WCMC logo
PMKB
  • WCMC logoPMKB
  • Genes
  • Variants
  • Interpretations
  • Tumor Types
  • Primary Sites
  • Activity
  • Login
MAP2K1
  • Information
  • View History
  • Pending Review
Interpretation 332
Tier 1
MAP2K1
Variants
MAP2K1 C121S
Primary Sites
Blood
Bone Marrow
Lymph Node
Tumor Types
Hairy Cell Leukemia
Follicular Lymphoma
Langerhans Cell Histiocytosis
Interpretation

The p.C121S mutation has been associated with resistance to mutant BRAF inhibitors.

Citations
  1. Waterfall JJ, et al. High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias. Nat Genet 2014;46(1):8-10
  2. Pasqualucci L, et al. Genetics of follicular lymphoma transformation. Cell Rep 2014;6(1):130-40
  3. Brown NA, et al. High prevalence of somatic MAP2K1 mutations in BRAF V600E-negative Langerhans cell histiocytosis. Blood 2014;124(10):1655-8
  4. Nelson DS, et al. MAP2K1 and MAP3K1 mutations in Langerhans cell histiocytosis. Genes Chromosomes Cancer 2015;54(6):361-8
Last updated: 2017-01-20 03:31:52 UTC
PMKB Bot
  • Genes
  • Variants
  • Interpretations
  • Tumor Types
  • Primary Sites
  • Activity

Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The Englander Institute for Precision Medicine at Weill Cornell Medicine makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.


When using PMKB, please cite: Huang et al., JAMIA 2017


HELP
User Guide
Video Tutorial
INFO
About
Latest
API
Twitter
CONTACT US
Contact

Englander Institute for Precision Medicine
© Weill Cornell Medicine | Version 1.7.2Privacy PolicyTerms of use