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Interpretation 394
Tier 2
ERBB2
Variants
ERBB2 L869R
Primary Sites
Breast
Tumor Types
Adenocarcinoma
Interpretation

This mutation is recognized as gain of function mutation. Tumor with this mutation responds to neratinib, a type of TKI which is against HER2 and EGFR.

Citations
  1. 10.1158/2159-8290
  2. 10.1200/JCO.2015.64.0334.
Last updated: 2018-12-13 21:07:39 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017

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