WCMC logo
PMKB
  • WCMC logoPMKB
  • Genes
  • Variants
  • Interpretations
  • Tumor Types
  • Primary Sites
  • Activity
  • Login
ERBB4
Variants
VariantGeneTypeCOSMIC IDDNA Change (Coding Nucleotide)Exon
ERBB4 P920HERBB4missenseCOSM460496123

Interpretations

Sort by
Page
Show

Tier 1
ERBB4
Variants
Primary Sites
Skin
Tumor Types
Melanoma
Interpretation

Melanomas with ERBB4 mutations may be associated with sensitivity to Lapatinib.

Last updated: 2017-01-20 03:41:12 UTC
Read More
Tier 2
ERBB4
Variants
ERBB4 P920H
Primary Sites
Lung
Tumor Types
Adenocarcinoma
Interpretation

ERBB4 is a member of the EGFR subfamily of receptor tyrosine kinases. Approximately 5.4% of non-small cell lung cancers harbor ERBB4 missense mutations (COSMIC). In addition, 5.2% of adenocarcinomas have mutations in the ERBB4 gene that encode an amino acid change in the receptor. Activating, potentially oncogenic ERBB4 mutations (in particular Y285C, D595V, D931Y, and K935I) have been identified. However, the functional effects of lung cancer associated ERBB4 mutations is largely unknown. ERBB4 P920H variant has been seen in one case of squamous cell carcinoma of the head and neck (cancer.sanger.ac.uk). However, further studies are warranted to assess the potential prognostic and therapeutic significance of this and other variants of ERBB4.

Last updated: 2019-02-22 18:06:43 UTC
Read More
PMKB Bot
  • Genes
  • Variants
  • Interpretations
  • Tumor Types
  • Primary Sites
  • Activity

Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The Englander Institute for Precision Medicine at Weill Cornell Medicine makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.


When using PMKB, please cite: Huang et al., JAMIA 2017


HELP
User Guide
Video Tutorial
INFO
About
Latest
API
Twitter
CONTACT US
Contact

Englander Institute for Precision Medicine
© Weill Cornell Medicine | Version 1.7.2Privacy PolicyTerms of use