Interpretation 108
Tier 2|
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Tumor Types
Interpretation
The D594E mutation in BRAF is believed to result in inactivation of BRAF and, therefore, BRAF inhibitors are not likely to be effective.
Citations
- Heidorn et al. Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell. 2010 Jan 22;140(2):209-21
Last updated: 2017-03-15 21:02:32 UTC