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EGFR
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Interpretation 356
Tier 1
EGFR
Variants
EGFR copy number gain
Primary Sites
Colon
Rectum
Tumor Types
Carcinoma
Adenocarcinoma
Interpretation

In colorectal cancer, EGFR gene amplification is associated with sensitivity EGFR-targeted therapies, such as Erbitux and Vectibix.

Citations
  1. Moroni M, et al. Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol 2005;6(5):279-86
  2. Bardelli A, et al. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov 2013;3(6):658-73
  3. Yang ZY, et al. EGFR gene copy number as a predictive biomarker for the treatment of metastatic colorectal cancer with anti-EGFR monoclonal antibodies: a meta-analysis. J Hematol Oncol 2012;5():52
Last updated: 2017-01-20 03:41:37 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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