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PIK3CA
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Interpretation 314
Tier 3
PIK3CA
Variants
Primary Sites
Prostate
Tumor Types
Adenocarcinoma
Carcinoma
Interpretation

PIK3CA mutations activate the PI3K-PTEN-AKT pathway which is downstream from both the EGFR and RAS-RAF-MAPK pathways. The somatic mutations found thus far in PIK3CA are oncogenic, and the majority of them are clustered within exon 9 and 20 (helical and kinase domains). Activating mutations in PIK3CA are found in a wide variety of human cancers including up to 4% of prostate cancers. The role of PIK3CA mutations as prognosticators of outcome or predictors of therapeutic response awaits further evaluation. Clinical trials are available for patients with PIK3CA mutated tumors.

Citations
  1. Samuels Y, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004;304(5670):554
  2. Taylor BS, et al. Integrative genomic profiling of human prostate cancer. Cancer Cell 2010;18(1):11-22
  3. Barbieri CE, et al. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat Genet 2012;44(6):685-9
Last updated: 2016-10-23 21:58:06 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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