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ERBB2
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Interpretation 302
Tier 2
ERBB2
Variants
ERBB2 L755S
Primary Sites
Breast
Tumor Types
Adenocarcinoma
Invasive Ductal Carcinoma
Interpretation

ERBB2 kinase domain mutations are seen in up to 4.3% of breast cancers. In vitro analyses demonstrated that L755S confer resistance to lapatinib and could potentially emerge as an acquired mutation during therapy. Another preclinical study has shown that L755S is sensitive to irreversible TKIs neratinib and canertinib. The predictive and prognostic as well as therapeutic implications of ERBB2 mutations need further elucidation.

Citations
  1. Herter-Sprie GS, et al. Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment. Front Oncol 2013;3():86
  2. Kancha RK, et al. Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib. PLoS One 2011;6(10):e26760
  3. Bose R, et al. Activating HER2 mutations in HER2 gene amplification negative breast cancer. Cancer Discov 2013;3(2):224-37
  4. Lee JW, et al. Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas. Clin Cancer Res 2006;12(1):57-61
Last updated: 2016-08-12 16:39:15 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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