|Amino Acid Change||Y273F|
|Transcript ID (GRCh37/hg19)||ENST00000354513|
|Tumor Type||Primary Site|
Although PDGFRA activating mutations in patients with GIST, primarily D842V, were reported to be associated with resistance to the tyrosine kinase inhibitor, Imatinib; however, PDGFRA mutations in breast cancer are very rare. Moreover, this specific missense mutation in the extracellular domain of PDGFRA, has not been reported and its clinical significance is unknown.