Gene | KDM6A |
Variant | any |
Transcript ID (GRCh37/hg19) | ENST00000377967 |
Germline/Somatic? | Somatic |
Tumor Type | Primary Site |
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This gene is a known cancer gene.
KDM6A is a histone demethylase. In a recent study, KDM6A was noted to be a recurrently altered gene in a subset of relapsed AML cases and may represent a mechanism of cytarabine resistance. These alterations include partial gene deletions and mutations that lead to decreased KDM6A expression/function.