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CCND1
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Interpretation 382
Tier 2
CCND1
Variants
CCND1 copy number gain
Primary Sites
Bladder
Esophagus
Oral Cavity
Larynx
Bladder
Lung
Breast
Prostate
Ovary
Stomach
Pancreas
Tumor Types
Adenocarcinoma
Urothelial Carcinoma
Squamous Cell Carcinoma
Interpretation

The protein of CCND1 (Cyclin D 1) belongs to the highly conserved cyclin family, functioning as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Amplification of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors. Cyclin D1 and the mechanisms it regulates have the potential to be a therapeutic target for cancer drugs, including inhibition of Cyclin D1, induction of Cyclin D1 degradation, and inhibition of Cyclin D1/CDK 4/6 complex.

Citations
  1. ClinicalTrials.gov
  2. Seiler R, et al. CCND1/CyclinD1 status in metastasizing bladder cancer: a prognosticator and predictor of chemotherapeutic response. Mod Pathol 2014;27(1):87-95
Last updated: 2017-02-09 20:02:30 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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