Interpretation 379
Tier 3|
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Variants
Primary Sites
Tumor Types
Interpretation
In lung adenocarcinomas, CRKL amplification may be associated with resistance to EGFR-directed therapy (Cheung et al, 2011). However, its significance in urothelial cancer is yet to be determined.
Citations
- Cheung HW, et al. Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers. Cancer Discov 2011;1(7):608-25
- Han B, et al. Clinical significance and biological roles of CRKL in human bladder carcinoma. Tumour Biol 2014;35(5):4101-6
Last updated: 2017-02-09 16:46:13 UTC