Interpretation 332
Tier 1|
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Variants
Primary Sites
Interpretation
The p.C121S mutation has been associated with resistance to mutant BRAF inhibitors.
Citations
- Waterfall JJ, et al. High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias. Nat Genet 2014;46(1):8-10
- Pasqualucci L, et al. Genetics of follicular lymphoma transformation. Cell Rep 2014;6(1):130-40
- Brown NA, et al. High prevalence of somatic MAP2K1 mutations in BRAF V600E-negative Langerhans cell histiocytosis. Blood 2014;124(10):1655-8
- Nelson DS, et al. MAP2K1 and MAP3K1 mutations in Langerhans cell histiocytosis. Genes Chromosomes Cancer 2015;54(6):361-8
Last updated: 2017-01-20 03:31:52 UTC