Interpretation 161
Tier 3|
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Variants
Primary Sites
Tumor Types
Interpretation
A subset of sporadic papillary renal carcinomas were caused by activating mutations in the tyrosine kinase domain of the MET proto-oncogene. Several of the MET mutations (M1268T, D1246 and V11101) were located in codons homologous to codons mutated in other protein receptor tyrosine kinases (Ret M918T, Kit D816V, and c-erbB V1571)
Citations
- Schmidt et al Novel mutations of the MET proto-oncogene in papillary renal carcinomas.Oncogene. 1999 Apr 8;18(14):2343-50.
- Lubensky et al . Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype. Am J Pathol. 1999 Aug;155(2):517-26.
Last updated: 2015-12-09 20:20:48 UTC