Interpretation 175
Tier 2|
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Primary Sites
Tumor Types
Interpretation
PIK3CA mutations have been identified in pediatric and adult gliomas including: anaplastic oligodendrogliomas, anaplastic astrocytomas, glioblastoma multiforme, rosette forming glioneuronal tumors and medulloblastomas. PIK3CA mutations provide a mechanism for disrupting the PI3K/Akt pathway.
Citations
- Hartmann et al PIK3CA mutations in glioblastoma multiforme.Acta Neuropathol (2005) 109: 639–642
- Gallia et al. PIK3CA Gene Mutations in Pediatric and Adult Glioblastoma Multiforme. Mol Cancer Res 2006;4(10):709–14)
- Broderick DK, Di C, Parrett TJ, Samuels YR, Cummins JM, McLendon RE, Fults DW, Velculescu VE, Bigner DD, Yan H. Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. Cancer Res. 2004 Aug 1;64(15):5048-50. PubMed PMID: 15289301.
- Theeler BJ, Ellezam B, Melguizo-Gavilanes I, de Groot JF, Mahajan A, Aldape KD, Bruner JM, Puduvalli VK. Adult brainstem gliomas: Correlation of clinical and molecular features. J Neurol Sci. 2015 Jun 15;353(1-2):92-7. doi: 10.1016/j.jns.2015.04.014. Epub 2015 Apr 18. PubMed PMID: 25934342.
- Gessi M, Moneim YA, Hammes J, Goschzik T, Scholz M, Denkhaus D, Waha A, Pietsch T. FGFR1 mutations in Rosette-forming glioneuronal tumors of the fourth ventricle. J Neuropathol Exp Neurol. 2014 Jun;73(6):580-4. doi: 10.1097/NEN.0000000000000080. PubMed PMID: 24806303.
Last updated: 2015-12-09 20:21:59 UTC