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Glioblastoma

Interpretations

IDTumorTissueVariantsTierInterpretation
121
Glioblastoma
Spinal Cord
Brain
Brain, Supratentorial
Brain, Infratentorial
EGFR A289V
EGFR A289D
EGFR G598V
EGFR P596L
EGFR codon(s) 289, 596, 598 any
2EGFR mutations in GBM cluster in the extracellular (EC) domain and include in-frame deletions (such as the common “variant III” del 6-273) and missense mutations (A289V, A289D, T263P, G598V). In vitro and in vivo studies reveal anchorage-independent growth and tumorigenic potential when the A289 and G598 variants are stably expressed in NIH-3T3 cells. The A289 and G598 mutations sensitize Ba/F3 cells to erlotinib in vitro according to some reports, although other reports state glioma-specific EGFR EC mutants are poorly inhibited by EGFR inhibitors that target the active kinase conformation (e.g., erlotinib). The A289 variant has been reported to show sensitivity towards BAY846, a tyrosine kinase inhibitor in brain tumors. In addition, according to some reports, inhibitors which bind to the inactive EGFR conformation potently inhibit EGFR EC mutants and induce cell death in EGFR mutant GBM cells.
128
Glioblastoma
Brain
Spinal Cord
Brain, Supratentorial
Brain, Infratentorial
EGFR exon(s) 20 insertion
2In GBM, EGFR mutations typically cluster in the extracellular domain and include in-frame deletions (such as the common “variant III” del 6-273) and missense mutations (A289V, A289D, T263P, G598V). EGFR exon 20 insertions have not been previously reported in GBM. The clinical significance of this mutation with regards to response to anti-EGFR therapy in GBM is unknown. In general, EGFR exon 20 mutations have been reported in approximately 9% of all EGFR-mutated cases of lung cancer and studies show that in contrast to the more classic activating EGFR mutations, these insertions have been associated with de novo resistance or only partial response to approved EGFR-TKIs (erlotinib and gefitinib) in lung cancer.
134
Glioblastoma
Spinal Cord
Brain
Brain, Supratentorial
Brain, Infratentorial
EGFR E709K
2In GBM, EGFR mutations typically cluster in the extracellular domain and include in-frame deletions (such as the common “variant III” del 6-273) and missense mutations (A289V, A289D, T263P, G598V). However, the p.E709K mutation in the tyrosine kinase domain of EGFR has not been previously reported in GBM. In vitro functional characterization of mutations at E709 have been reported to be activivating mutations that are associated with sensitivity to EGFR inhibitors in vitro in some cell systems. The clinical significance of this mutation with regards to response to anti-EGFR therapy in GBM is unknown.
194
Glioblastoma
Brain
Brain, Infratentorial
Brain, Supratentorial
EGFR copy number gain
2Greater than 40% of glioblastomas (GBM) harbor focal amplification of the EGFR locus and there is evidence to suggest that these are driver alterations in these patients, making the EGFR pathway a potential therapeutic target in some clinical settings. Moreover, this alteration is relatively specific for GBM with very few other diffusely infiltrative gliomas having been shown to carry focal amplification of this locus (<3%). In GBM, this alteration frequently occurs in combination with other alterations of EGFR including polysomy 7, intragenic inframe deletions (e.g. EGFRvIII), and/or somatic point mutations. Based on current evidence, the independent predictive value of EGFR amplification in GBM is unclear. The relationship between individual and concurrent EGFR alterations and clinical response to small molecular inhibitors targeting EGFR is currently under investigation in clinical trials.
143
Glioblastoma
Astrocytoma, Anaplastic
Oligodendroglioma
Astrocytoma, Diffusely Infiltrating
Infiltrating Glioma, NOS
Neuroepithelial neoplasm, high grade
Neuroepithelial Neoplasm, NOS
Spinal Cord
Brain
Brain, Supratentorial
Brain, Infratentorial
IDH1 R132H
IDH1 R132L
IDH1 R132C
IDH1 codon(s) 132 any
1IDH1 or IDH2 mutations are found in >70% of lower grade diffusely infiltrative gliomas and in >90% of secondary glioblastoma. IDH mutational status has been reported to be a favorable prognostic indicator relative to wild-type gliomas of similar histology, regardless of grade. Therapeutic strategies exploiting mutated IDH protein, including through direct inhibition and vaccine-based approaches, are currently the subject of preclinical research and clinical trials.
147
Glioblastoma
Astrocytoma, Anaplastic
Ependymoma
Oligodendroglioma
Spinal Cord
Brain
Brain, Supratentorial
Brain, Infratentorial
IDH2 R140Q
IDH2 R172K
IDH2 codon(s) 140, 172 any
1IDH1 or IDH2 mutations are found in >70% of lower grade diffusely infiltrative gliomas and in >90% of secondary glioblastoma. IDH mutational status has been reported to be a favorable prognostic indicator relative to wild-type gliomas of similar histology, regardless of grade. Therapeutic strategies exploiting mutated IDH protein, including through direct inhibition and vaccine-based approaches, are currently the subject of preclinical research and clinical trials.
202
Glioblastoma
Brain
2Somatic mutations in TP53 are frequent in human cancer. Germline TP53 mutations cause of Li-Fraumeni syndrome, which is associated with a range of early-onset cancers. The types and positions of TP53 mutations are diverse. TP53 mutations may be potential prognostic and predictive markers in some tumor types, as well as targets for pharmacological intervention in some clinical settings. The IARC TP53 Database (http://www-p53.iarc.fr/) is a useful resource which catalogues TP53 mutations found in cancer.
221
Glioblastoma
Brain
PTEN any deletion
PTEN G129R
2PTEN is an obligate haplo-insufficient tumor suppressor gene and is mutated in a large number of cancers. It encodes a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/mTOR signaling pathway. Most PTEN mutations are loss-of-function mutations. Mono-allelic or bi-allelic loss of PTEN is found in a considerable fraction of tumors, including gliomas (75%). In glioblastoma, PTEN loss/deletion is associated with poor patient prognosis, and/or shorter disease-free survival. There are ongoing clinical trials investigating anti-tumor activity of agents in recurrent glioblastoma with this mutation.
225
Glioblastoma
Brain
MET T1010I
3MET is frequently overexpressed in glioblastomas (GBM), and some gliomas show hepatocyte growth factor (HGF) autocrine activation of the MET signaling pathway. Several studies have found that HGF and MET are expressed at higher levels in human gliomas than in control brain tissue, and that expression levels correlate with tumor grade. Some studies have shown that the HGF expression in high-grade (WHO Grade III–IV) tumors was significantly higher than in low-grade (WHO I–II) tumors. Similarly, coexpression of HGF and MET is observed more frequently in Grade IV GBM than in low-grade glioma, consistent with the contribution of an HGF/MET autocrine loop to malignant progression in these tumors. However, MET sequence alterations have been rare. The p.T1010I mutation, in the cytoplasmic juxtamembrane domain of MET has been reported in some tumor types and also has been reported as a germline variant present in less than 1% of the general population. Its role in tumor development and progression continues to be studied. The utility of MET pathway inhibitors also continues to be explored.
229
Glioblastoma
Brain
3The APC gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. APC promotes rapid degradation of beta-catenin and participates in Wnt signaling as a negative regulator. APC is also involved in other processes including cell migration, cell adhesion, transcriptional activation and apoptosis. Germline defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. Somatic mutations in this gene may be observed in colorectal cancer (CRC), stomach cancer and desmoid tumors. Although APC mutations have been reported in up to 5% of low grade gliomas and up to 13% primary glioblastomas (GBM), evidence regarding their involvement in CNS tumors is still limited. Further studies are needed to explore the clinical value of these mutations in CNS tumors.
239
Adenocarcinoma
Cholangiocarcinoma
Glioblastoma
Colon
Gall Bladder
Brain
IRS2 copy number gain
3IRS1 and IRS2 are the key protein effectors for transmitting insulin signals from the insulin-like growth factor receptor to the nucleus via the PI3K / AKT / mTOR pathway. IRS2 has been previously noted to be recurrently focally amplified in several anecdotal studies across multiple cancer types (colorectal cancer PMID: 23594372, cholangiocarcinoma PMID:26684807, glioblastoma PMID: 14655756, rhabdomyosarcoma PMID: 23578105), suggesting that this could be a "driver" alteration in a subset of cancer.. IRS2 amplifications have also been associated with sensitivity to the insulin receptor inhibitor BMS-754807 in colorectal cancer cell lines (PMID: 25527633). There is no direct evidence to connect IRS2 amplification status with sensitivity to any targeted therapy regimen in patients; however, an attractive hypothesis is that tumors harboring IRS2 amplifications could be sensitive to drugs targeting insulin signaling, PI3K, AKT, and mTOR. Drug sensitivity and exome sequencing data from colorectal patient derived tumor xenografts have associated IRS2 copy gains with sensitivity to anti-EGFR therapies (PMID: 26416732).
252
Glioblastoma
Brain, Supratentorial
SEPT14 copy number gain
2The SEPT14 gene has been described as a fusion partner with EGFR in up to 4% of glioblastomas. In that context, glioma cell lines harboring this gene fusion were found to be susceptible to EGFR inhibitors in vitro. The functional significance of an isolated partial amplification of this gene would be of uncertain significance. Detection of rearrangement of this locus with a fusion partner such as EGFR would require an alternative methodology such as RNAseq or FISH analysis.
253
Glioblastoma
Brain
CDKN2A copy number loss
2The CDKN2A gene locus is altered in up to approximately 57% of glioblastoma, most commonly as a homozygous deletion, and frequently with concurrent deletion of the CDKN2B locus. CDKN2A/CDKN2B loss may be associated with increased sensitivity to CDK4/6 inhibitors. The efficacy and toxicity profiles of these inhibitors in the context of a variety of cancer types are currently under evaluation in clinical trials.
254
Glioblastoma
Brain
CDKN2B copy number loss
1The CDKN2B gene locus is altered in up to approximately 55% of glioblastoma, most commonly as a homozygous deletion, and frequently with concurrent deletion of the CDKN2A locus. CDKN2A/CDKN2B loss may be associated with increased sensitivity to CDK4/6 inhibitors. The efficacy and toxicity profiles of these inhibitors in the context of a variety of cancer types are currently under evaluation in clinical trials.
259
Glioblastoma
Brain
3The PTPN11gene encodes SHP-2, a widely expressed cytoplasmic protein tyrosine phosphatase. SHP-2 is essential for activation of the RAS/MAPK signaling cascade. Most mutations are gain-of-function and result in prolonged ligand-dependent activation of the RAS/MAPK cascade. Germ-line PTPN11 mutations cause Noonan syndrome, a developmental disorder characterized by an increased risk of malignancies. Activating somatic mutations in PTPN11 have been documented in certain hematologic malignancies but they are infrequent in solid tumors. According to TCGA data base, about 2% of all the glial tumors harbor somatic mutations in PTPN11 gene but their prognostic and therapeutic significance remains to be fully elucidated. The utility of SHP2 inhibitors continues to be explored in some preclinical studies.
322
Glioblastoma
Brain
2The protein encoded by the RB1 gene is a negative regulator of the cell cycle and was the first tumor suppressor gene identified. The active, hypophosphorylated form of the protein binds transcription factor E2F1. RB1 alterations including mutations and deletions are seen in up to 11% of glioblastomas. It has been suggested that patients with RB1-deficient tumors do not respond to cyclin-dependent kinase (CDK) inhibitors. The predictive and prognostic significance of RB1 mutations in glioblastoma needs to be further studied.
345
Glioblastoma
Neuroblastoma
Astrocytoma, Anaplastic
Oligodendroglioma
Ependymoma
Ependymoma, Anaplastic
Brain
Brain, Infratentorial
Brain, Supratentorial
1In AML, presence of exon 17 mutations in KIT may confer an adverse prognosis or increased relapse rate. However, its significance in brain tumors is yet to be determined.
349
Renal Cell Carcinoma
Glioblastoma
Kidney
Brain
1FGFR2 mutation in a patient with oral squamous cell carcinoma was associated with response to the multitargeted tyrosine kinase inhibitor pazopanib. The clinical significance of this finding in this tumor type is unknown.
372
Glioblastoma
Brain
EGFR V774M
2EGFR mutations have been reported in up to 21% of glioblastoma tumors (GBM). In GBM, EGFR mutations typically cluster in the extracellular domain and include in-frame deletions and missense mutations. However, mutations (such as V774M) in the tyrosine kinase domain of EGFR have been previously reported in GBM. The clinical significance of this mutation with regards to response to TKI therapy in GBM needs further elucidation. Results should be interpreted in conjunction with other laboratory and clinical findings.
405
Glioblastoma
Astrocytoma, Anaplastic
Astrocytoma, Pilocytic
Brain
MET E168D
3MET is a member of the receptor tyrosine kinase and proto-oncogene playing a major role in tumor development and metastasis. MET mutations have been reported in up to 3.3% of low-grade gliomas and 2.2% of glioblastomas. MET E168D mutation is located in a conserved domain containing the ligand binding site. In vitro studies have shown that E168D may be associated with higher ligand affinity and higher susceptibility to c-Met inhibitors in lung cancer. The predictive and prognostic significance of MET mutations in brain tumors is unclear and needs to be further studied. Correlation with other clinical and laboratory findings is recommended.
408
Glioblastoma
Brain
EGFR R108K
2EGFR mutations in GBM cluster in the extracellular (EC) domain and include in-frame deletions (such as the common “variant III” del 6-273) and missense mutations (A289V, A289D, T263P, G598V). Mutations involving residue R108 have been reported in GBM, frequently occurring with other EGFR mutations at amino acids A289, P596, and G598. In vitro studies have shown that R108K mutation leads to increased ligand-binding affinity and shows anchorage-independent growth and tumorigenic potential when stably expressed in NIH-3T3 cells. The predictive and prognostic significance of this mutation at R108 needs further elucidation. Correlation with other clinical and laboratory findings is recommended.
413
Astrocytoma, Anaplastic
Glioblastoma
Brain
Brain, Supratentorial
Brain, Infratentorial
PDGFRA copy number gain
2PDGFRA amplification is reportedly present in up to 29% of pediatric and 21% of adult high-grade astrocytomas when assessed by flourescent in situ hydridization. Copy number alterations of this gene have been repoted in approximately 11% of adult glioblastoma making it the second most commonly altered receptor tyrosine kinase after EGFR. In those adult glioblastomas that are IDH-mutant, there is evidence to suggest that amplification of PDGFRA is associated with worse overall survival.
