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MET
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Interpretation 390
Tier 1
MET
Variants
MET copy number gain
Primary Sites
Stomach
Gastroesophageal Junction
Tumor Types
Adenocarcinoma
Interpretation

Amplification of MET, the hepatocyte growth factor receptor, is identified in 7% of Esophagus-Stomach cancer in recent TCGA study. Several studies investigated the relationship between MET amplification and expression with the clinical outcome in patients with gastric cancer, but yielded conflicting results. Multiple clinical trials of using anti-MET agent in the treatment of Esophagus-Stomach cancer are available.

Citations
  1. Cancer Genome Atlas Research Network., et al. Integrated genomic characterization of oesophageal carcinoma. Nature 2017;541(7636):169-175
  2. Kawakami H, et al. MET amplification as a potential therapeutic target in gastric cancer. Oncotarget 2013;4(1):9-17
Last updated: 2017-09-06 15:00:56 UTC
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Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The Englander Institute for Precision Medicine at Weill Cornell Medicine makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.


When using PMKB, please cite: Huang et al., JAMIA 2017


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