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BRAF
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Interpretation 111
Tier 2
BRAF
Variants
BRAF T599_V600insT
Primary Sites
Spinal Cord
Brain
Brain, Supratentorial
Brain, Infratentorial
Tumor Types
Interpretation

BRAF mutants, with a 3bp insertion between codons 599 and 600, display increased in vitro kinase activity activation potential comparable to those of BRAF V600E mutants.

Citations
  1. Eisenhardt A et al… Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma. Int. J. Cancer: 129, 2297–2303 (2011)
Last updated: 2015-12-09 20:12:43 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017

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