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AR T878A
GeneAR
Variantmissense
Amino Acid ChangeT878A
DNA Change (Coding Nucleotide)2632A>G
Transcript ID (GRCh37/hg19)ENST00000374690
Codon878
Exon8
Genomic Coordinates (GRCh37/hg19)23:66943552-66943552
COSMIC ID236693
Germline/Somatic?Somatic
Pertinent Negative In
Tumor TypePrimary Site
See All Pertinent Negatives

Interpretations

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Tier 1
AR
Variants
AR T878A
AR H875Y
Primary Sites
Prostate
Tumor Types
Adenocarcinoma
Interpretation

Mutations in the Androgen Receptor are rare in untreated prostate cancer and have been described in 15-33% of castration resistant prostate cancer and hormone refractory tumors. Among these, the H875Y and T878A are recurrent mutations that have been previously described. These mutations alter responses to androgen receptor antagonists. Cases with two such mutations have been previously reported and the mutations may co-exist on the same allele.

Last updated: 2016-02-28 00:00:36 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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