Variant | Gene | Type | COSMIC ID | DNA Change (Coding Nucleotide) | Exon |
---|---|---|---|---|---|
BRCA2 copy number loss | BRCA2 | CNV | |||
BRCA2 any mutation | BRCA2 | any | |||
BRCA2 copy number gain | BRCA2 | CNV |
Some mutations in BRCA2 may be associated with sensitivity to PARP inhibitors. The effect of this missense mutation is not entirely clear. Drug: Rucaparib Niraparib Olaparib
This gene is a known cancer gene.
This gene is a known cancer gene.