | This gene is a known cancer gene. |
| 1870 | MLLT10 any mutation | 2 | This gene is a known cancer gene. |
| 1871 | MLLT11 any mutation | 2 | This gene is a known cancer gene. |
| 1872 | MLLT3 any mutation | 2 | This gene is a known cancer gene. |
| 1873 | MLLT4 any mutation | 2 | This gene is a known cancer gene. |
| 1874 | MLLT6 any mutation | 2 | This gene is a known cancer gene. |
| 1875 | MN1 any mutation | 2 | This gene is a known cancer gene. |
| 1876 | MNX1 any mutation | 2 | This gene is a known cancer gene. |
| 1877 | MPL any mutation | 2 | This gene is a known cancer gene. |
| 1878 | MSH2 any mutation | 2 | This gene is a known cancer gene. |
| 1879 | MSH6 any mutation | 2 | This gene is a known cancer gene. |
| 1880 | MSI2 any mutation | 2 | This gene is a known cancer gene. |
| 1881 | MSN any mutation | 2 | This gene is a known cancer gene. |
| 1882 | MTCP1 any mutation | 2 | This gene is a known cancer gene. |
| 1883 | MUC1 any mutation | 2 | This gene is a known cancer gene. |
| 1884 | MUTYH any mutation | 2 | This gene is a known cancer gene. |
| 1885 | MYB any mutation | 2 | This gene is a known cancer gene. |
| 1886 | MYC any mutation | 2 | This gene is a known cancer gene. |
| 1887 | MYCL any mutation | 2 | This gene is a known cancer gene. |
| 1888 | MYCN any mutation | 2 | This gene is a known cancer gene. |
| 1889 | MYD88 any mutation | 2 | This gene is a known cancer gene. |
| 1890 | MYH11 any mutation | 2 | This gene is a known cancer gene. |
| 1891 | MYH9 any mutation | 2 | This gene is a known cancer gene. |
| 1892 | MYO5A any mutation | 2 | This gene is a known cancer gene. |
| 1893 | MYOD1 any mutation | 2 | This gene is a known cancer gene. |
| 1894 | NAB2 any mutation | 2 | This gene is a known cancer gene. |
| 1895 | NACA any mutation | 2 | This gene is a known cancer gene. |
| 1896 | NBN any mutation | 2 | This gene is a known cancer gene. |
| 1897 | NCKIPSD any mutation | 2 | This gene is a known cancer gene. |
| 1898 | NCOA1 any mutation | 2 | This gene is a known cancer gene. |
| 1899 | NCOA2 any mutation | 2 | This gene is a known cancer gene. |
| 1900 | NCOA4 any mutation | 2 | This gene is a known cancer gene. |
| 1901 | NCOR1 any mutation | 2 | This gene is a known cancer gene. |
| 1902 | NDRG1 any mutation | 2 | This gene is a known cancer gene. |
| 1903 | NF1 any mutation | 2 | This gene is a known cancer gene. |
| 1904 | NF2 any mutation | 2 | This gene is a known cancer gene. |
| 1905 | NFATC2 any mutation | 2 | This gene is a known cancer gene. |
| 1906 | NFE2L2 any mutation | 2 | This gene is a known cancer gene. |
| 1907 | NFIB any mutation | 2 | This gene is a known cancer gene. |
| 1908 | NFKB2 any mutation | 2 | This gene is a known cancer gene. |
| 1909 | NFKBIE any mutation | 2 | This gene is a known cancer gene. |
| 1910 | NIN any mutation | 2 | This gene is a known cancer gene. |
| 1911 | NKX2-1 any mutation | 2 | This gene is a known cancer gene. |
| 1912 | NONO any mutation | 2 | This gene is a known cancer gene. |
| 1913 | NOTCH1 any mutation | 2 | This gene is a known cancer gene. |
| 1914 | NOTCH2 any mutation | 2 | This gene is a known cancer gene. |
| 1915 | NOTCH3 any mutation | 2 | This gene is a known cancer gene. |
| 1916 | NPM1 any mutation | 2 | This gene is a known cancer gene. |
| 1917 | NR4A3 any mutation | 2 | This gene is a known cancer gene. |
| 1918 | NRAS any mutation | 2 | This gene is a known cancer gene. |
| 1919 | NRG1 any mutation | 2 | This gene is a known cancer gene. |
| 1920 | NSD1 any mutation | 2 | This gene is a known cancer gene. |