1579
Acinar Cell Carcinoma
Acinic Cell Carcinoma
Acute Myeloid Leukemia
Adenocarcinoma
Adenoid Cystic Carcinoma
Adenosarcoma
Ameloblastic Tumor
Anaplastic Large Cell Lymphoma
Angioimmunoblastic T-Cell Lymphoma
Angiomatoid Fibrous Histiocytoma
Angiomatosis
Angiomyolipoma
Angiosarcoma
Astrocytoma, Anaplastic
Atypical Chronic Myeloid Leukemia
B Lymphoblastic Leukemia/Lymphoma
Basal Cell Carcinoma
Burkitt Lymphoma
Carcinoid Tumor
Carcinoma
Carcinosarcoma
Cholangiocarcinoma
Chondrosarcoma
Chordoma
Choriocarcinoma
Chromophobe Renal Cell Carcinoma
Chronic Lymphocytic Leukemia
Chronic Myeloid Leukemia
Chronic Myelomonocytic Leukemia
Chronic Neutrophilic Leukemia
Classical Hodgkin Lymphoma
Clear Cell Carcinoma
Clear Cell Renal Cell Carcinoma
Craniopharyngioma
Dermatofibrosarcoma
Desmoplastic Small Round Cell Tumor
Diffuse Large B Cell Lymphoma
Ductal Carcinoma
Ependymoma
Essential Thrombocythemia
Ewing Sarcoma
Fibromatosis
Follicular Carcinoma
Follicular Lymphoma
Gastrointestinal Stromal Tumor
Germ Cell Tumor
Giant Cell Tumor
Glioblastoma
Glomus Tumor
Granular Cell Tumor
Hairy Cell Leukemia
Hemangioendothelioma
Hepatocellular Carcinoma
Histiocytic and Dendritic Cell Neoplasms
Invasive Ductal Carcinoma
Kaposi Sarcoma
Langerhans Cell Histiocytosis
Leiomyoma
Leiomyosarcoma
Lipoma
Liposarcoma
Lobular Carcinoma
Lymphoplasmacytic Lymphoma
Malignant Mullerian Mixed Tumor
Mantle Cell Lymphoma
Marginal Zone B Cell Lymphoma
Mast Cell Neoplasm
MDS with Ring Sideroblasts
Medullary Carcinoma
Medulloblastoma
Melanoma
Meningioma
Merkel Cell Carcinoma
Mesothelioma
Mucinous Tumors of Appendix
Mucinous Tumors of Ovary
Mucoepidermoid Carcinoma
Myelodysplastic Syndrome
Myeloproliferative Neoplasm
Myxofibrosarcoma
Nasopharyngeal Carcinoma
Neuroblastoma
Neuroendocrine Carcinoma
Neuroendocrine Neoplasm
NK Cell Lymphoproliferative Disorder
NLPHL
Non-Small Cell Lung Carcinoma
Oligodendroglioma
Osteosarcoma
Papillary Carcinoma
Papillary Renal Cell Carcinoma
Peripheral T Cell Lymphoma
Pheochromocytoma
Plasma Cell Disorder
Polycythemia Vera
Post-Transplant Lymphoproliferative Disorder
Primary Myelofibrosis
Primitive Neuroectodermal Tumor
Renal Cell Carcinoma
Reninoma
Retinoblastoma
Rhabdomyosarcoma
Sarcoma
Schwannoma
Serous Carcinoma
Sex Cord Stromal Tumor
Small Cell Carcinoma
Solid Pseudopapillary Tumor of Pancreas
Spindle Cell Neoplasm
Squamous Cell Carcinoma
T Cell Lymphoproliferative Disorder
T Lymphoblastic Leukemia/Lymphoma
T-Cell LGL Leukemia
Thymic Carcinoma
Thymoma
Urothelial Carcinoma
Tumors of Peripheral Nerves
Unknown
Wilms Tumor
Ependymoma, Anaplastic
Astrocytoma, Pilocytic
Ganglioglioma
Neuroepithelial Neoplasm, NOS
Pleomorphic Carcinoma
Solitary Fibrous Tumor
Neuroepithelial neoplasm, high grade
Leukocytosis
Thrombocytosis
Monocytosis
Cytopenia
Other Acute Leukemia
Astrocytoma, NOS
Acute Leukemia of Unspecified Cell Type
Anemia, Unspecified
Astrocytoma, Diffusely Infiltrating
Diffuse Midline Glioma
Infiltrating Glioma, NOS
Intraductal Papillary Mucinous Neoplasm (IPMN)
Leukopenia
Lymphadenopathy
Lymphocytosis, Symptomatic
Monoclonal Gammopathy
Mucinous or Serous Cystic Neoplasms of Pancreas
Mycosis Fungoides, Unspecified Site
Oligodendroglioma, Anaplastic
Pleomorphic Xanthoastrocytoma
Rash and Other Nonspecific Skin Eruption
Thrombocytopenia, Unspecified
Adrenal Gland
Anus
Ampulla (Pancreaticobiliary Duct)
Appendix
Bladder
Blood
Bone
Bone Marrow
Brain
Breast
Spinal Cord
Cervix
Chest Wall
Colon
Endometrium
Esophagus
Eye
Fallopian Tube
Fibroadipose Tissue
Gall Bladder
Kidney
Larynx
Liver
Lung
Lymph Node
Nasal Cavity
Oral Cavity
Ovary
Pancreas
Parathyroid
Penis
Peripheral Nervous System
Peritoneum
Pharynx
Pituitary
Placenta
Pleura
Prostate
Retroperitoneum
Salivary Gland
Seminal Vesicle
Skeletal Muscle
Skin
Small Intestine
Soft Tissue
Spleen
Stomach
Testis
Thymus
Thyroid
Tonsil
Unknown
Ureter
Uterus
Vagina
Rectum
Cartilage
Blood Vessel
Buccal Swab
Heart
Trachea
Salivary Duct
Spermatic Cord
Vulva
Brain, Infratentorial
Brain, Supratentorial
Gastroesophageal Junction
Sellar
Suprasellar
ARID1A any mutation
2This gene is a known cancer gene. ARID1A/BAF250A subunit of the SWI/SNF (BAF) chromatin remodeling complex has emerged as recurrently mutated in a broad array of tumor types and a potential tumor suppressor. There is evidence indicating that ARID1A-mutated cancers may be subjected to therapeutic intervention.
2085
Acinar Cell Carcinoma
Acinic Cell Carcinoma
Adenocarcinoma
Adenoid Cystic Carcinoma
Adenosarcoma
Ameloblastic Tumor
Anaplastic Large Cell Lymphoma
Angioimmunoblastic T-Cell Lymphoma
Angiomatoid Fibrous Histiocytoma
Angiomatosis
Angiomyolipoma
Angiosarcoma
Astrocytoma, Anaplastic
Basal Cell Carcinoma
Burkitt Lymphoma
Carcinoid Tumor
Carcinoma
Carcinosarcoma
Cholangiocarcinoma
Chondrosarcoma
Chordoma
Choriocarcinoma
Chromophobe Renal Cell Carcinoma
Chronic Lymphocytic Leukemia
Classical Hodgkin Lymphoma
Clear Cell Carcinoma
Clear Cell Renal Cell Carcinoma
Craniopharyngioma
Dermatofibrosarcoma
Desmoplastic Small Round Cell Tumor
Diffuse Large B Cell Lymphoma
Ductal Carcinoma
Ependymoma
Ewing Sarcoma
Fibromatosis
Follicular Carcinoma
Follicular Lymphoma
Gastrointestinal Stromal Tumor
Germ Cell Tumor
Giant Cell Tumor
Glioblastoma
Glomus Tumor
Granular Cell Tumor
Hairy Cell Leukemia
Hemangioendothelioma
Hepatocellular Carcinoma
Invasive Ductal Carcinoma
Kaposi Sarcoma
Leiomyoma
Leiomyosarcoma
Lipoma
Liposarcoma
Lobular Carcinoma
Lymphoplasmacytic Lymphoma
Malignant Mullerian Mixed Tumor
Mantle Cell Lymphoma
Marginal Zone B Cell Lymphoma
Medullary Carcinoma
Medulloblastoma
Melanoma
Meningioma
Merkel Cell Carcinoma
Mesothelioma
Mucinous Tumors of Appendix
Mucinous Tumors of Ovary
Mucoepidermoid Carcinoma
Myxofibrosarcoma
Nasopharyngeal Carcinoma
Neuroblastoma
Neuroendocrine Carcinoma
Neuroendocrine Neoplasm
NK Cell Lymphoproliferative Disorder
NLPHL
Non-Small Cell Lung Carcinoma
Oligodendroglioma
Osteosarcoma
Papillary Carcinoma
Papillary Renal Cell Carcinoma
Peripheral T Cell Lymphoma
Pheochromocytoma
Plasma Cell Disorder
Post-Transplant Lymphoproliferative Disorder
Primitive Neuroectodermal Tumor
Renal Cell Carcinoma
Reninoma
Retinoblastoma
Rhabdomyosarcoma
Sarcoma
Schwannoma
Serous Carcinoma
Sex Cord Stromal Tumor
Small Cell Carcinoma
Solid Pseudopapillary Tumor of Pancreas
Spindle Cell Neoplasm
Squamous Cell Carcinoma
T Cell Lymphoproliferative Disorder
T-Cell LGL Leukemia
Thymic Carcinoma
Thymoma
Urothelial Carcinoma
Tumors of Peripheral Nerves
Unknown
Wilms Tumor
Ependymoma, Anaplastic
Astrocytoma, Pilocytic
Ganglioglioma
Neuroepithelial Neoplasm, NOS
Pleomorphic Carcinoma
Solitary Fibrous Tumor
Neuroepithelial neoplasm, high grade
Astrocytoma, NOS
Astrocytoma, Diffusely Infiltrating
Diffuse Midline Glioma
Infiltrating Glioma, NOS
Intraductal Papillary Mucinous Neoplasm (IPMN)
Lymphadenopathy
Lymphocytosis, Symptomatic
Monoclonal Gammopathy
Mucinous or Serous Cystic Neoplasms of Pancreas
Mycosis Fungoides, Unspecified Site
Oligodendroglioma, Anaplastic
Pleomorphic Xanthoastrocytoma
Rash and Other Nonspecific Skin Eruption
Adrenal Gland
Anus
Ampulla (Pancreaticobiliary Duct)
Appendix
Bladder
Blood
Bone
Bone Marrow
Brain
Breast
Spinal Cord
Cervix
Chest Wall
Endometrium
Esophagus
Eye
Fallopian Tube
Fibroadipose Tissue
Gall Bladder
Kidney
Larynx
Liver
Lung
Lymph Node
Nasal Cavity
Oral Cavity
Ovary
Pancreas
Parathyroid
Penis
Peripheral Nervous System
Peritoneum
Pharynx
Pituitary
Placenta
Pleura
Prostate
Retroperitoneum
Salivary Gland
Seminal Vesicle
Skeletal Muscle
Skin
Small Intestine
Soft Tissue
Spleen
Stomach
Testis
Thymus
Thyroid
Tonsil
Unknown
Ureter
Uterus
Vagina
Rectum
Cartilage
Blood Vessel
Buccal Swab
Heart
Trachea
Salivary Duct
Spermatic Cord
Vulva
Brain, Infratentorial
Brain, Supratentorial
Gastroesophageal Junction
Sellar
Suprasellar
Colon
TP53 any mutation
2Somatic mutations in TP53 are frequent in human cancer. Germline TP53 mutations cause of Li-Fraumeni syndrome, which is associated with a range of early-onset cancers. The types and positions of TP53 mutations are diverse. TP53 mutations may be potential prognostic and predictive markers in some tumor types, as well as targets for pharmacological intervention in some clinical settings. The IARC TP53 Database (http://www-p53.iarc.fr/) is a useful resource which catalogues TP53 mutations found in cancer.
2133
Glioblastoma
Brain
Brain, Infratentorial
Brain, Supratentorial
CDKN2A H83Y
2CDKN2A H83Y lies within the ANK3 domain of the CDKN2A protein. H83Y confers a loss of function to the CDKN2A protein as demonstrated by loss of cell cycle control. The CDKN2A gene locus is altered in up to approximately 57% of glioblastoma, most commonly as a homozygous deletion, and frequently with concurrent deletion of the CDKN2B locus. CDKN2A/CDKN2B loss may be associated with increased sensitivity to CDK4/6 inhibitors. The efficacy and toxicity profiles of these inhibitors in the context of a variety of cancer types are currently under evaluation in clinical trials. CDKN2A mutations account for only 1-3% of glioblastomas and the clinical significance remains to be elucidated.
2146
Astrocytoma, NOS
Astrocytoma, Anaplastic
Glioblastoma
Brain
SMAD4 I525V
3SMAD4 is tumor suppressor gene and it encodes an intracellular mediator in the transforming growth factor b (TGF b) signal transduction pathway. Somatic mutations in SMAD4 are exceedingly rare in glial neoplasms. SMAD4 I525V has been reported as a likely benign germline variant in ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/variation/41788/). These results should be interpreted in the clinical context.
2147
Astrocytoma, NOS
Astrocytoma, Anaplastic
Astrocytoma, Diffusely Infiltrating
Glioblastoma
Infiltrating Glioma, NOS
Brain
Spinal Cord
NRAS codon(s) 12, 13, 61, 146 any
2NRAS gene belongs to the family of RAS genes. It encodes a G protein that is important in the transmission of growth-promoting signals from the cell surface receptors to the nucleus through RAS-RAF-mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)-AKT cell signaling pathways. NRAS mutations are rare in glial neoplasms and are found in about 1% of cases. The clinicopathologic significance of NRAS mutations in glial neoplasms remains to be further elucidated.
2149
Glioblastoma
Astrocytoma, NOS
Astrocytoma, Anaplastic
Brain
CDKN2A W110*
2The CDKN2A gene locus is altered in up to approximately 57% of glioblastoma, most commonly as a homozygous deletion, and frequently with concurrent deletion of the CDKN2B locus. CDKN2A/CDKN2B loss may be associated with increased sensitivity to CDK4/6 inhibitors. W110* results in early truncation and confers a loss of function as demonstrated by loss of CDK binding and cell cycle control in culture. The clinicopathologic effects of the heterozygous rather than homozygous loss of CDKN2A in glial neoplasms remains to be further elucidated. The efficacy and toxicity profiles of these inhibitors in the context of a variety of cancer types are currently under evaluation in clinical trials.
2242
Glioblastoma
Astrocytoma, NOS
Astrocytoma, Pilocytic
Astrocytoma, Diffusely Infiltrating
Brain
MLH1 V384D
3MLH1 is a component of the cellular DNA mismatch repair (MMR) machinery. The MLH1 V384D mutation has been associated with cancer risk in some tumor types. This variant encodes in a partially impaired protein with diminished interaction with PMS2 protein and reduced MMR activity in vitro. The MLH1 V384D variant has not been reported as a somatic mutation in glial brain tumors. This variant has an allele frequency of 4% in the East Asian population. Some studies have shown that patients carrying the MLH V384D variant have an increased risk of the development of microsatellite-instable as well as -stable colorectal cancer. MLH1 V384D variant has also been reported to be associated with primary resistance to EGFR-TKIs in patients with EGFR L858R-positive lung adenocarcinoma. Of note, this variant is reported as a benign germline variant in ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/variation/41632/). Clinical correlation is recommended.
2249
Glioblastoma
Astrocytoma, NOS
Brain
PDGFRA N659K
2PDGFRA amplification is reportedly present in up to 29% of pediatric and 21% of adult high-grade astrocytomas when assessed by flourescent in situ hydridization. Copy number alterations of this gene have been reported in approximately 11% of adult glioblastoma making it the second most commonly altered receptor tyrosine kinase after EGFR. In those adult glioblastomas that are IDH-mutant, there is evidence to suggest that amplification of PDGFRA is associated with worse overall survival. Somatic mutations within the PDGFRA gene are less frequent than amplifications. PGDFRA N659K is within the tyrosine kinase domain and confers a gain of function. Preclinical trials in N659K mutant cell lines have shown sensitivity to multi-targeted tyrosine kinase inhibitors including imatinib and crenolanib.
2258
Glioblastoma
Brain
SMAD4 P472T
3SMAD4 is a tumor suppressor gene and it encodes an intracellular mediator in the transforming growth factor b (TGF b) signal transduction pathway. SMAD4 mutations are very rare in glioblastoma and are present in less than 1% of cases and the significance of these mutations are unclear in this tumor type. The effect on protein function of SMAD4 P472T remains to be further elucidated. These results should be interpreted in the clinicopathologic context.
