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CHD1
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CHD1 any indel
GeneCHD1
Variantindel
Transcript ID (GRCh37/hg19)ENST00000284049
Germline/Somatic?Somatic
Pertinent Negative In
Tumor TypePrimary Site
AdenocarcinomaProstate
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CHD1
Variants
CHD1 any indel
Primary Sites
Prostate
Tumor Types
Adenocarcinoma
Interpretation

CHD1 (chromodomain helicase DNA protein binding domain 1) gene controls the transcriptional activity across the genome. It is recurrently deleted in 10%-25% of primary and metastatic prostate cancer, and particularly focal homozygous deletions are restricted to ETS-negative tumors. CHD1 deletion may contribute to the distinctive patterns of genomic instability observed in CHD1del tumors.The SPOP-mutant/CHD1-deleted subset of prostate cancer have characteristic molecular features, including high levels of DNA methylation, homogeneous gene expression patterns, distinct somatic copy-number alterations (SCNA), as well as frequent overexpression of SPINK1 mRNA.

Last updated: 2016-02-09 20:13:33 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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