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AKT3
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Interpretation 363
Tier 1
AKT3
Variants
Primary Sites
Blood
Bone Marrow
Skin
Kidney
Tumor Types
Chronic Myeloid Leukemia
Other Acute Leukemia
Melanoma
Clear Cell Renal Cell Carcinoma
Interpretation

AKT3 is closely related to AKT1. Activating mutations in AKT1 such as p.E17K may be associated with sensitivity to AKT inhibitors. AKT3 activating mutations might also confer sensitivity to AKT inhibitors, although the significance of this variant is uncertain.

Citations
  1. Berger MF, et al. Melanoma genome sequencing reveals frequent PREX2 mutations. Nature 2012;485(7399):502-6
  2. Van Allen EM, et al. The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma. Cancer Discov 2014;4(1):94-109
Last updated: 2017-01-20 03:43:38 UTC
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Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The Englander Institute for Precision Medicine at Weill Cornell Medicine makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.


When using PMKB, please cite: Huang et al., JAMIA 2017


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