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MET V1110I
GeneMET
Variantmissense
Amino Acid ChangeV1110I
Transcript ID (GRCh37/hg19)ENST00000318493
Codon1110
Exon16
Germline/Somatic?Somatic
Pertinent Negative In
Tumor TypePrimary Site
See All Pertinent Negatives

Interpretations

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Tier 2
MET
Variants
MET V1110I
MET M1131T
MET M1149T
MET V1188L
MET L1195V
MET V1220I
MET L1213F
Primary Sites
Kidney
Tumor Types
Papillary Renal Cell Carcinoma
Interpretation

Activating somatic mutations in the tyrosine kinase domain of MET are found in about 10-15% of sporadic papillary renal cell carcinoma (pRCC). MET mutations are predominantly associated with Type 1 pRCC tumors. The responses to foretanib an oral inhibitor of MET and other tyrosine kinases including VEGFR2, have been described in patients with papillary renal cell cancer.

Last updated: 2020-07-24 14:52:06 UTC
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Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The Englander Institute for Precision Medicine at Weill Cornell Medicine makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.


When using PMKB, please cite: Huang et al., JAMIA 2017


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