2259
Glioblastoma
Brain
PTEN P169H
3PTEN is an obligate haplo-insufficient tumor suppressor gene and is mutated in a large number of cancers. It encodes a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/mTOR signaling pathway. Most PTEN mutations are loss-of-function mutations. Mono-allelic or bi-allelic loss of PTEN is found in a considerable fraction of tumors, including gliomas (75%). In glioblastoma, PTEN loss/deletion is associated with poor patient prognosis, and/or shorter disease-free survival. The PTEN P169H mutation, however, is not definitively known to cause a loss-of-function change in the PTEN protein and has been shown to confer a phosphatase activity similar to wild-type PTEN in yeast. This variant has been identified in one case of glioblastoma according to the literature. This result should be interpreted in the clinicopathologic context.
2260
Glioblastoma
Brain
KIT D45N
3KIT, also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a growth factor receptor of the tyrosine kinase subclass III family, normally expressed in a variety of tissue types. Signaling through CD117 plays a role in cell survival, proliferation, and differentiation. KIT is found in approximately 1% of glioblastomas. The KIT D45N variant is in the extracellular domain, however, its effect on protein function is unknown. The clinical significance of KIT in glioblastoma and the clinicopathologic effect of this variant remains to be further elucidated.
2261
Glioblastoma
Brain
CDH1 A403T
3CDH1 on 16q22.1 encodes E-cadherin which functions in intercellular adhesion. E-cadherin is involved in transmitting chemical signals and controlling cell maturation and movement, and acts as a tumor suppressor. CDH1 is rare in this tumor type and is found in approximately 1% of glioblastomas. The CDH1 A403T variant has not been characterized in the literature and therefore has an unknown effect on protein function and is best classified as a variant of uncertain significance (VUS). The clinical significance of CDH1 in glioblastoma is unknown and its clinicopathologic effect remains to be further elucidated.
109
Glioblastoma
Pleomorphic Xanthoastrocytoma
Ganglioglioma
Neuroepithelial Neoplasm, NOS
Neuroepithelial neoplasm, high grade
Astrocytoma, NOS
Astrocytoma, Pilocytic
Spinal Cord
Brain
Brain, Supratentorial
Brain, Infratentorial
BRAF V600E
BRAF codon(s) 600 any
1BRAF alterations have been described in a wide spectrum of brain tumors, including in gliomas and glioneuronal tumors. BRAFV600E mutations have been found in approximately 10--15% of pilocytic astrocytoma and in approximately 5--10% of pediatric diffusely infiltrating gliomas, including diffuse astrocytomas (WHO grade II), anaplastic astrocytomas (WHO grade III) and glioblastomas (WHO grade IV), but in less than 2% of comparable adult gliomas. This mutation is potentially targetable.

Generic Interpretations

IDVariantsTierInterpretation
417
ABI1 copy number gain
ABI1 copy number loss
2This gene is a known cancer gene.
418
ABL1 copy number gain
ABL1 copy number loss
2This gene is a known cancer gene.
419
ABL2 copy number gain
ABL2 copy number loss
2This gene is a known cancer gene.
420
ACKR3 copy number gain
ACKR3 copy number loss
2This gene is a known cancer gene.
421
ACSL3 copy number gain
ACSL3 copy number loss
2This gene is a known cancer gene.
422
ACSL6 copy number gain
ACSL6 copy number loss
2This gene is a known cancer gene.
423
ACVR1 copy number gain
ACVR1 copy number loss
2This gene is a known cancer gene.
424
AFF1 copy number gain
AFF1 copy number loss
2This gene is a known cancer gene.
425
AFF3 copy number gain
AFF3 copy number loss
2This gene is a known cancer gene.
426
AFF4 copy number gain
AFF4 copy number loss
2This gene is a known cancer gene.
427
AKAP9 copy number gain
AKAP9 copy number loss
2This gene is a known cancer gene.
428
AKT1 copy number gain
AKT1 copy number loss
2This gene is a known cancer gene.
429
AKT2 copy number gain
AKT2 copy number loss
2This gene is a known cancer gene.
430
ALDH2 copy number gain
ALDH2 copy number loss
2This gene is a known cancer gene.
431
ALK copy number gain
ALK copy number loss
2This gene is a known cancer gene.
432
AMER1 copy number gain
AMER1 copy number loss
2This gene is a known cancer gene.
433
APC copy number gain
APC copy number loss
2This gene is a known cancer gene.
434
AR copy number gain
AR copy number loss
2This gene is a known cancer gene.
435
ARHGAP26 copy number gain
ARHGAP26 copy number loss
2This gene is a known cancer gene.
436
ARHGEF12 copy number gain
ARHGEF12 copy number loss
2This gene is a known cancer gene.
437
ARID1A copy number gain
ARID1A copy number loss
2This gene is a known cancer gene.
438
ARID1B copy number gain
ARID1B copy number loss
2This gene is a known cancer gene.
439
ARID2 copy number gain
ARID2 copy number loss
2This gene is a known cancer gene.
440
ARNT copy number gain
ARNT copy number loss
2This gene is a known cancer gene.
441
ASPSCR1 copy number gain
ASPSCR1 copy number loss
2This gene is a known cancer gene.
442
ASXL1 copy number gain
ASXL1 copy number loss
2This gene is a known cancer gene.
443
ATF1 copy number gain
ATF1 copy number loss
2This gene is a known cancer gene.
444
ATIC copy number gain
ATIC copy number loss
2This gene is a known cancer gene.
445
ATM copy number gain
ATM copy number loss
2This gene is a known cancer gene.
446
ATP1A1 copy number gain
ATP1A1 copy number loss
2This gene is a known cancer gene.
447
ATP2B3 copy number gain
ATP2B3 copy number loss
2This gene is a known cancer gene.
448
ATR copy number gain
ATR copy number loss
2This gene is a known cancer gene.
449
ATRX copy number gain
ATRX copy number loss
2This gene is a known cancer gene.
450
AXIN1 copy number gain
AXIN1 copy number loss
2This gene is a known cancer gene.
451
AXIN2 copy number gain
AXIN2 copy number loss
2This gene is a known cancer gene.
452
BAP1 copy number gain
BAP1 copy number loss
2This gene is a known cancer gene.
453
BCL10 copy number gain
BCL10 copy number loss
2This gene is a known cancer gene.
454
BCL11A copy number gain
BCL11A copy number loss
2This gene is a known cancer gene.
455
BCL11B copy number gain
BCL11B copy number loss
2This gene is a known cancer gene.
456
BCL2 copy number gain
BCL2 copy number loss
2This gene is a known cancer gene.
457
BCL3 copy number gain
BCL3 copy number loss
2This gene is a known cancer gene.
458
BCL6 copy number gain
BCL6 copy number loss
2This gene is a known cancer gene.
459
BCL7A copy number gain
BCL7A copy number loss
2This gene is a known cancer gene.
460
BCL9 copy number gain
BCL9 copy number loss
2This gene is a known cancer gene.
461
BCOR copy number gain
BCOR copy number loss
2This gene is a known cancer gene.
462
BCR copy number gain
BCR copy number loss
2This gene is a known cancer gene.
463
BIRC3 copy number gain
BIRC3 copy number loss
2This gene is a known cancer gene.
464
BLM copy number gain
BLM copy number loss
2This gene is a known cancer gene.
465
BMPR1A copy number gain
BMPR1A copy number loss
2This gene is a known cancer gene.
466
BRAF copy number gain
BRAF copy number loss
2This gene is a known cancer gene.
467
BRCA1 copy number gain
BRCA1 copy number loss
2This gene is a known cancer gene.
468
BRCA2 copy number gain
BRCA2 copy number loss
2This gene is a known cancer gene.
469
BRD3 copy number gain
BRD3 copy number loss
2This gene is a known cancer gene.
470
BRD4 copy number gain
BRD4 copy number loss
2This gene is a known cancer gene.
471
BRIP1 copy number gain
BRIP1 copy number loss
2This gene is a known cancer gene.
472
BTG1 copy number gain
BTG1 copy number loss
2This gene is a known cancer gene.
473
BUB1B copy number gain
BUB1B copy number loss
2This gene is a known cancer gene.
474
C15ORF65 copy number gain
C15ORF65 copy number loss
2This gene is a known cancer gene.
475
C2ORF44 copy number gain
C2ORF44 copy number loss
2This gene is a known cancer gene.
476
CACNA1D copy number gain
CACNA1D copy number loss
2This gene is a known cancer gene.
477
CALR copy number gain
CALR copy number loss
2This gene is a known cancer gene.
478
CAMTA1 copy number gain
CAMTA1 copy number loss
2This gene is a known cancer gene.
479
CANT1 copy number gain
CANT1 copy number loss
2This gene is a known cancer gene.
480
CARD11 copy number gain
CARD11 copy number loss
2This gene is a known cancer gene.
481
CARS copy number gain
CARS copy number loss
2This gene is a known cancer gene.
482
CASC5 copy number gain
CASC5 copy number loss
2This gene is a known cancer gene.
483
CASP8 copy number gain
CASP8 copy number loss
2This gene is a known cancer gene.
484
CBFA2T3 copy number gain
CBFA2T3 copy number loss
2This gene is a known cancer gene.
485
CBFB copy number gain
CBFB copy number loss
2This gene is a known cancer gene.
486
CBL copy number gain
CBL copy number loss
2This gene is a known cancer gene.
487
CBLB copy number gain
CBLB copy number loss
2This gene is a known cancer gene.
488
CBLC copy number gain
CBLC copy number loss
2This gene is a known cancer gene.
489
CCDC6 copy number gain
CCDC6 copy number loss
2This gene is a known cancer gene.
490
CCNB1IP1 copy number gain
CCNB1IP1 copy number loss
2This gene is a known cancer gene.
491
CCND1 copy number gain
CCND1 copy number loss
2This gene is a known cancer gene.
492
CCND2 copy number gain
CCND2 copy number loss
2This gene is a known cancer gene.
493
CCND3 copy number gain
CCND3 copy number loss
2This gene is a known cancer gene.
494
CCNE1 copy number gain
CCNE1 copy number loss
2This gene is a known cancer gene.
495
CD274 copy number gain
CD274 copy number loss
2This gene is a known cancer gene.
496
CD74 copy number gain
CD74 copy number loss
2This gene is a known cancer gene.
497
CD79A copy number gain
CD79A copy number loss
2This gene is a known cancer gene.
498
CD79B copy number gain
CD79B copy number loss
2This gene is a known cancer gene.
499
CDC73 copy number gain
CDC73 copy number loss
2This gene is a known cancer gene.
500
CDH1 copy number gain
CDH1 copy number loss
2This gene is a known cancer gene.
501
CDH11 copy number gain
CDH11 copy number loss
2This gene is a known cancer gene.
502
CDK12 copy number gain
CDK12 copy number loss
2This gene is a known cancer gene.
503
CDK4 copy number gain
CDK4 copy number loss
2This gene is a known cancer gene.
504
CDK6 copy number gain
CDK6 copy number loss
2This gene is a known cancer gene.
505
CDKN1B copy number gain
CDKN1B copy number loss
2This gene is a known cancer gene.
507
CDKN2B copy number gain
CDKN2B copy number loss
2This gene is a known cancer gene.
508
CDKN2C copy number gain
CDKN2C copy number loss
2This gene is a known cancer gene.
509
CDX2 copy number gain
CDX2 copy number loss
2This gene is a known cancer gene.
510
CEBPA copy number gain
CEBPA copy number loss
2This gene is a known cancer gene.
511
CEP89 copy number gain
CEP89 copy number loss
2This gene is a known cancer gene.
512
CHCHD7 copy number gain
CHCHD7 copy number loss
2This gene is a known cancer gene.
513
CHEK2 copy number gain
CHEK2 copy number loss
2This gene is a known cancer gene.
514
CHIC2 copy number gain
CHIC2 copy number loss
2This gene is a known cancer gene.
515
CHN1 copy number gain
CHN1 copy number loss
2This gene is a known cancer gene.
516
CIC copy number gain
CIC copy number loss
2This gene is a known cancer gene.
517
CIITA copy number gain
CIITA copy number loss
2This gene is a known cancer gene.
518
CLIP1 copy number gain
CLIP1 copy number loss
2This gene is a known cancer gene.
519
CLP1 copy number gain
CLP1 copy number loss
2This gene is a known cancer gene.
520
CLTC copy number gain
CLTC copy number loss
2This gene is a known cancer gene.
521
CLTCL1 copy number gain
CLTCL1 copy number loss
2This gene is a known cancer gene.
522
CNBP copy number gain
CNBP copy number loss
2This gene is a known cancer gene.
523
CNOT3 copy number gain
CNOT3 copy number loss
2This gene is a known cancer gene.
524
CNTRL copy number gain
CNTRL copy number loss
2This gene is a known cancer gene.
525
COL1A1 copy number gain
COL1A1 copy number loss
2This gene is a known cancer gene.
526
COL2A1 copy number gain
COL2A1 copy number loss
2This gene is a known cancer gene.
527
COX6C copy number gain
COX6C copy number loss
2This gene is a known cancer gene.
528
CREB1 copy number gain
CREB1 copy number loss
2This gene is a known cancer gene.
529
CREB3L1 copy number gain
CREB3L1 copy number loss
2This gene is a known cancer gene.
530
CREB3L2 copy number gain
CREB3L2 copy number loss
2This gene is a known cancer gene.
531
CREBBP copy number gain
CREBBP copy number loss
2This gene is a known cancer gene.
532
CRLF2 copy number gain
CRLF2 copy number loss
2This gene is a known cancer gene.
533
CRTC1 copy number gain
CRTC1 copy number loss
2This gene is a known cancer gene.
534
CRTC3 copy number gain
CRTC3 copy number loss
2This gene is a known cancer gene.
535
CSF1R copy number gain
CSF1R copy number loss
2This gene is a known cancer gene.
536
CSF3R copy number gain
CSF3R copy number loss
2This gene is a known cancer gene.
537
CTNNB1 copy number gain
CTNNB1 copy number loss
2This gene is a known cancer gene.
538
CUX1 copy number gain
CUX1 copy number loss
2This gene is a known cancer gene.
539
CYLD copy number gain
CYLD copy number loss
2This gene is a known cancer gene.
540
DAXX copy number gain
DAXX copy number loss
2This gene is a known cancer gene.
541
DCTN1 copy number gain
DCTN1 copy number loss
2This gene is a known cancer gene.
542
DDB2 copy number gain
DDB2 copy number loss
2This gene is a known cancer gene.
543
DDIT3 copy number gain
DDIT3 copy number loss
2This gene is a known cancer gene.
544
DDX10 copy number gain
DDX10 copy number loss
2This gene is a known cancer gene.
545
DDX5 copy number gain
DDX5 copy number loss
2This gene is a known cancer gene.
546
DDX6 copy number gain
DDX6 copy number loss
2This gene is a known cancer gene.
547
DEK copy number gain
DEK copy number loss
2This gene is a known cancer gene.
548
DICER1 copy number gain
DICER1 copy number loss
2This gene is a known cancer gene.
549
DNM2 copy number gain
DNM2 copy number loss
2This gene is a known cancer gene.
550
DNMT3A copy number gain
DNMT3A copy number loss
2This gene is a known cancer gene.
551
DUX4 copy number gain
DUX4 copy number loss
2This gene is a known cancer gene.
552
EBF1 copy number gain
EBF1 copy number loss
2This gene is a known cancer gene.
553
ECT2L copy number gain
ECT2L copy number loss
2This gene is a known cancer gene.
