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CDKN2A
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Interpretation 253
Tier 2
CDKN2A
Variants
CDKN2A copy number loss
Primary Sites
Brain
Tumor Types
Glioblastoma
Interpretation

The CDKN2A gene locus is altered in up to approximately 57% of glioblastoma, most commonly as a homozygous deletion, and frequently with concurrent deletion of the CDKN2B locus. CDKN2A/CDKN2B loss may be associated with increased sensitivity to CDK4/6 inhibitors. The efficacy and toxicity profiles of these inhibitors in the context of a variety of cancer types are currently under evaluation in clinical trials.

Citations
  1. Brennan CW, et al. The somatic genomic landscape of glioblastoma. Cell 2013;155(2):462-77
Last updated: 2019-04-26 15:04:50 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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