WCMC logo
PMKB
  • WCMC logoPMKB
  • Genes
  • Variants
  • Interpretations
  • Tumor Types
  • Primary Sites
  • Activity
  • Login
AURKA
  • Information
  • View History
  • Pending Review
Interpretation 378
Tier 2
AURKA
Variants
AURKA copy number gain
Primary Sites
Prostate
Breast
Colon
Pancreas
Ovary
Stomach
Tumor Types
Adenocarcinoma
Interpretation

Aurora A is a member of a family of mitotic serine/threonine kinases, playing an important role in cell proliferation. AURKA amplification may be associated with sensitivity to Aurora Kinase inhibitors. However these inhibitors are currently undergoing clinical trials and their efficacy and/or lack of toxicity has not yet been demonstrated.

Citations
  1. Bavetsias V, et al. Aurora Kinase Inhibitors: Current Status and Outlook. Front Oncol 2015;5():278
  2. Hilton JF, et al. Aurora kinase inhibition as an anticancer strategy. J Clin Oncol 2014;32(1):57-9
Last updated: 2017-02-09 16:36:48 UTC
PMKB Bot
  • Genes
  • Variants
  • Interpretations
  • Tumor Types
  • Primary Sites
  • Activity

Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The Englander Institute for Precision Medicine at Weill Cornell Medicine makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.


When using PMKB, please cite: Huang et al., JAMIA 2017


HELP
User Guide
Video Tutorial
INFO
About
Latest
API
Twitter
CONTACT US
Contact

Englander Institute for Precision Medicine
© Weill Cornell Medicine | Version 1.7.2Privacy PolicyTerms of use