554
EGFR copy number gain
EGFR copy number loss
2This gene is a known cancer gene.
555
EIF3E copy number gain
EIF3E copy number loss
2This gene is a known cancer gene.
556
EIF4A2 copy number gain
EIF4A2 copy number loss
2This gene is a known cancer gene.
557
ELF4 copy number gain
ELF4 copy number loss
2This gene is a known cancer gene.
558
ELK4 copy number gain
ELK4 copy number loss
2This gene is a known cancer gene.
559
ELL copy number gain
ELL copy number loss
2This gene is a known cancer gene.
560
ELN copy number gain
ELN copy number loss
2This gene is a known cancer gene.
561
EML4 copy number gain
EML4 copy number loss
2This gene is a known cancer gene.
562
EPHA3 copy number gain
EPHA3 copy number loss
2This gene is a known cancer gene.
563
EP300 copy number gain
EP300 copy number loss
2This gene is a known cancer gene.
564
EPS15 copy number gain
EPS15 copy number loss
2This gene is a known cancer gene.
565
ERBB2 copy number gain
ERBB2 copy number loss
2This gene is a known cancer gene.
566
ERBB3 copy number gain
ERBB3 copy number loss
2This gene is a known cancer gene.
567
ERC1 copy number gain
ERC1 copy number loss
2This gene is a known cancer gene.
568
ERCC2 copy number gain
ERCC2 copy number loss
2This gene is a known cancer gene.
569
ERCC3 copy number gain
ERCC3 copy number loss
2This gene is a known cancer gene.
570
ERCC4 copy number gain
ERCC4 copy number loss
2This gene is a known cancer gene.
571
ERCC5 copy number gain
ERCC5 copy number loss
2This gene is a known cancer gene.
572
ERG copy number gain
ERG copy number loss
2This gene is a known cancer gene.
573
ESR1 copy number gain
ESR1 copy number loss
2This gene is a known cancer gene.
574
ETNK1 copy number gain
ETNK1 copy number loss
2This gene is a known cancer gene.
575
ETV1 copy number gain
ETV1 copy number loss
2This gene is a known cancer gene.
576
ETV4 copy number gain
ETV4 copy number loss
2This gene is a known cancer gene.
577
ETV5 copy number gain
ETV5 copy number loss
2This gene is a known cancer gene.
578
ETV6 copy number gain
ETV6 copy number loss
2This gene is a known cancer gene.
579
EWSR1 copy number gain
EWSR1 copy number loss
2This gene is a known cancer gene.
580
EXT1 copy number gain
EXT1 copy number loss
2This gene is a known cancer gene.
581
EXT2 copy number gain
EXT2 copy number loss
2This gene is a known cancer gene.
582
EZH2 copy number gain
EZH2 copy number loss
2This gene is a known cancer gene.
583
EZR copy number gain
EZR copy number loss
2This gene is a known cancer gene.
584
FAM131B copy number gain
FAM131B copy number loss
2This gene is a known cancer gene.
585
FAM46C copy number gain
FAM46C copy number loss
2This gene is a known cancer gene.
586
FANCA copy number gain
FANCA copy number loss
2This gene is a known cancer gene.
587
FANCC copy number gain
FANCC copy number loss
2This gene is a known cancer gene.
588
FANCD2 copy number gain
FANCD2 copy number loss
2This gene is a known cancer gene.
589
FANCE copy number gain
FANCE copy number loss
2This gene is a known cancer gene.
590
FANCF copy number gain
FANCF copy number loss
2This gene is a known cancer gene.
591
FANCG copy number gain
FANCG copy number loss
2This gene is a known cancer gene.
592
FAS copy number gain
FAS copy number loss
2This gene is a known cancer gene.
593
FBXO11 copy number gain
FBXO11 copy number loss
2This gene is a known cancer gene.
594
FBXW7 copy number gain
FBXW7 copy number loss
2This gene is a known cancer gene.
595
FCGR2B copy number gain
FCGR2B copy number loss
2This gene is a known cancer gene.
596
FCRL4 copy number gain
FCRL4 copy number loss
2This gene is a known cancer gene.
597
FEV copy number gain
FEV copy number loss
2This gene is a known cancer gene.
598
FGFR1 copy number gain
FGFR1 copy number loss
2This gene is a known cancer gene.
599
FGFR1OP copy number gain
FGFR1OP copy number loss
2This gene is a known cancer gene.
600
FGFR2 copy number gain
FGFR2 copy number loss
2This gene is a known cancer gene.
601
FGFR3 copy number gain
FGFR3 copy number loss
2This gene is a known cancer gene.
602
FGFR4 copy number gain
FGFR4 copy number loss
2This gene is a known cancer gene.
603
FH copy number gain
FH copy number loss
2This gene is a known cancer gene.
604
FHIT copy number gain
FHIT copy number loss
2This gene is a known cancer gene.
605
FIP1L1 copy number gain
FIP1L1 copy number loss
2This gene is a known cancer gene.
606
FLCN copy number gain
FLCN copy number loss
2This gene is a known cancer gene.
607
FLI1 copy number gain
FLI1 copy number loss
2This gene is a known cancer gene.
608
FLT3 copy number gain
FLT3 copy number loss
2This gene is a known cancer gene.
609
FLT4 copy number gain
FLT4 copy number loss
2This gene is a known cancer gene.
610
FNBP1 copy number gain
FNBP1 copy number loss
2This gene is a known cancer gene.
611
FOXA1 copy number gain
FOXA1 copy number loss
2This gene is a known cancer gene.
612
FOXL2 copy number gain
FOXL2 copy number loss
2This gene is a known cancer gene.
613
FOXO1 copy number gain
FOXO1 copy number loss
2This gene is a known cancer gene.
614
FOXO3 copy number gain
FOXO3 copy number loss
2This gene is a known cancer gene.
615
FOXO4 copy number gain
FOXO4 copy number loss
2This gene is a known cancer gene.
616
FOXO4 copy number gain
FOXO4 copy number loss
2This gene is a known cancer gene.
617
FOXP1 copy number gain
FOXP1 copy number loss
2This gene is a known cancer gene.
618
FSTL3 copy number gain
FSTL3 copy number loss
2This gene is a known cancer gene.
619
FUBP1 copy number gain
FUBP1 copy number loss
2This gene is a known cancer gene.
620
FUS copy number gain
FUS copy number loss
2This gene is a known cancer gene.
621
GAS7 copy number gain
GAS7 copy number loss
2This gene is a known cancer gene.
622
GATA1 copy number gain
GATA1 copy number loss
2This gene is a known cancer gene.
623
GATA2 copy number gain
GATA2 copy number loss
2This gene is a known cancer gene.
624
GATA3 copy number gain
GATA3 copy number loss
2This gene is a known cancer gene.
625
GMPS copy number gain
GMPS copy number loss
2This gene is a known cancer gene.
626
GNA11 copy number gain
GNA11 copy number loss
2This gene is a known cancer gene.
627
GNAQ copy number gain
GNAQ copy number loss
2This gene is a known cancer gene.
628
GNAS copy number gain
GNAS copy number loss
2This gene is a known cancer gene.
629
GOLGA5 copy number gain
GOLGA5 copy number loss
2This gene is a known cancer gene.
630
GOPC copy number gain
GOPC copy number loss
2This gene is a known cancer gene.
631
GPC3 copy number gain
GPC3 copy number loss
2This gene is a known cancer gene.
632
GPHN copy number gain
GPHN copy number loss
2This gene is a known cancer gene.
633
GRIN2A copy number gain
GRIN2A copy number loss
2This gene is a known cancer gene.
634
H3F3A copy number gain
H3F3A copy number loss
2This gene is a known cancer gene.
635
H3F3B copy number gain
H3F3B copy number loss
2This gene is a known cancer gene.
636
HERPUD1 copy number gain
HERPUD1 copy number loss
2This gene is a known cancer gene.
637
HEY1 copy number gain
HEY1 copy number loss
2This gene is a known cancer gene.
638
HIP1 copy number gain
HIP1 copy number loss
2This gene is a known cancer gene.
639
HIST1H3B copy number gain
HIST1H3B copy number loss
2This gene is a known cancer gene.
640
HIST1H4I copy number gain
HIST1H4I copy number loss
2This gene is a known cancer gene.
641
HLA-A copy number gain
HLA-A copy number loss
2This gene is a known cancer gene.
642
HLF copy number gain
HLF copy number loss
2This gene is a known cancer gene.
643
HMGA1 copy number gain
HMGA1 copy number loss
2This gene is a known cancer gene.
644
HMGA2 copy number gain
HMGA2 copy number loss
2This gene is a known cancer gene.
645
HNF1A copy number gain
HNF1A copy number loss
2This gene is a known cancer gene.
646
HNRNPA2B1 copy number gain
HNRNPA2B1 copy number loss
2This gene is a known cancer gene.
647
HOOK3 copy number gain
HOOK3 copy number loss
2This gene is a known cancer gene.
648
HOXA11 copy number gain
HOXA11 copy number loss
2This gene is a known cancer gene.
649
HOXA13 copy number gain
HOXA13 copy number loss
2This gene is a known cancer gene.
650
HOXA9 copy number gain
HOXA9 copy number loss
2This gene is a known cancer gene.
651
HOXC11 copy number gain
HOXC11 copy number loss
2This gene is a known cancer gene.
652
HOXC13 copy number gain
HOXC13 copy number loss
2This gene is a known cancer gene.
653
HOXD11 copy number gain
HOXD11 copy number loss
2This gene is a known cancer gene.
654
HOXD13 copy number gain
HOXD13 copy number loss
2This gene is a known cancer gene.
655
HRAS copy number gain
HRAS copy number loss
2This gene is a known cancer gene.
656
HSP90AA1 copy number gain
HSP90AA1 copy number loss
2This gene is a known cancer gene.
657
HSP90AB1 copy number gain
HSP90AB1 copy number loss
2This gene is a known cancer gene.
658
IDH1 copy number gain
IDH1 copy number loss
2This gene is a known cancer gene.
659
IDH2 copy number gain
IDH2 copy number loss
2This gene is a known cancer gene.
660
IKBKB copy number gain
IKBKB copy number loss
2This gene is a known cancer gene.
661
IKZF1 copy number gain
IKZF1 copy number loss
2This gene is a known cancer gene.
662
IL2 copy number gain
IL2 copy number loss
2This gene is a known cancer gene.
663
IL21R copy number gain
IL21R copy number loss
2This gene is a known cancer gene.
664
IL6ST copy number gain
IL6ST copy number loss
2This gene is a known cancer gene.
665
IL7R copy number gain
IL7R copy number loss
2This gene is a known cancer gene.
666
IRF4 copy number gain
IRF4 copy number loss
2This gene is a known cancer gene.
667
ITK copy number gain
ITK copy number loss
2This gene is a known cancer gene.
668
JAK1 copy number gain
JAK1 copy number loss
2This gene is a known cancer gene.
669
JAK2 copy number gain
JAK2 copy number loss
2This gene is a known cancer gene.
670
JAK3 copy number gain
JAK3 copy number loss
2This gene is a known cancer gene.
671
JAZF1 copy number gain
JAZF1 copy number loss
2This gene is a known cancer gene.
672
JUN copy number gain
JUN copy number loss
2This gene is a known cancer gene.
673
KAT6A copy number gain
KAT6A copy number loss
2This gene is a known cancer gene.
674
KAT6B copy number gain
KAT6B copy number loss
2This gene is a known cancer gene.
675
KCNJ5 copy number gain
KCNJ5 copy number loss
2This gene is a known cancer gene.
676
KDM5A copy number gain
KDM5A copy number loss
2This gene is a known cancer gene.
677
KDM5C copy number gain
KDM5C copy number loss
2This gene is a known cancer gene.
678
KDM6A copy number gain
KDM6A copy number loss
2This gene is a known cancer gene.
679
KDR copy number gain
KDR copy number loss
2This gene is a known cancer gene.
680
KDSR copy number gain
KDSR copy number loss
2This gene is a known cancer gene.
681
KIAA1549 copy number gain
KIAA1549 copy number loss
2This gene is a known cancer gene.
682
KIAA1598 copy number gain
KIAA1598 copy number loss
2This gene is a known cancer gene.
683
KIF5B copy number gain
KIF5B copy number loss
2This gene is a known cancer gene.
684
KIT copy number gain
KIT copy number loss
2This gene is a known cancer gene.
685
KLF4 copy number gain
KLF4 copy number loss
2This gene is a known cancer gene.
686
KLF6 copy number gain
KLF6 copy number loss
2This gene is a known cancer gene.
687
KLK2 copy number gain
KLK2 copy number loss
2This gene is a known cancer gene.
688
KMT2A copy number gain
KMT2A copy number loss
2This gene is a known cancer gene.
689
KMT2C copy number gain
KMT2C copy number loss
2This gene is a known cancer gene.
690
KMT2D copy number gain
KMT2D copy number loss
2This gene is a known cancer gene.
691
KRAS copy number gain
KRAS copy number loss
2This gene is a known cancer gene.
692
KTN1 copy number gain
KTN1 copy number loss
2This gene is a known cancer gene.
693
LASP1 copy number gain
LASP1 copy number loss
2This gene is a known cancer gene.
694
LCK copy number gain
LCK copy number loss
2This gene is a known cancer gene.
695
LCP1 copy number gain
LCP1 copy number loss
2This gene is a known cancer gene.
696
LHFP copy number gain
LHFP copy number loss
2This gene is a known cancer gene.
697
LIFR copy number gain
LIFR copy number loss
2This gene is a known cancer gene.
698
LMNA copy number gain
LMNA copy number loss
2This gene is a known cancer gene.
699
LMO1 copy number gain
LMO1 copy number loss
2This gene is a known cancer gene.
700
LMO2 copy number gain
LMO2 copy number loss
2This gene is a known cancer gene.
701
LPP copy number gain
LPP copy number loss
2This gene is a known cancer gene.
702
LRIG3 copy number gain
LRIG3 copy number loss
2This gene is a known cancer gene.
703
LSM14A copy number gain
LSM14A copy number loss
2This gene is a known cancer gene.
704
LYL1 copy number gain
LYL1 copy number loss
2This gene is a known cancer gene.
705
LZTR1 copy number gain
LZTR1 copy number loss
2This gene is a known cancer gene.
706
MAF copy number gain
MAF copy number loss
2This gene is a known cancer gene.
707
MAFB copy number gain
MAFB copy number loss
2This gene is a known cancer gene.
708
MALT1 copy number gain
MALT1 copy number loss
2This gene is a known cancer gene.
709
MAML2 copy number gain
MAML2 copy number loss
2This gene is a known cancer gene.
710
MAP2K1 copy number gain
MAP2K1 copy number loss
2This gene is a known cancer gene.
711
MAP2K2 copy number gain
MAP2K2 copy number loss
2This gene is a known cancer gene.
712
MAP2K4 copy number gain
MAP2K4 copy number loss
2This gene is a known cancer gene.
713
MAP3K1 copy number gain
MAP3K1 copy number loss
2This gene is a known cancer gene.
714
MAP3K13 copy number gain
MAP3K13 copy number loss
2This gene is a known cancer gene.
715
MAX copy number gain
MAX copy number loss
2This gene is a known cancer gene.
716
MDM2 copy number gain
MDM2 copy number loss
2This gene is a known cancer gene.
717
MDM4 copy number gain
MDM4 copy number loss
2This gene is a known cancer gene.
718
MDS2 copy number gain
MDS2 copy number loss
2This gene is a known cancer gene.
719
MECOM copy number gain
MECOM copy number loss
2This gene is a known cancer gene.
