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KRAS L19F
GeneKRAS
Variantmissense
Amino Acid ChangeL19F
DNA Change (Coding Nucleotide)57G>C
Transcript ID (GRCh37/hg19)ENST00000256078
Codon19
Exon2
Genomic Coordinates (GRCh37/hg19)12:25398262-25398262
Germline/Somatic?Somatic
Pertinent Negative In
Tumor TypePrimary Site
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Tier 2
KRAS
Variants
KRAS L19F
Primary Sites
Colon
Tumor Types
Adenocarcinoma
Interpretation

KRAS is a gene that encodes one of the several proteins in the epidermal growth factor receptor (EGFR) signaling pathway that is important in the development and progression of cancer. KRAS can harbor oncogenic mutations that yield a constitutively active protein. Such mutations are found in approximately 30% to 50% of metastatic colorectal tumors and are common in other tumor types. KRAS L19F has been previously reported in colorectal cancers, but its oncogenic and transforming potential was reported to be significantly lower compared to codons 12 or 13 KRAS mutants. The predictive and prognostic significance of this specific mutation in KRAS needs further elucidation. Results should be interpreted in conjunction with other laboratory and clinical findings.

Last updated: 2017-01-30 21:47:53 UTC
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Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The Englander Institute for Precision Medicine at Weill Cornell Medicine makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.


When using PMKB, please cite: Huang et al., JAMIA 2017


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