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Interpretation 173
Tier 2
PIK3CA
Variants
PIK3CA exon(s) 10, 20, 21 any
Primary Sites
Colon
Rectum
Tumor Types
Adenocarcinoma
Interpretation

Somatic mutations in PIK3CA have been found in 10-30% of colorectal cancers. According to some reports, co-occurrence of both exon 9 and exon 20 PIK3CA mutations, when present, may be associated with a poor prognosis. Recent 'molecular pathological epidemiology' (MPE) research has shown that aspirin use is associated with better prognosis and clinical outcome in PIK3CA-mutated colorectal carcinoma, suggesting somatic PIK3CA mutation may be a molecular biomarker that predicts response to aspirin therapy. PIK3CA may also be a target of directed therapy in some clinical settings.

Citations
  1. Liao X et al. Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature Review. Clinical Cancer Research 2012;18(8):2257-68
  2. Samuels et al High frequency of mutations of the PIK3CA gene in human cancers. Science. 2004 Apr 23;304(5670):554.
  3. Ogino et al..Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology. Oncogene (2014) 33, 2949-2955
Last updated: 2020-07-24 14:52:12 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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