720
MED12 copy number gain
MED12 copy number loss
2This gene is a known cancer gene.
721
MEN1 copy number gain
MEN1 copy number loss
2This gene is a known cancer gene.
722
MET copy number gain
MET copy number loss
2This gene is a known cancer gene.
723
MITF copy number gain
MITF copy number loss
2This gene is a known cancer gene.
724
MKL1 copy number gain
MKL1 copy number loss
2This gene is a known cancer gene.
725
MLF1 copy number gain
MLF1 copy number loss
2This gene is a known cancer gene.
726
MLH1 copy number gain
MLH1 copy number loss
2This gene is a known cancer gene.
727
MLLT1 copy number gain
MLLT1 copy number loss
2This gene is a known cancer gene.
728
MLLT10 copy number gain
MLLT10 copy number loss
2This gene is a known cancer gene.
729
MLLT11 copy number gain
MLLT11 copy number loss
2This gene is a known cancer gene.
730
MLLT3 copy number gain
MLLT3 copy number loss
2This gene is a known cancer gene.
731
MLLT4 copy number gain
MLLT4 copy number loss
2This gene is a known cancer gene.
732
MLLT6 copy number gain
MLLT6 copy number loss
2This gene is a known cancer gene.
733
MN1 copy number gain
MN1 copy number loss
2This gene is a known cancer gene.
734
MNX1 copy number gain
MNX1 copy number loss
2This gene is a known cancer gene.
735
MPL copy number gain
MPL copy number loss
2This gene is a known cancer gene.
736
MSH2 copy number gain
MSH2 copy number loss
2This gene is a known cancer gene.
737
MSH6 copy number gain
MSH6 copy number loss
2This gene is a known cancer gene.
738
MSI2 copy number gain
MSI2 copy number loss
2This gene is a known cancer gene.
739
MSN copy number gain
MSN copy number loss
2This gene is a known cancer gene.
740
MTCP1 copy number gain
MTCP1 copy number loss
2This gene is a known cancer gene.
741
MUC1 copy number gain
MUC1 copy number loss
2This gene is a known cancer gene.
742
MUTYH copy number gain
MUTYH copy number loss
2This gene is a known cancer gene.
743
MYB copy number gain
MYB copy number loss
2This gene is a known cancer gene.
744
MYC copy number gain
MYC copy number loss
2This gene is a known cancer gene.
745
MYCL copy number gain
MYCL copy number loss
2This gene is a known cancer gene.
746
MYCN copy number gain
MYCN copy number loss
2This gene is a known cancer gene.
747
MYD88 copy number gain
MYD88 copy number loss
2This gene is a known cancer gene.
748
MYH11 copy number gain
MYH11 copy number loss
2This gene is a known cancer gene.
749
MYH9 copy number gain
MYH9 copy number loss
2This gene is a known cancer gene.
750
MYO5A copy number gain
MYO5A copy number loss
2This gene is a known cancer gene.
751
MYOD1 copy number gain
MYOD1 copy number loss
2This gene is a known cancer gene.
752
NAB2 copy number gain
NAB2 copy number loss
2This gene is a known cancer gene.
753
NACA copy number gain
NACA copy number loss
2This gene is a known cancer gene.
754
NBN copy number gain
NBN copy number loss
2This gene is a known cancer gene.
755
NCKIPSD copy number gain
NCKIPSD copy number loss
2This gene is a known cancer gene.
756
NCOA1 copy number gain
NCOA1 copy number loss
2This gene is a known cancer gene.
757
NCOA2 copy number gain
NCOA2 copy number loss
2This gene is a known cancer gene.
758
NCOA4 copy number gain
NCOA4 copy number loss
2This gene is a known cancer gene.
759
NCOR1 copy number gain
NCOR1 copy number loss
2This gene is a known cancer gene.
760
NDRG1 copy number gain
NDRG1 copy number loss
2This gene is a known cancer gene.
761
NF1 copy number gain
NF1 copy number loss
2This gene is a known cancer gene.
762
NF2 copy number gain
NF2 copy number loss
2This gene is a known cancer gene.
763
NFATC2 copy number gain
NFATC2 copy number loss
2This gene is a known cancer gene.
764
NFE2L2 copy number gain
NFE2L2 copy number loss
2This gene is a known cancer gene.
765
NFIB copy number gain
NFIB copy number loss
2This gene is a known cancer gene.
766
NFKB2 copy number gain
NFKB2 copy number loss
2This gene is a known cancer gene.
767
NFKBIE copy number gain
NFKBIE copy number loss
2This gene is a known cancer gene.
768
NIN copy number gain
NIN copy number loss
2This gene is a known cancer gene.
769
NKX2-1 copy number gain
NKX2-1 copy number loss
2This gene is a known cancer gene.
770
NONO copy number gain
NONO copy number loss
2This gene is a known cancer gene.
771
NOTCH1 copy number gain
NOTCH1 copy number loss
2This gene is a known cancer gene.
772
NOTCH2 copy number gain
NOTCH2 copy number loss
2This gene is a known cancer gene.
773
NOTCH3 copy number gain
NOTCH3 copy number loss
2This gene is a known cancer gene.
774
NPM1 copy number gain
NPM1 copy number loss
2This gene is a known cancer gene.
775
NR4A3 copy number gain
NR4A3 copy number loss
2This gene is a known cancer gene.
776
NRAS copy number gain
NRAS copy number loss
2This gene is a known cancer gene.
777
NRG1 copy number gain
NRG1 copy number loss
2This gene is a known cancer gene.
778
NSD1 copy number gain
NSD1 copy number loss
2This gene is a known cancer gene.
779
NT5C2 copy number gain
NT5C2 copy number loss
2This gene is a known cancer gene.
780
NTRK1 copy number gain
NTRK1 copy number loss
2This gene is a known cancer gene.
781
NTRK3 copy number gain
NTRK3 copy number loss
2This gene is a known cancer gene.
782
NUMA1 copy number gain
NUMA1 copy number loss
2This gene is a known cancer gene.
783
NUP214 copy number gain
NUP214 copy number loss
2This gene is a known cancer gene.
784
NUP98 copy number gain
NUP98 copy number loss
2This gene is a known cancer gene.
785
NUTM1 copy number gain
NUTM1 copy number loss
2This gene is a known cancer gene.
786
NUTM2A copy number gain
NUTM2A copy number loss
2This gene is a known cancer gene.
787
NUTM2B copy number gain
NUTM2B copy number loss
2This gene is a known cancer gene.
788
OLIG2 copy number gain
OLIG2 copy number loss
2This gene is a known cancer gene.
789
OMD copy number gain
OMD copy number loss
2This gene is a known cancer gene.
790
P2RY8 copy number gain
P2RY8 copy number loss
2This gene is a known cancer gene.
791
PAFAH1B2 copy number gain
PAFAH1B2 copy number loss
2This gene is a known cancer gene.
792
PALB2 copy number gain
PALB2 copy number loss
2This gene is a known cancer gene.
793
PAX3 copy number gain
PAX3 copy number loss
2This gene is a known cancer gene.
794
PAX5 copy number gain
PAX5 copy number loss
2This gene is a known cancer gene.
795
PAX7 copy number gain
PAX7 copy number loss
2This gene is a known cancer gene.
796
PAX8 copy number gain
PAX8 copy number loss
2This gene is a known cancer gene.
797
PBRM1 copy number gain
PBRM1 copy number loss
2This gene is a known cancer gene.
798
PBX1 copy number gain
PBX1 copy number loss
2This gene is a known cancer gene.
799
PCM1 copy number gain
PCM1 copy number loss
2This gene is a known cancer gene.
800
PCSK7 copy number gain
PCSK7 copy number loss
2This gene is a known cancer gene.
801
PDCD1LG2 copy number gain
PDCD1LG2 copy number loss
2This gene is a known cancer gene.
802
PDE4DIP copy number gain
PDE4DIP copy number loss
2This gene is a known cancer gene.
803
PDGFB copy number gain
PDGFB copy number loss
2This gene is a known cancer gene.
804
PDGFRA copy number gain
PDGFRA copy number loss
2This gene is a known cancer gene.
805
PDGFRB copy number gain
PDGFRB copy number loss
2This gene is a known cancer gene.
806
PER1 copy number gain
PER1 copy number loss
2This gene is a known cancer gene.
807
PHF6 copy number gain
PHF6 copy number loss
2This gene is a known cancer gene.
808
PHOX2B copy number gain
PHOX2B copy number loss
2This gene is a known cancer gene.
809
PICALM copy number gain
PICALM copy number loss
2This gene is a known cancer gene.
810
PIK3CA copy number gain
PIK3CA copy number loss
2This gene is a known cancer gene.
811
PIK3R1 copy number gain
PIK3R1 copy number loss
2This gene is a known cancer gene.
812
PIM1 copy number gain
PIM1 copy number loss
2This gene is a known cancer gene.
813
PLAG1 copy number gain
PLAG1 copy number loss
2This gene is a known cancer gene.
814
PLCG1 copy number gain
PLCG1 copy number loss
2This gene is a known cancer gene.
815
PML copy number gain
PML copy number loss
2This gene is a known cancer gene.
816
PMS1 copy number gain
PMS1 copy number loss
2This gene is a known cancer gene.
817
PMS2 copy number gain
PMS2 copy number loss
2This gene is a known cancer gene.
818
POLE copy number gain
POLE copy number loss
2This gene is a known cancer gene.
819
POT1 copy number gain
POT1 copy number loss
2This gene is a known cancer gene.
820
POU2AF1 copy number gain
POU2AF1 copy number loss
2This gene is a known cancer gene.
821
POU5F1 copy number gain
POU5F1 copy number loss
2This gene is a known cancer gene.
822
PPARG copy number gain
PPARG copy number loss
2This gene is a known cancer gene.
823
PPFIBP1 copy number gain
PPFIBP1 copy number loss
2This gene is a known cancer gene.
824
PPP2R1A copy number gain
PPP2R1A copy number loss
2This gene is a known cancer gene.
825
PPP6C copy number gain
PPP6C copy number loss
2This gene is a known cancer gene.
826
PRCC copy number gain
PRCC copy number loss
2This gene is a known cancer gene.
827
PRDM1 copy number gain
PRDM1 copy number loss
2This gene is a known cancer gene.
828
PRDM16 copy number gain
PRDM16 copy number loss
2This gene is a known cancer gene.
829
PRF1 copy number gain
PRF1 copy number loss
2This gene is a known cancer gene.
830
PRKAR1A copy number gain
PRKAR1A copy number loss
2This gene is a known cancer gene.
831
PRRX1 copy number gain
PRRX1 copy number loss
2This gene is a known cancer gene.
832
PSIP1 copy number gain
PSIP1 copy number loss
2This gene is a known cancer gene.
833
PTCH1 copy number gain
PTCH1 copy number loss
2This gene is a known cancer gene.
834
PTEN copy number gain
PTEN copy number loss
2This gene is a known cancer gene.
835
PTPN11 copy number gain
PTPN11 copy number loss
2This gene is a known cancer gene.
836
PTPRB copy number gain
PTPRB copy number loss
2This gene is a known cancer gene.
837
PTPRC copy number gain
PTPRC copy number loss
2This gene is a known cancer gene.
838
PTPRK copy number gain
PTPRK copy number loss
2This gene is a known cancer gene.
839
PWWP2A copy number gain
PWWP2A copy number loss
2This gene is a known cancer gene.
840
RABEP1 copy number gain
RABEP1 copy number loss
2This gene is a known cancer gene.
841
RAC1 copy number gain
RAC1 copy number loss
2This gene is a known cancer gene.
842
RAD21 copy number gain
RAD21 copy number loss
2This gene is a known cancer gene.
843
RAD51B copy number gain
RAD51B copy number loss
2This gene is a known cancer gene.
844
RAF1 copy number gain
RAF1 copy number loss
2This gene is a known cancer gene.
845
RALGDS copy number gain
RALGDS copy number loss
2This gene is a known cancer gene.
846
RANBP17 copy number gain
RANBP17 copy number loss
2This gene is a known cancer gene.
847
RANBP2 copy number gain
RANBP2 copy number loss
2This gene is a known cancer gene.
848
RAP1GDS1 copy number gain
RAP1GDS1 copy number loss
2This gene is a known cancer gene.
849
RARA copy number gain
RARA copy number loss
2This gene is a known cancer gene.
850
RB1 copy number gain
RB1 copy number loss
2This gene is a known cancer gene.
851
RBM15 copy number gain
RBM15 copy number loss
2This gene is a known cancer gene.
852
RECQL4 copy number gain
RECQL4 copy number loss
2This gene is a known cancer gene.
853
REL copy number gain
REL copy number loss
2This gene is a known cancer gene.
854
RET copy number gain
RET copy number loss
2This gene is a known cancer gene.
855
RHOA copy number gain
RHOA copy number loss
2This gene is a known cancer gene.
856
RHOH copy number gain
RHOH copy number loss
2This gene is a known cancer gene.
857
RMI2 copy number gain
RMI2 copy number loss
2This gene is a known cancer gene.
858
RNF213 copy number gain
RNF213 copy number loss
2This gene is a known cancer gene.
859
RNF43 copy number gain
RNF43 copy number loss
2This gene is a known cancer gene.
860
ROS1 copy number gain
ROS1 copy number loss
2This gene is a known cancer gene.
861
RPL10 copy number gain
RPL10 copy number loss
2This gene is a known cancer gene.
862
RPL22 copy number gain
RPL22 copy number loss
2This gene is a known cancer gene.
863
RPL5 copy number gain
RPL5 copy number loss
2This gene is a known cancer gene.
864
RPN1 copy number gain
RPN1 copy number loss
2This gene is a known cancer gene.
865
RSPO2 copy number gain
RSPO2 copy number loss
2This gene is a known cancer gene.
866
RSPO3 copy number gain
RSPO3 copy number loss
2This gene is a known cancer gene.
867
SNX29 copy number gain
SNX29 copy number loss
2This gene is a known cancer gene.
868
RUNX1 copy number gain
RUNX1 copy number loss
2This gene is a known cancer gene.
869
RUNX1T1 copy number gain
RUNX1T1 copy number loss
2This gene is a known cancer gene.
870
SBDS copy number gain
SBDS copy number loss
2This gene is a known cancer gene.
871
SDC4 copy number gain
SDC4 copy number loss
2This gene is a known cancer gene.
872
SDHAF2 copy number gain
SDHAF2 copy number loss
2This gene is a known cancer gene.
873
SDHB copy number gain
SDHB copy number loss
2This gene is a known cancer gene.
874
SDHC copy number gain
SDHC copy number loss
2This gene is a known cancer gene.
875
SEPT5 copy number gain
SEPT5 copy number loss
2This gene is a known cancer gene.
876
SEPT6 copy number gain
SEPT6 copy number loss
2This gene is a known cancer gene.
877
SEPT9 copy number gain
SEPT9 copy number loss
2This gene is a known cancer gene.
878
SET copy number gain
SET copy number loss
2This gene is a known cancer gene.
879
SETBP1 copy number gain
SETBP1 copy number loss
2This gene is a known cancer gene.
880
SETD2 copy number gain
SETD2 copy number loss
2This gene is a known cancer gene.
881
SF3B1 copy number gain
SF3B1 copy number loss
2This gene is a known cancer gene.
882
SFPQ copy number gain
SFPQ copy number loss
2This gene is a known cancer gene.
883
SH2B3 copy number gain
SH2B3 copy number loss
2This gene is a known cancer gene.
884
SH3GL1 copy number gain
SH3GL1 copy number loss
2This gene is a known cancer gene.
