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KDR
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Interpretation 2245
Tier 3
KDR
Variants
KDR P263T
Primary Sites
Colon
Tumor Types
Adenocarcinoma
Interpretation

KDR encodes the protein VEGF2, a receptor tyrosine kinase that regulates angiogenesis and vascular development. While KDR mutations are rare, amplification or protein overexpression have been reported in small proportion of a variety of solid tumors. KDR P263T has not been characterized and the effect on protein function is unknown. These results should be interpreted in the clinical context.

Citations
  1. Smith NR, et al. Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers. Clin Cancer Res. 2010 Jul 15;16(14):3548-61.
Last updated: 2018-05-02 20:01:37 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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