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CRKL
Variants
VariantGeneTypeCOSMIC IDDNA Change (Coding Nucleotide)Exon
CRKL copy number gainCRKLCNV

Interpretations

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Tier 3
CRKL
Variants
CRKL copy number gain
Primary Sites
Bladder
Tumor Types
Urothelial Carcinoma
Interpretation

In lung adenocarcinomas, CRKL amplification may be associated with resistance to EGFR-directed therapy (Cheung et al, 2011). However, its significance in urothelial cancer is yet to be determined.

Last updated: 2017-02-09 16:46:13 UTC
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Tier 2
CRKL
Variants
CRKL copy number gain
Primary Sites
Lung
Tumor Types
Adenocarcinoma
Interpretation

CRKL (Crk-like protein) is a substrate of the BCR-ABL tyrosine kinase, and plays a role in fibroblast transformation by BCR-ABL. It is potentially oncogenic. In lung adenocarcinomas, CRKL amplification may be associated with resistance to anti-EGFR therapy.

Last updated: 2017-02-09 17:17:18 UTC
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Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The Englander Institute for Precision Medicine at Weill Cornell Medicine makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.


When using PMKB, please cite: Huang et al., JAMIA 2017


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