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BRAF
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BRAF codon(s) 469 any
GeneBRAF
Variantany
Transcript ID (GRCh37/hg19)ENST00000288602
Codon469
Exon11
Genomic Coordinates (GRCh37/hg19)7:140481401-140481403
Germline/Somatic?Somatic
Pertinent Negative In
Tumor TypePrimary Site
See All Pertinent Negatives

Interpretations

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Tier 2
BRAF
Variants
BRAF G469A
BRAF codon(s) 469 any
Primary Sites
Lung
Tumor Types
Adenocarcinoma
Interpretation

Somatic mutations in BRAF have been found in 1-4% of all NSCLC most of which are adenocarcinomas. The G469A mutation results in an amino acid substitution at position 469 in BRAF, occurs within the highly conserved motif of the kinase domain. Most mutant BRAF proteins, such as G469A, have increased kinase activity and are transforming in vitro. In preclinical studies, lung cancer cell lines harboring the BRAF G469A mutation were not sensitive to dasatinib

Last updated: 2020-07-24 14:51:34 UTC
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Tier 1
BRAF
Variants
BRAF codon(s) 469 any
BRAF G469V
Primary Sites
Unknown
Tumor Types
Melanoma
Interpretation

DRUG: Trametinib

Last updated: 2018-04-06 15:10:23 UTC
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Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The Englander Institute for Precision Medicine at Weill Cornell Medicine makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.


When using PMKB, please cite: Huang et al., JAMIA 2017


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