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Interpretation 202
Tier 2
TP53
Variants
Primary Sites
Brain
Tumor Types
Glioblastoma
Interpretation

Somatic mutations in TP53 are frequent in human cancer. Germline TP53 mutations cause of Li-Fraumeni syndrome, which is associated with a range of early-onset cancers. The types and positions of TP53 mutations are diverse. TP53 mutations may be potential prognostic and predictive markers in some tumor types, as well as targets for pharmacological intervention in some clinical settings. The IARC TP53 Database (http://www-p53.iarc.fr/) is a useful resource which catalogues TP53 mutations found in cancer.

Citations
  1. Olivier et al. TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use. 2010 Cold Spring Harb Perspect Biol ;2:a001011
Last updated: 2016-06-07 02:10:43 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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