|Amino Acid Change||R157W|
|Transcript ID (GRCh37/hg19)||ENST00000269571|
|Tumor Type||Primary Site|
Activating extracellular domain ERBB2 mutations (S310F, S310Y, R157W) have been identified in urothelial carcinoma (enriched in micropapillary variant) and adenocarcinomas of breast and lung. These activating mutations may have therapeutic potential in some clinical settings.