FBXW7 is a tumor suppressor gene that is mutated in several tumors including colorectal, liver, bladders and ovarian cancers. It is also mutated in endometrial and head and neck squamous cancers. Preclinical data suggest that FBXW7 mutations may sensitize cells to mTOR inhibitors.
Comprehensive molecular characterization of human colon and rectal cancer. Cancer Genome Atlas Network 2012 Nature;487(7407):330-7
Jardim et al 2014. FBXW7 Mutations in Patients with Advanced Cancers: Clinical and Molecular Characteristics and Outcomes with mTOR Inhibitors. PLoS ONE 9(2).
Gu Z et al ..The FBXW7 beta-form is suppressed in human glioma cells. Biochemical and biophysical research communications; 2007. 354(4):992-8
Aydin et al FBXW7 Mutations in Melanoma and a New Therapeutic Paradigm. JNCI J Natl Cancer Inst (2014) 106
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