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KRAS
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Interpretation 250
Tier 2
KRAS
Variants
Primary Sites
Bladder
Tumor Types
Urothelial Carcinoma
Interpretation

KRAS is a gene that encodes one of the several proteins in the growth factor signaling pathway(s) and is important in the development and progression of a variety of cancers. KRAS can harbor oncogenic mutations that yield a constitutively active protein. The frequency of the KRAS gene mutations in urothelial carcinoma of urinary bladder is very low (3% to 7%), and these mutations occur in all stages and grades. In the context of bladder tumors, mutations in the KRAS gene do not appear to be predictors for recurrence-free, progression-free and disease-specific survival according to some studies.

Citations
  1. Ouerhani S, et al. The prevalence and prognostic significance of KRAS mutation in bladder cancer, chronic myeloid leukemia and colorectal cancer. Mol Biol Rep 2013;40(6):4109-14
  2. Kompier LC, et al. FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy. PLoS One 2010;5(11):e13821
  3. Ouerhani S, et al. The mutational spectrum of HRAS, KRAS, NRAS and FGFR3 genes in bladder cancer. Cancer Biomark 2011-2012;10(6):259-66
Last updated: 2016-03-29 19:28:17 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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