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Interpretation 321
Tier 3
MET
Variants
MET E168D
Primary Sites
Skin
Tumor Types
Melanoma
Interpretation

MET is a member of the receptor tyrosine kinase and proto-oncogene playing a major role in tumor development and metastasis. Mutations in MET have been reported in 4-9% of cutaneous melanoma. MET E168D has not been reported in melanomas. This mutation is located in a conserved domain containing the ligand binding site. In vitro studies have shown that E168D may be associated with higher ligand affinity and higher susceptibility to c-Met inhibitors in lung cancer. The prognostic and predictive significance of MET mutations in melanoma is not clear and correlation with other clinical and laboratory findings is necessary.

Citations
  1. Krishnaswamy S, et al. Ethnic differences and functional analysis of MET mutations in lung cancer. Clin Cancer Res 2009;15(18):5714-23
  2. Hodis E, et al. A landscape of driver mutations in melanoma. Cell 2012;150(2):251-63
  3. Berger MF, et al. Melanoma genome sequencing reveals frequent PREX2 mutations. Nature 2012;485(7399):502-6
Last updated: 2016-11-04 01:04:05 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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