885
SLC34A2 copy number gain
SLC34A2 copy number loss
2This gene is a known cancer gene.
886
SLC45A3 copy number gain
SLC45A3 copy number loss
2This gene is a known cancer gene.
887
SMAD4 copy number gain
SMAD4 copy number loss
2This gene is a known cancer gene.
888
SMARCA4 copy number gain
SMARCA4 copy number loss
2This gene is a known cancer gene.
889
SMARCB1 copy number gain
SMARCB1 copy number loss
2This gene is a known cancer gene.
890
SMARCD1 copy number gain
SMARCD1 copy number loss
2This gene is a known cancer gene.
891
SMARCE1 copy number gain
SMARCE1 copy number loss
2This gene is a known cancer gene.
892
SMO copy number gain
SMO copy number loss
2This gene is a known cancer gene.
893
SND1 copy number gain
SND1 copy number loss
2This gene is a known cancer gene.
894
SOCS1 copy number gain
SOCS1 copy number loss
2This gene is a known cancer gene.
895
SOX2 copy number gain
SOX2 copy number loss
2This gene is a known cancer gene.
896
SPECC1 copy number gain
SPECC1 copy number loss
2This gene is a known cancer gene.
897
SPEN copy number gain
SPEN copy number loss
2This gene is a known cancer gene.
898
SPOP copy number gain
SPOP copy number loss
2This gene is a known cancer gene.
899
SRGAP3 copy number gain
SRGAP3 copy number loss
2This gene is a known cancer gene.
900
SRSF2 copy number gain
SRSF2 copy number loss
2This gene is a known cancer gene.
901
SRSF3 copy number gain
SRSF3 copy number loss
2This gene is a known cancer gene.
902
SS18 copy number gain
SS18 copy number loss
2This gene is a known cancer gene.
903
SS18L1 copy number gain
SS18L1 copy number loss
2This gene is a known cancer gene.
904
SSX1 copy number gain
SSX1 copy number loss
2This gene is a known cancer gene.
905
SSX2 copy number gain
SSX2 copy number loss
2This gene is a known cancer gene.
906
SSX4 copy number gain
SSX4 copy number loss
2This gene is a known cancer gene.
907
STAG2 copy number gain
STAG2 copy number loss
2This gene is a known cancer gene.
908
STAT3 copy number gain
STAT3 copy number loss
2This gene is a known cancer gene.
909
STAT5B copy number gain
STAT5B copy number loss
2This gene is a known cancer gene.
910
STAT6 copy number gain
STAT6 copy number loss
2This gene is a known cancer gene.
911
STIL copy number gain
STIL copy number loss
2This gene is a known cancer gene.
912
STK11 copy number gain
STK11 copy number loss
2This gene is a known cancer gene.
913
STRN copy number gain
STRN copy number loss
2This gene is a known cancer gene.
914
SUFU copy number gain
SUFU copy number loss
2This gene is a known cancer gene.
915
SUZ12 copy number gain
SUZ12 copy number loss
2This gene is a known cancer gene.
916
SYK copy number gain
SYK copy number loss
2This gene is a known cancer gene.
917
TAF15 copy number gain
TAF15 copy number loss
2This gene is a known cancer gene.
918
TAL1 copy number gain
TAL1 copy number loss
2This gene is a known cancer gene.
919
TAL2 copy number gain
TAL2 copy number loss
2This gene is a known cancer gene.
920
TBL1XR1 copy number gain
TBL1XR1 copy number loss
2This gene is a known cancer gene.
921
TBX3 copy number gain
TBX3 copy number loss
2This gene is a known cancer gene.
922
TCEA1 copy number gain
TCEA1 copy number loss
2This gene is a known cancer gene.
923
TCF12 copy number gain
TCF12 copy number loss
2This gene is a known cancer gene.
924
TCF3 copy number gain
TCF3 copy number loss
2This gene is a known cancer gene.
925
TCF7L2 copy number gain
TCF7L2 copy number loss
2This gene is a known cancer gene.
926
TCL1A copy number gain
TCL1A copy number loss
2This gene is a known cancer gene.
927
TERT copy number gain
TERT copy number loss
2This gene is a known cancer gene.
928
TET1 copy number gain
TET1 copy number loss
2This gene is a known cancer gene.
929
TET2 copy number gain
TET2 copy number loss
2This gene is a known cancer gene.
930
TFE3 copy number gain
TFE3 copy number loss
2This gene is a known cancer gene.
931
TFEB copy number gain
TFEB copy number loss
2This gene is a known cancer gene.
932
TFG copy number gain
TFG copy number loss
2This gene is a known cancer gene.
933
TFPT copy number gain
TFPT copy number loss
2This gene is a known cancer gene.
934
TFRC copy number gain
TFRC copy number loss
2This gene is a known cancer gene.
935
THRAP3 copy number gain
THRAP3 copy number loss
2This gene is a known cancer gene.
936
TLX1 copy number gain
TLX1 copy number loss
2This gene is a known cancer gene.
937
TLX3 copy number gain
TLX3 copy number loss
2This gene is a known cancer gene.
938
TMPRSS2 copy number gain
TMPRSS2 copy number loss
2This gene is a known cancer gene.
939
TNFAIP3 copy number gain
TNFAIP3 copy number loss
2This gene is a known cancer gene.
940
TNFRSF14 copy number gain
TNFRSF14 copy number loss
2This gene is a known cancer gene.
941
TNFRSF17 copy number gain
TNFRSF17 copy number loss
2This gene is a known cancer gene.
942
TOP1 copy number gain
TOP1 copy number loss
2This gene is a known cancer gene.
943
TP53 copy number gain
TP53 copy number loss
2This gene is a known cancer gene.
944
TPM3 copy number gain
TPM3 copy number loss
2This gene is a known cancer gene.
945
TPM4 copy number gain
TPM4 copy number loss
2This gene is a known cancer gene.
946
TPR copy number gain
TPR copy number loss
2This gene is a known cancer gene.
947
TRAF7 copy number gain
TRAF7 copy number loss
2This gene is a known cancer gene.
948
TRIM24 copy number gain
TRIM24 copy number loss
2This gene is a known cancer gene.
949
TRIM27 copy number gain
TRIM27 copy number loss
2This gene is a known cancer gene.
950
TRIM33 copy number gain
TRIM33 copy number loss
2This gene is a known cancer gene.
951
TRIP11 copy number gain
TRIP11 copy number loss
2This gene is a known cancer gene.
952
TRRAP copy number gain
TRRAP copy number loss
2This gene is a known cancer gene.
953
TSC1 copy number gain
TSC1 copy number loss
2This gene is a known cancer gene.
954
TSC2 copy number gain
TSC2 copy number loss
2This gene is a known cancer gene.
955
TSHR copy number gain
TSHR copy number loss
2This gene is a known cancer gene.
956
TTL copy number gain
TTL copy number loss
2This gene is a known cancer gene.
957
U2AF1 copy number gain
U2AF1 copy number loss
2This gene is a known cancer gene.
958
UBR5 copy number gain
UBR5 copy number loss
2This gene is a known cancer gene.
959
USP6 copy number gain
USP6 copy number loss
2This gene is a known cancer gene.
960
VHL copy number gain
VHL copy number loss
2This gene is a known cancer gene.
961
VTI1A copy number gain
VTI1A copy number loss
2This gene is a known cancer gene.
962
WAS copy number gain
WAS copy number loss
2This gene is a known cancer gene.
963
WHSC1 copy number gain
WHSC1 copy number loss
2This gene is a known cancer gene.
964
WHSC1L1 copy number gain
WHSC1L1 copy number loss
2This gene is a known cancer gene.
965
WIF1 copy number gain
WIF1 copy number loss
2This gene is a known cancer gene.
966
WRN copy number gain
WRN copy number loss
2This gene is a known cancer gene.
967
WT1 copy number gain
WT1 copy number loss
2This gene is a known cancer gene.
968
WWTR1 copy number gain
WWTR1 copy number loss
2This gene is a known cancer gene.
969
XPA copy number gain
XPA copy number loss
2This gene is a known cancer gene.
970
XPC copy number gain
XPC copy number loss
2This gene is a known cancer gene.
971
XPO1 copy number gain
XPO1 copy number loss
2This gene is a known cancer gene.
972
YWHAE copy number gain
YWHAE copy number loss
2This gene is a known cancer gene.
973
ZBTB16 copy number gain
ZBTB16 copy number loss
2This gene is a known cancer gene.
974
ZCCHC8 copy number gain
ZCCHC8 copy number loss
2This gene is a known cancer gene.
975
ZMYM2 copy number gain
ZMYM2 copy number loss
2This gene is a known cancer gene.
976
PATZ1 copy number gain
PATZ1 copy number loss
2This gene is a known cancer gene.
977
ZNF331 copy number gain
ZNF331 copy number loss
2This gene is a known cancer gene.
978
ZNF384 copy number gain
ZNF384 copy number loss
2This gene is a known cancer gene.
979
ZNF521 copy number gain
ZNF521 copy number loss
2This gene is a known cancer gene.
980
ZRSR2 copy number gain
ZRSR2 copy number loss
2This gene is a known cancer gene.
1547
ABI1 any mutation
2This gene is a known cancer gene.
1548
ABL1 any mutation
2This gene is a known cancer gene.
1550
ACKR3 any mutation
2This gene is a known cancer gene.
1551
ACSL3 any mutation
2This gene is a known cancer gene.
1552
ACSL6 any mutation
2This gene is a known cancer gene.
1561
ABL2 any mutation
2This gene is a known cancer gene.
1565
ACVR1 any mutation
2This gene is a known cancer gene.
1566
AFF1 any mutation
2This gene is a known cancer gene.
1567
AFF3 any mutation
2This gene is a known cancer gene.
1568
AFF4 any mutation
2This gene is a known cancer gene.
1569
AKAP9 any mutation
2This gene is a known cancer gene.
1570
AKT1 any mutation
2This gene is a known cancer gene.
1571
AKT2 any mutation
2This gene is a known cancer gene.
1572
ALDH2 any mutation
2This gene is a known cancer gene.
1573
ALK any mutation
2This gene is a known cancer gene.
1574
AMER1 any mutation
2This gene is a known cancer gene.
1575
APC any mutation
2This gene is a known cancer gene.
1576
AR any mutation
2This gene is a known cancer gene.
1577
ARHGAP26 any mutation
2This gene is a known cancer gene.
1578
ARHGEF12 any mutation
2This gene is a known cancer gene.
1580
ARID1B any mutation
2This gene is a known cancer gene.
1581
ARID2 any mutation
2This gene is a known cancer gene.
1582
ARNT any mutation
2This gene is a known cancer gene.
1583
ASPSCR1 any mutation
2This gene is a known cancer gene.
1584
ASXL1 any mutation
2This gene is a known cancer gene.
1585
ATF1 any mutation
2This gene is a known cancer gene.
1586
ATIC any mutation
2This gene is a known cancer gene.
1587
ATM any mutation
2This gene is a known cancer gene.
1588
ATP1A1 any mutation
2This gene is a known cancer gene.
1589
ATP2B3 any mutation
2This gene is a known cancer gene.
1590
ATR any mutation
2This gene is a known cancer gene.
1591
ATRX any mutation
2This gene is a known cancer gene.
1592
AXIN1 any mutation
2This gene is a known cancer gene.
1593
AXIN2 any mutation
2This gene is a known cancer gene.
1594
BAP1 any mutation
2This gene is a known cancer gene.
1595
BCL10 any mutation
2This gene is a known cancer gene.
1596
BCL11A any mutation
2This gene is a known cancer gene.
1597
BCL11B any mutation
2This gene is a known cancer gene.
1598
BCL2 any mutation
2This gene is a known cancer gene.
1599
BCL3 any mutation
2This gene is a known cancer gene.
1600
BCL6 any mutation
2This gene is a known cancer gene.
1601
BCL7A any mutation
2This gene is a known cancer gene.
1602
BCL9 any mutation
2This gene is a known cancer gene.
1603
BCOR any mutation
2This gene is a known cancer gene.
1604
BCR any mutation
2This gene is a known cancer gene.
1605
BIRC3 any mutation
2This gene is a known cancer gene.
1606
BLM any mutation
2This gene is a known cancer gene.
1607
BMPR1A any mutation
2This gene is a known cancer gene.
1608
BRAF any mutation
2This gene is a known cancer gene.
1609
BRCA1 any mutation
2This gene is a known cancer gene.
1610
BRCA2 any mutation
2This gene is a known cancer gene.
1611
BRD3 any mutation
2This gene is a known cancer gene.
1612
BRD4 any mutation
2This gene is a known cancer gene.
1613
BRIP1 any mutation
2This gene is a known cancer gene.
1614
BTG1 any mutation
2This gene is a known cancer gene.
1615
BUB1B any mutation
2This gene is a known cancer gene.
1616
C15ORF65 any mutation
2This gene is a known cancer gene.
1617
C2ORF44 any mutation
2This gene is a known cancer gene.
1618
CACNA1D any mutation
2This gene is a known cancer gene.
1619
CALR any mutation
2This gene is a known cancer gene.
1620
CAMTA1 any mutation
2This gene is a known cancer gene.
1621
CANT1 any mutation
2This gene is a known cancer gene.
1622
CARD11 any mutation
2This gene is a known cancer gene.
1623
CARS any mutation
2This gene is a known cancer gene.
1624
CASC5 any mutation
2This gene is a known cancer gene.
1625
CASP8 any mutation
2This gene is a known cancer gene.
1626
CBFA2T3 any mutation
2This gene is a known cancer gene.
1627
CBFB any mutation
2This gene is a known cancer gene.
1628
CBL any mutation
2This gene is a known cancer gene.
1629
CBLB any mutation
2This gene is a known cancer gene.
1630
CBLC any mutation
2This gene is a known cancer gene.
1631
CCDC6 any mutation
2This gene is a known cancer gene.
1632
CCNB1IP1 any mutation
2This gene is a known cancer gene.
1633
CCND1 any mutation
2This gene is a known cancer gene.
1634
CCND2 any mutation
2This gene is a known cancer gene.
1635
CCND3 any mutation
2This gene is a known cancer gene.
1636
CCNE1 any mutation
2This gene is a known cancer gene.
1637
CD274 any mutation
2This gene is a known cancer gene.
1638
CD74 any mutation
2This gene is a known cancer gene.
1639
CD79A any mutation
2This gene is a known cancer gene.
1640
CD79B any mutation
2This gene is a known cancer gene.
1641
CDC73 any mutation
2This gene is a known cancer gene.
1642
CDH1 any mutation
2This gene is a known cancer gene.
1643
CDH11 any mutation
2This gene is a known cancer gene.
1644
CDK12 any mutation
2This gene is a known cancer gene.
1645
CDK4 any mutation
2This gene is a known cancer gene.
1646
CDK6 any mutation
2This gene is a known cancer gene.
1647
CDKN1B any mutation
2This gene is a known cancer gene.
1648
CDKN2A any mutation
2This gene is a known cancer gene.
1649
CDKN2B any mutation
2This gene is a known cancer gene.
1650
CDKN2C any mutation
2This gene is a known cancer gene.
1651
CDX2 any mutation
2This gene is a known cancer gene.
1652
CEBPA any mutation
2This gene is a known cancer gene.
1653
CEP89 any mutation
2This gene is a known cancer gene.
1654
CHCHD7 any mutation
2This gene is a known cancer gene.
1655
CHEK2 any mutation
2This gene is a known cancer gene.
1656
CHIC2 any mutation
2This gene is a known cancer gene.
