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Interpretation 130
Tier 3
EGFR
Variants
EGFR G863D
Primary Sites
Lung
Stomach
Tumor Types
Adenocarcinoma
Interpretation

A low frequency mutation detected in lung and gastric cancer. Functional significance of this alteration has not yet been described. However, a single NSCLC patient with this mutation in a clinical trial shows partial response to gefitinb therapy

Citations
  1. Liu et al..Epidermal growth factor receptor mutation in gastric cancer.Pathology. 2011 Apr;43(3):234-8
Last updated: 2015-12-09 20:16:16 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017

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