| 1921 | NT5C2 any mutation | 2 | This gene is a known cancer gene. |
| 1922 | NTRK1 any mutation | 2 | This gene is a known cancer gene. |
| 1923 | NTRK3 any mutation | 2 | This gene is a known cancer gene. |
| 1924 | NUMA1 any mutation | 2 | This gene is a known cancer gene. |
| 1925 | NUP214 any mutation | 2 | This gene is a known cancer gene. |
| 1926 | NUP98 any mutation | 2 | This gene is a known cancer gene. |
| 1927 | NUTM1 any mutation | 2 | This gene is a known cancer gene. |
| 1928 | NUTM2A any mutation | 2 | This gene is a known cancer gene. |
| 1929 | NUTM2B any mutation | 2 | This gene is a known cancer gene. |
| 1930 | OLIG2 any mutation | 2 | This gene is a known cancer gene. |
| 1931 | OMD any mutation | 2 | This gene is a known cancer gene. |
| 1932 | P2RY8 any mutation | 2 | This gene is a known cancer gene. |
| 1933 | PAFAH1B2 any mutation | 2 | This gene is a known cancer gene. |
| 1934 | PALB2 any mutation | 2 | This gene is a known cancer gene. |
| 1935 | PAX3 any mutation | 2 | This gene is a known cancer gene. |
| 1936 | PAX5 any mutation | 2 | This gene is a known cancer gene. |
| 1937 | PAX7 any mutation | 2 | This gene is a known cancer gene. |
| 1938 | PAX8 any mutation | 2 | This gene is a known cancer gene. |
| 1939 | PBRM1 any mutation | 2 | This gene is a known cancer gene. |
| 1940 | PBX1 any mutation | 2 | This gene is a known cancer gene. |
| 1941 | PCM1 any mutation | 2 | This gene is a known cancer gene. |
| 1942 | PCSK7 any mutation | 2 | This gene is a known cancer gene. |
| 1943 | PDCD1LG2 any mutation | 2 | This gene is a known cancer gene. |
| 1944 | PDE4DIP any mutation | 2 | This gene is a known cancer gene. |
| 1945 | PDGFB any mutation | 2 | This gene is a known cancer gene. |
| 1946 | PDGFRA any mutation | 2 | This gene is a known cancer gene. |
| 1947 | PDGFRB any mutation | 2 | This gene is a known cancer gene. |
| 1948 | PER1 any mutation | 2 | This gene is a known cancer gene. |
| 1949 | PHF6 any mutation | 2 | This gene is a known cancer gene. |
| 1950 | PHOX2B any mutation | 2 | This gene is a known cancer gene. |
| 1951 | PICALM any mutation | 2 | This gene is a known cancer gene. |
| 1952 | PIK3CA any mutation | 2 | This gene is a known cancer gene. |
| 1953 | PIK3R1 any mutation | 2 | This gene is a known cancer gene. |
| 1954 | PIM1 any mutation | 2 | This gene is a known cancer gene. |
| 1955 | PLAG1 any mutation | 2 | This gene is a known cancer gene. |
| 1956 | PLCG1 any mutation | 2 | This gene is a known cancer gene. |
| 1957 | PML any mutation | 2 | This gene is a known cancer gene. |
| 1958 | PMS1 any mutation | 2 | This gene is a known cancer gene. |
| 1959 | PMS2 any mutation | 2 | This gene is a known cancer gene. |
| 1960 | POLE any mutation | 2 | This gene is a known cancer gene. |
| 1961 | POT1 any mutation | 2 | This gene is a known cancer gene. |
| 1962 | POU2AF1 any mutation | 2 | This gene is a known cancer gene. |
| 1963 | POU5F1 any mutation | 2 | This gene is a known cancer gene. |
| 1964 | PPARG any mutation | 2 | This gene is a known cancer gene. |
| 1965 | PPFIBP1 any mutation | 2 | This gene is a known cancer gene. |
| 1966 | PPP2R1A any mutation | 2 | This gene is a known cancer gene. |
| 1967 | PPP6C any mutation | 2 | This gene is a known cancer gene. |
| 1968 | PRCC any mutation | 2 | This gene is a known cancer gene. |
| 1969 | PRDM1 any mutation | 2 | This gene is a known cancer gene. |
| 1970 | PRDM16 any mutation | 2 | This gene is a known cancer gene. |
| 1971 | PRF1 any mutation | 2 | This gene is a known cancer gene. |
