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FGFR1
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Interpretation 334
Tier 1
FGFR1
Variants
FGFR1 copy number gain
Primary Sites
Colon
Rectum
Gastroesophageal Junction
Esophagus
Peritoneum
Retroperitoneum
Stomach
Appendix
Tumor Types
Gastrointestinal Stromal Tumor
Interpretation

FGFR1 activating mutations may be associated with response to the multitargeted tyrosine kinase inhibitor pazopanib.

Citations
  1. Liao RG, et al. Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma. Cancer Res 2013;73(16):5195-205
Last updated: 2017-01-20 03:32:36 UTC
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Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The Englander Institute for Precision Medicine at Weill Cornell Medicine makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.

When using PMKB, please cite: Huang et al., JAMIA 2017

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