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AKT2
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Interpretation 364
Tier 1
AKT2
Variants
Primary Sites
Blood
Bone Marrow
Tumor Types
Chronic Myeloid Leukemia
Other Acute Leukemia
Interpretation

AKT2 is closely related to AKT1. Activating mutations in AKT1 such as p.E17K may be associated with sensitivity to AKT inhibitors. AKT2 activating mutations might also confer sensitivity to AKT inhibitors, although the significance of this variant is uncertain.

Citations
  1. Stephens PJ, et al. The landscape of cancer genes and mutational processes in breast cancer. Nature 2012;486(7403):400-4
  2. Nik-Zainal S, et al. Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature 2016;534(7605):47-54
Last updated: 2017-01-20 03:44:03 UTC
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Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The Englander Institute for Precision Medicine at Weill Cornell Medicine makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.


When using PMKB, please cite: Huang et al., JAMIA 2017


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