| 1972 | PRKAR1A any mutation | 2 | This gene is a known cancer gene. |
| 1973 | PRRX1 any mutation | 2 | This gene is a known cancer gene. |
| 1974 | PSIP1 any mutation | 2 | This gene is a known cancer gene. |
| 1975 | PTCH1 any mutation | 2 | This gene is a known cancer gene. |
| 1976 | PTEN any mutation | 2 | This gene is a known cancer gene. |
| 1977 | PTPN11 any mutation | 2 | This gene is a known cancer gene. |
| 1978 | PTPRB any mutation | 2 | This gene is a known cancer gene. |
| 1979 | PTPRC any mutation | 2 | This gene is a known cancer gene. |
| 1980 | PTPRK any mutation | 2 | This gene is a known cancer gene. |
| 1981 | PWWP2A any mutation | 2 | This gene is a known cancer gene. |
| 1982 | RABEP1 any mutation | 2 | This gene is a known cancer gene. |
| 1983 | RAC1 any mutation | 2 | This gene is a known cancer gene. |
| 1984 | RAD21 any mutation | 2 | This gene is a known cancer gene. |
| 1985 | RAD51B any mutation | 2 | This gene is a known cancer gene. |
| 1986 | RAF1 any mutation | 2 | This gene is a known cancer gene. |
| 1987 | RALGDS any mutation | 2 | This gene is a known cancer gene. |
| 1988 | RANBP17 any mutation | 2 | This gene is a known cancer gene. |
| 1989 | RANBP2 any mutation | 2 | This gene is a known cancer gene. |
| 1990 | RAP1GDS1 any mutation | 2 | This gene is a known cancer gene. |
| 1991 | RARA any mutation | 2 | This gene is a known cancer gene. |
| 1992 | RB1 any mutation | 2 | This gene is a known cancer gene. |
| 1993 | RBM15 any mutation | 2 | This gene is a known cancer gene. |
| 1994 | RECQL4 any mutation | 2 | This gene is a known cancer gene. |
| 1995 | REL any mutation | 2 | This gene is a known cancer gene. |
| 1996 | RET any mutation | 2 | This gene is a known cancer gene. |
| 1997 | RHOA any mutation | 2 | This gene is a known cancer gene. |
| 1998 | RHOH any mutation | 2 | This gene is a known cancer gene. |
| 1999 | RMI2 any mutation | 2 | This gene is a known cancer gene. |
| 2000 | RNF213 any mutation | 2 | This gene is a known cancer gene. |
| 2001 | RNF43 any mutation | 2 | This gene is a known cancer gene. |
| 2002 | ROS1 any mutation | 2 | This gene is a known cancer gene. |
| 2003 | RPL10 any mutation | 2 | This gene is a known cancer gene. |
| 2004 | RPL22 any mutation | 2 | This gene is a known cancer gene. |
| 2005 | RPL5 any mutation | 2 | This gene is a known cancer gene. |
| 2006 | RPN1 any mutation | 2 | This gene is a known cancer gene. |
| 2007 | RSPO2 any mutation | 2 | This gene is a known cancer gene. |
| 2008 | RSPO3 any mutation | 2 | This gene is a known cancer gene. |
| 2009 | SNX29 any mutation | 2 | This gene is a known cancer gene. |
| 2010 | RUNX1 any mutation | 2 | This gene is a known cancer gene. |
| 2011 | RUNX1T1 any mutation | 2 | This gene is a known cancer gene. |
| 2012 | SBDS any mutation | 2 | This gene is a known cancer gene. |
| 2013 | SDC4 any mutation | 2 | This gene is a known cancer gene. |
| 2014 | SDHAF2 any mutation | 2 | This gene is a known cancer gene. |
| 2015 | SDHB any mutation | 2 | This gene is a known cancer gene. |
| 2016 | SDHC any mutation | 2 | This gene is a known cancer gene. |
| 2017 | SEPT5 any mutation | 2 | This gene is a known cancer gene. |
| 2018 | SEPT6 any mutation | 2 | This gene is a known cancer gene. |
| 2019 | SEPT9 any mutation | 2 | This gene is a known cancer gene. |
| 2020 | SET any mutation | 2 | This gene is a known cancer gene. |
| 2021 | SETBP1 any mutation | 2 | This gene is a known cancer gene. |
| 2022 | SETD2 any mutation | 2 | This gene is a known cancer gene. |
