|Variant||Gene||Type||COSMIC ID||DNA Change (Coding Nucleotide)||Exon|
|AURKA copy number gain||AURKA||CNV|
Aurora A is a member of a family of mitotic serine/threonine kinases, playing an important role in cell proliferation. AURKA amplification may be associated with sensitivity to Aurora Kinase inhibitors. However these inhibitors are currently undergoing clinical trials and their efficacy and/or lack of toxicity has not yet been demonstrated.