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MAP2K2
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Interpretation 330
Tier 1
MAP2K2
Variants
Primary Sites
Skin
Tumor Types
Melanoma
Interpretation

MAP2K2 mutations result in constitutive ERK phosphorylation and may be associated with higher resistance to MEK inhibitors. However these inhibitors are currently undergoing clinical trials and their efficacy and/or lack of toxicity has not yet been demonstrated.

Citations
  1. Nikolaev SI, et al. Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. Nat Genet 2011;44(2):133-9
Last updated: 2017-01-20 03:30:54 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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