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CDK6
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Interpretation 376
Tier 1
CDK6
Variants
CDK6 copy number gain
Primary Sites
Breast
Brain
Tumor Types
Adenocarcinoma
Medulloblastoma
Interpretation

CDK (cyclin-dependent kinase) 4 and CDK6 are key players in cell cycle progression. In many human cancers, CDK6 is overactive, for example one third of medulloblastoma patients show upregulated CDK6. In 2015, FDA has granted an approval to CDK4/6 inhibitor palbociclib (Ibrance) as a frontline treatment for postmenopausal women with ER-positive, HER2-negative metastatic breast cancer. However, per NCCN 2016 guideline for breast cancer, this treatment regime does not require the amplification of CDK4/6. Palbociclib, along with other CDK inhibitors, are actively under many other clinical trials targeting liposarcoma, various advanced solid tumors and hematologic malignancies.

Citations
  1. NCCN Guideline Version 2.2016 Breast Cancer
  2. Sherr CJ, et al. Targeting CDK4 and CDK6: From Discovery to Therapy. Cancer Discov 2016;6(4):353-67
  3. O'Leary B, et al. Treating cancer with selective CDK4/6 inhibitors. Nat Rev Clin Oncol 2016;13(7):417-30
Last updated: 2017-02-09 16:28:05 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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