DNAJB1-PRKACA rearrangement
| Gene | DNAJB1 |
| Variant | rearrangement |
| Partner Gene | PRKACA |
| Germline/Somatic? | Somatic |
Pertinent Negative In
| Tumor Type | Primary Site | |
|---|---|---|
| Hepatocellular Carcinoma | Liver |
Interpretations
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Interpretation
The DNAJB1-PRKACA fusion transcript is detected in 80 to 100% of fibrolamellar hepatocellular carcinomas. Detection of DNAJB1-PRKACA is thought to be a very sensitive and specific finding in support of the diagnosis of fibrolamellar carcinoma, and may contribute to tumor pathogenesis. The therapeutic targetability of this alteration remains to be elucidated.
Last updated: 2016-02-12 21:25:57 UTC
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