Somatic mutations in TP53 are frequent in human cancer. Germline TP53 mutations cause of Li-Fraumeni syndrome, which is associated with a range of early-onset cancers. The types and positions of TP53 mutations are diverse. TP53 mutations may be potential prognostic and predictive markers in some tumor types, as well as targets for pharmacological intervention in some clinical settings. The IARC TP53 Database (http://www-p53.iarc.fr/) is a useful resource which catalogues TP53 mutations found in cancer.
This gene is a known cancer gene. ARID1A/BAF250A subunit of the SWI/SNF (BAF) chromatin remodeling complex has emerged as recurrently mutated in a broad array of tumor types and a potential tumor suppressor. There is evidence indicating that ARID1A-mutated cancers may be subjected to therapeutic intervention.
Tier | Interpretation | Gene | Variants |
---|---|---|---|
2 | This gene is a known cancer gene. | ABI1 | ABI1 copy number gain ABI1 copy number loss |
2 | This gene is a known cancer gene. | ABL1 | ABL1 copy number gain ABL1 copy number loss |
2 | This gene is a known cancer gene. | ABL2 | ABL2 copy number gain ABL2 copy number loss |
2 | This gene is a known cancer gene. | ACKR3 | ACKR3 copy number gain ACKR3 copy number loss |
2 | This gene is a known cancer gene. | ACSL3 | ACSL3 copy number gain ACSL3 copy number loss |
2 | This gene is a known cancer gene. | ACSL6 | ACSL6 copy number gain ACSL6 copy number loss |
2 | This gene is a known cancer gene. | ACVR1 | ACVR1 copy number gain ACVR1 copy number loss |
2 | This gene is a known cancer gene. | AFF1 | AFF1 copy number gain AFF1 copy number loss |
2 | This gene is a known cancer gene. | AFF3 | AFF3 copy number gain AFF3 copy number loss |
2 | This gene is a known cancer gene. | AFF4 | AFF4 copy number gain AFF4 copy number loss |