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BRAF
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BRAF L597Q
GeneBRAF
Variantmissense
Amino Acid ChangeL597Q
DNA Change (Coding Nucleotide)1790T>A
Transcript ID (GRCh37/hg19)ENST00000288602
Codon597
Exon15
Genomic Coordinates (GRCh37/hg19)7:140453145-140453145
COSMIC ID1125
Germline/Somatic?Somatic
Pertinent Negative In
Tumor TypePrimary Site
See All Pertinent Negatives

Interpretations

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Tier 1
BRAF
Variants
BRAF L597Q
Primary Sites
Unknown
Tumor Types
Melanoma
Interpretation

Drug: Trametinib BGB659

Last updated: 2018-04-06 14:55:28 UTC
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Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The Englander Institute for Precision Medicine at Weill Cornell Medicine makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.

When using PMKB, please cite: Huang et al., JAMIA 2017

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