MET M1268T
| Gene | MET |
| Variant | missense |
| Amino Acid Change | M1268T |
| Transcript ID (GRCh37/hg19) | ENST00000318493 |
| Codon | 1268 |
| Exon | 19 |
| Germline/Somatic? | Somatic |
Pertinent Negative In
| Tumor Type | Primary Site |
|---|
Interpretations
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Interpretation
A subset of sporadic papillary renal carcinomas were caused by activating mutations in the tyrosine kinase domain of the MET proto-oncogene. Several of the MET mutations (M1268T, D1246 and V11101) were located in codons homologous to codons mutated in other protein receptor tyrosine kinases (Ret M918T, Kit D816V, and c-erbB V1571)
Last updated: 2015-12-09 20:20:48 UTC
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