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EGFR
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Interpretation 300
Tier 2
EGFR
Variants
Primary Sites
Stomach
Tumor Types
Adenocarcinoma
Interpretation

EGFR mutations have been reported in up to 5% of gastric cancers. The prognostic and predictive implications of EGFR mutations in gastric cancer have not been fully determined. Multiple clinical trials involving EGFR small molecule inhibitors and monoclonal antibodies are present, but limited and conflicting data preclude the therapeutic significance of EGFR mutations in gastric cancer.

Citations
  1. Liu Z, et al. Epidermal growth factor receptor mutation in gastric cancer. Pathology 2011;43(3):234-8
  2. Wong H, et al. Molecular targeted therapies in advanced gastric cancer: does tumor histology matter? Therap Adv Gastroenterol 2013;6(1):15-31
  3. Moutinho C, et al. Epidermal growth factor receptor structural alterations in gastric cancer. BMC Cancer 2008;8():10
  4. Dragovich T, et al. Anti-EGFR-Targeted Therapy for Esophageal and Gastric Cancers: An Evolving Concept. J Oncol 2009;2009():804108
Last updated: 2016-10-11 21:48:32 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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