| 2023 | SF3B1 any mutation | 2 | This gene is a known cancer gene. |
| 2024 | SFPQ any mutation | 2 | This gene is a known cancer gene. |
| 2025 | SH2B3 any mutation | 2 | This gene is a known cancer gene. |
| 2026 | SH3GL1 any mutation | 2 | This gene is a known cancer gene. |
| 2027 | SLC34A2 any mutation | 2 | This gene is a known cancer gene. |
| 2028 | SLC45A3 any mutation | 2 | This gene is a known cancer gene. |
| 2029 | SMAD4 any mutation | 2 | This gene is a known cancer gene. |
| 2030 | SMARCA4 any mutation | 2 | This gene is a known cancer gene. |
| 2031 | SMARCB1 any mutation | 2 | This gene is a known cancer gene. |
| 2032 | SMARCD1 any mutation | 2 | This gene is a known cancer gene. |
| 2033 | SMARCE1 any mutation | 2 | This gene is a known cancer gene. |
| 2034 | SMO any mutation | 2 | This gene is a known cancer gene. |
| 2035 | SND1 any mutation | 2 | This gene is a known cancer gene. |
| 2036 | SOCS1 any mutation | 2 | This gene is a known cancer gene. |
| 2037 | SOX2 any mutation | 2 | This gene is a known cancer gene. |
| 2038 | SPECC1 any mutation | 2 | This gene is a known cancer gene. |
| 2039 | SPEN any mutation | 2 | This gene is a known cancer gene. |
| 2040 | SPOP any mutation | 2 | This gene is a known cancer gene. |
| 2041 | SRGAP3 any mutation | 2 | This gene is a known cancer gene. |
| 2042 | SRSF2 any mutation | 2 | This gene is a known cancer gene. |
| 2043 | SRSF3 any mutation | 2 | This gene is a known cancer gene. |
| 2044 | SS18 any mutation | 2 | This gene is a known cancer gene. |
| 2045 | SS18L1 any mutation | 2 | This gene is a known cancer gene. |
| 2046 | SSX1 any mutation | 2 | This gene is a known cancer gene. |
| 2047 | SSX2 any mutation | 2 | This gene is a known cancer gene. |
| 2048 | SSX4 any mutation | 2 | This gene is a known cancer gene. |
| 2049 | STAG2 any mutation | 2 | This gene is a known cancer gene. |
| 2050 | STAT3 any mutation | 2 | This gene is a known cancer gene. |
| 2051 | STAT5B any mutation | 2 | This gene is a known cancer gene. |
| 2052 | STAT6 any mutation | 2 | This gene is a known cancer gene. |
| 2053 | STIL any mutation | 2 | This gene is a known cancer gene. |
| 2054 | STK11 any mutation | 2 | This gene is a known cancer gene. |
| 2055 | STRN any mutation | 2 | This gene is a known cancer gene. |
| 2056 | SUFU any mutation | 2 | This gene is a known cancer gene. |
| 2057 | SUZ12 any mutation | 2 | This gene is a known cancer gene. |
| 2058 | SYK any mutation | 2 | This gene is a known cancer gene. |
| 2059 | TAF15 any mutation | 2 | This gene is a known cancer gene. |
| 2060 | TAL1 any mutation | 2 | This gene is a known cancer gene. |
| 2061 | TAL2 any mutation | 2 | This gene is a known cancer gene. |
| 2062 | TBL1XR1 any mutation | 2 | This gene is a known cancer gene. |
| 2063 | TBX3 any mutation | 2 | This gene is a known cancer gene. |
| 2064 | TCEA1 any mutation | 2 | This gene is a known cancer gene. |
| 2065 | TCF12 any mutation | 2 | This gene is a known cancer gene. |
| 2066 | TCF3 any mutation | 2 | This gene is a known cancer gene. |
| 2067 | TCF7L2 any mutation | 2 | This gene is a known cancer gene. |
| 2068 | TCL1A any mutation | 2 | This gene is a known cancer gene. |
| 2069 | TERT any mutation | 2 | This gene is a known cancer gene. |
| 2070 | TET1 any mutation | 2 | This gene is a known cancer gene. |
| 2071 | TET2 any mutation | 2 | This gene is a known cancer gene. |
| 2072 | TFE3 any mutation | 2 | This gene is a known cancer gene. |
| 2073 | TFEB any mutation | 2 | This gene is a known cancer gene. |