1657
CHN1 any mutation
2This gene is a known cancer gene.
1658
CIC any mutation
2This gene is a known cancer gene.
1659
CIITA any mutation
2This gene is a known cancer gene.
1660
CLIP1 any mutation
2This gene is a known cancer gene.
1661
CLP1 any mutation
2This gene is a known cancer gene.
1662
CLTC any mutation
2This gene is a known cancer gene.
1663
CLTCL1 any mutation
2This gene is a known cancer gene.
1664
CNBP any mutation
2This gene is a known cancer gene.
1665
CNOT3 any mutation
2This gene is a known cancer gene.
1666
CNTRL any mutation
2This gene is a known cancer gene.
1667
COL1A1 any mutation
2This gene is a known cancer gene.
1668
COL2A1 any mutation
2This gene is a known cancer gene.
1669
COX6C any mutation
2This gene is a known cancer gene.
1670
CREB1 any mutation
2This gene is a known cancer gene.
1671
CREB3L1 any mutation
2This gene is a known cancer gene.
1672
CREB3L2 any mutation
2This gene is a known cancer gene.
1673
CREBBP any mutation
2This gene is a known cancer gene.
1674
CRLF2 any mutation
2This gene is a known cancer gene.
1675
CRTC1 any mutation
2This gene is a known cancer gene.
1676
CRTC3 any mutation
2This gene is a known cancer gene.
1677
CSF1R any mutation
2This gene is a known cancer gene.
1678
CSF3R any mutation
2This gene is a known cancer gene.
1679
CTNNB1 any mutation
2This gene is a known cancer gene.
1680
CUX1 any mutation
2This gene is a known cancer gene.
1681
CYLD any mutation
2This gene is a known cancer gene.
1682
DAXX any mutation
2This gene is a known cancer gene.
1683
DCTN1 any mutation
2This gene is a known cancer gene.
1684
DDB2 any mutation
2This gene is a known cancer gene.
1685
DDIT3 any mutation
2This gene is a known cancer gene.
1686
DDX10 any mutation
2This gene is a known cancer gene.
1687
DDX5 any mutation
2This gene is a known cancer gene.
1688
DDX6 any mutation
2This gene is a known cancer gene.
1689
DEK any mutation
2This gene is a known cancer gene.
1690
DICER1 any mutation
2This gene is a known cancer gene.
1691
DNM2 any mutation
2This gene is a known cancer gene.
1692
DNMT3A any mutation
2This gene is a known cancer gene.
1693
DUX4 any mutation
2This gene is a known cancer gene.
1694
EBF1 any mutation
2This gene is a known cancer gene.
1695
ECT2L any mutation
2This gene is a known cancer gene.
1696
EGFR any mutation
2This gene is a known cancer gene.
1697
EIF3E any mutation
2This gene is a known cancer gene.
1698
EIF4A2 any mutation
2This gene is a known cancer gene.
1699
ELF4 any mutation
2This gene is a known cancer gene.
1700
ELK4 any mutation
2This gene is a known cancer gene.
1701
ELL any mutation
2This gene is a known cancer gene.
1702
ELN any mutation
2This gene is a known cancer gene.
1703
EML4 any mutation
2This gene is a known cancer gene.
1704
EPHA3 any mutation
2This gene is a known cancer gene.
1705
EP300 any mutation
2This gene is a known cancer gene.
1706
EPS15 any mutation
2This gene is a known cancer gene.
1707
ERBB2 any mutation
2This gene is a known cancer gene.
1708
ERBB3 any mutation
2This gene is a known cancer gene.
1709
ERC1 any mutation
2This gene is a known cancer gene.
1710
ERCC2 any mutation
2This gene is a known cancer gene.
1711
ERCC3 any mutation
2This gene is a known cancer gene.
1712
ERCC4 any mutation
2This gene is a known cancer gene.
1713
ERCC5 any mutation
2This gene is a known cancer gene.
1714
ERG any mutation
2This gene is a known cancer gene.
1715
ESR1 any mutation
2This gene is a known cancer gene.
1716
ETNK1 any mutation
2This gene is a known cancer gene.
1717
ETV1 any mutation
2This gene is a known cancer gene.
1718
ETV4 any mutation
2This gene is a known cancer gene.
1719
ETV5 any mutation
2This gene is a known cancer gene.
1720
ETV6 any mutation
2This gene is a known cancer gene.
1721
EWSR1 any mutation
2This gene is a known cancer gene.
1722
EXT1 any mutation
2This gene is a known cancer gene.
1723
EXT2 any mutation
2This gene is a known cancer gene.
1724
EZH2 any mutation
2This gene is a known cancer gene.
1725
EZR any mutation
2This gene is a known cancer gene.
1726
FAM131B any mutation
2This gene is a known cancer gene.
1727
FAM46C any mutation
2This gene is a known cancer gene.
1728
FANCA any mutation
2This gene is a known cancer gene.
1729
FANCC any mutation
2This gene is a known cancer gene.
1730
FANCD2 any mutation
2This gene is a known cancer gene.
1731
FANCE any mutation
2This gene is a known cancer gene.
1732
FANCF any mutation
2This gene is a known cancer gene.
1733
FANCG any mutation
2This gene is a known cancer gene.
1734
FAS any mutation
2This gene is a known cancer gene.
1735
FBXO11 any mutation
2This gene is a known cancer gene.
1736
FBXW7 any mutation
2This gene is a known cancer gene.
1737
FCGR2B any mutation
2This gene is a known cancer gene.
1738
FCRL4 any mutation
2This gene is a known cancer gene.
1739
FEV any mutation
2This gene is a known cancer gene.
1740
FGFR1 any mutation
2This gene is a known cancer gene.
1741
FGFR1OP any mutation
2This gene is a known cancer gene.
1742
FGFR2 any mutation
2This gene is a known cancer gene.
1743
FGFR3 any mutation
2This gene is a known cancer gene.
1744
FGFR4 any mutation
2This gene is a known cancer gene.
1745
FH any mutation
2This gene is a known cancer gene.
1746
FHIT any mutation
2This gene is a known cancer gene.
1747
FIP1L1 any mutation
2This gene is a known cancer gene.
1748
FLCN any mutation
2This gene is a known cancer gene.
1749
FLI1 any mutation
2This gene is a known cancer gene.
1750
FLT3 any mutation
2This gene is a known cancer gene.
1751
FLT4 any mutation
2This gene is a known cancer gene.
1752
FNBP1 any mutation
2This gene is a known cancer gene.
1753
FOXA1 any mutation
2This gene is a known cancer gene.
1754
FOXL2 any mutation
2This gene is a known cancer gene.
1755
FOXO1 any mutation
2This gene is a known cancer gene.
1756
FOXO3 any mutation
2This gene is a known cancer gene.
1757
FOXO4 any mutation
2This gene is a known cancer gene.
1758
FOXO4 any mutation
2This gene is a known cancer gene.
1759
FOXP1 any mutation
2This gene is a known cancer gene.
1760
FSTL3 any mutation
2This gene is a known cancer gene.
1761
FUBP1 any mutation
2This gene is a known cancer gene.
1762
FUS any mutation
2This gene is a known cancer gene.
1763
GAS7 any mutation
2This gene is a known cancer gene.
1764
GATA1 any mutation
2This gene is a known cancer gene.
1765
GATA2 any mutation
2This gene is a known cancer gene.
1766
GATA3 any mutation
2This gene is a known cancer gene.
1767
GMPS any mutation
2This gene is a known cancer gene.
1768
GNA11 any mutation
2This gene is a known cancer gene.
1769
GNAQ any mutation
2This gene is a known cancer gene.
1770
GNAS any mutation
2This gene is a known cancer gene.
1771
GOLGA5 any mutation
2This gene is a known cancer gene.
1772
GOPC any mutation
2This gene is a known cancer gene.
1773
GPC3 any mutation
2This gene is a known cancer gene.
1774
GPHN any mutation
2This gene is a known cancer gene.
1775
GRIN2A any mutation
2This gene is a known cancer gene.
1776
H3F3A any mutation
2This gene is a known cancer gene.
1777
H3F3B any mutation
2This gene is a known cancer gene.
1778
HERPUD1 any mutation
2This gene is a known cancer gene.
1779
HEY1 any mutation
2This gene is a known cancer gene.
1780
HIP1 any mutation
2This gene is a known cancer gene.
1781
HIST1H3B any mutation
2This gene is a known cancer gene.
1782
HIST1H4I any mutation
2This gene is a known cancer gene.
1783
HLA-A any mutation
2This gene is a known cancer gene.
1784
HLF any mutation
2This gene is a known cancer gene.
1785
HMGA1 any mutation
2This gene is a known cancer gene.
1786
HMGA2 any mutation
2This gene is a known cancer gene.
1787
HNF1A any mutation
2This gene is a known cancer gene.
1788
HNRNPA2B1 any mutation
2This gene is a known cancer gene.
1789
HOOK3 any mutation
2This gene is a known cancer gene.
1790
HOXA11 any mutation
2This gene is a known cancer gene.
1791
HOXA13 any mutation
2This gene is a known cancer gene.
1792
HOXA9 any mutation
2This gene is a known cancer gene.
1793
HOXC11 any mutation
2This gene is a known cancer gene.
1794
HOXC13 any mutation
2This gene is a known cancer gene.
1795
HOXD11 any mutation
2This gene is a known cancer gene.
1796
HOXD13 any mutation
2This gene is a known cancer gene.
1797
HRAS any mutation
2This gene is a known cancer gene.
1798
HSP90AA1 any mutation
2This gene is a known cancer gene.
1799
HSP90AB1 any mutation
2This gene is a known cancer gene.
1800
IDH1 any mutation
2This gene is a known cancer gene.
1801
IDH2 any mutation
2This gene is a known cancer gene.
1802
IKBKB any mutation
2This gene is a known cancer gene.
1803
IKZF1 any mutation
2This gene is a known cancer gene.
1804
IL2 any mutation
2This gene is a known cancer gene.
1805
IL21R any mutation
2This gene is a known cancer gene.
1806
IL6ST any mutation
2This gene is a known cancer gene.
1807
IL7R any mutation
2This gene is a known cancer gene.
1808
IRF4 any mutation
2This gene is a known cancer gene.
1809
ITK any mutation
2This gene is a known cancer gene.
1810
JAK1 any mutation
2This gene is a known cancer gene.
1811
JAK2 any mutation
2This gene is a known cancer gene.
1812
JAK3 any mutation
2This gene is a known cancer gene.
1813
JAZF1 any mutation
2This gene is a known cancer gene.
1814
JUN any mutation
2This gene is a known cancer gene.
1815
KAT6A any mutation
2This gene is a known cancer gene.
1816
KAT6B any mutation
2This gene is a known cancer gene.
1817
KCNJ5 any mutation
2This gene is a known cancer gene.
1818
KDM5A any mutation
2This gene is a known cancer gene.
1819
KDM5C any mutation
2This gene is a known cancer gene.
1820
KDM6A any mutation
2This gene is a known cancer gene.
1821
KDR any mutation
2This gene is a known cancer gene.
1822
KDSR any mutation
2This gene is a known cancer gene.
1823
KIAA1549 any mutation
2This gene is a known cancer gene.
1824
KIAA1598 any mutation
2This gene is a known cancer gene.
1825
KIF5B any mutation
2This gene is a known cancer gene.
1826
KIT any mutation
2This gene is a known cancer gene.
1827
KLF4 any mutation
2This gene is a known cancer gene.
1828
KLF6 any mutation
2This gene is a known cancer gene.
1829
KLK2 any mutation
2This gene is a known cancer gene.
1830
KMT2A any mutation
2This gene is a known cancer gene.
1831
KMT2C any mutation
2This gene is a known cancer gene.
1832
KMT2D any mutation
2This gene is a known cancer gene.
1833
KRAS any mutation
2This gene is a known cancer gene.
1834
KTN1 any mutation
2This gene is a known cancer gene.
1835
LASP1 any mutation
2This gene is a known cancer gene.
1836
LCK any mutation
2This gene is a known cancer gene.
1837
LCP1 any mutation
2This gene is a known cancer gene.
1838
LHFP any mutation
2This gene is a known cancer gene.
1839
LIFR any mutation
2This gene is a known cancer gene.
1840
LMNA any mutation
2This gene is a known cancer gene.
1841
LMO1 any mutation
2This gene is a known cancer gene.
1842
LMO2 any mutation
2This gene is a known cancer gene.
1843
LPP any mutation
2This gene is a known cancer gene.
1844
LRIG3 any mutation
2This gene is a known cancer gene.
1845
LSM14A any mutation
2This gene is a known cancer gene.
1846
LYL1 any mutation
2This gene is a known cancer gene.
1847
LZTR1 any mutation
2This gene is a known cancer gene.
1848
MAF any mutation
2This gene is a known cancer gene.
1849
MAFB any mutation
2This gene is a known cancer gene.
1850
MALT1 any mutation
2This gene is a known cancer gene.
1851
MAML2 any mutation
2This gene is a known cancer gene.
1852
MAP2K1 any mutation
2This gene is a known cancer gene.
1853
MAP2K2 any mutation
2This gene is a known cancer gene.
1854
MAP2K4 any mutation
2This gene is a known cancer gene.
1855
MAP3K1 any mutation
2This gene is a known cancer gene.
1856
MAP3K13 any mutation
2This gene is a known cancer gene.
1857
MAX any mutation
2This gene is a known cancer gene.
1858
MDM2 any mutation
2This gene is a known cancer gene.
1859
MDM4 any mutation
2This gene is a known cancer gene.
1860
MDS2 any mutation
2This gene is a known cancer gene.
1861
MECOM any mutation
2This gene is a known cancer gene.
1862
MED12 any mutation
2This gene is a known cancer gene.
1863
MEN1 any mutation
2This gene is a known cancer gene.
1864
MET any mutation
2This gene is a known cancer gene.
1865
MITF any mutation
2This gene is a known cancer gene.
1866
MKL1 any mutation
2This gene is a known cancer gene.
1867
MLF1 any mutation
2This gene is a known cancer gene.
1868
MLH1 any mutation
2This gene is a known cancer gene.
1869
MLLT1 any mutation
2This gene is a known cancer gene.
1870
MLLT10 any mutation
2This gene is a known cancer gene.
1871
MLLT11 any mutation
2This gene is a known cancer gene.
1872
MLLT3 any mutation
2This gene is a known cancer gene.
1873
MLLT4 any mutation
2This gene is a known cancer gene.
1874
MLLT6 any mutation
2This gene is a known cancer gene.
1875
MN1 any mutation
2This gene is a known cancer gene.
1876
MNX1 any mutation
2This gene is a known cancer gene.
1877
MPL any mutation
2This gene is a known cancer gene.
1878
MSH2 any mutation
2This gene is a known cancer gene.
1879
MSH6 any mutation
2This gene is a known cancer gene.
1880
MSI2 any mutation
2This gene is a known cancer gene.
1881
MSN any mutation
2This gene is a known cancer gene.
1882
MTCP1 any mutation
2This gene is a known cancer gene.
1883
MUC1 any mutation
2This gene is a known cancer gene.
1884
MUTYH any mutation
2This gene is a known cancer gene.
1885
MYB any mutation
2This gene is a known cancer gene.
1886
MYC any mutation
2This gene is a known cancer gene.
1887
MYCL any mutation
2This gene is a known cancer gene.
1888
MYCN any mutation
2This gene is a known cancer gene.
1889
MYD88 any mutation
2This gene is a known cancer gene.
1890
MYH11 any mutation
2This gene is a known cancer gene.
