WCMC logo
PMKB
  • WCMC logoPMKB
  • Genes
  • Variants
  • Interpretations
  • Tumor Types
  • Primary Sites
  • Activity
  • Login
NRAS
  • Information
  • View History
  • Pending Review
Interpretation 2147
Tier 2
NRAS
Variants
NRAS codon(s) 12, 13, 61, 146 any
Primary Sites
Brain
Spinal Cord
Tumor Types
Astrocytoma, NOS
Astrocytoma, Anaplastic
Astrocytoma, Diffusely Infiltrating
Glioblastoma
Infiltrating Glioma, NOS
Interpretation

NRAS gene belongs to the family of RAS genes. It encodes a G protein that is important in the transmission of growth-promoting signals from the cell surface receptors to the nucleus through RAS-RAF-mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)-AKT cell signaling pathways. NRAS mutations are rare in glial neoplasms and are found in about 1% of cases. The clinicopathologic significance of NRAS mutations in glial neoplasms remains to be further elucidated.

Citations
  1. Fernandez-Medarde A, Santos E. Ras in cancer and developmental diseases. Genes
  2. Cancer. 2011 Mar;2(3):344-58.
  3. Ceccarelli M, et al. Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. Cell. 2016 Jan 28;164(3):550-63.
Last updated: 2018-03-21 18:18:35 UTC
PMKB Bot
  • Genes
  • Variants
  • Interpretations
  • Tumor Types
  • Primary Sites
  • Activity

Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The Englander Institute for Precision Medicine at Weill Cornell Medicine makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.


When using PMKB, please cite: Huang et al., JAMIA 2017


HELP
User Guide
Video Tutorial
INFO
About
Latest
API
Twitter
CONTACT US
Contact

Englander Institute for Precision Medicine
© Weill Cornell Medicine | Version 1.7.2Privacy PolicyTerms of use