| 2074 | TFG any mutation | 2 | This gene is a known cancer gene. |
| 2075 | TFPT any mutation | 2 | This gene is a known cancer gene. |
| 2076 | TFRC any mutation | 2 | This gene is a known cancer gene. |
| 2077 | THRAP3 any mutation | 2 | This gene is a known cancer gene. |
| 2078 | TLX1 any mutation | 2 | This gene is a known cancer gene. |
| 2079 | TLX3 any mutation | 2 | This gene is a known cancer gene. |
| 2080 | TMPRSS2 any mutation | 2 | This gene is a known cancer gene. |
| 2081 | TNFAIP3 any mutation | 2 | This gene is a known cancer gene. |
| 2082 | TNFRSF14 any mutation | 2 | This gene is a known cancer gene. |
| 2083 | TNFRSF17 any mutation | 2 | This gene is a known cancer gene. |
| 2084 | TOP1 any mutation | 2 | This gene is a known cancer gene. |
| 2086 | TPM3 any mutation | 2 | This gene is a known cancer gene. |
| 2087 | TPM4 any mutation | 2 | This gene is a known cancer gene. |
| 2088 | TPR any mutation | 2 | This gene is a known cancer gene. |
| 2089 | TRAF7 any mutation | 2 | This gene is a known cancer gene. |
| 2090 | TRIM24 any mutation | 2 | This gene is a known cancer gene. |
| 2091 | TRIM27 any mutation | 2 | This gene is a known cancer gene. |
| 2092 | TRIM33 any mutation | 2 | This gene is a known cancer gene. |
| 2093 | TRIP11 any mutation | 2 | This gene is a known cancer gene. |
| 2094 | TRRAP any mutation | 2 | This gene is a known cancer gene. |
| 2095 | TSC1 any mutation | 2 | This gene is a known cancer gene. |
| 2096 | TSC2 any mutation | 2 | This gene is a known cancer gene. |
| 2097 | TSHR any mutation | 2 | This gene is a known cancer gene. |
| 2098 | TTL any mutation | 2 | This gene is a known cancer gene. |
| 2099 | U2AF1 any mutation | 2 | This gene is a known cancer gene. |
| 2100 | UBR5 any mutation | 2 | This gene is a known cancer gene. |
| 2101 | USP6 any mutation | 2 | This gene is a known cancer gene. |
| 2102 | VHL any mutation | 2 | This gene is a known cancer gene. |
| 2103 | VTI1A any mutation | 2 | This gene is a known cancer gene. |
| 2104 | WAS any mutation | 2 | This gene is a known cancer gene. |
| 2105 | WHSC1 any mutation | 2 | This gene is a known cancer gene. |
| 2106 | WHSC1L1 any mutation | 2 | This gene is a known cancer gene. |
| 2107 | WIF1 any mutation | 2 | This gene is a known cancer gene. |
| 2108 | WRN any mutation | 2 | This gene is a known cancer gene. |
| 2109 | WT1 any mutation | 2 | This gene is a known cancer gene. |
| 2110 | WWTR1 any mutation | 2 | This gene is a known cancer gene. |
| 2111 | XPA any mutation | 2 | This gene is a known cancer gene. |
| 2112 | XPC any mutation | 2 | This gene is a known cancer gene. |
| 2113 | XPO1 any mutation | 2 | This gene is a known cancer gene. |
| 2114 | YWHAE any mutation | 2 | This gene is a known cancer gene. |
| 2115 | ZBTB16 any mutation | 2 | This gene is a known cancer gene. |
| 2116 | ZCCHC8 any mutation | 2 | This gene is a known cancer gene. |
| 2117 | ZMYM2 any mutation | 2 | This gene is a known cancer gene. |
| 2118 | PATZ1 any mutation | 2 | This gene is a known cancer gene. |
| 2119 | ZNF331 any mutation | 2 | This gene is a known cancer gene. |
| 2120 | ZNF384 any mutation | 2 | This gene is a known cancer gene. |
| 2121 | ZNF521 any mutation | 2 | This gene is a known cancer gene. |
| 2122 | ZRSR2 any mutation | 2 | This gene is a known cancer gene. |
Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The IPM makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and the IPM assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.