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NRAS
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Interpretation 411
Tier 2
NRAS
Variants
Primary Sites
Pancreas
Tumor Types
Adenocarcinoma
Interpretation

NRAS is a member of the RAS family of oncogenes. Activating point mutations in NRAS gene have been reported in a wide variety of tumors and they mostly concentrate in codons 12, 13 and codon 61. Activating mutations in NRAS are rare in pancreatic ductal adenocarcinomas (PDAC). The predictive and prognostic significance of NRAS mutations in PDAC is unclear and needs to be further studied. Correlation with other clinical and laboratory findings is recommended.

Citations
  1. Bailey P, et al. Genomic analyses identify molecular subtypes of pancreatic cancer. Nature 2016;531(7592):47-52
  2. Vujic I, et al. Mutant NRASQ61 shares signaling similarities across various cancer types--potential implications for future therapies. Oncotarget 2014;5(17):7936-44
  3. Cox AD, et al. Drugging the undruggable RAS: Mission possible? Nat Rev Drug Discov 2014;13(11):828-51
Last updated: 2017-05-01 15:05:50 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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