1891
MYH9 any mutation
2This gene is a known cancer gene.
1892
MYO5A any mutation
2This gene is a known cancer gene.
1893
MYOD1 any mutation
2This gene is a known cancer gene.
1894
NAB2 any mutation
2This gene is a known cancer gene.
1895
NACA any mutation
2This gene is a known cancer gene.
1896
NBN any mutation
2This gene is a known cancer gene.
1897
NCKIPSD any mutation
2This gene is a known cancer gene.
1898
NCOA1 any mutation
2This gene is a known cancer gene.
1899
NCOA2 any mutation
2This gene is a known cancer gene.
1900
NCOA4 any mutation
2This gene is a known cancer gene.
1901
NCOR1 any mutation
2This gene is a known cancer gene.
1902
NDRG1 any mutation
2This gene is a known cancer gene.
1903
NF1 any mutation
2This gene is a known cancer gene.
1904
NF2 any mutation
2This gene is a known cancer gene.
1905
NFATC2 any mutation
2This gene is a known cancer gene.
1906
NFE2L2 any mutation
2This gene is a known cancer gene.
1907
NFIB any mutation
2This gene is a known cancer gene.
1908
NFKB2 any mutation
2This gene is a known cancer gene.
1909
NFKBIE any mutation
2This gene is a known cancer gene.
1910
NIN any mutation
2This gene is a known cancer gene.
1911
NKX2-1 any mutation
2This gene is a known cancer gene.
1912
NONO any mutation
2This gene is a known cancer gene.
1913
NOTCH1 any mutation
2This gene is a known cancer gene.
1914
NOTCH2 any mutation
2This gene is a known cancer gene.
1915
NOTCH3 any mutation
2This gene is a known cancer gene.
1916
NPM1 any mutation
2This gene is a known cancer gene.
1917
NR4A3 any mutation
2This gene is a known cancer gene.
1918
NRAS any mutation
2This gene is a known cancer gene.
1919
NRG1 any mutation
2This gene is a known cancer gene.
1920
NSD1 any mutation
2This gene is a known cancer gene.
1921
NT5C2 any mutation
2This gene is a known cancer gene.
1922
NTRK1 any mutation
2This gene is a known cancer gene.
1923
NTRK3 any mutation
2This gene is a known cancer gene.
1924
NUMA1 any mutation
2This gene is a known cancer gene.
1925
NUP214 any mutation
2This gene is a known cancer gene.
1926
NUP98 any mutation
2This gene is a known cancer gene.
1927
NUTM1 any mutation
2This gene is a known cancer gene.
1928
NUTM2A any mutation
2This gene is a known cancer gene.
1929
NUTM2B any mutation
2This gene is a known cancer gene.
1930
OLIG2 any mutation
2This gene is a known cancer gene.
1931
OMD any mutation
2This gene is a known cancer gene.
1932
P2RY8 any mutation
2This gene is a known cancer gene.
1933
PAFAH1B2 any mutation
2This gene is a known cancer gene.
1934
PALB2 any mutation
2This gene is a known cancer gene.
1935
PAX3 any mutation
2This gene is a known cancer gene.
1936
PAX5 any mutation
2This gene is a known cancer gene.
1937
PAX7 any mutation
2This gene is a known cancer gene.
1938
PAX8 any mutation
2This gene is a known cancer gene.
1939
PBRM1 any mutation
2This gene is a known cancer gene.
1940
PBX1 any mutation
2This gene is a known cancer gene.
1941
PCM1 any mutation
2This gene is a known cancer gene.
1942
PCSK7 any mutation
2This gene is a known cancer gene.
1943
PDCD1LG2 any mutation
2This gene is a known cancer gene.
1944
PDE4DIP any mutation
2This gene is a known cancer gene.
1945
PDGFB any mutation
2This gene is a known cancer gene.
1946
PDGFRA any mutation
2This gene is a known cancer gene.
1947
PDGFRB any mutation
2This gene is a known cancer gene.
1948
PER1 any mutation
2This gene is a known cancer gene.
1949
PHF6 any mutation
2This gene is a known cancer gene.
1950
PHOX2B any mutation
2This gene is a known cancer gene.
1951
PICALM any mutation
2This gene is a known cancer gene.
1952
PIK3CA any mutation
2This gene is a known cancer gene.
1953
PIK3R1 any mutation
2This gene is a known cancer gene.
1954
PIM1 any mutation
2This gene is a known cancer gene.
1955
PLAG1 any mutation
2This gene is a known cancer gene.
1956
PLCG1 any mutation
2This gene is a known cancer gene.
1957
PML any mutation
2This gene is a known cancer gene.
1958
PMS1 any mutation
2This gene is a known cancer gene.
1959
PMS2 any mutation
2This gene is a known cancer gene.
1960
POLE any mutation
2This gene is a known cancer gene.
1961
POT1 any mutation
2This gene is a known cancer gene.
1962
POU2AF1 any mutation
2This gene is a known cancer gene.
1963
POU5F1 any mutation
2This gene is a known cancer gene.
1964
PPARG any mutation
2This gene is a known cancer gene.
1965
PPFIBP1 any mutation
2This gene is a known cancer gene.
1966
PPP2R1A any mutation
2This gene is a known cancer gene.
1967
PPP6C any mutation
2This gene is a known cancer gene.
1968
PRCC any mutation
2This gene is a known cancer gene.
1969
PRDM1 any mutation
2This gene is a known cancer gene.
1970
PRDM16 any mutation
2This gene is a known cancer gene.
1971
PRF1 any mutation
2This gene is a known cancer gene.
1972
PRKAR1A any mutation
2This gene is a known cancer gene.
1973
PRRX1 any mutation
2This gene is a known cancer gene.
1974
PSIP1 any mutation
2This gene is a known cancer gene.
1975
PTCH1 any mutation
2This gene is a known cancer gene.
1976
PTEN any mutation
2This gene is a known cancer gene.
1977
PTPN11 any mutation
2This gene is a known cancer gene.
1978
PTPRB any mutation
2This gene is a known cancer gene.
1979
PTPRC any mutation
2This gene is a known cancer gene.
1980
PTPRK any mutation
2This gene is a known cancer gene.
1981
PWWP2A any mutation
2This gene is a known cancer gene.
1982
RABEP1 any mutation
2This gene is a known cancer gene.
1983
RAC1 any mutation
2This gene is a known cancer gene.
1984
RAD21 any mutation
2This gene is a known cancer gene.
1985
RAD51B any mutation
2This gene is a known cancer gene.
1986
RAF1 any mutation
2This gene is a known cancer gene.
1987
RALGDS any mutation
2This gene is a known cancer gene.
1988
RANBP17 any mutation
2This gene is a known cancer gene.
1989
RANBP2 any mutation
2This gene is a known cancer gene.
1990
RAP1GDS1 any mutation
2This gene is a known cancer gene.
1991
RARA any mutation
2This gene is a known cancer gene.
1992
RB1 any mutation
2This gene is a known cancer gene.
1993
RBM15 any mutation
2This gene is a known cancer gene.
1994
RECQL4 any mutation
2This gene is a known cancer gene.
1995
REL any mutation
2This gene is a known cancer gene.
1996
RET any mutation
2This gene is a known cancer gene.
1997
RHOA any mutation
2This gene is a known cancer gene.
1998
RHOH any mutation
2This gene is a known cancer gene.
1999
RMI2 any mutation
2This gene is a known cancer gene.
2000
RNF213 any mutation
2This gene is a known cancer gene.
2001
RNF43 any mutation
2This gene is a known cancer gene.
2002
ROS1 any mutation
2This gene is a known cancer gene.
2003
RPL10 any mutation
2This gene is a known cancer gene.
2004
RPL22 any mutation
2This gene is a known cancer gene.
2005
RPL5 any mutation
2This gene is a known cancer gene.
2006
RPN1 any mutation
2This gene is a known cancer gene.
2007
RSPO2 any mutation
2This gene is a known cancer gene.
2008
RSPO3 any mutation
2This gene is a known cancer gene.
2009
SNX29 any mutation
2This gene is a known cancer gene.
2010
RUNX1 any mutation
2This gene is a known cancer gene.
2011
RUNX1T1 any mutation
2This gene is a known cancer gene.
2012
SBDS any mutation
2This gene is a known cancer gene.
2013
SDC4 any mutation
2This gene is a known cancer gene.
2014
SDHAF2 any mutation
2This gene is a known cancer gene.
2015
SDHB any mutation
2This gene is a known cancer gene.
2016
SDHC any mutation
2This gene is a known cancer gene.
2017
SEPT5 any mutation
2This gene is a known cancer gene.
2018
SEPT6 any mutation
2This gene is a known cancer gene.
2019
SEPT9 any mutation
2This gene is a known cancer gene.
2020
SET any mutation
2This gene is a known cancer gene.
2021
SETBP1 any mutation
2This gene is a known cancer gene.
2022
SETD2 any mutation
2This gene is a known cancer gene.
2023
SF3B1 any mutation
2This gene is a known cancer gene.
2024
SFPQ any mutation
2This gene is a known cancer gene.
2025
SH2B3 any mutation
2This gene is a known cancer gene.
2026
SH3GL1 any mutation
2This gene is a known cancer gene.
2027
SLC34A2 any mutation
2This gene is a known cancer gene.
2028
SLC45A3 any mutation
2This gene is a known cancer gene.
2029
SMAD4 any mutation
2This gene is a known cancer gene.
2030
SMARCA4 any mutation
2This gene is a known cancer gene.
2031
SMARCB1 any mutation
2This gene is a known cancer gene.
2032
SMARCD1 any mutation
2This gene is a known cancer gene.
2033
SMARCE1 any mutation
2This gene is a known cancer gene.
2034
SMO any mutation
2This gene is a known cancer gene.
2035
SND1 any mutation
2This gene is a known cancer gene.
2036
SOCS1 any mutation
2This gene is a known cancer gene.
2037
SOX2 any mutation
2This gene is a known cancer gene.
2038
SPECC1 any mutation
2This gene is a known cancer gene.
2039
SPEN any mutation
2This gene is a known cancer gene.
2040
SPOP any mutation
2This gene is a known cancer gene.
2041
SRGAP3 any mutation
2This gene is a known cancer gene.
2042
SRSF2 any mutation
2This gene is a known cancer gene.
2043
SRSF3 any mutation
2This gene is a known cancer gene.
2044
SS18 any mutation
2This gene is a known cancer gene.
2045
SS18L1 any mutation
2This gene is a known cancer gene.
2046
SSX1 any mutation
2This gene is a known cancer gene.
2047
SSX2 any mutation
2This gene is a known cancer gene.
2048
SSX4 any mutation
2This gene is a known cancer gene.
2049
STAG2 any mutation
2This gene is a known cancer gene.
2050
STAT3 any mutation
2This gene is a known cancer gene.
2051
STAT5B any mutation
2This gene is a known cancer gene.
2052
STAT6 any mutation
2This gene is a known cancer gene.
2053
STIL any mutation
2This gene is a known cancer gene.
2054
STK11 any mutation
2This gene is a known cancer gene.
2055
STRN any mutation
2This gene is a known cancer gene.
2056
SUFU any mutation
2This gene is a known cancer gene.
2057
SUZ12 any mutation
2This gene is a known cancer gene.
2058
SYK any mutation
2This gene is a known cancer gene.
2059
TAF15 any mutation
2This gene is a known cancer gene.
2060
TAL1 any mutation
2This gene is a known cancer gene.
2061
TAL2 any mutation
2This gene is a known cancer gene.
2062
TBL1XR1 any mutation
2This gene is a known cancer gene.
2063
TBX3 any mutation
2This gene is a known cancer gene.
2064
TCEA1 any mutation
2This gene is a known cancer gene.
2065
TCF12 any mutation
2This gene is a known cancer gene.
2066
TCF3 any mutation
2This gene is a known cancer gene.
2067
TCF7L2 any mutation
2This gene is a known cancer gene.
2068
TCL1A any mutation
2This gene is a known cancer gene.
2069
TERT any mutation
2This gene is a known cancer gene.
2070
TET1 any mutation
2This gene is a known cancer gene.
2071
TET2 any mutation
2This gene is a known cancer gene.
2072
TFE3 any mutation
2This gene is a known cancer gene.
2073
TFEB any mutation
2This gene is a known cancer gene.
2074
TFG any mutation
2This gene is a known cancer gene.
2075
TFPT any mutation
2This gene is a known cancer gene.
2076
TFRC any mutation
2This gene is a known cancer gene.
2077
THRAP3 any mutation
2This gene is a known cancer gene.
2078
TLX1 any mutation
2This gene is a known cancer gene.
2079
TLX3 any mutation
2This gene is a known cancer gene.
2080
TMPRSS2 any mutation
2This gene is a known cancer gene.
2081
TNFAIP3 any mutation
2This gene is a known cancer gene.
2082
TNFRSF14 any mutation
2This gene is a known cancer gene.
2083
TNFRSF17 any mutation
2This gene is a known cancer gene.
2084
TOP1 any mutation
2This gene is a known cancer gene.
2086
TPM3 any mutation
2This gene is a known cancer gene.
2087
TPM4 any mutation
2This gene is a known cancer gene.
2088
TPR any mutation
2This gene is a known cancer gene.
2089
TRAF7 any mutation
2This gene is a known cancer gene.
2090
TRIM24 any mutation
2This gene is a known cancer gene.
2091
TRIM27 any mutation
2This gene is a known cancer gene.
2092
TRIM33 any mutation
2This gene is a known cancer gene.
2093
TRIP11 any mutation
2This gene is a known cancer gene.
2094
TRRAP any mutation
2This gene is a known cancer gene.
2095
TSC1 any mutation
2This gene is a known cancer gene.
2096
TSC2 any mutation
2This gene is a known cancer gene.
2097
TSHR any mutation
2This gene is a known cancer gene.
2098
TTL any mutation
2This gene is a known cancer gene.
2099
U2AF1 any mutation
2This gene is a known cancer gene.
2100
UBR5 any mutation
2This gene is a known cancer gene.
2101
USP6 any mutation
2This gene is a known cancer gene.
2102
VHL any mutation
2This gene is a known cancer gene.
2103
VTI1A any mutation
2This gene is a known cancer gene.
2104
WAS any mutation
2This gene is a known cancer gene.
2105
WHSC1 any mutation
2This gene is a known cancer gene.
2106
WHSC1L1 any mutation
2This gene is a known cancer gene.
2107
WIF1 any mutation
2This gene is a known cancer gene.
2108
WRN any mutation
2This gene is a known cancer gene.
2109
WT1 any mutation
2This gene is a known cancer gene.
2110
WWTR1 any mutation
2This gene is a known cancer gene.
2111
XPA any mutation
2This gene is a known cancer gene.
2112
XPC any mutation
2This gene is a known cancer gene.
2113
XPO1 any mutation
2This gene is a known cancer gene.
2114
YWHAE any mutation
2This gene is a known cancer gene.
2115
ZBTB16 any mutation
2This gene is a known cancer gene.
2116
ZCCHC8 any mutation
2This gene is a known cancer gene.
2117
ZMYM2 any mutation
2This gene is a known cancer gene.
2118
PATZ1 any mutation
2This gene is a known cancer gene.
2119
ZNF331 any mutation
2This gene is a known cancer gene.
2120
ZNF384 any mutation
2This gene is a known cancer gene.
2121
ZNF521 any mutation
2This gene is a known cancer gene.
2122
ZRSR2 any mutation
2This gene is a known cancer gene.

Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The IPM makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and the IPM assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.

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