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Interpretation 412
Tier 1
IDH2
Variants
IDH2 R172K
IDH2 codon(s) 172 missense
Primary Sites
Nasal Cavity
Tumor Types
Carcinoma
Interpretation

IDH2 R172X mutations have been detected in 55-82% of sinonasal undifferentiated carcinomas (SNUC). These tumors may be amenable to IDH2-targeted therapies.

Citations
  1. Dogan S, et al. Frequent IDH2 R172 Mutations in Undifferentiated and Poorly-Differentiated Sinonasal Carcinomas. J Pathol 2017;():
  2. Jo VY, et al. Recurrent IDH2 R172X mutations in sinonasal undifferentiated carcinoma. Mod Pathol 2017;30(5):650-659
Last updated: 2018-11-12 20:40:30 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017

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